Incidental Mutation 'R5030:Sgo2a'
ID 391596
Institutional Source Beutler Lab
Gene Symbol Sgo2a
Ensembl Gene ENSMUSG00000026039
Gene Name shugoshin 2A
Synonyms Tripin, 5730576N04Rik, D1Ertd8e, Sgol2, Sgol2a, 1110007N04Rik
MMRRC Submission 042621-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5030 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 58035130-58065058 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 58056918 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 1034 (L1034*)
Ref Sequence ENSEMBL: ENSMUSP00000027202 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027202] [ENSMUST00000163061]
AlphaFold Q7TSY8
Predicted Effect probably null
Transcript: ENSMUST00000027202
AA Change: L1034*
SMART Domains Protein: ENSMUSP00000027202
Gene: ENSMUSG00000026039
AA Change: L1034*

DomainStartEndE-ValueType
coiled coil region 54 109 N/A INTRINSIC
low complexity region 182 198 N/A INTRINSIC
low complexity region 371 381 N/A INTRINSIC
low complexity region 396 431 N/A INTRINSIC
low complexity region 583 597 N/A INTRINSIC
low complexity region 718 729 N/A INTRINSIC
low complexity region 1068 1078 N/A INTRINSIC
low complexity region 1112 1125 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000163061
SMART Domains Protein: ENSMUSP00000124053
Gene: ENSMUSG00000054770

DomainStartEndE-ValueType
BTB 23 123 1.01e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000190746
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.1%
Validation Efficiency 98% (87/89)
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation display male and female infertility with abnormalities in meiosis but not in mitosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930584F24Rik A C 5: 26,684,783 (GRCm39) noncoding transcript Het
Abca15 A T 7: 119,939,224 (GRCm39) E206V probably damaging Het
Acy1 A G 9: 106,310,596 (GRCm39) F343L probably benign Het
Adam22 T C 5: 8,229,645 (GRCm39) probably benign Het
Adgrv1 A T 13: 81,607,948 (GRCm39) D4041E probably benign Het
Akr1c14 T C 13: 4,129,102 (GRCm39) S166P probably damaging Het
Alms1 T A 6: 85,604,946 (GRCm39) C2199S probably damaging Het
Atm A T 9: 53,431,409 (GRCm39) Y316* probably null Het
Atp1a1 T C 3: 101,487,133 (GRCm39) D892G probably benign Het
Auts2 A G 5: 131,472,336 (GRCm39) V581A probably benign Het
Bltp1 A G 3: 36,997,548 (GRCm39) probably benign Het
Boll T A 1: 55,394,894 (GRCm39) N57I probably damaging Het
C1s2 A C 6: 124,612,547 (GRCm39) V36G possibly damaging Het
Capza1 T C 3: 104,748,154 (GRCm39) Y70C probably damaging Het
Carnmt1 T C 19: 18,668,950 (GRCm39) S292P possibly damaging Het
Cemip2 T G 19: 21,819,469 (GRCm39) F1087V probably benign Het
Cyp2g1 T G 7: 26,520,226 (GRCm39) V486G probably benign Het
Dennd6b T A 15: 89,080,454 (GRCm39) T49S possibly damaging Het
Dhx58 A T 11: 100,586,963 (GRCm39) I610N probably damaging Het
Elapor2 T A 5: 9,478,502 (GRCm39) N455K probably damaging Het
Fam170a T A 18: 50,415,021 (GRCm39) N222K probably benign Het
Fbn1 A G 2: 125,254,624 (GRCm39) V213A possibly damaging Het
Frem3 A C 8: 81,339,876 (GRCm39) D723A possibly damaging Het
Fsip2 A T 2: 82,818,836 (GRCm39) K4856N possibly damaging Het
Galnt17 A G 5: 130,905,351 (GRCm39) V571A probably damaging Het
Gm6124 A G 7: 38,872,454 (GRCm39) noncoding transcript Het
Gm8973 A G 15: 98,904,136 (GRCm39) noncoding transcript Het
Gpd2 A G 2: 57,194,417 (GRCm39) T107A probably damaging Het
Hsd17b11 G A 5: 104,151,158 (GRCm39) A192V probably damaging Het
Igkv6-25 C T 6: 70,192,426 (GRCm39) Q4* probably null Het
Kalrn A G 16: 33,796,112 (GRCm39) I1221T probably benign Het
Klhl9 G T 4: 88,638,771 (GRCm39) T490K possibly damaging Het
Lnpep A G 17: 17,799,571 (GRCm39) V28A probably damaging Het
Lrrc37 G A 11: 103,425,675 (GRCm39) P1419S unknown Het
Man2c1 A G 9: 57,047,923 (GRCm39) H843R probably benign Het
Map1b T C 13: 99,570,682 (GRCm39) K680E unknown Het
Metap2 A T 10: 93,715,539 (GRCm39) probably null Het
Mfsd2a A T 4: 122,843,949 (GRCm39) I340N possibly damaging Het
Mgll T C 6: 88,795,647 (GRCm39) probably null Het
Myh9 A G 15: 77,691,998 (GRCm39) probably benign Het
Ncapd3 A T 9: 26,983,062 (GRCm39) I937F probably damaging Het
Neb T C 2: 52,224,504 (GRCm39) probably benign Het
Nova1 A G 12: 46,747,030 (GRCm39) S416P probably damaging Het
Oosp3 T C 19: 11,678,308 (GRCm39) W95R probably benign Het
Or1e16 AGCGGTCGTAGGC AGC 11: 73,286,480 (GRCm39) probably null Het
Or2t26 A T 11: 49,039,188 (GRCm39) M35L probably benign Het
Or5p76 T A 7: 108,122,384 (GRCm39) I258F possibly damaging Het
Or7e175 A T 9: 20,049,363 (GRCm39) K317M probably benign Het
Pcdha7 T A 18: 37,108,501 (GRCm39) S509T probably damaging Het
Pdgfrb T C 18: 61,198,207 (GRCm39) V296A probably benign Het
Pdzd2 A T 15: 12,592,494 (GRCm39) L50* probably null Het
Plcl2 G T 17: 50,914,347 (GRCm39) R452L possibly damaging Het
Poldip3 A T 15: 83,022,392 (GRCm39) F131I possibly damaging Het
Pwwp3a T C 10: 80,076,209 (GRCm39) probably benign Het
Rffl G A 11: 82,703,543 (GRCm39) R127* probably null Het
Sec24d T A 3: 123,152,550 (GRCm39) V854E probably damaging Het
Slc39a4 C T 15: 76,498,283 (GRCm39) D385N probably damaging Het
Spaca1 A T 4: 34,039,247 (GRCm39) N95K possibly damaging Het
Spag17 C T 3: 99,992,657 (GRCm39) Q1718* probably null Het
Spdl1 C T 11: 34,714,267 (GRCm39) A141T probably benign Het
Stxbp3-ps A T 19: 9,535,714 (GRCm39) noncoding transcript Het
Supv3l1 G T 10: 62,266,394 (GRCm39) A594D probably damaging Het
Tcaf3 A G 6: 42,573,867 (GRCm39) V115A probably benign Het
Tmem131 T C 1: 36,866,255 (GRCm39) N483S possibly damaging Het
Tonsl A T 15: 76,522,301 (GRCm39) C231S probably damaging Het
Trav9n-4 T C 14: 53,532,305 (GRCm39) F53S possibly damaging Het
Trgv7 G T 13: 19,362,558 (GRCm39) L82F probably damaging Het
Trim45 T G 3: 100,835,388 (GRCm39) V457G probably damaging Het
Trpm1 T A 7: 63,885,579 (GRCm39) I865N probably damaging Het
Trpm3 C A 19: 22,676,130 (GRCm39) L99I probably benign Het
Twist1 T A 12: 34,008,440 (GRCm39) L155Q probably damaging Het
Vac14 A G 8: 111,437,018 (GRCm39) E577G possibly damaging Het
Vmn1r184 T C 7: 25,966,881 (GRCm39) V209A probably benign Het
Xdh C T 17: 74,198,288 (GRCm39) G1200R probably damaging Het
Zbbx C T 3: 74,990,990 (GRCm39) D290N possibly damaging Het
Zbtb40 T C 4: 136,725,263 (GRCm39) T585A probably benign Het
Zc3h4 T A 7: 16,156,155 (GRCm39) D262E unknown Het
Zfp777 G T 6: 48,014,601 (GRCm39) D368E probably damaging Het
Other mutations in Sgo2a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00507:Sgo2a APN 1 58,055,753 (GRCm39) missense probably damaging 1.00
IGL00534:Sgo2a APN 1 58,055,503 (GRCm39) missense probably damaging 1.00
IGL00902:Sgo2a APN 1 58,055,258 (GRCm39) missense probably benign 0.00
IGL01571:Sgo2a APN 1 58,057,133 (GRCm39) missense probably damaging 0.99
IGL02268:Sgo2a APN 1 58,056,881 (GRCm39) missense probably benign 0.10
IGL02756:Sgo2a APN 1 58,055,509 (GRCm39) missense probably damaging 1.00
IGL02887:Sgo2a APN 1 58,055,511 (GRCm39) missense probably damaging 0.99
IGL02991:Sgo2a APN 1 58,054,514 (GRCm39) intron probably benign
crazy UTSW 1 58,056,954 (GRCm39) missense probably benign 0.11
harpo UTSW 1 58,058,819 (GRCm39) nonsense probably null
mashugana UTSW 1 58,055,726 (GRCm39) missense probably damaging 1.00
meshugas UTSW 1 58,042,092 (GRCm39) nonsense probably null
R0036:Sgo2a UTSW 1 58,054,787 (GRCm39) missense probably benign 0.14
R0036:Sgo2a UTSW 1 58,054,787 (GRCm39) missense probably benign 0.14
R0095:Sgo2a UTSW 1 58,054,714 (GRCm39) missense probably benign 0.11
R0325:Sgo2a UTSW 1 58,055,856 (GRCm39) missense probably benign
R0464:Sgo2a UTSW 1 58,039,253 (GRCm39) missense probably damaging 0.98
R0699:Sgo2a UTSW 1 58,037,308 (GRCm39) nonsense probably null
R1251:Sgo2a UTSW 1 58,039,121 (GRCm39) critical splice acceptor site probably null
R1355:Sgo2a UTSW 1 58,057,124 (GRCm39) missense possibly damaging 0.91
R1457:Sgo2a UTSW 1 58,054,965 (GRCm39) missense probably benign 0.00
R2244:Sgo2a UTSW 1 58,056,213 (GRCm39) missense probably benign 0.00
R3896:Sgo2a UTSW 1 58,052,805 (GRCm39) missense probably damaging 0.99
R4919:Sgo2a UTSW 1 58,037,293 (GRCm39) missense probably damaging 0.99
R5123:Sgo2a UTSW 1 58,055,726 (GRCm39) missense probably damaging 1.00
R5317:Sgo2a UTSW 1 58,054,683 (GRCm39) missense probably benign
R5767:Sgo2a UTSW 1 58,058,819 (GRCm39) nonsense probably null
R5844:Sgo2a UTSW 1 58,055,556 (GRCm39) missense probably damaging 0.99
R6018:Sgo2a UTSW 1 58,056,118 (GRCm39) missense probably benign 0.01
R6039:Sgo2a UTSW 1 58,055,775 (GRCm39) missense possibly damaging 0.78
R6039:Sgo2a UTSW 1 58,055,775 (GRCm39) missense possibly damaging 0.78
R6450:Sgo2a UTSW 1 58,042,092 (GRCm39) nonsense probably null
R6998:Sgo2a UTSW 1 58,055,799 (GRCm39) missense probably damaging 0.99
R7073:Sgo2a UTSW 1 58,056,944 (GRCm39) missense possibly damaging 0.73
R7508:Sgo2a UTSW 1 58,056,954 (GRCm39) missense probably benign 0.11
R7722:Sgo2a UTSW 1 58,055,696 (GRCm39) missense probably benign 0.45
R8094:Sgo2a UTSW 1 58,056,300 (GRCm39) missense possibly damaging 0.77
R8176:Sgo2a UTSW 1 58,056,252 (GRCm39) missense possibly damaging 0.93
R8782:Sgo2a UTSW 1 58,056,616 (GRCm39) start gained probably benign
R8899:Sgo2a UTSW 1 58,058,822 (GRCm39) missense possibly damaging 0.85
R8912:Sgo2a UTSW 1 58,056,560 (GRCm39) missense probably damaging 0.99
R9106:Sgo2a UTSW 1 58,037,283 (GRCm39) missense possibly damaging 0.59
R9256:Sgo2a UTSW 1 58,058,772 (GRCm39) missense possibly damaging 0.77
R9688:Sgo2a UTSW 1 58,056,737 (GRCm39) missense probably damaging 1.00
X0065:Sgo2a UTSW 1 58,055,517 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGAGAAAGCTCCCTCTCGG -3'
(R):5'- TAAAACTCTGGCCTACCCGG -3'

Sequencing Primer
(F):5'- GTTGTTCTCCTGAAACCCACGG -3'
(R):5'- ACCCGGTGTCGACTTCTGTG -3'
Posted On 2016-06-06