Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03052:Or7g25'

392187

Institutional Source

Beutler Lab

Gene Symbol

Or7g25

Ensembl Gene

ENSMUSG00000048391

Gene Name

olfactory receptor family 7 subfamily G member 25

Synonyms

GA_x6K02T2PVTD-12986331-12985390, Olfr843, MOR155-2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.128) question?

Stock #

IGL03052 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

19159653-19160759 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 19159938 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 252 (Y252*)

Ref Sequence

ENSEMBL: ENSMUSP00000151203 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061365] [ENSMUST00000214019] [ENSMUST00000214267]

AlphaFold

Q7TRG4

Predicted Effect

probably null
Transcript: ENSMUST00000061365
AA Change: Y252*

SMART Domains

Protein: ENSMUSP00000051027
Gene: ENSMUSG00000048391
AA Change: Y252*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	2.4e-51	PFAM
Pfam:7tm_1	41	290	3.3e-24	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000214019
AA Change: Y252*

Predicted Effect

probably null
Transcript: ENSMUST00000214267
AA Change: Y252*

Meta Mutation Damage Score

0.9665

Coding Region Coverage

1x: 0.0%
3x: 0.0%
10x: 0.0%
20x: 0.0%

Validation Efficiency

100% (53/53)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acap3	T	C	4: 155,987,815 (GRCm39)	F517S	probably damaging	Het
Afap1l1	A	G	18: 61,881,894 (GRCm39)	V267A	probably benign	Het
Asap1	A	G	15: 64,025,683 (GRCm39)		probably benign	Het
Bcl6	T	C	16: 23,793,788 (GRCm39)		probably benign	Het
Ccdc73	C	A	2: 104,782,281 (GRCm39)	H212Q	possibly damaging	Het
Cct5	A	T	15: 31,597,633 (GRCm39)	H85Q	probably damaging	Het
Cfap69	A	C	5: 5,639,206 (GRCm39)	L238R	probably damaging	Het
Chl1	A	T	6: 103,668,628 (GRCm39)	T470S	probably benign	Het
Cnga4	T	C	7: 105,053,932 (GRCm39)	S12P	probably benign	Het
Cyp2c29	C	T	19: 39,275,662 (GRCm39)	T34M	possibly damaging	Het
Cyp2c67	T	C	19: 39,637,329 (GRCm39)	D49G	possibly damaging	Het
Dab2ip	A	G	2: 35,533,909 (GRCm39)	Q45R	probably benign	Het
Ddhd1	A	G	14: 45,858,240 (GRCm39)	V164A	probably damaging	Het
Dnaaf8	A	T	16: 4,795,358 (GRCm39)		noncoding transcript	Het
Dnah7c	A	G	1: 46,671,309 (GRCm39)	Y1566C	probably damaging	Het
Dnase1l2	T	C	17: 24,659,968 (GRCm39)		probably benign	Het
Dock2	G	T	11: 34,182,853 (GRCm39)	N1593K	probably benign	Het
Dpp6	G	T	5: 27,914,506 (GRCm39)	M530I	probably benign	Het
Epm2a	T	C	10: 11,332,974 (GRCm39)	V269A	possibly damaging	Het
Fcna	G	C	2: 25,520,693 (GRCm39)		probably benign	Het
Fgf2	A	G	3: 37,403,161 (GRCm39)	S55G	probably benign	Het
Frem3	C	T	8: 81,341,159 (GRCm39)	P1151S	probably damaging	Het
Gm15737	T	C	6: 92,846,481 (GRCm39)		probably benign	Het
Gpi-ps	T	A	8: 5,689,816 (GRCm39)		noncoding transcript	Het
Gvin-ps6	T	C	7: 106,022,902 (GRCm39)		noncoding transcript	Het
Hoxa3	G	A	6: 52,147,267 (GRCm39)		probably benign	Het
Larp7-ps	A	G	4: 92,079,287 (GRCm39)	L178P	probably benign	Het
Macf1	T	C	4: 123,281,188 (GRCm39)	I3770V	probably damaging	Het
Mapk15	G	T	15: 75,865,731 (GRCm39)	R8L	probably benign	Het
Mecom	C	T	3: 30,015,112 (GRCm39)		probably benign	Het
Mknk2	C	T	10: 80,505,496 (GRCm39)	R154H	probably benign	Het
Mrgprb3	A	T	7: 48,293,341 (GRCm39)	V70E	possibly damaging	Het
Mtdh	A	G	15: 34,140,876 (GRCm39)	K570E	possibly damaging	Het
Myo5c	G	T	9: 75,159,798 (GRCm39)		probably benign	Het
Myom2	T	C	8: 15,173,442 (GRCm39)		probably benign	Het
Or52m2	C	T	7: 102,263,656 (GRCm39)	R180Q	probably benign	Het
Or5b124	T	C	19: 13,611,090 (GRCm39)	I205T	probably benign	Het
Pcca	A	T	14: 123,124,513 (GRCm39)	M695L	probably benign	Het
Pcdha2	A	T	18: 37,074,670 (GRCm39)	D767V	probably damaging	Het
Plekhs1	G	A	19: 56,459,189 (GRCm39)	D16N	probably benign	Het
Prr11	T	C	11: 86,994,478 (GRCm39)	N56S	possibly damaging	Het
Rxfp2	A	T	5: 149,966,645 (GRCm39)		probably benign	Het
Sacs	G	T	14: 61,445,307 (GRCm39)	G2451V	probably damaging	Het
Scarb1	G	A	5: 125,371,163 (GRCm39)	A4V	probably damaging	Het
Scart2	G	A	7: 139,828,827 (GRCm39)	C162Y	probably damaging	Het
Sik3	C	A	9: 46,109,447 (GRCm39)	T475K	probably damaging	Het
Slco1b2	A	T	6: 141,594,311 (GRCm39)	I59L	probably benign	Het
Sspo	G	A	6: 48,437,387 (GRCm39)	G1382R	probably damaging	Het
Stx16	C	A	2: 173,934,231 (GRCm39)	P145T	probably benign	Het
Tnrc18	G	A	5: 142,760,974 (GRCm39)	A674V	unknown	Het
Uqcrq	A	G	11: 53,321,476 (GRCm39)	V14A	possibly damaging	Het
Vmn2r79	A	T	7: 86,652,799 (GRCm39)	E497V	probably benign	Het
Vps8	T	A	16: 21,267,115 (GRCm39)	I166K	probably damaging	Het
Vwa8	A	G	14: 79,302,361 (GRCm39)	D1010G	probably benign	Het
Wnk1	T	A	6: 119,921,760 (GRCm39)		probably benign	Het
Zfand3	T	A	17: 30,279,798 (GRCm39)	M29K	probably benign	Het

Other mutations in Or7g25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02104:Or7g25	APN	9	19,160,166 (GRCm39)	missense	probably benign	0.21
IGL02338:Or7g25	APN	9	19,159,960 (GRCm39)	missense	probably damaging	0.98
IGL03197:Or7g25	APN	9	19,160,098 (GRCm39)	missense	probably benign	0.37
IGL03227:Or7g25	APN	9	19,160,518 (GRCm39)	missense	probably damaging	1.00
IGL03046:Or7g25	UTSW	9	19,160,441 (GRCm39)	missense	probably damaging	0.99
R0423:Or7g25	UTSW	9	19,160,248 (GRCm39)	nonsense	probably null
R1316:Or7g25	UTSW	9	19,160,035 (GRCm39)	missense	probably benign	0.06
R1759:Or7g25	UTSW	9	19,160,384 (GRCm39)	missense	probably benign	0.36
R1782:Or7g25	UTSW	9	19,159,877 (GRCm39)	missense	probably benign	0.04
R2517:Or7g25	UTSW	9	19,160,357 (GRCm39)	missense	probably benign	0.21
R3196:Or7g25	UTSW	9	19,160,495 (GRCm39)	missense	probably damaging	1.00
R3742:Or7g25	UTSW	9	19,159,979 (GRCm39)	missense	possibly damaging	0.91
R4191:Or7g25	UTSW	9	19,160,383 (GRCm39)	missense	probably benign	0.05
R4320:Or7g25	UTSW	9	19,160,052 (GRCm39)	missense	probably damaging	1.00
R4523:Or7g25	UTSW	9	19,160,525 (GRCm39)	missense	probably damaging	0.98
R4756:Or7g25	UTSW	9	19,160,153 (GRCm39)	missense	possibly damaging	0.56
R4908:Or7g25	UTSW	9	19,160,149 (GRCm39)	missense	probably benign	0.00
R5319:Or7g25	UTSW	9	19,160,329 (GRCm39)	missense	possibly damaging	0.60
R5554:Or7g25	UTSW	9	19,160,039 (GRCm39)	missense	probably benign	0.02
R6011:Or7g25	UTSW	9	19,159,807 (GRCm39)	missense	probably damaging	0.98
R7330:Or7g25	UTSW	9	19,160,567 (GRCm39)	missense	probably benign	0.01
R7862:Or7g25	UTSW	9	19,160,736 (GRCm39)	start gained	probably benign
R9544:Or7g25	UTSW	9	19,160,561 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TTTATGGAGATGATAAGACCACAGG -3'
(R):5'- TTGTTCAAGTCATCAAACATGCCTG -3'

Sequencing Primer
(F):5'- CCACAGGAAAGAGAAGGTGTC -3'
(R):5'- AGTCATCAAACATGCCTGCTCTG -3'

Posted On

2016-06-09