Incidental Mutation 'R5040:Virma'
ID 393157
Institutional Source Beutler Lab
Gene Symbol Virma
Ensembl Gene ENSMUSG00000040720
Gene Name vir like m6A methyltransferase associated
Synonyms 1110037F02Rik
MMRRC Submission 042630-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5040 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 11485958-11550684 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 11528746 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 1328 (C1328S)
Ref Sequence ENSEMBL: ENSMUSP00000103943 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055372] [ENSMUST00000059914] [ENSMUST00000108307]
AlphaFold A2AIV2
Predicted Effect probably benign
Transcript: ENSMUST00000055372
SMART Domains Protein: ENSMUSP00000063188
Gene: ENSMUSG00000040720

DomainStartEndE-ValueType
low complexity region 139 153 N/A INTRINSIC
low complexity region 172 198 N/A INTRINSIC
low complexity region 236 267 N/A INTRINSIC
low complexity region 276 297 N/A INTRINSIC
low complexity region 615 625 N/A INTRINSIC
low complexity region 1008 1020 N/A INTRINSIC
low complexity region 1112 1124 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000059914
AA Change: C1278S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000058078
Gene: ENSMUSG00000040720
AA Change: C1278S

DomainStartEndE-ValueType
low complexity region 139 153 N/A INTRINSIC
low complexity region 172 198 N/A INTRINSIC
low complexity region 236 267 N/A INTRINSIC
low complexity region 276 297 N/A INTRINSIC
low complexity region 615 625 N/A INTRINSIC
low complexity region 1008 1020 N/A INTRINSIC
low complexity region 1112 1124 N/A INTRINSIC
low complexity region 1224 1232 N/A INTRINSIC
low complexity region 1443 1458 N/A INTRINSIC
low complexity region 1460 1474 N/A INTRINSIC
low complexity region 1618 1634 N/A INTRINSIC
low complexity region 1684 1697 N/A INTRINSIC
low complexity region 1750 1757 N/A INTRINSIC
low complexity region 1796 1808 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108307
AA Change: C1328S

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000103943
Gene: ENSMUSG00000040720
AA Change: C1328S

DomainStartEndE-ValueType
Pfam:VIR_N 5 266 2e-110 PFAM
low complexity region 276 297 N/A INTRINSIC
low complexity region 615 625 N/A INTRINSIC
low complexity region 1058 1070 N/A INTRINSIC
low complexity region 1162 1174 N/A INTRINSIC
low complexity region 1274 1282 N/A INTRINSIC
low complexity region 1493 1508 N/A INTRINSIC
low complexity region 1510 1524 N/A INTRINSIC
low complexity region 1668 1684 N/A INTRINSIC
low complexity region 1734 1747 N/A INTRINSIC
low complexity region 1800 1807 N/A INTRINSIC
low complexity region 1846 1858 N/A INTRINSIC
Meta Mutation Damage Score 0.0850 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.2%
Validation Efficiency 98% (63/64)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 T C 7: 45,669,578 (GRCm39) Q159R probably benign Het
Ap2a1 T C 7: 44,555,228 (GRCm39) I446V possibly damaging Het
Areg A T 5: 91,292,198 (GRCm39) H166L possibly damaging Het
Arhgap15 T C 2: 43,734,825 (GRCm39) probably null Het
Arhgef17 T C 7: 100,526,032 (GRCm39) D874G probably benign Het
Cast T C 13: 74,872,932 (GRCm39) T452A probably damaging Het
Ccdc154 A T 17: 25,383,566 (GRCm39) T208S probably benign Het
Chst11 T A 10: 83,026,780 (GRCm39) L69Q probably benign Het
Clec2d G A 6: 129,161,793 (GRCm39) R142K probably damaging Het
Dis3l2 A T 1: 86,785,059 (GRCm39) I303F probably damaging Het
Dync2h1 A G 9: 6,992,625 (GRCm39) Y3979H probably benign Het
Ehmt1 A T 2: 24,774,316 (GRCm39) C162S probably benign Het
Eif4g3 G T 4: 137,824,200 (GRCm39) M239I probably damaging Het
Eif5 A G 12: 111,506,284 (GRCm39) D41G probably damaging Het
Elapor1 T A 3: 108,382,317 (GRCm39) D284V probably damaging Het
Fat1 C T 8: 45,476,417 (GRCm39) A1821V probably damaging Het
Fry G A 5: 150,312,319 (GRCm39) A745T probably damaging Het
Galnt9 T C 5: 110,765,771 (GRCm39) L491P probably damaging Het
Gata3 A G 2: 9,863,326 (GRCm39) L396P probably damaging Het
Gyg1 A G 3: 20,176,823 (GRCm39) probably benign Het
Hhip C A 8: 80,724,235 (GRCm39) V336L probably benign Het
Hipk2 G A 6: 38,707,816 (GRCm39) P660S possibly damaging Het
Hnrnpul1 G A 7: 25,442,414 (GRCm39) T276I possibly damaging Het
Ifnl2 G T 7: 28,208,511 (GRCm39) R147S possibly damaging Het
Ilvbl A G 10: 78,419,152 (GRCm39) D467G probably damaging Het
Kcnh1 A T 1: 192,187,783 (GRCm39) H748L probably benign Het
Lyg1 A C 1: 37,989,892 (GRCm39) probably benign Het
Mak A G 13: 41,183,574 (GRCm39) Y544H possibly damaging Het
Med1 A G 11: 98,046,230 (GRCm39) probably benign Het
Mogat2 T C 7: 98,887,724 (GRCm39) T17A possibly damaging Het
Myom3 T C 4: 135,516,970 (GRCm39) S847P probably damaging Het
Nprl2 T G 9: 107,419,599 (GRCm39) C9G probably null Het
Or5b125-ps1 T A 19: 13,056,307 (GRCm39) noncoding transcript Het
Pcmtd1 T C 1: 7,190,599 (GRCm39) Y23H probably damaging Het
Pkd1 C A 17: 24,790,234 (GRCm39) H972Q probably benign Het
Rbm26 A G 14: 105,358,452 (GRCm39) I929T probably benign Het
Scrn2 A G 11: 96,921,709 (GRCm39) T60A probably damaging Het
Setdb2 A T 14: 59,653,156 (GRCm39) I398N probably damaging Het
Setx A G 2: 29,029,350 (GRCm39) E206G probably damaging Het
Sez6 T C 11: 77,859,915 (GRCm39) probably null Het
Sh3bp4 C T 1: 89,071,962 (GRCm39) S270L probably damaging Het
Stac3 T C 10: 127,343,993 (GRCm39) I297T probably damaging Het
Styxl2 G A 1: 165,927,914 (GRCm39) T566I probably benign Het
Supv3l1 A T 10: 62,282,844 (GRCm39) V139E possibly damaging Het
Syce1 A T 7: 140,358,978 (GRCm39) H178Q probably damaging Het
Tamalin G A 15: 101,126,923 (GRCm39) V134I probably damaging Het
Tcp10c T A 17: 13,588,453 (GRCm39) M344K possibly damaging Het
Tcstv7a C T 13: 120,290,025 (GRCm39) W57* probably null Het
Tmc1 A G 19: 20,801,394 (GRCm39) V502A possibly damaging Het
Tmco4 G T 4: 138,747,477 (GRCm39) G242V probably damaging Het
Trp53bp2 G A 1: 182,272,271 (GRCm39) R460H probably damaging Het
Zfp366 A G 13: 99,364,875 (GRCm39) D12G probably damaging Het
Zfp457 C T 13: 67,440,899 (GRCm39) A463T probably benign Het
Other mutations in Virma
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00428:Virma APN 4 11,519,424 (GRCm39) splice site probably benign
IGL00477:Virma APN 4 11,519,006 (GRCm39) missense probably damaging 0.99
IGL01293:Virma APN 4 11,521,114 (GRCm39) missense probably damaging 1.00
IGL01410:Virma APN 4 11,518,929 (GRCm39) nonsense probably null
IGL01531:Virma APN 4 11,528,753 (GRCm39) missense probably damaging 1.00
IGL01672:Virma APN 4 11,527,792 (GRCm39) missense probably damaging 1.00
IGL01724:Virma APN 4 11,528,672 (GRCm39) missense probably damaging 1.00
IGL01747:Virma APN 4 11,526,877 (GRCm39) missense probably damaging 1.00
IGL01776:Virma APN 4 11,527,792 (GRCm39) missense probably damaging 1.00
IGL02064:Virma APN 4 11,513,163 (GRCm39) missense possibly damaging 0.87
IGL02243:Virma APN 4 11,546,031 (GRCm39) missense probably damaging 1.00
IGL02244:Virma APN 4 11,546,031 (GRCm39) missense probably damaging 1.00
IGL02445:Virma APN 4 11,527,029 (GRCm39) missense probably damaging 0.97
IGL02546:Virma APN 4 11,494,804 (GRCm39) missense probably damaging 0.99
IGL02807:Virma APN 4 11,507,079 (GRCm39) splice site probably benign
IGL02967:Virma APN 4 11,514,096 (GRCm39) missense probably benign 0.01
IGL03211:Virma APN 4 11,548,770 (GRCm39) nonsense probably null
IGL03242:Virma APN 4 11,527,669 (GRCm39) missense possibly damaging 0.70
IGL03256:Virma APN 4 11,542,207 (GRCm39) splice site probably benign
IGL03327:Virma APN 4 11,518,984 (GRCm39) missense probably benign 0.00
IGL03346:Virma APN 4 11,518,984 (GRCm39) missense probably benign 0.00
PIT4802001:Virma UTSW 4 11,546,008 (GRCm39) missense probably damaging 0.99
R0142:Virma UTSW 4 11,548,783 (GRCm39) missense probably benign 0.04
R0355:Virma UTSW 4 11,528,626 (GRCm39) nonsense probably null
R0522:Virma UTSW 4 11,519,416 (GRCm39) critical splice donor site probably null
R0600:Virma UTSW 4 11,498,769 (GRCm39) missense probably damaging 0.99
R1435:Virma UTSW 4 11,528,621 (GRCm39) missense probably damaging 1.00
R1489:Virma UTSW 4 11,521,164 (GRCm39) missense probably damaging 1.00
R1568:Virma UTSW 4 11,528,776 (GRCm39) missense probably damaging 0.99
R1616:Virma UTSW 4 11,544,954 (GRCm39) missense probably damaging 1.00
R1655:Virma UTSW 4 11,494,786 (GRCm39) missense probably damaging 1.00
R1695:Virma UTSW 4 11,494,814 (GRCm39) missense probably damaging 0.98
R1835:Virma UTSW 4 11,540,511 (GRCm39) missense probably benign 0.02
R1951:Virma UTSW 4 11,513,907 (GRCm39) missense probably benign 0.00
R1991:Virma UTSW 4 11,519,242 (GRCm39) missense probably benign 0.06
R2145:Virma UTSW 4 11,548,726 (GRCm39) splice site probably benign
R2172:Virma UTSW 4 11,527,843 (GRCm39) missense possibly damaging 0.82
R2217:Virma UTSW 4 11,544,924 (GRCm39) missense probably damaging 1.00
R2218:Virma UTSW 4 11,544,924 (GRCm39) missense probably damaging 1.00
R2248:Virma UTSW 4 11,518,927 (GRCm39) missense probably damaging 1.00
R2342:Virma UTSW 4 11,501,316 (GRCm39) missense probably damaging 1.00
R3424:Virma UTSW 4 11,513,177 (GRCm39) nonsense probably null
R4397:Virma UTSW 4 11,513,901 (GRCm39) missense possibly damaging 0.81
R4449:Virma UTSW 4 11,498,828 (GRCm39) critical splice donor site probably null
R4660:Virma UTSW 4 11,513,505 (GRCm39) missense probably damaging 1.00
R4698:Virma UTSW 4 11,528,636 (GRCm39) missense probably damaging 0.99
R4878:Virma UTSW 4 11,544,971 (GRCm39) missense probably damaging 1.00
R4937:Virma UTSW 4 11,521,147 (GRCm39) nonsense probably null
R5031:Virma UTSW 4 11,542,116 (GRCm39) nonsense probably null
R5061:Virma UTSW 4 11,494,840 (GRCm39) missense possibly damaging 0.95
R5091:Virma UTSW 4 11,519,392 (GRCm39) missense probably benign 0.00
R5137:Virma UTSW 4 11,546,297 (GRCm39) missense probably damaging 1.00
R5262:Virma UTSW 4 11,539,926 (GRCm39) missense probably benign 0.01
R5297:Virma UTSW 4 11,494,819 (GRCm39) missense probably damaging 1.00
R5730:Virma UTSW 4 11,542,154 (GRCm39) missense probably benign 0.44
R5818:Virma UTSW 4 11,513,319 (GRCm39) missense possibly damaging 0.92
R5835:Virma UTSW 4 11,514,036 (GRCm39) missense probably damaging 1.00
R6125:Virma UTSW 4 11,521,172 (GRCm39) missense probably damaging 0.98
R6197:Virma UTSW 4 11,505,498 (GRCm39) missense probably damaging 0.96
R6222:Virma UTSW 4 11,527,820 (GRCm39) missense probably damaging 1.00
R6793:Virma UTSW 4 11,539,968 (GRCm39) missense probably damaging 1.00
R7028:Virma UTSW 4 11,519,249 (GRCm39) missense possibly damaging 0.50
R7356:Virma UTSW 4 11,513,595 (GRCm39) missense probably damaging 0.99
R7383:Virma UTSW 4 11,514,026 (GRCm39) missense probably damaging 0.98
R7391:Virma UTSW 4 11,508,099 (GRCm39) missense probably damaging 0.99
R7425:Virma UTSW 4 11,546,211 (GRCm39) missense possibly damaging 0.95
R7556:Virma UTSW 4 11,518,927 (GRCm39) missense probably damaging 1.00
R7715:Virma UTSW 4 11,513,016 (GRCm39) splice site probably null
R7715:Virma UTSW 4 11,549,682 (GRCm39) missense probably damaging 1.00
R7986:Virma UTSW 4 11,540,023 (GRCm39) missense probably benign 0.01
R7990:Virma UTSW 4 11,513,983 (GRCm39) missense probably benign 0.00
R8048:Virma UTSW 4 11,539,918 (GRCm39) nonsense probably null
R8050:Virma UTSW 4 11,528,643 (GRCm39) missense probably benign 0.22
R8165:Virma UTSW 4 11,542,128 (GRCm39) missense probably benign 0.00
R8412:Virma UTSW 4 11,521,261 (GRCm39) critical splice donor site probably null
R8544:Virma UTSW 4 11,516,949 (GRCm39) missense probably benign
R8551:Virma UTSW 4 11,513,397 (GRCm39) missense probably damaging 1.00
R8699:Virma UTSW 4 11,528,678 (GRCm39) missense probably benign 0.04
R8739:Virma UTSW 4 11,540,643 (GRCm39) critical splice donor site probably null
R8950:Virma UTSW 4 11,519,047 (GRCm39) nonsense probably null
R9015:Virma UTSW 4 11,540,494 (GRCm39) missense probably benign 0.27
R9038:Virma UTSW 4 11,526,922 (GRCm39) missense possibly damaging 0.93
R9115:Virma UTSW 4 11,498,744 (GRCm39) missense probably benign 0.15
R9294:Virma UTSW 4 11,513,507 (GRCm39) nonsense probably null
R9404:Virma UTSW 4 11,513,626 (GRCm39) missense probably benign 0.17
R9477:Virma UTSW 4 11,528,753 (GRCm39) missense probably damaging 1.00
R9532:Virma UTSW 4 11,507,078 (GRCm39) critical splice donor site probably null
R9649:Virma UTSW 4 11,486,045 (GRCm39) start codon destroyed probably null 0.08
R9657:Virma UTSW 4 11,544,898 (GRCm39) missense probably damaging 0.99
R9780:Virma UTSW 4 11,513,442 (GRCm39) missense possibly damaging 0.75
R9800:Virma UTSW 4 11,546,007 (GRCm39) missense probably damaging 0.99
X0020:Virma UTSW 4 11,486,055 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TTGCAGTGACTATAAGCTTCTGG -3'
(R):5'- ACCATGCACCAACTTAATTTGC -3'

Sequencing Primer
(F):5'- GTATACTAGCCAAACCACCAGG -3'
(R):5'- ATGCACCAACTTAATTTGCTTTTC -3'
Posted On 2016-06-15