Incidental Mutation 'R5047:Or11g24'
ID 394424
Institutional Source Beutler Lab
Gene Symbol Or11g24
Ensembl Gene ENSMUSG00000057903
Gene Name olfactory receptor family 11 subfamily G member 24
Synonyms GA_x6K02T2PMLR-6121675-6122604, MOR106-2, Olfr739
MMRRC Submission 042637-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R5047 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 50661978-50662907 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 50662696 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 240 (F240S)
Ref Sequence ENSEMBL: ENSMUSP00000150559 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075261] [ENSMUST00000216949]
AlphaFold E9Q1P0
Predicted Effect probably damaging
Transcript: ENSMUST00000075261
AA Change: F240S

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000074740
Gene: ENSMUSG00000057903
AA Change: F240S

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 1.1e-53 PFAM
Pfam:7tm_1 43 292 1.9e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216949
AA Change: F240S

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Meta Mutation Damage Score 0.1593 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.5%
  • 20x: 89.5%
Validation Efficiency 96% (49/51)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503E14Rik A T 14: 44,406,698 (GRCm39) M117K possibly damaging Het
Adamts13 G A 2: 26,886,922 (GRCm39) A1020T probably damaging Het
Armh4 G T 14: 50,007,895 (GRCm39) A526D probably damaging Het
Atg3 C A 16: 44,998,595 (GRCm39) D132E probably benign Het
Blzf1 A G 1: 164,134,037 (GRCm39) M4T possibly damaging Het
Cdon G A 9: 35,389,935 (GRCm39) R863Q probably damaging Het
Cyp2d40 C T 15: 82,644,460 (GRCm39) R255H unknown Het
Evi5 T C 5: 107,969,740 (GRCm39) K57R probably damaging Het
Fam186b T C 15: 99,178,567 (GRCm39) E253G probably damaging Het
Fcgr1 A T 3: 96,193,200 (GRCm39) F266I probably benign Het
Fchsd1 C T 18: 38,092,926 (GRCm39) probably benign Het
Gm10142 G T 10: 77,551,996 (GRCm39) C119F probably damaging Het
Gpr63 A G 4: 25,008,202 (GRCm39) S309G probably benign Het
Herc3 C T 6: 58,832,745 (GRCm39) Q137* probably null Het
Jmy T A 13: 93,578,080 (GRCm39) H696L possibly damaging Het
Kif13a T C 13: 46,941,561 (GRCm39) H972R probably benign Het
Lama1 C T 17: 68,050,276 (GRCm39) Q296* probably null Het
Lmf1 C T 17: 25,850,812 (GRCm39) probably benign Het
Lpp T C 16: 24,790,596 (GRCm39) C352R probably damaging Het
Ltbp1 T C 17: 75,599,881 (GRCm39) probably benign Het
Maml3 G T 3: 51,598,262 (GRCm39) D807E possibly damaging Het
Mdc1 T A 17: 36,158,736 (GRCm39) V372D probably benign Het
Mst1 C A 9: 107,961,508 (GRCm39) H579Q probably benign Het
Or1r1 T C 11: 73,875,204 (GRCm39) T77A probably damaging Het
Or4a39 A G 2: 89,237,057 (GRCm39) V122A probably damaging Het
Or8d1 G A 9: 38,766,585 (GRCm39) V76I probably benign Het
Pcdhb22 G T 18: 37,652,179 (GRCm39) G216C probably damaging Het
Phlpp2 A T 8: 110,640,251 (GRCm39) H472L probably benign Het
Plscr3 A G 11: 69,740,917 (GRCm39) probably null Het
Rab7 A T 6: 87,982,205 (GRCm39) probably null Het
Rad50 A G 11: 53,565,523 (GRCm39) probably null Het
Scgb1b20 A G 7: 33,072,737 (GRCm39) probably null Het
Scn9a A C 2: 66,392,824 (GRCm39) L256R probably damaging Het
Spag1 G T 15: 36,195,588 (GRCm39) Q260H probably damaging Het
Tatdn3 T A 1: 190,778,475 (GRCm39) I239F probably damaging Het
Tcof1 A G 18: 60,964,986 (GRCm39) S578P possibly damaging Het
Top3b A G 16: 16,709,282 (GRCm39) T657A probably benign Het
Tstd3 A G 4: 21,759,621 (GRCm39) probably null Het
Ttc4 A T 4: 106,525,435 (GRCm39) L233H probably damaging Het
Vmn2r130 T A 17: 23,282,794 (GRCm39) M158K probably benign Het
Yeats2 A T 16: 20,027,215 (GRCm39) Q822L probably damaging Het
Zfp976 A T 7: 42,262,843 (GRCm39) C331* probably null Het
Other mutations in Or11g24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01719:Or11g24 APN 14 50,662,018 (GRCm39) missense possibly damaging 0.88
IGL02430:Or11g24 APN 14 50,662,608 (GRCm39) missense probably benign
IGL02603:Or11g24 APN 14 50,662,657 (GRCm39) missense probably damaging 1.00
IGL02959:Or11g24 APN 14 50,662,389 (GRCm39) missense possibly damaging 0.76
IGL03154:Or11g24 APN 14 50,662,080 (GRCm39) missense probably benign 0.00
R0455:Or11g24 UTSW 14 50,662,359 (GRCm39) missense possibly damaging 0.45
R1984:Or11g24 UTSW 14 50,662,848 (GRCm39) missense possibly damaging 0.93
R3160:Or11g24 UTSW 14 50,662,488 (GRCm39) missense probably damaging 0.99
R3161:Or11g24 UTSW 14 50,662,488 (GRCm39) missense probably damaging 0.99
R3162:Or11g24 UTSW 14 50,662,488 (GRCm39) missense probably damaging 0.99
R4821:Or11g24 UTSW 14 50,662,206 (GRCm39) missense possibly damaging 0.96
R4880:Or11g24 UTSW 14 50,662,758 (GRCm39) missense possibly damaging 0.90
R5384:Or11g24 UTSW 14 50,662,846 (GRCm39) missense possibly damaging 0.77
R5385:Or11g24 UTSW 14 50,662,846 (GRCm39) missense possibly damaging 0.77
R5386:Or11g24 UTSW 14 50,662,846 (GRCm39) missense possibly damaging 0.77
R5640:Or11g24 UTSW 14 50,662,111 (GRCm39) missense probably benign 0.18
R5809:Or11g24 UTSW 14 50,662,905 (GRCm39) makesense probably null
R6035:Or11g24 UTSW 14 50,661,984 (GRCm39) missense probably benign
R6035:Or11g24 UTSW 14 50,661,984 (GRCm39) missense probably benign
R6229:Or11g24 UTSW 14 50,662,662 (GRCm39) missense probably benign 0.38
R6614:Or11g24 UTSW 14 50,662,546 (GRCm39) missense probably benign 0.00
R7308:Or11g24 UTSW 14 50,662,722 (GRCm39) missense possibly damaging 0.57
R7443:Or11g24 UTSW 14 50,662,507 (GRCm39) missense probably damaging 1.00
R7699:Or11g24 UTSW 14 50,662,792 (GRCm39) missense probably benign
R7700:Or11g24 UTSW 14 50,662,792 (GRCm39) missense probably benign
R7851:Or11g24 UTSW 14 50,662,827 (GRCm39) missense probably damaging 0.99
R8397:Or11g24 UTSW 14 50,662,137 (GRCm39) missense probably damaging 1.00
R8906:Or11g24 UTSW 14 50,662,291 (GRCm39) missense probably damaging 1.00
R9393:Or11g24 UTSW 14 50,662,255 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGTCCTTCTGTGGATCCAGAAT -3'
(R):5'- AAAATCTTCTGCAGGGCATTTT -3'

Sequencing Primer
(F):5'- CCAGAATTATAGACCACTTCCTGTG -3'
(R):5'- TCTGCAGGGCATTTTTCATATC -3'
Posted On 2016-06-15