Incidental Mutation 'R5145:Or7a36'
ID 395088
Institutional Source Beutler Lab
Gene Symbol Or7a36
Ensembl Gene ENSMUSG00000046493
Gene Name olfactory receptor family 7 subfamily A member 36
Synonyms GA_x6K02T2QGN0-2828447-2827518, MOR139-1, Olfr1352
MMRRC Submission 042729-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R5145 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 78816884-78820555 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 78820143 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 173 (E173G)
Ref Sequence ENSEMBL: ENSMUSP00000054355 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058991] [ENSMUST00000203973]
AlphaFold Q8VGX5
Predicted Effect probably benign
Transcript: ENSMUST00000058991
AA Change: E173G

PolyPhen 2 Score 0.346 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000054355
Gene: ENSMUSG00000046493
AA Change: E173G

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.7e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 305 9.1e-6 PFAM
Pfam:7tm_1 41 290 4.7e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203973
SMART Domains Protein: ENSMUSP00000144895
Gene: ENSMUSG00000046493

DomainStartEndE-ValueType
Pfam:7tm_4 1 122 6.1e-25 PFAM
Pfam:7TM_GPCR_Srx 1 123 7.5e-5 PFAM
Pfam:7TM_GPCR_Srsx 2 123 4.5e-8 PFAM
Pfam:7tm_1 8 123 2.1e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219714
Meta Mutation Damage Score 0.4556 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency 100% (37/37)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts12 G A 15: 11,285,962 (GRCm39) G724R probably damaging Het
Adgrg7 T A 16: 56,562,682 (GRCm39) I552L probably benign Het
Ankrd11 A G 8: 123,617,943 (GRCm39) probably benign Het
Col12a1 T C 9: 79,613,582 (GRCm39) T88A probably benign Het
Col6a5 T G 9: 105,811,444 (GRCm39) I692L unknown Het
Cry2 T C 2: 92,243,405 (GRCm39) I479V probably benign Het
Ddx21 T C 10: 62,423,318 (GRCm39) probably null Het
Efcab12 T A 6: 115,800,238 (GRCm39) I262F probably damaging Het
Eif2ak2 T C 17: 79,183,633 (GRCm39) D72G possibly damaging Het
Fry T C 5: 150,293,689 (GRCm39) F461L probably damaging Het
Gm38706 G A 6: 130,460,731 (GRCm39) noncoding transcript Het
Gm9772 C T 17: 22,226,107 (GRCm39) C59Y probably damaging Het
Meig1 T C 2: 3,410,263 (GRCm39) E79G probably damaging Het
Mfng C T 15: 78,648,588 (GRCm39) R163H probably benign Het
Mfsd2b T A 12: 4,915,908 (GRCm39) probably benign Het
Nfatc2 A C 2: 168,431,987 (GRCm39) I42S probably benign Het
Nlgn3 G A X: 100,361,891 (GRCm39) V287I probably benign Het
Npy6r C T 18: 44,409,686 (GRCm39) T369I probably benign Het
Ptprb A G 10: 116,179,820 (GRCm39) T1413A probably benign Het
Ptprc A G 1: 138,017,304 (GRCm39) S624P probably benign Het
Pum3 A G 19: 27,377,169 (GRCm39) V441A probably damaging Het
Ranbp2 T A 10: 58,315,860 (GRCm39) D2193E probably damaging Het
Rbl1 A T 2: 157,017,397 (GRCm39) probably benign Het
Rnf167 T C 11: 70,540,906 (GRCm39) probably benign Het
Sdr9c7 T C 10: 127,738,259 (GRCm39) V179A probably damaging Het
Sema3c A G 5: 17,932,615 (GRCm39) N706S possibly damaging Het
Stt3a T C 9: 36,646,762 (GRCm39) Y617C probably damaging Het
Tdrd6 T A 17: 43,936,966 (GRCm39) S1361C probably damaging Het
Tha1 A C 11: 117,760,502 (GRCm39) S241A probably damaging Het
Tti1 G A 2: 157,850,432 (GRCm39) A269V probably benign Het
Ugt2a1 A G 5: 87,633,886 (GRCm39) probably null Het
Vmn2r10 T C 5: 109,143,761 (GRCm39) T730A possibly damaging Het
Other mutations in Or7a36
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01468:Or7a36 APN 10 78,819,696 (GRCm39) missense probably damaging 0.96
IGL01865:Or7a36 APN 10 78,820,512 (GRCm39) missense possibly damaging 0.94
R0196:Or7a36 UTSW 10 78,820,023 (GRCm39) missense possibly damaging 0.89
R0362:Or7a36 UTSW 10 78,820,220 (GRCm39) missense probably benign 0.00
R1574:Or7a36 UTSW 10 78,819,820 (GRCm39) missense probably damaging 1.00
R1574:Or7a36 UTSW 10 78,819,820 (GRCm39) missense probably damaging 1.00
R2982:Or7a36 UTSW 10 78,820,274 (GRCm39) missense probably damaging 1.00
R4724:Or7a36 UTSW 10 78,820,356 (GRCm39) missense probably damaging 1.00
R5000:Or7a36 UTSW 10 78,820,514 (GRCm39) missense probably benign 0.00
R5085:Or7a36 UTSW 10 78,819,928 (GRCm39) missense probably benign 0.03
R5455:Or7a36 UTSW 10 78,820,371 (GRCm39) missense possibly damaging 0.59
R5777:Or7a36 UTSW 10 78,820,512 (GRCm39) missense possibly damaging 0.78
R5822:Or7a36 UTSW 10 78,820,023 (GRCm39) missense possibly damaging 0.89
R6283:Or7a36 UTSW 10 78,820,113 (GRCm39) missense probably benign 0.01
R7242:Or7a36 UTSW 10 78,820,331 (GRCm39) nonsense probably null
R7504:Or7a36 UTSW 10 78,820,494 (GRCm39) missense possibly damaging 0.78
R8198:Or7a36 UTSW 10 78,820,443 (GRCm39) missense probably benign 0.03
R8268:Or7a36 UTSW 10 78,819,831 (GRCm39) missense probably damaging 0.98
R8684:Or7a36 UTSW 10 78,820,212 (GRCm39) missense probably benign 0.06
R8928:Or7a36 UTSW 10 78,820,547 (GRCm39) missense
R9408:Or7a36 UTSW 10 78,820,220 (GRCm39) missense probably benign 0.01
R9626:Or7a36 UTSW 10 78,820,213 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- TTCCTCCTGGCTGTAATGGC -3'
(R):5'- TGTGACTTACTGCAGAACTGAGG -3'

Sequencing Primer
(F):5'- GCTGTAATGGCCTATGACCG -3'
(R):5'- CTGAGGTATACTCCTAGACCAGTG -3'
Posted On 2016-06-21