Incidental Mutation 'R5042:St13'
ID 393271
Institutional Source Beutler Lab
Gene Symbol St13
Ensembl Gene ENSMUSG00000022403
Gene Name suppression of tumorigenicity 13
Synonyms 3110002K08Rik, HSPABP1, PRO0786, SNC6, 1110007I03Rik, p48, Hsp70 interacting protein
MMRRC Submission 042632-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.294) question?
Stock # R5042 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 81247870-81284278 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 81249693 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 349 (N349K)
Ref Sequence ENSEMBL: ENSMUSP00000023039 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023039] [ENSMUST00000023040] [ENSMUST00000172107] [ENSMUST00000230309] [ENSMUST00000231140]
AlphaFold Q99L47
Predicted Effect probably damaging
Transcript: ENSMUST00000023039
AA Change: N349K

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000023039
Gene: ENSMUSG00000022403
AA Change: N349K

DomainStartEndE-ValueType
PDB:4J8C|B 1 44 6e-25 PDB
low complexity region 52 72 N/A INTRINSIC
TPR 104 137 1.2e1 SMART
TPR 138 171 6.95e-4 SMART
TPR 172 205 4.8e1 SMART
coiled coil region 225 264 N/A INTRINSIC
low complexity region 271 305 N/A INTRINSIC
STI1 312 351 3.37e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000023040
SMART Domains Protein: ENSMUSP00000023040
Gene: ENSMUSG00000022404

DomainStartEndE-ValueType
Pfam:Mito_carr 6 97 1e-17 PFAM
Pfam:Mito_carr 97 197 6.3e-24 PFAM
Pfam:Mito_carr 199 297 3.2e-16 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000172107
AA Change: N358K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000130195
Gene: ENSMUSG00000022403
AA Change: N358K

DomainStartEndE-ValueType
PDB:4J8C|B 1 44 6e-25 PDB
low complexity region 52 66 N/A INTRINSIC
low complexity region 71 81 N/A INTRINSIC
TPR 113 146 1.2e1 SMART
TPR 147 180 6.95e-4 SMART
TPR 181 214 4.8e1 SMART
coiled coil region 234 273 N/A INTRINSIC
low complexity region 280 314 N/A INTRINSIC
STI1 321 360 3.37e-10 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229617
Predicted Effect probably benign
Transcript: ENSMUST00000230309
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231078
Predicted Effect probably benign
Transcript: ENSMUST00000231140
Meta Mutation Damage Score 0.0607 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 89.8%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432E11Rik T A 7: 29,273,927 (GRCm39) noncoding transcript Het
4933413J09Rik C A 14: 26,097,436 (GRCm39) noncoding transcript Het
Aldh1a2 A G 9: 71,192,286 (GRCm39) I413V possibly damaging Het
Alpk2 C T 18: 65,483,579 (GRCm39) W143* probably null Het
Anpep G T 7: 79,489,217 (GRCm39) N318K probably benign Het
Art5 A T 7: 101,748,672 (GRCm39) L10H probably damaging Het
Atg2b T G 12: 105,587,521 (GRCm39) H1981P probably benign Het
B3gnt3 T C 8: 72,145,532 (GRCm39) T279A probably damaging Het
Bmp10 G T 6: 87,411,039 (GRCm39) E277D probably damaging Het
Ccdc180 A G 4: 45,916,255 (GRCm39) T191A probably damaging Het
Dars2 T A 1: 160,872,664 (GRCm39) probably benign Het
F5 T A 1: 164,047,020 (GRCm39) I2160N probably damaging Het
Fndc7 A T 3: 108,770,102 (GRCm39) V608D probably damaging Het
Gad1-ps A T 10: 99,281,516 (GRCm39) noncoding transcript Het
Gbp2b A G 3: 142,317,224 (GRCm39) K527E probably benign Het
Gm10719 T A 9: 3,018,970 (GRCm39) F72I probably damaging Het
Hes3 T A 4: 152,371,500 (GRCm39) S150C possibly damaging Het
Hp1bp3 T A 4: 137,949,419 (GRCm39) M1K probably null Het
Il17rd T A 14: 26,817,998 (GRCm39) V229E probably damaging Het
Iqch A G 9: 63,403,516 (GRCm39) M634T possibly damaging Het
Magel2 C T 7: 62,029,354 (GRCm39) R753W unknown Het
Med26 A G 8: 73,250,919 (GRCm39) V60A probably damaging Het
Myo1d T A 11: 80,448,347 (GRCm39) D926V probably damaging Het
Nat1 T G 8: 67,944,228 (GRCm39) D201E probably benign Het
Nav3 G T 10: 109,605,129 (GRCm39) S981R probably benign Het
Nbn C A 4: 15,981,446 (GRCm39) L513M probably benign Het
Nfatc3 T C 8: 106,834,757 (GRCm39) V701A probably benign Het
Nlrp9a A G 7: 26,270,703 (GRCm39) D911G probably damaging Het
Npr2 A T 4: 43,647,002 (GRCm39) I712F probably damaging Het
Oplah G A 15: 76,189,909 (GRCm39) R235* probably null Het
Or10a48 A G 7: 108,424,678 (GRCm39) I176T possibly damaging Het
Pcdha11 T A 18: 37,144,649 (GRCm39) Y247N probably damaging Het
Pcdhga9 A G 18: 37,870,630 (GRCm39) Y153C probably damaging Het
Pkd1 A T 17: 24,788,861 (GRCm39) D873V probably benign Het
Pnpla1 A G 17: 29,100,021 (GRCm39) N296S probably benign Het
Ppfia3 A G 7: 44,991,765 (GRCm39) V839A probably damaging Het
Ppm1j A T 3: 104,690,036 (GRCm39) Q148L probably null Het
Prune2 T A 19: 17,097,161 (GRCm39) N888K possibly damaging Het
Sh3bgr A G 16: 96,007,066 (GRCm39) D12G probably benign Het
Snph T A 2: 151,442,977 (GRCm39) I35F possibly damaging Het
Spag17 A T 3: 99,979,465 (GRCm39) D1442V probably damaging Het
Spidr T C 16: 15,936,767 (GRCm39) T113A probably benign Het
Ttll6 C T 11: 96,045,430 (GRCm39) S549F possibly damaging Het
Uap1l1 A T 2: 25,252,097 (GRCm39) S473T possibly damaging Het
Vmn1r54 T C 6: 90,246,422 (GRCm39) V112A possibly damaging Het
Vmn2r57 G A 7: 41,078,086 (GRCm39) S124L probably benign Het
Wasf2 A T 4: 132,903,875 (GRCm39) R28W probably benign Het
Wwp2 T A 8: 108,275,117 (GRCm39) N417K possibly damaging Het
Zc3h13 A T 14: 75,576,836 (GRCm39) D1648V probably damaging Het
Other mutations in St13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01647:St13 APN 15 81,255,708 (GRCm39) missense probably damaging 0.99
IGL01933:St13 APN 15 81,273,899 (GRCm39) critical splice acceptor site probably null
IGL02152:St13 APN 15 81,250,583 (GRCm39) missense probably damaging 1.00
R0714:St13 UTSW 15 81,267,228 (GRCm39) missense probably benign 0.16
R3417:St13 UTSW 15 81,253,651 (GRCm39) splice site probably benign
R4845:St13 UTSW 15 81,283,786 (GRCm39) missense probably benign 0.09
R4925:St13 UTSW 15 81,283,786 (GRCm39) missense probably benign 0.09
R4934:St13 UTSW 15 81,283,786 (GRCm39) missense probably benign 0.09
R5029:St13 UTSW 15 81,283,786 (GRCm39) missense probably benign 0.09
R5048:St13 UTSW 15 81,283,786 (GRCm39) missense probably benign 0.09
R5139:St13 UTSW 15 81,283,786 (GRCm39) missense probably benign 0.09
R5970:St13 UTSW 15 81,261,999 (GRCm39) missense probably damaging 0.99
R6158:St13 UTSW 15 81,283,802 (GRCm39) splice site probably null
R6175:St13 UTSW 15 81,283,506 (GRCm39) critical splice donor site probably null
R6872:St13 UTSW 15 81,250,547 (GRCm39) critical splice donor site probably null
R7320:St13 UTSW 15 81,273,854 (GRCm39) missense probably damaging 0.99
R7912:St13 UTSW 15 81,283,719 (GRCm39) missense possibly damaging 0.52
R9258:St13 UTSW 15 81,272,569 (GRCm39) missense probably benign 0.01
R9281:St13 UTSW 15 81,261,927 (GRCm39) missense probably damaging 0.99
R9442:St13 UTSW 15 81,272,575 (GRCm39) missense possibly damaging 0.88
R9483:St13 UTSW 15 81,250,587 (GRCm39) missense probably damaging 0.99
R9549:St13 UTSW 15 81,259,063 (GRCm39) missense possibly damaging 0.64
X0065:St13 UTSW 15 81,250,637 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CAGCCGCATTTGATGTAGAGG -3'
(R):5'- TGGCTGAAGCATTTTACAGTG -3'

Sequencing Primer
(F):5'- AGGGTAGGGATTATCTTCGAAGC -3'
(R):5'- AAATCCTAAAGTTCATCCATTGGCC -3'
Posted On 2016-06-15