Incidental Mutation 'IGL00508:Fpr2'
ID3920
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fpr2
Ensembl Gene ENSMUSG00000052270
Gene Nameformyl peptide receptor 2
SynonymsE330010I07Rik, Fpr-rs2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.111) question?
Stock #IGL00508
Quality Score
Status
Chromosome17
Chromosomal Location17887824-17893952 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 17892772 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Isoleucine at position 10 (N10I)
Ref Sequence ENSEMBL: ENSMUSP00000065799 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054871] [ENSMUST00000064068] [ENSMUST00000149944]
Predicted Effect probably benign
Transcript: ENSMUST00000054871
SMART Domains Protein: ENSMUSP00000093316
Gene: ENSMUSG00000079700

DomainStartEndE-ValueType
Pfam:7tm_1 43 302 2.2e-43 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000064068
AA Change: N10I

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000065799
Gene: ENSMUSG00000052270
AA Change: N10I

DomainStartEndE-ValueType
Pfam:7tm_1 43 302 4.3e-36 PFAM
low complexity region 326 341 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000149944
AA Change: N10I
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted reporter allele exhibit altered leukocyte responses and experimentally induced inflammation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A C 13: 81,506,187 D2188E probably damaging Het
Atrx A G X: 105,823,799 S2026P probably damaging Het
Cacna1b A C 2: 24,657,289 probably null Het
Cfap46 C T 7: 139,660,689 S56N probably damaging Het
Cfap57 C T 4: 118,581,170 probably null Het
Ckap5 T G 2: 91,606,256 V1567G probably damaging Het
Cyp2c38 A T 19: 39,460,725 Y61* probably null Het
D130052B06Rik A G 11: 33,599,402 E7G unknown Het
Dhx38 A G 8: 109,556,934 L527P possibly damaging Het
Dnaaf5 A G 5: 139,177,946 N653D probably benign Het
Dnah8 T G 17: 30,855,930 M4541R probably damaging Het
Dpyd A T 3: 119,064,987 T617S probably benign Het
Frmd4a A T 2: 4,594,734 K524* probably null Het
Gpr45 C T 1: 43,032,292 P32S possibly damaging Het
H2-Eb2 A T 17: 34,334,367 I176F probably damaging Het
Hcrtr1 T A 4: 130,137,269 N74I probably damaging Het
Ifi47 C T 11: 49,095,414 Q3* probably null Het
Krt8 T A 15: 101,998,025 M350L probably benign Het
Lilra6 A G 7: 3,911,554 S533P probably benign Het
Map1b A T 13: 99,429,233 S2327T unknown Het
Mcoln3 T A 3: 146,133,928 I345N probably damaging Het
Mettl3 C A 14: 52,294,979 probably benign Het
Mgat4a G A 1: 37,449,123 R472* probably null Het
Micall1 A G 15: 79,130,568 K715E probably damaging Het
Pak1 G T 7: 97,854,568 G37C probably benign Het
Pomt2 T G 12: 87,119,627 H426P probably damaging Het
Pou2f3 G A 9: 43,139,963 P155S probably benign Het
Psg25 A G 7: 18,529,731 Y56H probably benign Het
Rab9 G T X: 166,457,864 Y150* probably null Het
Rhox2g T A X: 37,642,810 N152I probably damaging Het
Sema6d T C 2: 124,656,924 probably benign Het
Simc1 C A 13: 54,525,176 Q446K probably benign Het
Svs2 G T 2: 164,237,042 T315K possibly damaging Het
Syt9 C T 7: 107,425,367 R156* probably null Het
Tmem260 A T 14: 48,509,121 Y618F probably damaging Het
Wdr44 A G X: 23,800,544 I719V possibly damaging Het
Zfp518a T G 19: 40,913,470 I614M probably damaging Het
Other mutations in Fpr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01481:Fpr2 APN 17 17892763 missense probably benign 0.01
IGL02320:Fpr2 APN 17 17893346 missense probably benign 0.05
IGL02479:Fpr2 APN 17 17892812 missense probably benign 0.01
R1553:Fpr2 UTSW 17 17893594 missense possibly damaging 0.87
R3906:Fpr2 UTSW 17 17893549 missense probably benign 0.03
R4424:Fpr2 UTSW 17 17893132 missense probably damaging 1.00
R4480:Fpr2 UTSW 17 17893753 missense probably benign 0.01
R4521:Fpr2 UTSW 17 17893247 missense probably benign 0.01
R4718:Fpr2 UTSW 17 17893336 missense probably benign 0.00
R5385:Fpr2 UTSW 17 17893047 missense probably benign 0.00
R7184:Fpr2 UTSW 17 17893271 missense unknown
R7233:Fpr2 UTSW 17 17893504 missense probably damaging 1.00
Posted On2012-04-20