Incidental Mutation 'R5130:Or7g28'
ID 394956
Institutional Source Beutler Lab
Gene Symbol Or7g28
Ensembl Gene ENSMUSG00000058692
Gene Name olfactory receptor family 7 subfamily G member 28
Synonyms GA_x6K02T2PVTD-13098546-13097608, MOR149-3, Olfr846
MMRRC Submission 042718-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.130) question?
Stock # R5130 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 19271711-19272652 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 19272369 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 94 (Y94F)
Ref Sequence ENSEMBL: ENSMUSP00000150672 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078774] [ENSMUST00000214810]
AlphaFold Q8VET8
Predicted Effect possibly damaging
Transcript: ENSMUST00000078774
AA Change: Y94F

PolyPhen 2 Score 0.810 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000077830
Gene: ENSMUSG00000058692
AA Change: Y94F

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.2e-54 PFAM
Pfam:7tm_1 41 290 4.7e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212868
Predicted Effect possibly damaging
Transcript: ENSMUST00000214810
AA Change: Y94F

PolyPhen 2 Score 0.810 (Sensitivity: 0.84; Specificity: 0.93)
Meta Mutation Damage Score 0.1641 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 93.4%
Validation Efficiency 96% (51/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930558K02Rik T C 1: 161,780,184 (GRCm39) N110S possibly damaging Het
Acss3 T C 10: 106,840,586 (GRCm39) I392V possibly damaging Het
Agbl5 G A 5: 31,060,403 (GRCm39) R141Q probably damaging Het
Arhgef11 A G 3: 87,633,321 (GRCm39) H696R possibly damaging Het
Baiap3 G T 17: 25,464,316 (GRCm39) D847E probably benign Het
Cdc27 T C 11: 104,425,600 (GRCm39) K72R probably benign Het
Cry2 T C 2: 92,254,944 (GRCm39) E137G probably benign Het
Dhodh A T 8: 110,322,388 (GRCm39) L237Q possibly damaging Het
Dscam A T 16: 96,620,979 (GRCm39) N576K probably benign Het
Eng A G 2: 32,571,518 (GRCm39) N636S probably damaging Het
Ephx2 A T 14: 66,345,511 (GRCm39) I151K probably damaging Het
Fahd1 A G 17: 25,068,733 (GRCm39) C115R probably damaging Het
Fer1l4 T A 2: 155,891,386 (GRCm39) I143F possibly damaging Het
Iqgap3 C A 3: 88,016,161 (GRCm39) N981K probably damaging Het
Kcna5 T C 6: 126,511,496 (GRCm39) I211V probably benign Het
Mcm9 A T 10: 53,506,495 (GRCm39) V14E possibly damaging Het
Mlh1 A G 9: 111,058,906 (GRCm39) probably null Het
Mylk A G 16: 34,809,367 (GRCm39) K1775E probably damaging Het
Myo18b T C 5: 113,021,769 (GRCm39) D541G probably benign Het
Ncapd2 A T 6: 125,146,887 (GRCm39) M1233K possibly damaging Het
Nf2 A T 11: 4,779,862 (GRCm39) probably benign Het
Nova2 C T 7: 18,660,069 (GRCm39) T22I unknown Het
Or3a1d A T 11: 74,237,993 (GRCm39) M19K probably damaging Het
Or8b12 T A 9: 37,657,805 (GRCm39) I125N probably damaging Het
Pcdha2 A T 18: 37,073,722 (GRCm39) N451I probably damaging Het
Pcdhb12 T A 18: 37,568,877 (GRCm39) F8I probably benign Het
Pdzph1 A C 17: 59,229,604 (GRCm39) L1018W probably damaging Het
Prdm9 T C 17: 15,764,729 (GRCm39) R684G probably benign Het
Rabep1 T A 11: 70,795,557 (GRCm39) V261E probably damaging Het
Ros1 T A 10: 52,040,037 (GRCm39) Y318F possibly damaging Het
Samd9l A T 6: 3,374,548 (GRCm39) D904E possibly damaging Het
Siah3 A T 14: 75,763,381 (GRCm39) K211* probably null Het
Slc5a8 T A 10: 88,762,077 (GRCm39) N572K probably benign Het
Slfn8 A G 11: 82,894,647 (GRCm39) F664S probably benign Het
Sowahb T A 5: 93,190,630 (GRCm39) K696N possibly damaging Het
St7l A T 3: 104,803,080 (GRCm39) H330L probably damaging Het
Tnrc6c T A 11: 117,629,176 (GRCm39) probably null Het
Ttc28 G T 5: 111,040,722 (GRCm39) V37F probably benign Het
Uaca C A 9: 60,787,510 (GRCm39) Q1409K probably damaging Het
V1rd19 T A 7: 23,702,537 (GRCm39) M1K probably null Het
Vmn1r225 A G 17: 20,723,047 (GRCm39) R163G possibly damaging Het
Wdr87-ps T C 7: 29,228,699 (GRCm39) noncoding transcript Het
Zc3h3 C A 15: 75,651,139 (GRCm39) V694L probably damaging Het
Zfp442 G T 2: 150,251,530 (GRCm39) T123K possibly damaging Het
Zmym1 A T 4: 126,942,451 (GRCm39) S646T probably damaging Het
Other mutations in Or7g28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01560:Or7g28 APN 9 19,271,842 (GRCm39) missense probably benign 0.00
IGL01677:Or7g28 APN 9 19,272,441 (GRCm39) missense probably damaging 1.00
PIT4378001:Or7g28 UTSW 9 19,272,471 (GRCm39) missense probably damaging 1.00
R0471:Or7g28 UTSW 9 19,272,177 (GRCm39) nonsense probably null
R2381:Or7g28 UTSW 9 19,271,753 (GRCm39) missense probably benign 0.01
R4320:Or7g28 UTSW 9 19,272,254 (GRCm39) nonsense probably null
R5093:Or7g28 UTSW 9 19,272,274 (GRCm39) missense probably damaging 1.00
R5109:Or7g28 UTSW 9 19,272,438 (GRCm39) missense probably damaging 1.00
R6049:Or7g28 UTSW 9 19,272,640 (GRCm39) nonsense probably null
R6937:Or7g28 UTSW 9 19,271,985 (GRCm39) missense probably damaging 0.99
R7024:Or7g28 UTSW 9 19,272,579 (GRCm39) missense possibly damaging 0.64
R8139:Or7g28 UTSW 9 19,272,504 (GRCm39) missense probably damaging 0.99
R9211:Or7g28 UTSW 9 19,271,824 (GRCm39) missense possibly damaging 0.53
R9476:Or7g28 UTSW 9 19,272,383 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- CTAATGATCAGGGACAGTAGAATTAGC -3'
(R):5'- GTGATCCTACAATGGAGCTCC -3'

Sequencing Primer
(F):5'- TTAGCAGATCACAGAAGTGGGGATTC -3'
(R):5'- ACAATGGAGCTCCTCATATTTAGCC -3'
Posted On 2016-06-21