Incidental Mutation 'R5102:Or1n1b'
ID 392399
Institutional Source Beutler Lab
Gene Symbol Or1n1b
Ensembl Gene ENSMUSG00000075382
Gene Name olfactory receptor family 1 subfamily N member 1B
Synonyms GA_x6K02T2NLDC-33585366-33584431, Olfr353, MOR127-3
MMRRC Submission 042690-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.211) question?
Stock # R5102 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 36779923-36780858 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 36780056 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Methionine at position 268 (K268M)
Ref Sequence ENSEMBL: ENSMUSP00000149378 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100149] [ENSMUST00000215925] [ENSMUST00000217215]
AlphaFold Q8VGK0
Predicted Effect possibly damaging
Transcript: ENSMUST00000100149
AA Change: K268M

PolyPhen 2 Score 0.871 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000097726
Gene: ENSMUSG00000075382
AA Change: K268M

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.3e-56 PFAM
Pfam:7tm_1 39 288 3e-27 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215925
AA Change: K268M

PolyPhen 2 Score 0.871 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217215
AA Change: K268M

PolyPhen 2 Score 0.871 (Sensitivity: 0.83; Specificity: 0.93)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox4 C T 1: 58,279,937 (GRCm39) R518C probably damaging Het
Apbb2 A T 5: 66,469,592 (GRCm39) probably null Het
Arhgap45 C T 10: 79,857,262 (GRCm39) P254S probably benign Het
Arl4c T C 1: 88,629,322 (GRCm39) D22G probably damaging Het
Asxl1 A G 2: 153,242,875 (GRCm39) T1142A probably benign Het
BC035044 T C 6: 128,861,949 (GRCm39) probably benign Het
Bmp4 T C 14: 46,621,458 (GRCm39) N362S probably damaging Het
Cbll1 G T 12: 31,537,912 (GRCm39) T280N probably damaging Het
Cdh10 A T 15: 18,986,971 (GRCm39) T401S probably benign Het
Cmklr2 A G 1: 63,222,326 (GRCm39) V303A probably damaging Het
Cps1 A T 1: 67,245,952 (GRCm39) M1148L probably benign Het
Crybg1 T C 10: 43,873,832 (GRCm39) D1092G probably damaging Het
Cyth2 A G 7: 45,460,126 (GRCm39) S173P probably damaging Het
D6Ertd527e A T 6: 87,088,793 (GRCm39) I319F unknown Het
Dchs1 A T 7: 105,421,384 (GRCm39) H345Q probably benign Het
Ddx50 A T 10: 62,476,640 (GRCm39) V211E probably damaging Het
Dlx6 AGG AG 6: 6,865,180 (GRCm39) probably null Het
Dnajb5 G A 4: 42,956,639 (GRCm39) D109N possibly damaging Het
Dner A T 1: 84,383,691 (GRCm39) N564K probably damaging Het
Fam234b T C 6: 135,186,282 (GRCm39) S97P probably benign Het
Fam53b G A 7: 132,317,684 (GRCm39) R60* probably null Het
Fmo3 T G 1: 162,791,546 (GRCm39) K244Q probably benign Het
Golim4 A G 3: 75,810,579 (GRCm39) I192T possibly damaging Het
Gprin1 T C 13: 54,887,576 (GRCm39) M233V probably benign Het
Gtf2f1 A T 17: 57,310,626 (GRCm39) V443D probably damaging Het
Hmgcs2 T C 3: 98,187,786 (GRCm39) probably benign Het
Ide T A 19: 37,292,383 (GRCm39) I271L unknown Het
Kat8 G A 7: 127,523,988 (GRCm39) E343K probably damaging Het
Kif14 A G 1: 136,444,141 (GRCm39) I1378V probably benign Het
Lhx3 TCCTACGGGCCGGCCC TCC 2: 26,091,435 (GRCm39) probably null Het
Lhx6 T C 2: 35,984,222 (GRCm39) probably null Het
Lrp2 C T 2: 69,319,502 (GRCm39) G2007D probably damaging Het
Lrp5 T C 19: 3,709,304 (GRCm39) K142R probably damaging Het
Macroh2a1 C G 13: 56,243,936 (GRCm39) probably null Het
Mrpl2 G A 17: 46,960,964 (GRCm39) R286Q probably benign Het
Mtrfr A G 5: 124,476,954 (GRCm39) N83D probably damaging Het
Nacad T A 11: 6,548,528 (GRCm39) D1402V probably damaging Het
Ndfip2 T C 14: 105,535,539 (GRCm39) I275T possibly damaging Het
Neb A C 2: 52,116,582 (GRCm39) V4131G possibly damaging Het
Nfe2l1 G A 11: 96,712,934 (GRCm39) A83V probably damaging Het
Nos3 A G 5: 24,576,625 (GRCm39) D418G probably damaging Het
Or12e7 A T 2: 87,288,138 (GRCm39) M210L probably benign Het
Plcd4 A G 1: 74,604,313 (GRCm39) T764A probably damaging Het
Plppr3 G T 10: 79,701,220 (GRCm39) P541T possibly damaging Het
Polr2a A G 11: 69,637,771 (GRCm39) I191T possibly damaging Het
Pramel18 T C 4: 101,766,436 (GRCm39) F40S probably damaging Het
Rab11fip1 T C 8: 27,646,402 (GRCm39) K225E probably damaging Het
Rara A T 11: 98,857,185 (GRCm39) Q64L possibly damaging Het
Rtkn G A 6: 83,126,754 (GRCm39) V305M probably damaging Het
Sh2b1 A C 7: 126,070,408 (GRCm39) F399V probably benign Het
Slc7a4 T C 16: 17,393,482 (GRCm39) T106A probably damaging Het
Srcap G A 7: 127,129,795 (GRCm39) G539D probably damaging Het
Stab1 C T 14: 30,869,974 (GRCm39) probably null Het
Zfp267 G A 3: 36,216,814 (GRCm39) C55Y possibly damaging Het
Other mutations in Or1n1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02706:Or1n1b APN 2 36,780,731 (GRCm39) missense probably damaging 1.00
IGL02944:Or1n1b APN 2 36,780,800 (GRCm39) missense possibly damaging 0.83
R0101:Or1n1b UTSW 2 36,780,138 (GRCm39) missense probably damaging 1.00
R0118:Or1n1b UTSW 2 36,780,035 (GRCm39) missense probably benign 0.07
R0276:Or1n1b UTSW 2 36,780,035 (GRCm39) missense probably benign 0.26
R0944:Or1n1b UTSW 2 36,780,698 (GRCm39) missense probably damaging 1.00
R0975:Or1n1b UTSW 2 36,780,562 (GRCm39) missense possibly damaging 0.52
R1895:Or1n1b UTSW 2 36,780,458 (GRCm39) missense possibly damaging 0.92
R1946:Or1n1b UTSW 2 36,780,458 (GRCm39) missense possibly damaging 0.92
R2847:Or1n1b UTSW 2 36,780,536 (GRCm39) missense probably damaging 1.00
R4573:Or1n1b UTSW 2 36,780,202 (GRCm39) missense probably damaging 1.00
R4631:Or1n1b UTSW 2 36,780,630 (GRCm39) missense probably benign 0.01
R4647:Or1n1b UTSW 2 36,780,663 (GRCm39) missense probably benign 0.00
R4918:Or1n1b UTSW 2 36,780,344 (GRCm39) missense probably damaging 0.98
R4967:Or1n1b UTSW 2 36,780,719 (GRCm39) missense probably damaging 1.00
R5188:Or1n1b UTSW 2 36,780,405 (GRCm39) missense probably benign
R5392:Or1n1b UTSW 2 36,780,686 (GRCm39) missense probably benign 0.34
R5608:Or1n1b UTSW 2 36,780,527 (GRCm39) missense probably damaging 1.00
R6527:Or1n1b UTSW 2 36,780,594 (GRCm39) missense probably benign 0.02
R8508:Or1n1b UTSW 2 36,780,366 (GRCm39) missense probably damaging 1.00
R8820:Or1n1b UTSW 2 36,780,622 (GRCm39) missense probably benign 0.01
R9052:Or1n1b UTSW 2 36,780,105 (GRCm39) missense probably damaging 1.00
X0017:Or1n1b UTSW 2 36,779,999 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGTTAGCAAGCAATCATTTCC -3'
(R):5'- ATGGTCCCCTTTGTAAGCATTGTC -3'

Sequencing Primer
(F):5'- TGAACACTACTTATCTAACTCATCCC -3'
(R):5'- GTAAGCATTGTCATCTCTTATGTCCG -3'
Posted On 2016-06-15