Incidental Mutation 'R5127:Gm5773'
ID 394810
Institutional Source Beutler Lab
Gene Symbol Gm5773
Ensembl Gene ENSMUSG00000068879
Gene Name predicted pseudogene 5773
Synonyms
MMRRC Submission 042715-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.858) question?
Stock # R5127 (G1)
Quality Score 206
Status Not validated
Chromosome 3
Chromosomal Location 93680307-93681449 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 93680735 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 136 (W136R)
Ref Sequence ENSEMBL: ENSMUSP00000088366 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090853]
AlphaFold Q717B2
Predicted Effect probably benign
Transcript: ENSMUST00000090853
AA Change: W136R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000088366
Gene: ENSMUSG00000068879
AA Change: W136R

DomainStartEndE-ValueType
MATH 40 130 2.58e-7 SMART
BTB 188 287 2.82e-24 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency 93% (42/45)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610008E11Rik T C 10: 78,902,826 (GRCm39) K497E probably damaging Het
4933413J09Rik A G 14: 26,097,462 (GRCm39) noncoding transcript Het
Aox1 A T 1: 58,069,185 (GRCm39) I4F probably benign Het
Arhgef5 A T 6: 43,250,148 (GRCm39) N300Y probably damaging Het
B530045E10Rik A G 10: 99,257,983 (GRCm39) noncoding transcript Het
Ccnb1 C G 13: 100,918,283 (GRCm39) Q121H possibly damaging Het
Cdh20 A G 1: 104,875,073 (GRCm39) E285G probably damaging Het
Cfap54 A T 10: 92,722,249 (GRCm39) probably null Het
Col6a3 A G 1: 90,696,067 (GRCm39) C2667R unknown Het
Cts8 C T 13: 61,401,149 (GRCm39) V126M probably damaging Het
Dag1 A T 9: 108,084,771 (GRCm39) I790N possibly damaging Het
Ddit4 A G 10: 59,786,491 (GRCm39) I186T probably damaging Het
Dnajc11 T A 4: 152,054,271 (GRCm39) probably benign Het
Farsa A G 8: 85,595,593 (GRCm39) D495G probably benign Het
Gm1527 T A 3: 28,957,567 (GRCm39) I157N probably damaging Het
Hpse C A 5: 100,867,403 (GRCm39) A20S unknown Het
Igfn1 A G 1: 135,887,634 (GRCm39) Y2477H probably damaging Het
Kcnh5 A G 12: 74,944,858 (GRCm39) V797A probably benign Het
Kptn T A 7: 15,859,710 (GRCm39) C311* probably null Het
Lpcat2 A T 8: 93,635,819 (GRCm39) N407I possibly damaging Het
Lrp1 T A 10: 127,375,503 (GRCm39) probably benign Het
Ovol2 C T 2: 144,159,780 (GRCm39) C120Y probably damaging Het
Pcdhac2 G T 18: 37,277,352 (GRCm39) E111* probably null Het
Pknox1 C T 17: 31,809,713 (GRCm39) P106S probably benign Het
Plet1 C T 9: 50,415,595 (GRCm39) T155I probably benign Het
Ppfia2 A G 10: 106,671,621 (GRCm39) K444R probably damaging Het
Prrc2c A T 1: 162,525,415 (GRCm39) I397N unknown Het
Ranbp1 A G 16: 18,065,151 (GRCm39) probably null Het
Raver2 T C 4: 100,960,182 (GRCm39) C221R probably damaging Het
Reps1 A G 10: 17,969,628 (GRCm39) T244A probably benign Het
Slc22a16 G A 10: 40,449,953 (GRCm39) V130I probably benign Het
Stmnd1 G A 13: 46,453,071 (GRCm39) S249N probably benign Het
Styx A G 14: 45,610,961 (GRCm39) probably null Het
Sult1b1 T G 5: 87,669,407 (GRCm39) N147T probably damaging Het
Tbc1d2 G A 4: 46,633,639 (GRCm39) probably benign Het
Tm4sf1 T G 3: 57,200,289 (GRCm39) I109L possibly damaging Het
Ufl1 T C 4: 25,256,010 (GRCm39) E423G probably benign Het
Unc13c T C 9: 73,840,654 (GRCm39) I66V probably benign Het
Wfdc10 C T 2: 164,499,060 (GRCm39) Q57* probably null Het
Zeb1os1 T C 18: 5,567,390 (GRCm39) noncoding transcript Het
Zfp369 A T 13: 65,426,847 (GRCm39) probably benign Het
Other mutations in Gm5773
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02954:Gm5773 APN 3 93,680,358 (GRCm39) missense probably benign 0.15
IGL03411:Gm5773 APN 3 93,681,264 (GRCm39) missense probably damaging 1.00
BB005:Gm5773 UTSW 3 93,680,997 (GRCm39) missense probably damaging 0.96
BB015:Gm5773 UTSW 3 93,680,997 (GRCm39) missense probably damaging 0.96
R0239:Gm5773 UTSW 3 93,681,339 (GRCm39) missense probably benign 0.01
R0239:Gm5773 UTSW 3 93,681,339 (GRCm39) missense probably benign 0.01
R1087:Gm5773 UTSW 3 93,681,065 (GRCm39) missense probably damaging 1.00
R1884:Gm5773 UTSW 3 93,681,348 (GRCm39) missense probably benign 0.00
R2122:Gm5773 UTSW 3 93,680,624 (GRCm39) missense possibly damaging 0.78
R2182:Gm5773 UTSW 3 93,680,820 (GRCm39) missense probably benign 0.00
R4615:Gm5773 UTSW 3 93,681,339 (GRCm39) missense probably benign 0.01
R4650:Gm5773 UTSW 3 93,680,712 (GRCm39) missense probably benign 0.04
R5141:Gm5773 UTSW 3 93,681,034 (GRCm39) missense probably benign 0.04
R5347:Gm5773 UTSW 3 93,681,090 (GRCm39) missense probably damaging 0.99
R6883:Gm5773 UTSW 3 93,681,162 (GRCm39) missense probably benign 0.31
R6962:Gm5773 UTSW 3 93,681,234 (GRCm39) missense possibly damaging 0.90
R7444:Gm5773 UTSW 3 93,680,850 (GRCm39) missense probably damaging 1.00
R7549:Gm5773 UTSW 3 93,680,323 (GRCm39) start gained probably benign
R7743:Gm5773 UTSW 3 93,680,565 (GRCm39) missense probably damaging 0.97
R7916:Gm5773 UTSW 3 93,680,586 (GRCm39) missense possibly damaging 0.52
R7928:Gm5773 UTSW 3 93,680,997 (GRCm39) missense probably damaging 0.96
R7992:Gm5773 UTSW 3 93,680,373 (GRCm39) missense possibly damaging 0.66
R8024:Gm5773 UTSW 3 93,680,475 (GRCm39) missense probably benign 0.06
R8500:Gm5773 UTSW 3 93,680,835 (GRCm39) missense probably benign 0.00
R8805:Gm5773 UTSW 3 93,681,042 (GRCm39) missense probably damaging 1.00
R9135:Gm5773 UTSW 3 93,681,179 (GRCm39) missense possibly damaging 0.94
R9281:Gm5773 UTSW 3 93,680,891 (GRCm39) missense probably benign 0.12
R9554:Gm5773 UTSW 3 93,680,340 (GRCm39) missense probably benign 0.00
R9566:Gm5773 UTSW 3 93,680,742 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTCAACTGCCCAAAGAGAC -3'
(R):5'- CTCTGAAAACTGGAGAGCGAGC -3'

Sequencing Primer
(F):5'- GACAAGTTAGGGCAAAGTTTGAATTC -3'
(R):5'- TGATTTCATGGCCAGCTACCAAC -3'
Posted On 2016-06-21