Incidental Mutation 'R5043:Yeats2'
ID 393318
Institutional Source Beutler Lab
Gene Symbol Yeats2
Ensembl Gene ENSMUSG00000041215
Gene Name YEATS domain containing 2
Synonyms
MMRRC Submission 042633-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.964) question?
Stock # R5043 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 19959813-20051323 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 20027215 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 822 (Q822L)
Ref Sequence ENSEMBL: ENSMUSP00000155892 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090052] [ENSMUST00000115560] [ENSMUST00000232019] [ENSMUST00000232338]
AlphaFold Q3TUF7
Predicted Effect probably damaging
Transcript: ENSMUST00000090052
AA Change: Q807L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000087506
Gene: ENSMUSG00000041215
AA Change: Q807L

DomainStartEndE-ValueType
Pfam:YEATS 179 262 2.6e-27 PFAM
low complexity region 299 309 N/A INTRINSIC
low complexity region 312 333 N/A INTRINSIC
low complexity region 409 429 N/A INTRINSIC
low complexity region 458 467 N/A INTRINSIC
internal_repeat_1 471 675 3.72e-6 PROSPERO
low complexity region 683 702 N/A INTRINSIC
low complexity region 738 775 N/A INTRINSIC
internal_repeat_1 785 978 3.72e-6 PROSPERO
low complexity region 1240 1249 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000115560
AA Change: Q860L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000111222
Gene: ENSMUSG00000041215
AA Change: Q860L

DomainStartEndE-ValueType
Pfam:YEATS 232 314 2.1e-28 PFAM
low complexity region 352 362 N/A INTRINSIC
low complexity region 365 386 N/A INTRINSIC
low complexity region 462 482 N/A INTRINSIC
low complexity region 511 520 N/A INTRINSIC
internal_repeat_1 524 728 4.68e-6 PROSPERO
low complexity region 736 755 N/A INTRINSIC
low complexity region 791 828 N/A INTRINSIC
internal_repeat_1 838 1031 4.68e-6 PROSPERO
low complexity region 1293 1302 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231671
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231795
Predicted Effect probably damaging
Transcript: ENSMUST00000232019
AA Change: Q822L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232094
Predicted Effect probably benign
Transcript: ENSMUST00000232613
Predicted Effect silent
Transcript: ENSMUST00000232338
Meta Mutation Damage Score 0.1380 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.4%
Validation Efficiency 98% (44/45)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] YEATS2 is a scaffolding subunit of the ADA2A (TADA2A; MIM 602276)-containing (ATAC) histone acetyltransferase complex (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]
Allele List at MGI

All alleles(34) : Targeted(1) Gene trapped(33)

Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018F24Rik T A 5: 144,980,910 (GRCm39) Y106* probably null Het
Acsbg3 A G 17: 57,192,198 (GRCm39) Y587C probably damaging Het
Akap12 G C 10: 4,305,047 (GRCm39) G619A probably damaging Het
Arhgap29 A G 3: 121,767,653 (GRCm39) K32E probably benign Het
Capg T A 6: 72,535,237 (GRCm39) Y253* probably null Het
Cntnap3 A T 13: 64,942,162 (GRCm39) F189L probably damaging Het
Cp T C 3: 20,028,081 (GRCm39) S496P probably benign Het
Cxcl11 T C 5: 92,511,011 (GRCm39) probably null Het
Dennd3 T C 15: 73,399,785 (GRCm39) L217P probably benign Het
Dip2c G T 13: 9,601,863 (GRCm39) R274L possibly damaging Het
Dnah12 C T 14: 26,606,147 (GRCm39) S3776L probably damaging Het
Emcn A G 3: 137,097,362 (GRCm39) T94A possibly damaging Het
Fnip2 A T 3: 79,400,174 (GRCm39) Y397* probably null Het
Gabrp T C 11: 33,518,072 (GRCm39) N79D probably benign Het
Glmp T G 3: 88,233,983 (GRCm39) probably benign Het
Gm5921 C T 9: 115,267,087 (GRCm39) noncoding transcript Het
Gm6483 A G 8: 19,743,686 (GRCm39) T104A probably benign Het
Ifi206 A T 1: 173,314,284 (GRCm39) M52K probably damaging Het
Iqcc T C 4: 129,512,070 (GRCm39) probably benign Het
Klra2 T A 6: 131,197,135 (GRCm39) H288L probably benign Het
Myo5b T C 18: 74,771,224 (GRCm39) probably null Het
Nisch A G 14: 30,898,422 (GRCm39) probably benign Het
Nlrp4c A G 7: 6,069,824 (GRCm39) N575S probably benign Het
Or1n2 A C 2: 36,796,977 (GRCm39) R6S probably benign Het
Or8b49 A G 9: 38,506,137 (GRCm39) I207V probably damaging Het
Phlda1 T A 10: 111,343,152 (GRCm39) L296Q unknown Het
Pramel19 T C 4: 101,797,721 (GRCm39) F40L possibly damaging Het
Rab36 G A 10: 74,886,837 (GRCm39) E182K probably benign Het
Rasa3 G A 8: 13,620,368 (GRCm39) T767M possibly damaging Het
Serpinb11 G A 1: 107,297,195 (GRCm39) V24M probably damaging Het
Slc7a14 T G 3: 31,291,615 (GRCm39) N221T probably damaging Het
Smg6 T C 11: 74,820,721 (GRCm39) S331P possibly damaging Het
Snx1 C T 9: 66,004,718 (GRCm39) A183T probably benign Het
Srpk2 T C 5: 23,729,515 (GRCm39) T375A probably benign Het
Tecpr1 T C 5: 144,134,672 (GRCm39) probably null Het
Topaz1 A T 9: 122,577,469 (GRCm39) E126D probably benign Het
Ugt2b1 C G 5: 87,065,503 (GRCm39) C512S possibly damaging Het
Ugt2b37 C T 5: 87,399,719 (GRCm39) W263* probably null Het
Utp20 A T 10: 88,634,608 (GRCm39) M750K possibly damaging Het
Zfp609 T C 9: 65,608,109 (GRCm39) Y1257C probably damaging Het
Other mutations in Yeats2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01118:Yeats2 APN 16 20,005,054 (GRCm39) missense probably damaging 0.99
IGL01128:Yeats2 APN 16 19,980,718 (GRCm39) splice site probably benign
IGL01139:Yeats2 APN 16 20,033,143 (GRCm39) missense probably damaging 1.00
IGL01394:Yeats2 APN 16 19,980,782 (GRCm39) missense probably damaging 0.99
IGL01482:Yeats2 APN 16 20,041,671 (GRCm39) missense probably damaging 1.00
IGL01924:Yeats2 APN 16 20,024,917 (GRCm39) missense probably damaging 1.00
IGL01925:Yeats2 APN 16 19,998,430 (GRCm39) splice site probably benign
IGL02106:Yeats2 APN 16 20,011,970 (GRCm39) missense possibly damaging 0.79
IGL02370:Yeats2 APN 16 19,969,221 (GRCm39) missense probably damaging 0.99
IGL02447:Yeats2 APN 16 20,012,429 (GRCm39) missense probably benign 0.00
IGL02669:Yeats2 APN 16 20,005,033 (GRCm39) missense probably benign 0.13
IGL03155:Yeats2 APN 16 20,048,323 (GRCm39) critical splice donor site probably null
tyrion UTSW 16 20,032,151 (GRCm39) splice site probably benign
P0045:Yeats2 UTSW 16 19,975,695 (GRCm39) missense possibly damaging 0.47
R0051:Yeats2 UTSW 16 20,012,474 (GRCm39) nonsense probably null
R0051:Yeats2 UTSW 16 20,012,474 (GRCm39) nonsense probably null
R0118:Yeats2 UTSW 16 19,975,692 (GRCm39) nonsense probably null
R0157:Yeats2 UTSW 16 20,040,427 (GRCm39) makesense probably null
R0184:Yeats2 UTSW 16 20,022,435 (GRCm39) missense possibly damaging 0.79
R0194:Yeats2 UTSW 16 19,971,719 (GRCm39) start codon destroyed probably null 1.00
R0612:Yeats2 UTSW 16 20,005,175 (GRCm39) missense probably benign 0.00
R0655:Yeats2 UTSW 16 20,012,574 (GRCm39) nonsense probably null
R0826:Yeats2 UTSW 16 20,011,966 (GRCm39) nonsense probably null
R1526:Yeats2 UTSW 16 20,024,836 (GRCm39) missense probably damaging 1.00
R1535:Yeats2 UTSW 16 20,008,115 (GRCm39) missense probably damaging 0.99
R1749:Yeats2 UTSW 16 20,005,018 (GRCm39) nonsense probably null
R1842:Yeats2 UTSW 16 19,989,988 (GRCm39) missense probably damaging 1.00
R1843:Yeats2 UTSW 16 20,048,314 (GRCm39) missense probably benign 0.01
R1926:Yeats2 UTSW 16 20,033,176 (GRCm39) missense probably benign
R2000:Yeats2 UTSW 16 20,005,141 (GRCm39) missense probably benign 0.20
R2017:Yeats2 UTSW 16 19,977,931 (GRCm39) missense probably benign 0.01
R2076:Yeats2 UTSW 16 20,005,032 (GRCm39) missense possibly damaging 0.47
R2153:Yeats2 UTSW 16 19,972,916 (GRCm39) missense probably damaging 1.00
R2167:Yeats2 UTSW 16 20,032,151 (GRCm39) splice site probably benign
R2981:Yeats2 UTSW 16 20,005,051 (GRCm39) missense probably damaging 0.99
R3160:Yeats2 UTSW 16 20,012,395 (GRCm39) missense probably damaging 1.00
R3161:Yeats2 UTSW 16 20,012,395 (GRCm39) missense probably damaging 1.00
R3162:Yeats2 UTSW 16 20,012,395 (GRCm39) missense probably damaging 1.00
R3774:Yeats2 UTSW 16 19,969,245 (GRCm39) missense probably damaging 1.00
R4250:Yeats2 UTSW 16 19,975,685 (GRCm39) missense possibly damaging 0.90
R4305:Yeats2 UTSW 16 20,027,172 (GRCm39) missense probably damaging 1.00
R4455:Yeats2 UTSW 16 19,980,743 (GRCm39) missense possibly damaging 0.88
R4458:Yeats2 UTSW 16 20,032,071 (GRCm39) missense probably damaging 0.99
R4811:Yeats2 UTSW 16 19,971,645 (GRCm39) splice site probably null
R4902:Yeats2 UTSW 16 20,026,418 (GRCm39) missense probably benign 0.00
R5047:Yeats2 UTSW 16 20,027,215 (GRCm39) missense probably damaging 1.00
R5319:Yeats2 UTSW 16 20,005,175 (GRCm39) missense probably benign 0.01
R5328:Yeats2 UTSW 16 19,989,955 (GRCm39) missense probably damaging 1.00
R5360:Yeats2 UTSW 16 19,972,912 (GRCm39) missense probably damaging 0.97
R5416:Yeats2 UTSW 16 20,030,319 (GRCm39) missense probably benign 0.01
R5672:Yeats2 UTSW 16 19,980,779 (GRCm39) missense probably damaging 1.00
R5684:Yeats2 UTSW 16 20,012,553 (GRCm39) missense possibly damaging 0.94
R5932:Yeats2 UTSW 16 20,011,913 (GRCm39) missense probably benign 0.06
R5946:Yeats2 UTSW 16 20,026,513 (GRCm39) nonsense probably null
R6168:Yeats2 UTSW 16 19,998,308 (GRCm39) missense probably benign 0.01
R6169:Yeats2 UTSW 16 20,038,417 (GRCm39) missense probably damaging 1.00
R6179:Yeats2 UTSW 16 20,033,225 (GRCm39) missense probably benign 0.16
R6371:Yeats2 UTSW 16 20,040,460 (GRCm39) missense possibly damaging 0.54
R6877:Yeats2 UTSW 16 19,998,344 (GRCm39) missense probably benign 0.00
R7149:Yeats2 UTSW 16 19,972,939 (GRCm39) missense probably damaging 1.00
R7405:Yeats2 UTSW 16 20,041,663 (GRCm39) missense probably damaging 1.00
R8353:Yeats2 UTSW 16 20,041,637 (GRCm39) nonsense probably null
R8367:Yeats2 UTSW 16 20,041,575 (GRCm39) missense probably damaging 1.00
R8453:Yeats2 UTSW 16 20,041,637 (GRCm39) nonsense probably null
R8506:Yeats2 UTSW 16 19,971,684 (GRCm39) missense probably damaging 0.98
R8535:Yeats2 UTSW 16 19,977,926 (GRCm39) missense probably damaging 1.00
R8828:Yeats2 UTSW 16 19,969,260 (GRCm39) missense probably benign 0.45
R8905:Yeats2 UTSW 16 20,009,144 (GRCm39) missense probably benign 0.02
R8924:Yeats2 UTSW 16 19,969,312 (GRCm39) critical splice donor site probably null
R9087:Yeats2 UTSW 16 20,030,500 (GRCm39) critical splice donor site probably null
R9276:Yeats2 UTSW 16 19,975,786 (GRCm39) missense probably benign 0.34
R9338:Yeats2 UTSW 16 20,041,533 (GRCm39) missense probably damaging 0.99
R9338:Yeats2 UTSW 16 20,032,078 (GRCm39) missense possibly damaging 0.69
R9378:Yeats2 UTSW 16 20,033,228 (GRCm39) missense probably benign
R9569:Yeats2 UTSW 16 19,972,902 (GRCm39) missense probably damaging 1.00
R9664:Yeats2 UTSW 16 20,047,491 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CAGACATGGTCCAGTCGTTC -3'
(R):5'- TTTGACAGAAAATACAGCACGC -3'

Sequencing Primer
(F):5'- CATGGTCCAGTCGTTCCAATTGAAG -3'
(R):5'- ACCTAGTCCTGCGGTGACTTAAG -3'
Posted On 2016-06-15