Incidental Mutation 'R5102:Plppr3'
ID 392431
Institutional Source Beutler Lab
Gene Symbol Plppr3
Ensembl Gene ENSMUSG00000035835
Gene Name phospholipid phosphatase related 3
Synonyms BC005764, Lppr3
MMRRC Submission 042690-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R5102 (G1)
Quality Score 164
Status Not validated
Chromosome 10
Chromosomal Location 79696309-79710468 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 79701220 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Threonine at position 541 (P541T)
Ref Sequence ENSEMBL: ENSMUSP00000089979 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057343] [ENSMUST00000092325] [ENSMUST00000095457] [ENSMUST00000167250] [ENSMUST00000165704] [ENSMUST00000167897] [ENSMUST00000165724] [ENSMUST00000166023] [ENSMUST00000165601] [ENSMUST00000167707] [ENSMUST00000172282]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000057343
SMART Domains Protein: ENSMUSP00000059481
Gene: ENSMUSG00000006498

DomainStartEndE-ValueType
low complexity region 32 38 N/A INTRINSIC
RRM 59 128 9.8e-9 SMART
low complexity region 161 178 N/A INTRINSIC
RRM 184 253 4.75e-7 SMART
low complexity region 305 330 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000092325
AA Change: P541T

PolyPhen 2 Score 0.838 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000089979
Gene: ENSMUSG00000035835
AA Change: P541T

DomainStartEndE-ValueType
transmembrane domain 17 39 N/A INTRINSIC
transmembrane domain 69 91 N/A INTRINSIC
acidPPc 132 276 1.38e-16 SMART
coiled coil region 430 460 N/A INTRINSIC
low complexity region 562 581 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000095457
SMART Domains Protein: ENSMUSP00000093109
Gene: ENSMUSG00000006498

DomainStartEndE-ValueType
Pfam:RRM_6 36 86 1.9e-5 PFAM
Pfam:RRM_5 38 90 3.6e-12 PFAM
low complexity region 121 138 N/A INTRINSIC
RRM 144 213 4.75e-7 SMART
low complexity region 265 290 N/A INTRINSIC
RRM 296 365 1.84e-13 SMART
RRM 413 483 2.6e-13 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000113452
Predicted Effect noncoding transcript
Transcript: ENSMUST00000163111
Predicted Effect noncoding transcript
Transcript: ENSMUST00000164385
Predicted Effect noncoding transcript
Transcript: ENSMUST00000166057
Predicted Effect noncoding transcript
Transcript: ENSMUST00000169580
Predicted Effect noncoding transcript
Transcript: ENSMUST00000166593
Predicted Effect noncoding transcript
Transcript: ENSMUST00000170910
Predicted Effect noncoding transcript
Transcript: ENSMUST00000165153
Predicted Effect probably benign
Transcript: ENSMUST00000167250
SMART Domains Protein: ENSMUSP00000130695
Gene: ENSMUSG00000035835

DomainStartEndE-ValueType
transmembrane domain 17 39 N/A INTRINSIC
transmembrane domain 69 91 N/A INTRINSIC
acidPPc 132 276 1.38e-16 SMART
low complexity region 437 454 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000165704
SMART Domains Protein: ENSMUSP00000127783
Gene: ENSMUSG00000006498

DomainStartEndE-ValueType
low complexity region 32 38 N/A INTRINSIC
RRM 59 128 9.8e-9 SMART
low complexity region 161 178 N/A INTRINSIC
RRM 184 253 4.75e-7 SMART
low complexity region 305 330 N/A INTRINSIC
RRM 336 405 1.84e-13 SMART
RRM 453 523 2.6e-13 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000167897
SMART Domains Protein: ENSMUSP00000127972
Gene: ENSMUSG00000035835

DomainStartEndE-ValueType
transmembrane domain 17 39 N/A INTRINSIC
transmembrane domain 69 91 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000165724
SMART Domains Protein: ENSMUSP00000130749
Gene: ENSMUSG00000006498

DomainStartEndE-ValueType
Pfam:RRM_5 2 40 5.3e-7 PFAM
low complexity region 114 139 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000166023
SMART Domains Protein: ENSMUSP00000127171
Gene: ENSMUSG00000035835

DomainStartEndE-ValueType
transmembrane domain 17 39 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000165601
SMART Domains Protein: ENSMUSP00000128681
Gene: ENSMUSG00000035835

DomainStartEndE-ValueType
transmembrane domain 17 39 N/A INTRINSIC
transmembrane domain 69 91 N/A INTRINSIC
acidPPc 132 266 7.27e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000167707
SMART Domains Protein: ENSMUSP00000132994
Gene: ENSMUSG00000035835

DomainStartEndE-ValueType
transmembrane domain 17 39 N/A INTRINSIC
transmembrane domain 69 91 N/A INTRINSIC
Blast:acidPPc 125 159 8e-11 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184090
Predicted Effect probably benign
Transcript: ENSMUST00000172282
SMART Domains Protein: ENSMUSP00000126192
Gene: ENSMUSG00000006498

DomainStartEndE-ValueType
low complexity region 32 38 N/A INTRINSIC
RRM 59 128 9.8e-9 SMART
low complexity region 161 178 N/A INTRINSIC
RRM 184 253 4.75e-7 SMART
low complexity region 331 356 N/A INTRINSIC
RRM 362 431 1.84e-13 SMART
RRM 479 549 2.6e-13 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox4 C T 1: 58,279,937 (GRCm39) R518C probably damaging Het
Apbb2 A T 5: 66,469,592 (GRCm39) probably null Het
Arhgap45 C T 10: 79,857,262 (GRCm39) P254S probably benign Het
Arl4c T C 1: 88,629,322 (GRCm39) D22G probably damaging Het
Asxl1 A G 2: 153,242,875 (GRCm39) T1142A probably benign Het
BC035044 T C 6: 128,861,949 (GRCm39) probably benign Het
Bmp4 T C 14: 46,621,458 (GRCm39) N362S probably damaging Het
Cbll1 G T 12: 31,537,912 (GRCm39) T280N probably damaging Het
Cdh10 A T 15: 18,986,971 (GRCm39) T401S probably benign Het
Cmklr2 A G 1: 63,222,326 (GRCm39) V303A probably damaging Het
Cps1 A T 1: 67,245,952 (GRCm39) M1148L probably benign Het
Crybg1 T C 10: 43,873,832 (GRCm39) D1092G probably damaging Het
Cyth2 A G 7: 45,460,126 (GRCm39) S173P probably damaging Het
D6Ertd527e A T 6: 87,088,793 (GRCm39) I319F unknown Het
Dchs1 A T 7: 105,421,384 (GRCm39) H345Q probably benign Het
Ddx50 A T 10: 62,476,640 (GRCm39) V211E probably damaging Het
Dlx6 AGG AG 6: 6,865,180 (GRCm39) probably null Het
Dnajb5 G A 4: 42,956,639 (GRCm39) D109N possibly damaging Het
Dner A T 1: 84,383,691 (GRCm39) N564K probably damaging Het
Fam234b T C 6: 135,186,282 (GRCm39) S97P probably benign Het
Fam53b G A 7: 132,317,684 (GRCm39) R60* probably null Het
Fmo3 T G 1: 162,791,546 (GRCm39) K244Q probably benign Het
Golim4 A G 3: 75,810,579 (GRCm39) I192T possibly damaging Het
Gprin1 T C 13: 54,887,576 (GRCm39) M233V probably benign Het
Gtf2f1 A T 17: 57,310,626 (GRCm39) V443D probably damaging Het
Hmgcs2 T C 3: 98,187,786 (GRCm39) probably benign Het
Ide T A 19: 37,292,383 (GRCm39) I271L unknown Het
Kat8 G A 7: 127,523,988 (GRCm39) E343K probably damaging Het
Kif14 A G 1: 136,444,141 (GRCm39) I1378V probably benign Het
Lhx3 TCCTACGGGCCGGCCC TCC 2: 26,091,435 (GRCm39) probably null Het
Lhx6 T C 2: 35,984,222 (GRCm39) probably null Het
Lrp2 C T 2: 69,319,502 (GRCm39) G2007D probably damaging Het
Lrp5 T C 19: 3,709,304 (GRCm39) K142R probably damaging Het
Macroh2a1 C G 13: 56,243,936 (GRCm39) probably null Het
Mrpl2 G A 17: 46,960,964 (GRCm39) R286Q probably benign Het
Mtrfr A G 5: 124,476,954 (GRCm39) N83D probably damaging Het
Nacad T A 11: 6,548,528 (GRCm39) D1402V probably damaging Het
Ndfip2 T C 14: 105,535,539 (GRCm39) I275T possibly damaging Het
Neb A C 2: 52,116,582 (GRCm39) V4131G possibly damaging Het
Nfe2l1 G A 11: 96,712,934 (GRCm39) A83V probably damaging Het
Nos3 A G 5: 24,576,625 (GRCm39) D418G probably damaging Het
Or12e7 A T 2: 87,288,138 (GRCm39) M210L probably benign Het
Or1n1b T A 2: 36,780,056 (GRCm39) K268M possibly damaging Het
Plcd4 A G 1: 74,604,313 (GRCm39) T764A probably damaging Het
Polr2a A G 11: 69,637,771 (GRCm39) I191T possibly damaging Het
Pramel18 T C 4: 101,766,436 (GRCm39) F40S probably damaging Het
Rab11fip1 T C 8: 27,646,402 (GRCm39) K225E probably damaging Het
Rara A T 11: 98,857,185 (GRCm39) Q64L possibly damaging Het
Rtkn G A 6: 83,126,754 (GRCm39) V305M probably damaging Het
Sh2b1 A C 7: 126,070,408 (GRCm39) F399V probably benign Het
Slc7a4 T C 16: 17,393,482 (GRCm39) T106A probably damaging Het
Srcap G A 7: 127,129,795 (GRCm39) G539D probably damaging Het
Stab1 C T 14: 30,869,974 (GRCm39) probably null Het
Zfp267 G A 3: 36,216,814 (GRCm39) C55Y possibly damaging Het
Other mutations in Plppr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00324:Plppr3 APN 10 79,702,503 (GRCm39) missense probably damaging 1.00
IGL01108:Plppr3 APN 10 79,703,355 (GRCm39) missense probably damaging 1.00
IGL01116:Plppr3 APN 10 79,702,757 (GRCm39) missense probably damaging 1.00
IGL01362:Plppr3 APN 10 79,701,795 (GRCm39) missense probably damaging 1.00
IGL03065:Plppr3 APN 10 79,701,880 (GRCm39) missense probably benign 0.06
R0972:Plppr3 UTSW 10 79,700,920 (GRCm39) missense probably damaging 0.99
R1508:Plppr3 UTSW 10 79,703,374 (GRCm39) missense probably damaging 1.00
R1844:Plppr3 UTSW 10 79,702,244 (GRCm39) critical splice donor site probably null
R1907:Plppr3 UTSW 10 79,709,903 (GRCm39) missense probably damaging 1.00
R1982:Plppr3 UTSW 10 79,702,259 (GRCm39) missense probably damaging 1.00
R1984:Plppr3 UTSW 10 79,703,294 (GRCm39) nonsense probably null
R1985:Plppr3 UTSW 10 79,703,294 (GRCm39) nonsense probably null
R2116:Plppr3 UTSW 10 79,701,572 (GRCm39) missense probably benign 0.01
R2355:Plppr3 UTSW 10 79,701,194 (GRCm39) missense possibly damaging 0.81
R4092:Plppr3 UTSW 10 79,703,314 (GRCm39) missense probably damaging 1.00
R4572:Plppr3 UTSW 10 79,701,897 (GRCm39) missense probably benign 0.03
R4685:Plppr3 UTSW 10 79,703,359 (GRCm39) missense probably damaging 1.00
R4824:Plppr3 UTSW 10 79,701,507 (GRCm39) missense possibly damaging 0.81
R5212:Plppr3 UTSW 10 79,698,279 (GRCm39) missense probably benign 0.00
R5584:Plppr3 UTSW 10 79,702,286 (GRCm39) missense probably damaging 1.00
R5684:Plppr3 UTSW 10 79,701,151 (GRCm39) missense possibly damaging 0.81
R5778:Plppr3 UTSW 10 79,702,337 (GRCm39) missense possibly damaging 0.78
R5954:Plppr3 UTSW 10 79,701,960 (GRCm39) missense probably benign 0.05
R6306:Plppr3 UTSW 10 79,697,566 (GRCm39) nonsense probably null
R6357:Plppr3 UTSW 10 79,701,240 (GRCm39) missense probably benign 0.06
R7134:Plppr3 UTSW 10 79,701,537 (GRCm39) missense probably damaging 0.96
R7657:Plppr3 UTSW 10 79,702,272 (GRCm39) missense probably benign 0.21
R8051:Plppr3 UTSW 10 79,702,838 (GRCm39) missense probably damaging 1.00
R8463:Plppr3 UTSW 10 79,703,397 (GRCm39) missense probably damaging 1.00
R9472:Plppr3 UTSW 10 79,702,711 (GRCm39) missense probably damaging 1.00
X0067:Plppr3 UTSW 10 79,701,118 (GRCm39) missense probably benign 0.14
Predicted Primers PCR Primer
(F):5'- CTGTTTACAGCTGCTTCTGAAG -3'
(R):5'- ACTCTACCCTACTGTCCAGG -3'

Sequencing Primer
(F):5'- AGCAGACAGGTGCACCACTG -3'
(R):5'- AGTCATCCTGCCTCCAAGG -3'
Posted On 2016-06-15