Incidental Mutation 'R5058:Or10c1'
ID 391061
Institutional Source Beutler Lab
Gene Symbol Or10c1
Ensembl Gene ENSMUSG00000049561
Gene Name olfactory receptor family 10 subfamily C member 1
Synonyms Olfr95, GA_x6K02T2PSCP-1651760-1650822, MOR263-6
MMRRC Submission 042648-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R5058 (G1)
Quality Score 110
Status Validated
Chromosome 17
Chromosomal Location 37521804-37522742 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 37522558 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 62 (L62P)
Ref Sequence ENSEMBL: ENSMUSP00000150480 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060728] [ENSMUST00000216318]
AlphaFold Q8VFE2
Predicted Effect probably damaging
Transcript: ENSMUST00000060728
AA Change: L62P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000058929
Gene: ENSMUSG00000049561
AA Change: L62P

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 1.9e-57 PFAM
Pfam:7TM_GPCR_Srsx 34 259 1.7e-6 PFAM
Pfam:7tm_1 40 289 2.2e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216318
AA Change: L62P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.4168 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.2%
Validation Efficiency 100% (79/79)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adprhl1 T C 8: 13,292,625 (GRCm39) Y222C probably damaging Het
Adprs A G 4: 126,212,238 (GRCm39) S94P probably damaging Het
Atp11b A G 3: 35,863,510 (GRCm39) E202G probably benign Het
Cacna1d G T 14: 29,836,201 (GRCm39) S849* probably null Het
Camsap1 T C 2: 25,829,375 (GRCm39) D783G probably benign Het
Cbfa2t2 T A 2: 154,346,665 (GRCm39) I124N probably damaging Het
Ccdc13 A T 9: 121,646,613 (GRCm39) probably benign Het
Cfap44 G A 16: 44,240,567 (GRCm39) probably null Het
Col17a1 C A 19: 47,673,989 (GRCm39) E13* probably null Het
Cybb C G X: 9,316,989 (GRCm39) D246H probably benign Het
Dennd6b A G 15: 89,071,553 (GRCm39) L288P possibly damaging Het
Dhx37 A C 5: 125,499,295 (GRCm39) Y638D probably benign Het
Epb41 G A 4: 131,734,746 (GRCm39) probably benign Het
Esp31 A T 17: 38,955,500 (GRCm39) I48L possibly damaging Het
Fat3 T C 9: 15,908,154 (GRCm39) Q2616R probably damaging Het
Fbxo33 A G 12: 59,265,919 (GRCm39) I116T probably benign Het
Flnb G T 14: 7,924,262 (GRCm38) E1792* probably null Het
Fzd2 G A 11: 102,495,633 (GRCm39) G26R probably damaging Het
Gm11677 T A 11: 111,616,264 (GRCm39) noncoding transcript Het
Gm7137 A T 10: 77,623,905 (GRCm39) probably benign Het
Hnrnpr A G 4: 136,063,648 (GRCm39) T252A possibly damaging Het
Hyal5 T C 6: 24,891,484 (GRCm39) F433L probably damaging Het
Kcnmb4 T A 10: 116,299,833 (GRCm39) probably benign Het
Meltf A G 16: 31,706,421 (GRCm39) probably null Het
Mllt6 G A 11: 97,560,326 (GRCm39) S210N possibly damaging Het
Muc6 T C 7: 141,230,491 (GRCm39) D1213G probably benign Het
Ncam1 A C 9: 49,709,995 (GRCm39) F12C probably benign Het
Nfxl1 A T 5: 72,713,582 (GRCm39) D120E probably benign Het
Nrg1 T C 8: 32,314,587 (GRCm39) Q142R probably damaging Het
Or1j18 T G 2: 36,625,011 (GRCm39) L226R possibly damaging Het
Or2h15 G A 17: 38,441,432 (GRCm39) S217F probably damaging Het
Or56a4 T C 7: 104,806,355 (GRCm39) N178S probably damaging Het
Or5k16 T C 16: 58,736,435 (GRCm39) T190A probably benign Het
Or8c10 C A 9: 38,279,220 (GRCm39) T116K probably damaging Het
Or8g30 C A 9: 39,229,960 (GRCm39) V317L probably benign Het
Or9s18 C A 13: 65,300,743 (GRCm39) A235D possibly damaging Het
Padi2 G T 4: 140,659,432 (GRCm39) V246L probably benign Het
Pgghg C T 7: 140,522,455 (GRCm39) T63I possibly damaging Het
Pitpnm1 A G 19: 4,162,758 (GRCm39) N1117S probably benign Het
Plch1 G T 3: 63,630,202 (GRCm39) T534K probably damaging Het
Poc1a G T 9: 106,227,012 (GRCm39) probably benign Het
Polr3c T C 3: 96,630,833 (GRCm39) I196V probably benign Het
Prph A T 15: 98,953,113 (GRCm39) probably benign Het
Ptprg C A 14: 12,037,387 (GRCm38) T189K possibly damaging Het
R3hcc1 A T 14: 69,941,463 (GRCm39) I183N probably damaging Het
Rundc1 T C 11: 101,316,363 (GRCm39) L145P probably benign Het
Slc26a3 A G 12: 31,520,964 (GRCm39) K723E possibly damaging Het
Slc38a3 T C 9: 107,536,390 (GRCm39) E2G possibly damaging Het
Slc9a5 G T 8: 106,082,490 (GRCm39) V252L probably benign Het
Smim26 C T 2: 144,437,043 (GRCm39) T64M probably benign Het
Socs4 C T 14: 47,527,589 (GRCm39) R175* probably null Het
Srebf2 T C 15: 82,066,251 (GRCm39) S600P probably damaging Het
Tas2r107 A T 6: 131,636,705 (GRCm39) S115T probably damaging Het
Tenm2 T C 11: 36,097,907 (GRCm39) D447G possibly damaging Het
Thbs2 T A 17: 14,896,591 (GRCm39) D766V probably damaging Het
Tinagl1 A G 4: 130,061,250 (GRCm39) V300A probably benign Het
Tle6 T A 10: 81,430,072 (GRCm39) N332I possibly damaging Het
Tle6 C A 10: 81,431,791 (GRCm39) W151L probably damaging Het
Tnfrsf13c C T 15: 82,108,408 (GRCm39) V36M probably damaging Het
Tns2 T C 15: 102,016,295 (GRCm39) I211T possibly damaging Het
Trp63 A G 16: 25,701,344 (GRCm39) N379D probably damaging Het
Trpc2 T C 7: 101,738,316 (GRCm39) W433R probably damaging Het
Tyw1 T A 5: 130,305,927 (GRCm39) L350Q probably benign Het
Usf3 T C 16: 44,033,070 (GRCm39) L76P probably damaging Het
Vmn2r79 T C 7: 86,651,423 (GRCm39) L274P probably damaging Het
Other mutations in Or10c1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02147:Or10c1 APN 17 37,521,877 (GRCm39) missense probably damaging 1.00
IGL03306:Or10c1 APN 17 37,522,568 (GRCm39) missense probably damaging 1.00
PIT4377001:Or10c1 UTSW 17 37,521,980 (GRCm39) missense probably benign 0.00
R0668:Or10c1 UTSW 17 37,522,535 (GRCm39) missense probably damaging 1.00
R0909:Or10c1 UTSW 17 37,521,809 (GRCm39) missense probably benign 0.33
R1442:Or10c1 UTSW 17 37,522,595 (GRCm39) missense probably benign 0.00
R1557:Or10c1 UTSW 17 37,522,244 (GRCm39) missense probably damaging 1.00
R1758:Or10c1 UTSW 17 37,522,204 (GRCm39) missense possibly damaging 0.88
R3195:Or10c1 UTSW 17 37,522,427 (GRCm39) missense possibly damaging 0.87
R3749:Or10c1 UTSW 17 37,522,691 (GRCm39) missense possibly damaging 0.55
R3778:Or10c1 UTSW 17 37,522,649 (GRCm39) missense probably benign
R4458:Or10c1 UTSW 17 37,522,204 (GRCm39) missense possibly damaging 0.88
R4591:Or10c1 UTSW 17 37,522,010 (GRCm39) missense probably benign
R5060:Or10c1 UTSW 17 37,522,307 (GRCm39) missense probably benign 0.00
R5903:Or10c1 UTSW 17 37,521,912 (GRCm39) nonsense probably null
R6294:Or10c1 UTSW 17 37,522,517 (GRCm39) missense probably benign 0.19
R6689:Or10c1 UTSW 17 37,522,048 (GRCm39) missense probably damaging 1.00
R7196:Or10c1 UTSW 17 37,522,084 (GRCm39) missense probably damaging 1.00
R7677:Or10c1 UTSW 17 37,522,386 (GRCm39) nonsense probably null
R8132:Or10c1 UTSW 17 37,522,207 (GRCm39) missense probably damaging 1.00
R8340:Or10c1 UTSW 17 37,522,075 (GRCm39) missense possibly damaging 0.78
R8380:Or10c1 UTSW 17 37,522,232 (GRCm39) missense possibly damaging 0.90
R9716:Or10c1 UTSW 17 37,522,355 (GRCm39) missense possibly damaging 0.50
Predicted Primers PCR Primer
(F):5'- CATAGCGGTCATAGGCCATG -3'
(R):5'- TCAGTTCTAAGCCTTGATAGCC -3'

Sequencing Primer
(F):5'- GTCATAGGCCATGGCAGC -3'
(R):5'- TCTCTCTTGACCAAAGGCTGAAG -3'
Posted On 2016-06-06