Incidental Mutation 'R5113:Tex19.1'
ID 394033
Institutional Source Beutler Lab
Gene Symbol Tex19.1
Ensembl Gene ENSMUSG00000039329
Gene Name testis expressed gene 19.1
Synonyms Tex19.1, Tex19, 2410081M02Rik
MMRRC Submission 042701-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.205) question?
Stock # R5113 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 121036969-121039140 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 121038625 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 328 (T328A)
Ref Sequence ENSEMBL: ENSMUSP00000048592 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039088] [ENSMUST00000155694]
AlphaFold Q99MV2
Predicted Effect probably benign
Transcript: ENSMUST00000039088
AA Change: T328A

PolyPhen 2 Score 0.408 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000048592
Gene: ENSMUSG00000039329
AA Change: T328A

DomainStartEndE-ValueType
Pfam:TEX19 1 164 2.3e-73 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000155694
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.6%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased fertility, which in males is due to impaired spermatogenesis and increased male germ cell apoptosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox12e A G 11: 70,206,821 (GRCm39) V622A possibly damaging Het
Ankef1 A G 2: 136,394,361 (GRCm39) N590S probably benign Het
Anks6 C T 4: 47,030,795 (GRCm39) G601S probably damaging Het
Ano3 A T 2: 110,491,825 (GRCm39) N867K possibly damaging Het
Ash1l T C 3: 88,973,582 (GRCm39) V2547A probably damaging Het
Chil5 A T 3: 105,925,294 (GRCm39) V209E possibly damaging Het
Cltc A T 11: 86,613,147 (GRCm39) C459S probably damaging Het
Col6a4 T A 9: 105,944,159 (GRCm39) D1105V possibly damaging Het
Cyp2c66 A G 19: 39,151,882 (GRCm39) D199G probably benign Het
Cyp4f18 A G 8: 72,742,902 (GRCm39) probably null Het
Cysrt1 A T 2: 25,129,363 (GRCm39) C50S possibly damaging Het
Dapk1 A G 13: 60,869,592 (GRCm39) K278R probably benign Het
Eefsec C A 6: 88,258,557 (GRCm39) S512I probably damaging Het
Emilin1 T C 5: 31,077,964 (GRCm39) F908L possibly damaging Het
Eml1 T C 12: 108,503,596 (GRCm39) V731A possibly damaging Het
Erc2 T C 14: 27,374,829 (GRCm39) S16P probably benign Het
Gfpt2 A G 11: 49,714,626 (GRCm39) R342G probably damaging Het
Gpr142 A T 11: 114,695,143 (GRCm39) Q36L probably benign Het
Grik5 A G 7: 24,714,952 (GRCm39) S681P probably damaging Het
Hecw1 A T 13: 14,520,614 (GRCm39) S208T possibly damaging Het
Hmgcr G A 13: 96,793,240 (GRCm39) A464V probably benign Het
Igkv2-109 A G 6: 68,280,069 (GRCm39) T97A possibly damaging Het
Ino80 G T 2: 119,262,426 (GRCm39) Q687K probably damaging Het
Kdm4d T C 9: 14,375,409 (GRCm39) N150D probably damaging Het
Klf4 A G 4: 55,530,481 (GRCm39) I210T possibly damaging Het
Klkb1 C A 8: 45,723,734 (GRCm39) Q560H probably benign Het
Lce1a2 A T 3: 92,576,442 (GRCm39) V40E unknown Het
Maob T C X: 16,582,662 (GRCm39) T400A probably benign Het
Mipol1 C T 12: 57,543,285 (GRCm39) T393I probably benign Het
Mst1 A G 9: 107,959,446 (GRCm39) D244G probably damaging Het
Nexn G A 3: 151,949,525 (GRCm39) R258C probably damaging Het
Optc T C 1: 133,828,715 (GRCm39) probably benign Het
Or10d5 T C 9: 39,861,221 (GRCm39) N282S probably damaging Het
Or11h23 A C 14: 50,948,371 (GRCm39) I195L probably benign Het
Or6c207 A G 10: 129,104,535 (GRCm39) I219T probably damaging Het
Or7a37 A G 10: 78,806,037 (GRCm39) I185V probably benign Het
Pabpc2 C A 18: 39,908,436 (GRCm39) P567Q probably benign Het
Pierce2 T A 9: 72,887,175 (GRCm39) R111* probably null Het
Ppm1j A G 3: 104,691,990 (GRCm39) H324R possibly damaging Het
Reg3g A T 6: 78,443,544 (GRCm39) probably null Het
Sipa1l1 C T 12: 82,487,682 (GRCm39) A1652V probably benign Het
Ski T C 4: 155,243,849 (GRCm39) T554A probably benign Het
Slfn5 G A 11: 82,852,522 (GRCm39) V883M probably benign Het
Stradb T C 1: 59,030,333 (GRCm39) probably benign Het
Tpsab1 T C 17: 25,564,373 (GRCm39) N27S possibly damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Ttn A T 2: 76,643,244 (GRCm39) L13225Q probably damaging Het
Vmn1r28 A G 6: 58,242,843 (GRCm39) T229A probably benign Het
Wapl A G 14: 34,446,711 (GRCm39) K600E probably damaging Het
Zfp217 T C 2: 169,955,978 (GRCm39) probably null Het
Other mutations in Tex19.1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01351:Tex19.1 APN 11 121,038,072 (GRCm39) missense probably damaging 0.98
R1420:Tex19.1 UTSW 11 121,037,872 (GRCm39) missense probably damaging 0.97
R1593:Tex19.1 UTSW 11 121,038,079 (GRCm39) missense probably damaging 0.99
R6906:Tex19.1 UTSW 11 121,037,948 (GRCm39) missense probably benign 0.42
R7389:Tex19.1 UTSW 11 121,037,986 (GRCm39) missense possibly damaging 0.92
R7943:Tex19.1 UTSW 11 121,037,986 (GRCm39) missense possibly damaging 0.92
R8049:Tex19.1 UTSW 11 121,038,148 (GRCm39) missense probably benign
R9445:Tex19.1 UTSW 11 121,038,283 (GRCm39) missense probably benign 0.00
X0026:Tex19.1 UTSW 11 121,037,872 (GRCm39) missense possibly damaging 0.84
Z1176:Tex19.1 UTSW 11 121,038,389 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- ATCAGAGCCTGAATCCCTGG -3'
(R):5'- AGGATGTTCAAGATGCCCC -3'

Sequencing Primer
(F):5'- AATCCCTGGAGGCTGAGCATC -3'
(R):5'- AAGTCCTGGACCAACTGTTC -3'
Posted On 2016-06-15