Incidental Mutation 'R0448:Cdc20b'
ID 39468
Institutional Source Beutler Lab
Gene Symbol Cdc20b
Ensembl Gene ENSMUSG00000078926
Gene Name cell division cycle 20B
Synonyms EG238896, EG622422
MMRRC Submission 038648-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R0448 (G1)
Quality Score 198
Status Validated
Chromosome 13
Chromosomal Location 113171645-113227729 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 113215191 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 253 (V253E)
Ref Sequence ENSEMBL: ENSMUSP00000137915 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109244] [ENSMUST00000181117] [ENSMUST00000181568]
AlphaFold D3Z3I0
Predicted Effect probably damaging
Transcript: ENSMUST00000109244
AA Change: V253E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000104867
Gene: ENSMUSG00000078926
AA Change: V253E

DomainStartEndE-ValueType
low complexity region 85 97 N/A INTRINSIC
WD40 218 257 6.6e1 SMART
WD40 266 301 5.75e-1 SMART
WD40 304 341 9.24e-1 SMART
WD40 345 383 9.02e-7 SMART
WD40 391 432 3.55e1 SMART
WD40 473 517 2.01e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000181117
AA Change: V253E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000137915
Gene: ENSMUSG00000078926
AA Change: V253E

DomainStartEndE-ValueType
low complexity region 85 97 N/A INTRINSIC
WD40 218 257 6.6e1 SMART
WD40 266 301 5.75e-1 SMART
WD40 304 341 9.24e-1 SMART
WD40 345 383 9.02e-7 SMART
WD40 391 432 3.55e1 SMART
WD40 473 513 1.78e-5 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000181568
AA Change: V253E

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000137849
Gene: ENSMUSG00000078926
AA Change: V253E

DomainStartEndE-ValueType
low complexity region 85 97 N/A INTRINSIC
WD40 218 257 6.6e1 SMART
WD40 266 301 5.75e-1 SMART
WD40 304 341 9.24e-1 SMART
WD40 345 383 9.02e-7 SMART
WD40 431 475 2.01e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232584
Meta Mutation Damage Score 0.7213 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 93.1%
Validation Efficiency 100% (74/74)
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 G A 16: 20,218,687 (GRCm39) R232C probably damaging Het
Adam9 A G 8: 25,454,926 (GRCm39) S732P probably damaging Het
Add2 G A 6: 86,069,901 (GRCm39) V140I probably benign Het
Ahi1 G A 10: 20,847,974 (GRCm39) G461S probably damaging Het
Aoc1l2 A T 6: 48,909,991 (GRCm39) S643C probably damaging Het
Arhgef7 A G 8: 11,869,659 (GRCm39) T432A possibly damaging Het
Arsi T C 18: 61,050,374 (GRCm39) I419T probably damaging Het
Brca1 G A 11: 101,399,047 (GRCm39) P1515L possibly damaging Het
Brcc3 T A X: 74,493,647 (GRCm39) L222* probably null Het
Brpf3 A T 17: 29,025,010 (GRCm39) T28S probably benign Het
Cnot6l T A 5: 96,227,905 (GRCm39) S443C probably benign Het
Copg1 G A 6: 87,881,908 (GRCm39) A587T probably benign Het
Crebrf A G 17: 26,962,076 (GRCm39) D391G probably benign Het
Crocc A T 4: 140,769,502 (GRCm39) D283E probably damaging Het
Cryga T C 1: 65,142,318 (GRCm39) N25S probably benign Het
Csnk1g1 T C 9: 65,888,230 (GRCm39) F90L possibly damaging Het
Cyp2j6 A G 4: 96,433,965 (GRCm39) V115A probably benign Het
Cyp3a11 T C 5: 145,799,204 (GRCm39) I328V probably benign Het
Dchs1 C A 7: 105,415,134 (GRCm39) E683D probably benign Het
Dnah9 T C 11: 65,809,539 (GRCm39) probably benign Het
Dqx1 T C 6: 83,037,326 (GRCm39) S330P probably damaging Het
Epg5 A G 18: 78,066,580 (GRCm39) Y2160C probably damaging Het
Ercc5 T C 1: 44,213,100 (GRCm39) L742P probably damaging Het
Fcgbpl1 T C 7: 27,839,660 (GRCm39) I491T probably benign Het
Flt1 C T 5: 147,503,204 (GRCm39) probably benign Het
Grip2 A G 6: 91,756,194 (GRCm39) S498P probably damaging Het
H2-T22 A G 17: 36,353,278 (GRCm39) L14P possibly damaging Het
Hephl1 C T 9: 14,988,222 (GRCm39) G629S probably damaging Het
Hsdl2 T A 4: 59,606,523 (GRCm39) M162K unknown Het
Kcnh8 C A 17: 53,284,648 (GRCm39) probably null Het
Krt76 T C 15: 101,799,082 (GRCm39) Q201R probably damaging Het
Lrpprc A T 17: 85,078,322 (GRCm39) Y319N probably benign Het
Lrrk2 T G 15: 91,593,508 (GRCm39) I489R probably damaging Het
Mboat1 G T 13: 30,386,393 (GRCm39) D136Y probably damaging Het
Mcmdc2 T C 1: 10,010,767 (GRCm39) *682Q probably null Het
Msx2 C A 13: 53,622,431 (GRCm39) R193L probably damaging Het
Nfatc4 T G 14: 56,069,111 (GRCm39) D625E possibly damaging Het
Nup153 T C 13: 46,870,657 (GRCm39) E86G probably benign Het
Or2g7 G T 17: 38,378,563 (GRCm39) R167L probably benign Het
Or4k45 T A 2: 111,395,559 (GRCm39) I77F probably benign Het
Pard3b T C 1: 62,205,628 (GRCm39) L474P probably damaging Het
Pate11 T A 9: 36,388,412 (GRCm39) M79K probably benign Het
Pggt1b A T 18: 46,396,039 (GRCm39) probably benign Het
Pik3r2 A G 8: 71,224,688 (GRCm39) probably benign Het
Prr14 A G 7: 127,073,898 (GRCm39) probably benign Het
Rcbtb2 T C 14: 73,415,869 (GRCm39) probably benign Het
Rufy2 G A 10: 62,840,515 (GRCm39) D429N probably benign Het
S1pr5 T A 9: 21,155,503 (GRCm39) T308S probably damaging Het
Sephs1 A G 2: 4,904,371 (GRCm39) T250A probably benign Het
Serpina12 A G 12: 104,004,354 (GRCm39) S93P probably benign Het
Serpinb1b T G 13: 33,273,675 (GRCm39) H123Q probably benign Het
Sftpc C T 14: 70,760,120 (GRCm39) V46I probably benign Het
Skint8 T A 4: 111,794,087 (GRCm39) V159D probably damaging Het
Slc25a11 T C 11: 70,536,405 (GRCm39) N134S probably benign Het
Slc25a24 T C 3: 109,064,332 (GRCm39) probably benign Het
Sorl1 C G 9: 41,915,384 (GRCm39) V1282L probably damaging Het
Sptan1 T A 2: 29,916,822 (GRCm39) I2170N probably damaging Het
Syne4 A G 7: 30,014,345 (GRCm39) probably benign Het
Tcam1 G A 11: 106,174,904 (GRCm39) E120K probably benign Het
Tg C A 15: 66,636,291 (GRCm39) P626Q probably damaging Het
Thoc6 T A 17: 23,888,550 (GRCm39) D196V probably damaging Het
Tpi1 A G 6: 124,791,066 (GRCm39) F57S probably damaging Het
Tril A G 6: 53,794,793 (GRCm39) *810Q probably null Het
Trrap T A 5: 144,776,377 (GRCm39) V2972D possibly damaging Het
Ttn A T 2: 76,591,624 (GRCm39) V12688E probably damaging Het
Ttn T C 2: 76,551,283 (GRCm39) M31370V probably damaging Het
Txndc11 A G 16: 10,909,625 (GRCm39) F307S probably damaging Het
Vmn1r40 C T 6: 89,691,642 (GRCm39) S153L probably benign Het
Vmn2r95 A G 17: 18,672,005 (GRCm39) T581A possibly damaging Het
Wdtc1 A G 4: 133,024,811 (GRCm39) F462S probably damaging Het
Zfp101 A G 17: 33,601,295 (GRCm39) S154P possibly damaging Het
Zmym6 A G 4: 127,002,487 (GRCm39) N481D probably benign Het
Other mutations in Cdc20b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01625:Cdc20b APN 13 113,196,319 (GRCm39) missense possibly damaging 0.74
IGL02603:Cdc20b APN 13 113,215,289 (GRCm39) missense possibly damaging 0.88
IGL02663:Cdc20b APN 13 113,192,665 (GRCm39) critical splice donor site probably null
IGL03024:Cdc20b APN 13 113,227,576 (GRCm39) missense possibly damaging 0.58
IGL03379:Cdc20b APN 13 113,217,736 (GRCm39) missense probably damaging 1.00
H8930:Cdc20b UTSW 13 113,220,500 (GRCm39) missense probably damaging 1.00
R0207:Cdc20b UTSW 13 113,215,146 (GRCm39) missense probably damaging 1.00
R0347:Cdc20b UTSW 13 113,196,361 (GRCm39) missense probably damaging 0.97
R0499:Cdc20b UTSW 13 113,192,484 (GRCm39) missense probably benign 0.00
R1573:Cdc20b UTSW 13 113,192,478 (GRCm39) missense probably benign 0.26
R1651:Cdc20b UTSW 13 113,215,258 (GRCm39) nonsense probably null
R1786:Cdc20b UTSW 13 113,217,668 (GRCm39) missense probably damaging 1.00
R1929:Cdc20b UTSW 13 113,208,451 (GRCm39) missense probably benign 0.07
R2118:Cdc20b UTSW 13 113,215,232 (GRCm39) missense probably benign 0.30
R3436:Cdc20b UTSW 13 113,215,233 (GRCm39) missense probably damaging 0.99
R3508:Cdc20b UTSW 13 113,217,576 (GRCm39) missense possibly damaging 0.80
R3837:Cdc20b UTSW 13 113,220,542 (GRCm39) missense probably damaging 1.00
R4050:Cdc20b UTSW 13 113,200,819 (GRCm39) missense probably benign
R4521:Cdc20b UTSW 13 113,217,725 (GRCm39) missense probably damaging 1.00
R4786:Cdc20b UTSW 13 113,215,268 (GRCm39) missense probably damaging 1.00
R6079:Cdc20b UTSW 13 113,220,576 (GRCm39) missense probably damaging 1.00
R6610:Cdc20b UTSW 13 113,200,796 (GRCm39) missense probably benign 0.02
R6814:Cdc20b UTSW 13 113,220,509 (GRCm39) missense probably damaging 1.00
R6872:Cdc20b UTSW 13 113,220,509 (GRCm39) missense probably damaging 1.00
R6887:Cdc20b UTSW 13 113,215,187 (GRCm39) missense possibly damaging 0.88
R7144:Cdc20b UTSW 13 113,219,905 (GRCm39) missense probably benign 0.36
R7579:Cdc20b UTSW 13 113,173,582 (GRCm39) splice site probably null
R7770:Cdc20b UTSW 13 113,215,193 (GRCm39) missense probably benign 0.01
R8669:Cdc20b UTSW 13 113,208,460 (GRCm39) missense possibly damaging 0.83
R8985:Cdc20b UTSW 13 113,196,330 (GRCm39) nonsense probably null
R9182:Cdc20b UTSW 13 113,208,503 (GRCm39) critical splice donor site probably null
R9309:Cdc20b UTSW 13 113,216,472 (GRCm39) missense probably damaging 1.00
R9378:Cdc20b UTSW 13 113,192,631 (GRCm39) missense probably benign 0.03
U15987:Cdc20b UTSW 13 113,220,576 (GRCm39) missense probably damaging 1.00
X0064:Cdc20b UTSW 13 113,196,276 (GRCm39) missense possibly damaging 0.59
Predicted Primers PCR Primer
(F):5'- CATGGTGGATGAACACACTAAGTCCAA -3'
(R):5'- TGGACGTTATCTAGTGACTGCACAGAG -3'

Sequencing Primer
(F):5'- GACTATGAGTCTTGAACAAGAGTCTG -3'
(R):5'- TGACTGCACAGAGGACGC -3'
Posted On 2013-05-23