Incidental Mutation 'IGL00500:Fpr1'
ID 3921
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fpr1
Ensembl Gene ENSMUSG00000045551
Gene Name formyl peptide receptor 1
Synonyms fMLF-R, FPR
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00500
Quality Score
Status
Chromosome 17
Chromosomal Location 18096733-18104201 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 18097263 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 242 (Q242L)
Ref Sequence ENSEMBL: ENSMUSP00000052894 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061516]
AlphaFold P33766
Predicted Effect probably benign
Transcript: ENSMUST00000061516
AA Change: Q242L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000052894
Gene: ENSMUSG00000045551
AA Change: Q242L

DomainStartEndE-ValueType
Pfam:7tm_1 51 312 8.2e-40 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
PHENOTYPE: Targeted null mice are viable and developmentally normal but show increased susceptibility to L. monocytogenes challenge, as shown by increased mortality and bacterial burden in liver/spleen early post-infection. Mutant neutrophils fail to respond to fMLF either in calcium flux or chemotaxis assays. [provided by MGI curators]
Allele List at MGI

All alleles(1) : Targeted, knock-out(1)

Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm3 A G 7: 119,383,567 (GRCm39) E576G probably damaging Het
Adnp A G 2: 168,025,243 (GRCm39) V684A possibly damaging Het
Agl A G 3: 116,566,469 (GRCm39) W965R probably damaging Het
AI467606 G A 7: 126,691,505 (GRCm39) V27I probably benign Het
Ankrd34b G A 13: 92,575,295 (GRCm39) G176R probably benign Het
Atp2a1 C T 7: 126,046,388 (GRCm39) W72* probably null Het
Atp6v1a T C 16: 43,931,946 (GRCm39) Q114R probably benign Het
B4galt2 A T 4: 117,734,378 (GRCm39) L257Q probably damaging Het
Chrna10 A T 7: 101,761,615 (GRCm39) C325* probably null Het
Clip2 A G 5: 134,529,011 (GRCm39) probably benign Het
Crocc2 C T 1: 93,144,766 (GRCm39) Q1437* probably null Het
Csmd1 C T 8: 15,971,139 (GRCm39) V3059M probably damaging Het
Cst5 C A 2: 149,247,501 (GRCm39) S72R probably damaging Het
Dapk1 A G 13: 60,908,618 (GRCm39) D1077G probably damaging Het
Dhx9 T C 1: 153,341,494 (GRCm39) T585A probably damaging Het
Fam210a G A 18: 68,408,854 (GRCm39) T152I possibly damaging Het
Fbn1 T A 2: 125,159,436 (GRCm39) Q2214L probably damaging Het
G2e3 A G 12: 51,400,581 (GRCm39) probably null Het
Gcdh C T 8: 85,615,146 (GRCm39) probably benign Het
Gm18856 T C 13: 14,140,319 (GRCm39) probably benign Het
Itgb2 T A 10: 77,400,558 (GRCm39) W724R probably damaging Het
Klhl2 T C 8: 65,202,120 (GRCm39) T519A probably benign Het
Krtap12-1 G T 10: 77,556,814 (GRCm39) C119F possibly damaging Het
Nrap T A 19: 56,361,341 (GRCm39) K369N probably damaging Het
Nrg1 T A 8: 32,312,342 (GRCm39) probably null Het
Plekhh3 T A 11: 101,056,519 (GRCm39) probably null Het
Ppm1b A G 17: 85,310,712 (GRCm39) S289G probably damaging Het
Prol1 A T 5: 88,476,550 (GRCm39) *313C probably null Het
Rab40c T C 17: 26,104,059 (GRCm39) E111G probably damaging Het
Skint11 T A 4: 114,051,906 (GRCm39) C85S probably benign Het
Slc9a2 G A 1: 40,802,743 (GRCm39) E598K possibly damaging Het
Slfn8 T A 11: 82,904,310 (GRCm39) D360V possibly damaging Het
Sspo C A 6: 48,474,355 (GRCm39) C4925* probably null Het
Vps8 A G 16: 21,261,084 (GRCm39) T75A possibly damaging Het
Wfdc12 A T 2: 164,032,170 (GRCm39) I40N probably damaging Het
Zfp608 T A 18: 55,121,405 (GRCm39) T61S probably benign Het
Other mutations in Fpr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01473:Fpr1 APN 17 18,097,954 (GRCm39) missense possibly damaging 0.95
IGL01704:Fpr1 APN 17 18,097,234 (GRCm39) missense possibly damaging 0.64
IGL01900:Fpr1 APN 17 18,097,783 (GRCm39) missense probably damaging 0.96
IGL02548:Fpr1 APN 17 18,096,915 (GRCm39) missense probably benign 0.01
G5030:Fpr1 UTSW 17 18,097,068 (GRCm39) missense probably damaging 1.00
PIT4445001:Fpr1 UTSW 17 18,097,155 (GRCm39) missense probably benign
R0284:Fpr1 UTSW 17 18,097,618 (GRCm39) missense probably damaging 0.99
R1440:Fpr1 UTSW 17 18,097,525 (GRCm39) missense probably benign 0.01
R1631:Fpr1 UTSW 17 18,097,263 (GRCm39) missense probably benign 0.00
R1823:Fpr1 UTSW 17 18,097,315 (GRCm39) missense probably benign 0.00
R1994:Fpr1 UTSW 17 18,097,879 (GRCm39) missense probably benign 0.01
R2168:Fpr1 UTSW 17 18,097,471 (GRCm39) missense possibly damaging 0.52
R2364:Fpr1 UTSW 17 18,097,872 (GRCm39) nonsense probably null
R3110:Fpr1 UTSW 17 18,096,897 (GRCm39) missense probably benign 0.01
R3111:Fpr1 UTSW 17 18,096,897 (GRCm39) missense probably benign 0.01
R3112:Fpr1 UTSW 17 18,096,897 (GRCm39) missense probably benign 0.01
R3440:Fpr1 UTSW 17 18,097,420 (GRCm39) missense probably benign
R3949:Fpr1 UTSW 17 18,097,191 (GRCm39) missense probably benign
R5745:Fpr1 UTSW 17 18,097,344 (GRCm39) missense probably benign 0.05
R5750:Fpr1 UTSW 17 18,097,525 (GRCm39) missense probably benign 0.01
R6130:Fpr1 UTSW 17 18,097,897 (GRCm39) missense probably benign 0.13
R6187:Fpr1 UTSW 17 18,097,190 (GRCm39) nonsense probably null
R7017:Fpr1 UTSW 17 18,097,654 (GRCm39) missense probably benign 0.00
R7358:Fpr1 UTSW 17 18,097,242 (GRCm39) missense probably damaging 0.99
R7840:Fpr1 UTSW 17 18,097,634 (GRCm39) missense probably benign 0.15
R8762:Fpr1 UTSW 17 18,097,851 (GRCm39) missense probably damaging 1.00
R9033:Fpr1 UTSW 17 18,097,691 (GRCm39) nonsense probably null
R9080:Fpr1 UTSW 17 18,097,212 (GRCm39) missense probably benign 0.02
R9144:Fpr1 UTSW 17 18,097,626 (GRCm39) missense probably damaging 1.00
R9260:Fpr1 UTSW 17 18,098,006 (GRCm39) splice site probably benign
R9655:Fpr1 UTSW 17 18,097,618 (GRCm39) missense probably damaging 0.99
Posted On 2012-04-20