Incidental Mutation 'R5045:Or10ag58'
ID 394298
Institutional Source Beutler Lab
Gene Symbol Or10ag58
Ensembl Gene ENSMUSG00000050772
Gene Name olfactory receptor family 10 subfamily AG member 58
Synonyms GA_x6K02T2Q125-48936945-48937901, Olfr1124, GA_x6K02T2Q125-48935224-48935664, Olfr1125, MOR264-24, MOR264-3
MMRRC Submission 042635-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R5045 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87264833-87265789 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 87265490 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 220 (I220L)
Ref Sequence ENSEMBL: ENSMUSP00000150244 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062494] [ENSMUST00000215909]
AlphaFold A2AT86
Predicted Effect probably damaging
Transcript: ENSMUST00000062494
AA Change: I220L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000062513
Gene: ENSMUSG00000050772
AA Change: I220L

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 4.2e-52 PFAM
Pfam:7tm_1 47 296 2.4e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215909
AA Change: I220L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810062G17Rik T C 3: 36,530,327 (GRCm39) probably benign Het
2210408I21Rik A G 13: 77,415,927 (GRCm39) probably null Het
4930519P11Rik A T 2: 154,454,950 (GRCm39) C136* probably null Het
4930519P11Rik G T 2: 154,454,982 (GRCm39) probably benign Het
Adgrb3 T A 1: 25,113,860 (GRCm39) H1189L probably damaging Het
Arhgap24 A G 5: 103,039,743 (GRCm39) I227V possibly damaging Het
Arhgap29 C A 3: 121,796,244 (GRCm39) N445K probably benign Het
Atp13a3 T C 16: 30,158,694 (GRCm39) H811R probably benign Het
Cd2ap T C 17: 43,118,851 (GRCm39) N529S probably benign Het
Cdh20 T A 1: 110,026,080 (GRCm39) S439T probably benign Het
Ces3a G T 8: 105,777,248 (GRCm39) probably null Het
Cftr T A 6: 18,230,080 (GRCm39) N408K probably benign Het
Chil5 T C 3: 105,931,456 (GRCm39) N136S possibly damaging Het
Col20a1 A G 2: 180,648,638 (GRCm39) D933G probably damaging Het
Crh A T 3: 19,748,153 (GRCm39) L163* probably null Het
Ctps1 A C 4: 120,410,075 (GRCm39) probably null Het
Cyb5d2 A G 11: 72,686,401 (GRCm39) V63A probably damaging Het
Cyp2d11 T A 15: 82,275,272 (GRCm39) probably null Het
Dclk3 A T 9: 111,296,856 (GRCm39) E133D probably damaging Het
Dhrs9 A G 2: 69,223,339 (GRCm39) D29G probably benign Het
Disp2 G A 2: 118,622,543 (GRCm39) E1092K probably benign Het
Enpp3 A G 10: 24,652,665 (GRCm39) I764T probably damaging Het
Epm2aip1 C A 9: 111,102,427 (GRCm39) R467S possibly damaging Het
Fam20a T C 11: 109,568,711 (GRCm39) I272V probably benign Het
Fgb T C 3: 82,950,680 (GRCm39) Y358C probably damaging Het
Gm11596 A T 11: 99,683,695 (GRCm39) S142T unknown Het
Golga4 A G 9: 118,394,724 (GRCm39) T9A probably benign Het
Hmcn2 C T 2: 31,299,093 (GRCm39) P2813L probably damaging Het
Ighv1-9 C T 12: 114,547,440 (GRCm39) G34R probably damaging Het
Kalrn A C 16: 34,134,722 (GRCm39) Y353* probably null Het
Klrk1 T C 6: 129,594,466 (GRCm39) Y42C probably benign Het
Lin9 T A 1: 180,496,763 (GRCm39) L351I probably benign Het
Mbtd1 T C 11: 93,822,641 (GRCm39) Y484H probably benign Het
Mki67 T C 7: 135,309,633 (GRCm39) R273G possibly damaging Het
Myh11 A T 16: 14,057,391 (GRCm39) L308* probably null Het
Nacc2 G A 2: 25,980,150 (GRCm39) probably null Het
Nadsyn1 A G 7: 143,360,706 (GRCm39) L354P probably damaging Het
Ntrk3 T A 7: 78,110,172 (GRCm39) Q354L probably benign Het
Or52r1c G A 7: 102,735,664 (GRCm39) G308E probably benign Het
Phactr3 T C 2: 177,973,412 (GRCm39) I470T probably damaging Het
Pkd1l3 C T 8: 110,349,787 (GRCm39) P211S unknown Het
Potefam1 T A 2: 111,023,804 (GRCm39) Q110L unknown Het
Prickle2 T C 6: 92,353,375 (GRCm39) D753G probably damaging Het
Prr12 A G 7: 44,699,318 (GRCm39) probably benign Het
Psd3 T C 8: 68,166,477 (GRCm39) E917G probably damaging Het
Rgsl1 T A 1: 153,697,268 (GRCm39) K551* probably null Het
Stag3 T C 5: 138,302,740 (GRCm39) L1033P probably damaging Het
Tcaf3 T A 6: 42,570,618 (GRCm39) Q378L possibly damaging Het
Tdpoz8 G T 3: 92,981,524 (GRCm39) D181Y probably damaging Het
Tespa1 A T 10: 130,197,904 (GRCm39) K309* probably null Het
Trim69 A G 2: 122,004,727 (GRCm39) T275A probably benign Het
Txndc17 T C 11: 72,098,537 (GRCm39) Y30H probably damaging Het
Ugt2a2 A T 5: 87,622,751 (GRCm39) F72L probably damaging Het
Vmn2r59 A T 7: 41,695,496 (GRCm39) D305E possibly damaging Het
Vmn2r71 A G 7: 85,273,597 (GRCm39) I804V probably benign Het
Zfy2 T C Y: 2,107,159 (GRCm39) K492E possibly damaging Het
Zkscan1 A G 5: 138,099,182 (GRCm39) H375R probably damaging Het
Other mutations in Or10ag58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00162:Or10ag58 APN 2 87,265,407 (GRCm39) missense probably benign 0.00
IGL01655:Or10ag58 APN 2 87,265,229 (GRCm39) missense probably damaging 1.00
IGL01878:Or10ag58 APN 2 87,265,314 (GRCm39) missense possibly damaging 0.55
IGL02265:Or10ag58 APN 2 87,265,688 (GRCm39) missense probably benign 0.00
IGL02379:Or10ag58 APN 2 87,265,668 (GRCm39) missense probably benign 0.07
IGL02512:Or10ag58 APN 2 87,265,402 (GRCm39) missense possibly damaging 0.59
IGL02578:Or10ag58 APN 2 87,265,401 (GRCm39) missense probably damaging 0.96
R0617:Or10ag58 UTSW 2 87,265,005 (GRCm39) missense probably damaging 1.00
R1376:Or10ag58 UTSW 2 87,264,903 (GRCm39) missense possibly damaging 0.62
R1376:Or10ag58 UTSW 2 87,264,903 (GRCm39) missense possibly damaging 0.62
R4993:Or10ag58 UTSW 2 87,265,496 (GRCm39) missense probably benign 0.00
R6119:Or10ag58 UTSW 2 87,265,733 (GRCm39) nonsense probably null
R6146:Or10ag58 UTSW 2 87,265,662 (GRCm39) missense possibly damaging 0.78
R6699:Or10ag58 UTSW 2 87,265,160 (GRCm39) missense probably benign
R6883:Or10ag58 UTSW 2 87,265,623 (GRCm39) missense probably damaging 0.99
R6966:Or10ag58 UTSW 2 87,265,623 (GRCm39) missense probably damaging 0.98
R7383:Or10ag58 UTSW 2 87,265,721 (GRCm39) missense possibly damaging 0.91
R8069:Or10ag58 UTSW 2 87,265,364 (GRCm39) missense possibly damaging 0.89
R9294:Or10ag58 UTSW 2 87,265,010 (GRCm39) missense probably benign 0.24
R9325:Or10ag58 UTSW 2 87,265,290 (GRCm39) missense possibly damaging 0.67
Z1088:Or10ag58 UTSW 2 87,265,503 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AACCAAAAGGTGTGTTCACAACTG -3'
(R):5'- ATCTGTCTCACCTGAATGACTAC -3'

Sequencing Primer
(F):5'- GCTCCTGGATAAGTGGAATCC -3'
(R):5'- GTCTCACCTGAATGACTACTATTGG -3'
Posted On 2016-06-15