Incidental Mutation 'R5048:Fam181b'
ID 394462
Institutional Source Beutler Lab
Gene Symbol Fam181b
Ensembl Gene ENSMUSG00000051515
Gene Name family with sequence similarity 181, member B
Synonyms A830059I20Rik
MMRRC Submission 042638-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.203) question?
Stock # R5048 (G1)
Quality Score 102
Status Validated
Chromosome 7
Chromosomal Location 92729087-92730929 bp(+) (GRCm39)
Type of Mutation utr 5 prime
DNA Base Change (assembly) A to G at 92729147 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000146473 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051179]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000051179
Predicted Effect noncoding transcript
Transcript: ENSMUST00000098303
SMART Domains Protein: ENSMUSP00000095904
Gene: ENSMUSG00000054061

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
low complexity region 41 62 N/A INTRINSIC
low complexity region 111 143 N/A INTRINSIC
low complexity region 167 195 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181886
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191246
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 92.1%
Validation Efficiency 98% (64/65)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal fertility and morphology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 T C 2: 69,138,850 (GRCm39) I144V probably benign Het
Abhd5 T C 9: 122,206,968 (GRCm39) Y85H probably damaging Het
Acadsb G A 7: 131,039,198 (GRCm39) G323D probably damaging Het
Amotl2 A G 9: 102,600,997 (GRCm39) R322G probably benign Het
Aox1 A T 1: 58,098,641 (GRCm39) probably benign Het
Aste1 C T 9: 105,274,188 (GRCm39) R82W probably damaging Het
Atg4b T C 1: 93,703,380 (GRCm39) I139T possibly damaging Het
Btnl5-ps T A 17: 34,707,697 (GRCm39) noncoding transcript Het
Ccdc85c A G 12: 108,187,966 (GRCm39) probably null Het
Clasp1 A G 1: 118,475,340 (GRCm39) probably benign Het
Defb10 G A 8: 22,351,887 (GRCm39) C44Y probably damaging Het
Dhrs9 T C 2: 69,224,744 (GRCm39) V144A probably damaging Het
Dnhd1 G C 7: 105,342,904 (GRCm39) S1416T probably benign Het
Dok1 T A 6: 83,009,087 (GRCm39) probably benign Het
Emilin2 G A 17: 71,580,962 (GRCm39) T588M probably damaging Het
Fhad1 T C 4: 141,691,987 (GRCm39) probably null Het
Foxi2 A G 7: 135,013,364 (GRCm39) E198G probably damaging Het
Fsip2 C A 2: 82,823,494 (GRCm39) A6409E probably damaging Het
Gje1 T C 10: 14,593,021 (GRCm39) Y65C probably damaging Het
Gm6401 T C 14: 41,789,724 (GRCm39) probably null Het
Gprc5c T C 11: 114,761,177 (GRCm39) *442Q probably null Het
Iars1 T A 13: 49,841,713 (GRCm39) I67N probably damaging Het
Igkv4-79 T C 6: 69,019,971 (GRCm39) S115G probably benign Het
Itga4 C A 2: 79,103,378 (GRCm39) S156R probably benign Het
Lilra6 C T 7: 3,918,440 (GRCm39) probably null Het
Majin C A 19: 6,272,684 (GRCm39) A208E probably benign Het
Megf8 A G 7: 25,030,517 (GRCm39) Q490R possibly damaging Het
Mfng C T 15: 78,648,588 (GRCm39) R163H probably benign Het
Mgarp G A 3: 51,298,707 (GRCm39) R88C probably damaging Het
Msh2 T C 17: 87,980,196 (GRCm39) F58S probably damaging Het
Nemp1 T C 10: 127,526,804 (GRCm39) probably null Het
Nlrp10 A T 7: 108,523,772 (GRCm39) N569K probably benign Het
Nxpe2 T C 9: 48,237,388 (GRCm39) probably null Het
Or4c106 T C 2: 88,682,807 (GRCm39) V171A possibly damaging Het
Or5w16 C A 2: 87,576,663 (GRCm39) A41E probably benign Het
Pdcd11 C A 19: 47,095,554 (GRCm39) S625R probably benign Het
Pigb T A 9: 72,936,990 (GRCm39) probably null Het
Pitpnb T C 5: 111,530,869 (GRCm39) F221L possibly damaging Het
Prox2 A T 12: 85,141,115 (GRCm39) W363R probably damaging Het
Psmg1 T A 16: 95,785,171 (GRCm39) R139S probably benign Het
Rab11fip3 A G 17: 26,286,554 (GRCm39) probably null Het
Samd9l G A 6: 3,374,157 (GRCm39) R1035C probably benign Het
Shkbp1 G A 7: 27,051,521 (GRCm39) probably benign Het
Slc30a5 C A 13: 100,943,249 (GRCm39) L536F probably damaging Het
Slc6a17 A T 3: 107,378,753 (GRCm39) L643* probably null Het
Slit3 T C 11: 35,479,812 (GRCm39) Y330H probably damaging Het
St13 G C 15: 81,283,786 (GRCm39) R4G probably benign Het
Stoml3 A C 3: 53,408,213 (GRCm39) K86N possibly damaging Het
Tmtc1 A T 6: 148,139,344 (GRCm39) L926Q possibly damaging Het
Tns4 T G 11: 98,969,605 (GRCm39) R285S possibly damaging Het
Uncx C T 5: 139,532,874 (GRCm39) T313M probably benign Het
Vmn2r75 G A 7: 85,814,735 (GRCm39) R253C possibly damaging Het
Zbed6 T C 1: 133,586,462 (GRCm39) S292G probably damaging Het
Zfp143 A G 7: 109,673,325 (GRCm39) T142A probably damaging Het
Zfp287 T C 11: 62,605,777 (GRCm39) K366E probably damaging Het
Other mutations in Fam181b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1328:Fam181b UTSW 7 92,729,437 (GRCm39) missense probably damaging 0.96
R1447:Fam181b UTSW 7 92,729,368 (GRCm39) missense probably damaging 0.99
R2055:Fam181b UTSW 7 92,729,634 (GRCm39) missense probably benign
R4086:Fam181b UTSW 7 92,729,788 (GRCm39) missense probably benign
R4600:Fam181b UTSW 7 92,729,992 (GRCm39) missense possibly damaging 0.73
R5096:Fam181b UTSW 7 92,730,452 (GRCm39) utr 3 prime probably benign
R7171:Fam181b UTSW 7 92,729,943 (GRCm39) missense possibly damaging 0.49
R7429:Fam181b UTSW 7 92,729,403 (GRCm39) missense probably benign 0.17
R7430:Fam181b UTSW 7 92,729,403 (GRCm39) missense probably benign 0.17
R8555:Fam181b UTSW 7 92,729,296 (GRCm39) missense probably damaging 0.99
R9001:Fam181b UTSW 7 92,730,356 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- GTCAAAACAAATGCCCCGGG -3'
(R):5'- AGCCTTTGTCCAGACTTCCG -3'

Sequencing Primer
(F):5'- TTAAGGTCTGAGAAAGCTCGG -3'
(R):5'- CCGAAGGCGCTCACCAG -3'
Posted On 2016-06-15