Incidental Mutation 'R0449:Neurl4'
| ID |
39539 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Neurl4
|
| Ensembl Gene |
ENSMUSG00000047284 |
| Gene Name |
neuralized E3 ubiquitin protein ligase 4 |
| Synonyms |
0610025P10Rik |
| MMRRC Submission |
038649-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0449 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
69792545-69804648 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 69796393 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 424
(S424P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104257
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018714]
[ENSMUST00000061837]
[ENSMUST00000100969]
[ENSMUST00000102580]
[ENSMUST00000108617]
[ENSMUST00000108621]
[ENSMUST00000128046]
[ENSMUST00000177138]
[ENSMUST00000177476]
[ENSMUST00000133203]
[ENSMUST00000129475]
[ENSMUST00000129234]
[ENSMUST00000144431]
|
| AlphaFold |
Q5NCX5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000018714
|
| SMART Domains |
Protein: ENSMUSP00000018714
Gene: ENSMUSG00000018570
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
86 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
132 |
144 |
N/A |
INTRINSIC |
|
Pfam:IPP-2
|
150 |
277 |
1.3e-44 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000061837
AA Change: S446P
PolyPhen 2
Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000053235
Gene: ENSMUSG00000047284
AA Change: S446P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
1.02e-28 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
317 |
442 |
7.22e-52 |
SMART |
|
low complexity region
|
492 |
503 |
N/A |
INTRINSIC |
|
NEUZ
|
520 |
644 |
6.15e-46 |
SMART |
|
low complexity region
|
686 |
700 |
N/A |
INTRINSIC |
|
NEUZ
|
716 |
840 |
7.81e-39 |
SMART |
|
NEUZ
|
913 |
1043 |
2.27e-17 |
SMART |
|
low complexity region
|
1108 |
1117 |
N/A |
INTRINSIC |
|
NEUZ
|
1130 |
1250 |
4.93e-6 |
SMART |
|
low complexity region
|
1453 |
1464 |
N/A |
INTRINSIC |
|
low complexity region
|
1474 |
1483 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000100969
|
| SMART Domains |
Protein: ENSMUSP00000098529
Gene: ENSMUSG00000018570
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
86 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
132 |
144 |
N/A |
INTRINSIC |
|
Pfam:IPP-2
|
150 |
272 |
5.7e-41 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000102580
|
| SMART Domains |
Protein: ENSMUSP00000099640
Gene: ENSMUSG00000018570
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
86 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
132 |
144 |
N/A |
INTRINSIC |
|
Pfam:IPP-2
|
153 |
270 |
6.2e-31 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000108617
AA Change: S424P
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000104257
Gene: ENSMUSG00000047284
AA Change: S424P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
3.5e-31 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
295 |
420 |
2.5e-54 |
SMART |
|
low complexity region
|
470 |
481 |
N/A |
INTRINSIC |
|
NEUZ
|
498 |
622 |
2e-48 |
SMART |
|
low complexity region
|
664 |
678 |
N/A |
INTRINSIC |
|
NEUZ
|
694 |
818 |
2.6e-41 |
SMART |
|
NEUZ
|
891 |
1021 |
7.6e-20 |
SMART |
|
low complexity region
|
1086 |
1095 |
N/A |
INTRINSIC |
|
NEUZ
|
1108 |
1228 |
1.7e-8 |
SMART |
|
low complexity region
|
1431 |
1442 |
N/A |
INTRINSIC |
|
low complexity region
|
1452 |
1461 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108621
|
| SMART Domains |
Protein: ENSMUSP00000104261
Gene: ENSMUSG00000018570
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
86 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
132 |
144 |
N/A |
INTRINSIC |
|
Pfam:IPP-2
|
150 |
277 |
1.3e-44 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000128046
|
| SMART Domains |
Protein: ENSMUSP00000137547
Gene: ENSMUSG00000018570
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:IPP-2
|
1 |
77 |
1.7e-26 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177138
AA Change: S424P
PolyPhen 2
Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000135277
Gene: ENSMUSG00000047284
AA Change: S424P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
1.02e-28 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
295 |
420 |
7.22e-52 |
SMART |
|
low complexity region
|
470 |
481 |
N/A |
INTRINSIC |
|
NEUZ
|
498 |
622 |
6.15e-46 |
SMART |
|
low complexity region
|
664 |
678 |
N/A |
INTRINSIC |
|
NEUZ
|
694 |
818 |
7.81e-39 |
SMART |
|
NEUZ
|
889 |
1019 |
2.27e-17 |
SMART |
|
low complexity region
|
1084 |
1093 |
N/A |
INTRINSIC |
|
NEUZ
|
1106 |
1226 |
4.93e-6 |
SMART |
|
low complexity region
|
1429 |
1440 |
N/A |
INTRINSIC |
|
low complexity region
|
1450 |
1459 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177476
AA Change: S446P
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000135185
Gene: ENSMUSG00000047284
AA Change: S446P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
1.02e-28 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
317 |
442 |
7.22e-52 |
SMART |
|
low complexity region
|
492 |
503 |
N/A |
INTRINSIC |
|
NEUZ
|
520 |
644 |
6.15e-46 |
SMART |
|
low complexity region
|
686 |
700 |
N/A |
INTRINSIC |
|
NEUZ
|
716 |
840 |
7.81e-39 |
SMART |
|
NEUZ
|
911 |
1041 |
2.27e-17 |
SMART |
|
low complexity region
|
1106 |
1115 |
N/A |
INTRINSIC |
|
NEUZ
|
1128 |
1248 |
4.93e-6 |
SMART |
|
low complexity region
|
1451 |
1462 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1481 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000133203
AA Change: S189P
PolyPhen 2
Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000117917
Gene: ENSMUSG00000047284
AA Change: S189P
| Domain | Start | End | E-Value | Type |
|---|
|
NEUZ
|
60 |
185 |
7.22e-52 |
SMART |
|
low complexity region
|
235 |
246 |
N/A |
INTRINSIC |
|
NEUZ
|
263 |
387 |
6.15e-46 |
SMART |
|
low complexity region
|
429 |
443 |
N/A |
INTRINSIC |
|
NEUZ
|
459 |
583 |
7.81e-39 |
SMART |
|
NEUZ
|
656 |
786 |
2.27e-17 |
SMART |
|
low complexity region
|
851 |
860 |
N/A |
INTRINSIC |
|
Pfam:Neuralized
|
875 |
942 |
6.5e-10 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000129475
AA Change: S123P
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000135733
Gene: ENSMUSG00000047284
AA Change: S123P
| Domain | Start | End | E-Value | Type |
|---|
|
NEUZ
|
1 |
119 |
4.22e-44 |
SMART |
|
low complexity region
|
169 |
180 |
N/A |
INTRINSIC |
|
low complexity region
|
182 |
201 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
206 |
246 |
1.46e-10 |
PROSPERO |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137122
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153041
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176614
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000175761
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000175742
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000177160
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143861
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000129234
|
| SMART Domains |
Protein: ENSMUSP00000136835
Gene: ENSMUSG00000018570
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
86 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
132 |
144 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144431
|
| SMART Domains |
Protein: ENSMUSP00000135926
Gene: ENSMUSG00000018570
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
86 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
132 |
144 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.0%
- 20x: 94.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively spliced transcript variants. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb4 |
A |
T |
5: 8,989,885 (GRCm39) |
R813* |
probably null |
Het |
| Accsl |
T |
A |
2: 93,696,419 (GRCm39) |
I60F |
probably benign |
Het |
| Adam29 |
C |
T |
8: 56,325,716 (GRCm39) |
G246D |
probably benign |
Het |
| Ankrd13c |
A |
G |
3: 157,697,351 (GRCm39) |
I319V |
probably benign |
Het |
| Bag6 |
T |
G |
17: 35,360,442 (GRCm39) |
V327G |
probably damaging |
Het |
| Barhl1 |
C |
T |
2: 28,805,304 (GRCm39) |
A130T |
probably benign |
Het |
| Bend4 |
T |
C |
5: 67,555,583 (GRCm39) |
D541G |
probably damaging |
Het |
| Birc6 |
A |
C |
17: 74,999,290 (GRCm39) |
T4673P |
probably damaging |
Het |
| Ccdc81 |
T |
C |
7: 89,539,679 (GRCm39) |
R186G |
probably damaging |
Het |
| Cdyl2 |
A |
G |
8: 117,309,931 (GRCm39) |
F342L |
probably damaging |
Het |
| Chd3 |
C |
A |
11: 69,248,367 (GRCm39) |
V748L |
probably damaging |
Het |
| CN725425 |
G |
T |
15: 91,123,147 (GRCm39) |
R72I |
possibly damaging |
Het |
| Col22a1 |
A |
G |
15: 71,834,520 (GRCm39) |
|
probably null |
Het |
| Cops3 |
A |
G |
11: 59,709,243 (GRCm39) |
|
probably null |
Het |
| Ctnnd1 |
G |
T |
2: 84,433,606 (GRCm39) |
Q940K |
possibly damaging |
Het |
| Dtnb |
C |
T |
12: 3,641,971 (GRCm39) |
Q45* |
probably null |
Het |
| Efr3a |
T |
A |
15: 65,714,553 (GRCm39) |
I280K |
probably damaging |
Het |
| Eml6 |
A |
C |
11: 29,843,213 (GRCm39) |
V167G |
probably benign |
Het |
| Fam83c |
T |
A |
2: 155,672,215 (GRCm39) |
M407L |
probably benign |
Het |
| Fasn |
T |
C |
11: 120,701,894 (GRCm39) |
T1862A |
probably benign |
Het |
| Fbxl6 |
A |
G |
15: 76,420,155 (GRCm39) |
I486T |
probably damaging |
Het |
| Gpr182 |
A |
G |
10: 127,586,565 (GRCm39) |
Y129H |
probably damaging |
Het |
| Gpr75 |
A |
G |
11: 30,842,456 (GRCm39) |
S454G |
probably damaging |
Het |
| Hectd4 |
G |
A |
5: 121,502,653 (GRCm39) |
|
probably null |
Het |
| Hsf4 |
A |
G |
8: 106,002,222 (GRCm39) |
T411A |
probably benign |
Het |
| Hsh2d |
G |
A |
8: 72,954,304 (GRCm39) |
D229N |
probably benign |
Het |
| Il4 |
A |
T |
11: 53,509,432 (GRCm39) |
M1K |
probably null |
Het |
| Ints11 |
G |
T |
4: 155,972,405 (GRCm39) |
R463L |
probably benign |
Het |
| Ints4 |
G |
A |
7: 97,178,430 (GRCm39) |
E677K |
probably damaging |
Het |
| Klk1b11 |
G |
A |
7: 43,647,216 (GRCm39) |
C50Y |
probably damaging |
Het |
| Krt14 |
C |
A |
11: 100,098,221 (GRCm39) |
G21C |
unknown |
Het |
| Krt81 |
C |
A |
15: 101,361,508 (GRCm39) |
R24L |
possibly damaging |
Het |
| L3mbtl2 |
C |
T |
15: 81,552,942 (GRCm39) |
A125V |
probably damaging |
Het |
| Lama3 |
A |
G |
18: 12,633,569 (GRCm39) |
|
probably null |
Het |
| Lrrk2 |
T |
C |
15: 91,634,478 (GRCm39) |
L1414P |
probably damaging |
Het |
| Matn2 |
T |
C |
15: 34,428,687 (GRCm39) |
S684P |
probably damaging |
Het |
| Mga |
T |
A |
2: 119,771,862 (GRCm39) |
V1574D |
probably damaging |
Het |
| Mia2 |
T |
C |
12: 59,219,380 (GRCm39) |
|
probably null |
Het |
| Mrpl21 |
T |
A |
19: 3,342,459 (GRCm39) |
|
probably benign |
Het |
| Msh5 |
T |
A |
17: 35,260,458 (GRCm39) |
Q266L |
probably benign |
Het |
| Mybpc1 |
C |
A |
10: 88,376,822 (GRCm39) |
C758F |
probably damaging |
Het |
| Myo15a |
G |
A |
11: 60,400,422 (GRCm39) |
A2932T |
possibly damaging |
Het |
| Nbas |
T |
A |
12: 13,569,109 (GRCm39) |
I2021K |
probably benign |
Het |
| Or10j5 |
T |
A |
1: 172,784,965 (GRCm39) |
V201E |
probably damaging |
Het |
| Or2w3 |
A |
C |
11: 58,556,789 (GRCm39) |
I135L |
probably benign |
Het |
| Or6c6 |
A |
G |
10: 129,187,103 (GRCm39) |
M224V |
probably benign |
Het |
| Or7g17 |
T |
C |
9: 18,767,945 (GRCm39) |
M8T |
probably benign |
Het |
| Or7g32 |
T |
A |
9: 19,389,388 (GRCm39) |
I53F |
possibly damaging |
Het |
| Phlpp1 |
C |
T |
1: 106,278,308 (GRCm39) |
R907W |
probably damaging |
Het |
| Pigg |
T |
C |
5: 108,484,277 (GRCm39) |
V508A |
probably benign |
Het |
| Pkhd1l1 |
T |
G |
15: 44,364,915 (GRCm39) |
Y685D |
probably damaging |
Het |
| Polr3a |
A |
T |
14: 24,534,534 (GRCm39) |
I34N |
probably damaging |
Het |
| Pramel17 |
T |
C |
4: 101,694,158 (GRCm39) |
S242G |
probably benign |
Het |
| Prex1 |
A |
G |
2: 166,411,297 (GRCm39) |
V1434A |
probably benign |
Het |
| Ptprh |
T |
A |
7: 4,601,005 (GRCm39) |
D124V |
probably damaging |
Het |
| Rad54b |
T |
A |
4: 11,606,131 (GRCm39) |
I513N |
probably benign |
Het |
| Rbm12b1 |
A |
G |
4: 12,145,507 (GRCm39) |
N493S |
probably benign |
Het |
| Rfx7 |
A |
T |
9: 72,517,586 (GRCm39) |
|
probably null |
Het |
| Serpini1 |
A |
G |
3: 75,520,648 (GRCm39) |
K82E |
probably benign |
Het |
| Slc27a6 |
T |
G |
18: 58,742,237 (GRCm39) |
|
probably null |
Het |
| Slc35f2 |
G |
T |
9: 53,724,201 (GRCm39) |
L358F |
probably damaging |
Het |
| Slc45a1 |
A |
C |
4: 150,727,762 (GRCm39) |
I158M |
probably damaging |
Het |
| Slurp2 |
G |
A |
15: 74,614,955 (GRCm39) |
P62L |
probably damaging |
Het |
| Sspo |
C |
T |
6: 48,443,674 (GRCm39) |
H1949Y |
probably damaging |
Het |
| Tiam1 |
A |
T |
16: 89,634,715 (GRCm39) |
V865E |
possibly damaging |
Het |
| Tlr4 |
A |
C |
4: 66,757,857 (GRCm39) |
I217L |
probably damaging |
Het |
| Top1 |
C |
T |
2: 160,554,628 (GRCm39) |
R460* |
probably null |
Het |
| Trpm3 |
T |
A |
19: 22,965,418 (GRCm39) |
S1638T |
probably benign |
Het |
| Tubgcp5 |
C |
T |
7: 55,473,315 (GRCm39) |
R798C |
probably benign |
Het |
| Vars1 |
T |
G |
17: 35,231,703 (GRCm39) |
|
probably null |
Het |
| Xylt2 |
A |
G |
11: 94,557,159 (GRCm39) |
Y111H |
probably benign |
Het |
| Zbed5 |
G |
A |
5: 129,930,567 (GRCm39) |
G172D |
probably damaging |
Het |
| Zfp53 |
C |
T |
17: 21,729,095 (GRCm39) |
T376I |
probably benign |
Het |
| Zfp937 |
G |
T |
2: 150,081,466 (GRCm39) |
V499L |
probably benign |
Het |
| Zyx |
T |
A |
6: 42,328,247 (GRCm39) |
L152Q |
probably damaging |
Het |
|
| Other mutations in Neurl4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00339:Neurl4
|
APN |
11 |
69,795,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00516:Neurl4
|
APN |
11 |
69,801,219 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01409:Neurl4
|
APN |
11 |
69,797,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01951:Neurl4
|
APN |
11 |
69,800,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02056:Neurl4
|
APN |
11 |
69,796,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02206:Neurl4
|
APN |
11 |
69,801,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02557:Neurl4
|
APN |
11 |
69,797,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02878:Neurl4
|
APN |
11 |
69,797,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0022:Neurl4
|
UTSW |
11 |
69,799,891 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
PIT4377001:Neurl4
|
UTSW |
11 |
69,801,232 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0388:Neurl4
|
UTSW |
11 |
69,802,559 (GRCm39) |
splice site |
probably benign |
|
|
R0421:Neurl4
|
UTSW |
11 |
69,799,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1174:Neurl4
|
UTSW |
11 |
69,794,547 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1345:Neurl4
|
UTSW |
11 |
69,794,702 (GRCm39) |
missense |
probably benign |
0.21 |
|
R1536:Neurl4
|
UTSW |
11 |
69,794,252 (GRCm39) |
nonsense |
probably null |
|
|
R1642:Neurl4
|
UTSW |
11 |
69,794,485 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1857:Neurl4
|
UTSW |
11 |
69,796,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1935:Neurl4
|
UTSW |
11 |
69,797,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1936:Neurl4
|
UTSW |
11 |
69,797,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1967:Neurl4
|
UTSW |
11 |
69,794,036 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1973:Neurl4
|
UTSW |
11 |
69,800,118 (GRCm39) |
missense |
probably benign |
|
|
R2046:Neurl4
|
UTSW |
11 |
69,799,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2165:Neurl4
|
UTSW |
11 |
69,794,047 (GRCm39) |
missense |
probably benign |
|
|
R2393:Neurl4
|
UTSW |
11 |
69,797,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3810:Neurl4
|
UTSW |
11 |
69,794,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4299:Neurl4
|
UTSW |
11 |
69,799,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4749:Neurl4
|
UTSW |
11 |
69,801,894 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4898:Neurl4
|
UTSW |
11 |
69,793,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4968:Neurl4
|
UTSW |
11 |
69,798,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4969:Neurl4
|
UTSW |
11 |
69,801,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5503:Neurl4
|
UTSW |
11 |
69,797,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6655:Neurl4
|
UTSW |
11 |
69,801,742 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6791:Neurl4
|
UTSW |
11 |
69,799,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7029:Neurl4
|
UTSW |
11 |
69,801,562 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7216:Neurl4
|
UTSW |
11 |
69,801,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Neurl4
|
UTSW |
11 |
69,802,905 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7367:Neurl4
|
UTSW |
11 |
69,799,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7804:Neurl4
|
UTSW |
11 |
69,796,700 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7871:Neurl4
|
UTSW |
11 |
69,794,012 (GRCm39) |
missense |
probably benign |
|
|
R8092:Neurl4
|
UTSW |
11 |
69,801,891 (GRCm39) |
missense |
probably benign |
|
|
R8121:Neurl4
|
UTSW |
11 |
69,799,056 (GRCm39) |
splice site |
probably null |
|
|
R8131:Neurl4
|
UTSW |
11 |
69,800,067 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8289:Neurl4
|
UTSW |
11 |
69,800,206 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8354:Neurl4
|
UTSW |
11 |
69,800,062 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8494:Neurl4
|
UTSW |
11 |
69,801,871 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8529:Neurl4
|
UTSW |
11 |
69,799,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8850:Neurl4
|
UTSW |
11 |
69,794,788 (GRCm39) |
unclassified |
probably benign |
|
|
R8992:Neurl4
|
UTSW |
11 |
69,798,958 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R9334:Neurl4
|
UTSW |
11 |
69,796,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9509:Neurl4
|
UTSW |
11 |
69,792,971 (GRCm39) |
nonsense |
probably null |
|
|
R9705:Neurl4
|
UTSW |
11 |
69,799,679 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9707:Neurl4
|
UTSW |
11 |
69,799,679 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9746:Neurl4
|
UTSW |
11 |
69,798,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0025:Neurl4
|
UTSW |
11 |
69,797,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Neurl4
|
UTSW |
11 |
69,794,916 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCTGCCCAAGAGTGGCTTTATTTG -3'
(R):5'- TAGTCTGATACCCACTGCCCCAAG -3'
Sequencing Primer
(F):5'- CCCAAGAGTGGCTTTATTTGAAATTC -3'
(R):5'- ATGGACGATGGTCACTTTCAC -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation