Incidental Mutation 'R5125:Trgc4'
ID 393512
Institutional Source Beutler Lab
Gene Symbol Trgc4
Ensembl Gene ENSMUSG00000076757
Gene Name T cell receptor gamma, constant 4
Synonyms Tcrg-C4
MMRRC Submission 042713-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R5125 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 19528728-19536513 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 19528932 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143068 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103564] [ENSMUST00000184430]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000103564
SMART Domains Protein: ENSMUSP00000100342
Gene: ENSMUSG00000076755

DomainStartEndE-ValueType
IGv 34 113 8.44e-11 SMART
Predicted Effect unknown
Transcript: ENSMUST00000179181
AA Change: Y68C
Predicted Effect probably benign
Transcript: ENSMUST00000184430
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 91.9%
Validation Efficiency 96% (49/51)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abt1 G T 13: 23,606,819 (GRCm39) A94E possibly damaging Het
Carmil2 G T 8: 106,423,521 (GRCm39) G1207V probably damaging Het
Cyp2c66 A G 19: 39,159,473 (GRCm39) Y308C probably damaging Het
Dcc A G 18: 71,589,948 (GRCm39) F683L probably benign Het
Denr A T 5: 124,065,144 (GRCm39) I166F probably damaging Het
Dhx29 T G 13: 113,069,134 (GRCm39) S155A possibly damaging Het
Dsg1b G A 18: 20,530,560 (GRCm39) G405E probably damaging Het
Ei24 T A 9: 36,693,742 (GRCm39) probably benign Het
Exo5 A T 4: 120,778,734 (GRCm39) probably null Het
Gm7356 T C 17: 14,221,576 (GRCm39) D151G probably damaging Het
Grin1 T C 2: 25,186,839 (GRCm39) probably benign Het
Grin2b C T 6: 135,900,297 (GRCm39) V195M possibly damaging Het
Hephl1 T A 9: 14,997,468 (GRCm39) K399N probably damaging Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Kmt2c A G 5: 25,489,379 (GRCm39) V4520A probably damaging Het
Lair1 G A 7: 4,013,488 (GRCm39) T82I possibly damaging Het
Lmx1a C T 1: 167,658,256 (GRCm39) S213L possibly damaging Het
Ly6g6d A G 17: 35,293,418 (GRCm39) I8T possibly damaging Het
Mcm4 T A 16: 15,453,167 (GRCm39) D174V probably benign Het
Mcph1 T A 8: 18,657,342 (GRCm39) D60E probably damaging Het
Med12l G A 3: 59,174,635 (GRCm39) G1851D possibly damaging Het
Or13c7b T A 4: 43,820,480 (GRCm39) I294F probably benign Het
Or7e174 T A 9: 20,012,488 (GRCm39) C144* probably null Het
P2rx2 G A 5: 110,490,517 (GRCm39) T66I possibly damaging Het
Pcdh15 A G 10: 74,419,912 (GRCm39) E1197G probably damaging Het
Pira1 T A 7: 3,742,396 (GRCm39) K44* probably null Het
Ppwd1 A T 13: 104,356,943 (GRCm39) S191T probably benign Het
Rbm39 A T 2: 156,004,785 (GRCm39) M184K probably damaging Het
Reln A G 5: 22,118,239 (GRCm39) V2935A possibly damaging Het
Robo4 T C 9: 37,319,256 (GRCm39) W535R probably damaging Het
Rsf1 A G 7: 97,311,079 (GRCm39) D603G possibly damaging Het
Sh3rf3 C G 10: 58,967,012 (GRCm39) P785A probably benign Het
Slc22a26 T C 19: 7,767,540 (GRCm39) T289A possibly damaging Het
Slc24a3 T C 2: 145,360,767 (GRCm39) V120A possibly damaging Het
Sost C T 11: 101,854,767 (GRCm39) G181R probably damaging Het
Sp2 A G 11: 96,846,664 (GRCm39) F554L probably benign Het
Stim2 T C 5: 54,267,939 (GRCm39) S87P probably damaging Het
Tecta T C 9: 42,286,481 (GRCm39) D725G probably damaging Het
Ube4b T C 4: 149,427,449 (GRCm39) M900V probably damaging Het
Ugt2b38 A G 5: 87,559,671 (GRCm39) M407T probably damaging Het
Vmn1r87 G T 7: 12,865,792 (GRCm39) A165E possibly damaging Het
Zc3h6 A G 2: 128,856,399 (GRCm39) H493R possibly damaging Het
Zfhx2 A T 14: 55,312,232 (GRCm39) F154Y probably benign Het
Zfp729a A G 13: 67,785,764 (GRCm39) probably null Het
Zfp976 A G 7: 42,261,925 (GRCm39) probably null Het
Zhx1 C G 15: 57,917,470 (GRCm39) G259R probably damaging Het
Znfx1 A T 2: 166,888,859 (GRCm39) V783E possibly damaging Het
Other mutations in Trgc4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03328:Trgc4 APN 13 19,536,416 (GRCm39) missense unknown
R4633:Trgc4 UTSW 13 19,536,457 (GRCm39) missense probably benign 0.00
R5035:Trgc4 UTSW 13 19,536,506 (GRCm39) missense unknown
R5178:Trgc4 UTSW 13 19,528,932 (GRCm39) unclassified probably benign
R5556:Trgc4 UTSW 13 19,536,477 (GRCm39) missense unknown
R7006:Trgc4 UTSW 13 19,528,995 (GRCm39) unclassified probably benign
R7952:Trgc4 UTSW 13 19,533,740 (GRCm39) missense
R8556:Trgc4 UTSW 13 19,528,952 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- GACTCAGACTTTTCTCCCAAGC -3'
(R):5'- AACATTCTCGGGGACAGAAG -3'

Sequencing Primer
(F):5'- AAGCCTACTATTTTCCTTCCTTCTG -3'
(R):5'- GCAACAGGACAATTCCCTTTTACATG -3'
Posted On 2016-06-15