Incidental Mutation 'R5025:Tnfsf15'
ID 391288
Institutional Source Beutler Lab
Gene Symbol Tnfsf15
Ensembl Gene ENSMUSG00000050395
Gene Name tumor necrosis factor (ligand) superfamily, member 15
Synonyms TL1A, VEGI, TL1
MMRRC Submission 042616-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R5025 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 63642837-63663296 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 63648125 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 172 (I172V)
Ref Sequence ENSEMBL: ENSMUSP00000050144 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062246]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000062246
AA Change: I172V

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000050144
Gene: ENSMUSG00000050395
AA Change: I172V

DomainStartEndE-ValueType
transmembrane domain 56 78 N/A INTRINSIC
TNF 114 270 1.25e-28 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.0%
Validation Efficiency 100% (40/40)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
PHENOTYPE: Homozygous targeted mutants display decreased clinical severity in experimental autoimmune encephalomyelitis (EAE) and collagen-induced arthritis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm2 T A 7: 119,153,719 (GRCm39) F10I unknown Het
Adad1 G T 3: 37,119,359 (GRCm39) A147S probably damaging Het
Atg14 T G 14: 47,783,273 (GRCm39) N354T probably damaging Het
Brip1 T A 11: 85,955,806 (GRCm39) E902D probably benign Het
Brwd1 A G 16: 95,855,172 (GRCm39) S419P probably damaging Het
Camsap3 A G 8: 3,654,244 (GRCm39) K638R probably damaging Het
Dennd4c T A 4: 86,713,536 (GRCm39) probably null Het
Dnah3 T C 7: 119,671,128 (GRCm39) N585S probably benign Het
Eef1akmt2 C A 7: 132,453,218 (GRCm39) W38L probably damaging Het
Fasn A T 11: 120,702,734 (GRCm39) D1709E probably benign Het
Fbrsl1 T C 5: 110,565,767 (GRCm39) D179G probably damaging Het
Fbxl18 A T 5: 142,872,068 (GRCm39) I389N probably damaging Het
Fuca1 G T 4: 135,660,237 (GRCm39) G252C probably damaging Het
Fut9 T A 4: 25,620,502 (GRCm39) H104L probably damaging Het
Glra1 C T 11: 55,427,331 (GRCm39) probably null Het
Gpsm1 T C 2: 26,210,008 (GRCm39) V45A possibly damaging Het
Hadha A G 5: 30,359,959 (GRCm39) probably benign Het
Hddc2 C T 10: 31,203,949 (GRCm39) T192I probably benign Het
Herc1 A T 9: 66,377,608 (GRCm39) K3458M possibly damaging Het
Igkv14-100 A G 6: 68,496,383 (GRCm39) D92G probably damaging Het
Il17rc T C 6: 113,449,327 (GRCm39) V88A possibly damaging Het
Inpp5j T C 11: 3,450,664 (GRCm39) D563G probably damaging Het
Lamc3 T A 2: 31,798,681 (GRCm39) N462K probably benign Het
Mrpl15 T C 1: 4,854,368 (GRCm39) probably benign Het
Myh7b G C 2: 155,474,293 (GRCm39) R1669S possibly damaging Het
Obi1 C T 14: 104,745,466 (GRCm39) G70E probably damaging Het
Or2n1c T C 17: 38,519,334 (GRCm39) L66P probably damaging Het
Or5b122 G T 19: 13,562,886 (GRCm39) A30S probably benign Het
Psg20 T C 7: 18,408,291 (GRCm39) *473W probably null Het
Rimbp3 A G 16: 17,027,671 (GRCm39) E365G probably damaging Het
Snai2 A G 16: 14,526,053 (GRCm39) T235A possibly damaging Het
Tg A T 15: 66,579,779 (GRCm39) Y1528F probably damaging Het
Tlr3 A G 8: 45,856,075 (GRCm39) V35A probably benign Het
Tns1 G A 1: 73,964,641 (GRCm39) T1330I probably damaging Het
Zc3h6 T A 2: 128,852,353 (GRCm39) F330I possibly damaging Het
Zdbf2 A G 1: 63,342,809 (GRCm39) E396G possibly damaging Het
Other mutations in Tnfsf15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00674:Tnfsf15 APN 4 63,652,483 (GRCm39) splice site probably benign
IGL00743:Tnfsf15 APN 4 63,652,518 (GRCm39) missense probably benign 0.00
IGL03189:Tnfsf15 APN 4 63,648,289 (GRCm39) splice site probably benign
R0158:Tnfsf15 UTSW 4 63,648,229 (GRCm39) missense possibly damaging 0.95
R1824:Tnfsf15 UTSW 4 63,651,588 (GRCm39) missense probably benign 0.03
R3122:Tnfsf15 UTSW 4 63,652,522 (GRCm39) missense probably benign 0.00
R4595:Tnfsf15 UTSW 4 63,648,180 (GRCm39) nonsense probably null
R6123:Tnfsf15 UTSW 4 63,663,162 (GRCm39) missense probably benign 0.00
R6376:Tnfsf15 UTSW 4 63,663,267 (GRCm39) missense probably damaging 0.98
R7104:Tnfsf15 UTSW 4 63,647,887 (GRCm39) missense probably damaging 1.00
R7173:Tnfsf15 UTSW 4 63,647,889 (GRCm39) missense probably damaging 1.00
R9448:Tnfsf15 UTSW 4 63,663,305 (GRCm39) missense possibly damaging 0.46
Predicted Primers PCR Primer
(F):5'- TCTTCCAAGGAGAACGTGGC -3'
(R):5'- GTTCTGACCTGTGCCATTTAAAC -3'

Sequencing Primer
(F):5'- AACGTGGCCCCAAGGTAG -3'
(R):5'- GACCTGTGCCATTTAAACTTCTC -3'
Posted On 2016-06-06