Incidental Mutation 'R5133:Sema6a'
| ID |
395985 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sema6a
|
| Ensembl Gene |
ENSMUSG00000019647 |
| Gene Name |
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A |
| Synonyms |
VIa, Semaq, Sema6A-1, sema, A730020P05Rik |
| MMRRC Submission |
042721-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5133 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
47378321-47504267 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 47433195 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Phenylalanine
at position 79
(V79F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000121442
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000019791]
[ENSMUST00000076043]
[ENSMUST00000115449]
[ENSMUST00000126684]
[ENSMUST00000135790]
[ENSMUST00000156422]
|
| AlphaFold |
O35464 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000019791
AA Change: V79F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000019791
Gene: ENSMUSG00000019647
AA Change: V79F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
648 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
932 |
951 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000076043
AA Change: V79F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000075420
Gene: ENSMUSG00000019647
AA Change: V79F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
593 |
615 |
N/A |
INTRINSIC |
|
low complexity region
|
877 |
896 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115449
AA Change: V79F
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000111109
Gene: ENSMUSG00000019647
AA Change: V79F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
461 |
1.24e-168 |
SMART |
|
PSI
|
488 |
543 |
9.57e-1 |
SMART |
|
transmembrane domain
|
622 |
644 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
925 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000126684
AA Change: V79F
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000118655
Gene: ENSMUSG00000019647
AA Change: V79F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:Sema
|
56 |
216 |
2.5e-51 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000135790
AA Change: V79F
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000120011
Gene: ENSMUSG00000019647
AA Change: V79F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
665 |
687 |
N/A |
INTRINSIC |
|
low complexity region
|
949 |
968 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141224
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144223
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000156422
AA Change: V79F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000121442
Gene: ENSMUSG00000019647
AA Change: V79F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
648 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
932 |
951 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151382
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 96.9%
- 20x: 94.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit defects in lamina-specific neurite stratification of specific retinal neuron subtypes and disruption of the dendritic plexus organization of On but not Off starburst amacrine cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 101 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A3galt2 |
A |
T |
4: 128,655,934 (GRCm39) |
T101S |
probably damaging |
Het |
| Abraxas2 |
C |
T |
7: 132,484,875 (GRCm39) |
A306V |
probably benign |
Het |
| Acvr1c |
T |
A |
2: 58,173,518 (GRCm39) |
N248I |
probably damaging |
Het |
| Adgrv1 |
C |
T |
13: 81,587,560 (GRCm39) |
R4537Q |
probably damaging |
Het |
| Adrb3 |
A |
C |
8: 27,717,798 (GRCm39) |
M217R |
probably damaging |
Het |
| Afg3l1 |
T |
C |
8: 124,216,532 (GRCm39) |
V257A |
probably benign |
Het |
| Agbl1 |
C |
A |
7: 76,071,904 (GRCm39) |
Q334K |
probably benign |
Het |
| Aox4 |
A |
T |
1: 58,275,835 (GRCm39) |
D389V |
probably benign |
Het |
| Apob |
A |
T |
12: 8,058,898 (GRCm39) |
Q2427L |
probably damaging |
Het |
| Asxl3 |
T |
C |
18: 22,649,765 (GRCm39) |
C585R |
probably damaging |
Het |
| Baz2a |
G |
A |
10: 127,951,995 (GRCm39) |
G571D |
probably damaging |
Het |
| Baz2b |
A |
T |
2: 59,792,368 (GRCm39) |
S587T |
probably benign |
Het |
| Bicdl2 |
T |
C |
17: 23,880,795 (GRCm39) |
L14P |
unknown |
Het |
| Cachd1 |
G |
A |
4: 100,851,935 (GRCm39) |
S1177N |
probably damaging |
Het |
| Cacna2d3 |
A |
G |
14: 29,015,135 (GRCm39) |
F86L |
possibly damaging |
Het |
| Ccdc192 |
C |
T |
18: 57,697,041 (GRCm39) |
T65I |
possibly damaging |
Het |
| Cd3d |
A |
T |
9: 44,896,296 (GRCm39) |
E28D |
probably damaging |
Het |
| Cmya5 |
T |
C |
13: 93,229,880 (GRCm39) |
K1736R |
possibly damaging |
Het |
| Col12a1 |
A |
G |
9: 79,512,456 (GRCm39) |
V2913A |
probably damaging |
Het |
| Cops8 |
A |
G |
1: 90,538,724 (GRCm39) |
D51G |
probably damaging |
Het |
| Csgalnact1 |
T |
C |
8: 68,913,623 (GRCm39) |
E194G |
probably benign |
Het |
| Csn1s1 |
A |
G |
5: 87,828,737 (GRCm39) |
D267G |
possibly damaging |
Het |
| Cyp2c40 |
T |
C |
19: 39,795,663 (GRCm39) |
N172S |
probably benign |
Het |
| Dhtkd1 |
T |
A |
2: 5,908,813 (GRCm39) |
K760N |
probably damaging |
Het |
| Dnah17 |
T |
C |
11: 118,007,939 (GRCm39) |
K691E |
probably benign |
Het |
| Dppa4 |
G |
A |
16: 48,113,334 (GRCm39) |
R189Q |
probably benign |
Het |
| Dsp |
G |
A |
13: 38,381,678 (GRCm39) |
D2808N |
possibly damaging |
Het |
| Egr2 |
A |
G |
10: 67,375,605 (GRCm39) |
E17G |
probably damaging |
Het |
| Ehmt1 |
G |
T |
2: 24,767,509 (GRCm39) |
P135T |
probably damaging |
Het |
| Epas1 |
A |
G |
17: 87,116,882 (GRCm39) |
N184S |
probably damaging |
Het |
| Ezh2 |
C |
T |
6: 47,517,684 (GRCm39) |
C584Y |
probably damaging |
Het |
| F10 |
T |
C |
8: 13,105,698 (GRCm39) |
V421A |
probably damaging |
Het |
| Fabp3 |
C |
T |
4: 130,206,180 (GRCm39) |
T57I |
probably benign |
Het |
| Fam186a |
T |
G |
15: 99,853,374 (GRCm39) |
D122A |
unknown |
Het |
| Fam227b |
G |
A |
2: 125,958,043 (GRCm39) |
P241S |
probably damaging |
Het |
| Fam234b |
T |
C |
6: 135,186,193 (GRCm39) |
V67A |
probably benign |
Het |
| Fbn2 |
T |
C |
18: 58,172,412 (GRCm39) |
D2131G |
probably damaging |
Het |
| Fgfr4 |
T |
C |
13: 55,307,828 (GRCm39) |
Y271H |
probably damaging |
Het |
| Gnmt |
A |
T |
17: 47,036,860 (GRCm39) |
S250T |
probably benign |
Het |
| Golgb1 |
C |
A |
16: 36,711,819 (GRCm39) |
Q208K |
possibly damaging |
Het |
| Grn |
C |
A |
11: 102,321,380 (GRCm39) |
|
probably benign |
Het |
| Grwd1 |
T |
C |
7: 45,475,298 (GRCm39) |
T415A |
probably benign |
Het |
| Gsk3b |
G |
A |
16: 38,060,882 (GRCm39) |
R418H |
probably damaging |
Het |
| Hap1 |
T |
G |
11: 100,242,357 (GRCm39) |
M382L |
probably benign |
Het |
| Hspa12b |
A |
G |
2: 130,981,428 (GRCm39) |
E221G |
possibly damaging |
Het |
| Hspa4l |
T |
A |
3: 40,741,179 (GRCm39) |
D709E |
possibly damaging |
Het |
| Il17ra |
A |
G |
6: 120,458,514 (GRCm39) |
E555G |
possibly damaging |
Het |
| Il27ra |
T |
C |
8: 84,760,688 (GRCm39) |
T426A |
possibly damaging |
Het |
| Jup |
T |
C |
11: 100,273,941 (GRCm39) |
D200G |
probably benign |
Het |
| Kcnq1 |
T |
C |
7: 142,748,083 (GRCm39) |
|
probably null |
Het |
| Kctd9 |
C |
T |
14: 67,966,805 (GRCm39) |
T106I |
probably damaging |
Het |
| Kmt5b |
T |
A |
19: 3,852,240 (GRCm39) |
H159Q |
probably damaging |
Het |
| Kprp |
C |
T |
3: 92,731,829 (GRCm39) |
R407Q |
unknown |
Het |
| Kras |
T |
C |
6: 145,177,879 (GRCm39) |
Q131R |
probably benign |
Het |
| Krt16 |
T |
A |
11: 100,138,457 (GRCm39) |
R230S |
probably damaging |
Het |
| Lpar6 |
G |
A |
14: 73,476,147 (GRCm39) |
C36Y |
probably damaging |
Het |
| Lrp10 |
T |
C |
14: 54,707,067 (GRCm39) |
S635P |
probably benign |
Het |
| Mapre2 |
C |
A |
18: 23,991,190 (GRCm39) |
H153N |
possibly damaging |
Het |
| Mark3 |
C |
A |
12: 111,621,762 (GRCm39) |
R703S |
probably damaging |
Het |
| Mboat2 |
A |
G |
12: 25,009,065 (GRCm39) |
D457G |
probably benign |
Het |
| Med13 |
T |
C |
11: 86,210,675 (GRCm39) |
D489G |
probably benign |
Het |
| Msh2 |
C |
A |
17: 88,030,841 (GRCm39) |
A906E |
probably benign |
Het |
| Mtus1 |
T |
C |
8: 41,536,229 (GRCm39) |
T496A |
probably benign |
Het |
| Nckap5 |
T |
C |
1: 125,961,697 (GRCm39) |
H204R |
probably benign |
Het |
| Nlrc4 |
G |
T |
17: 74,753,712 (GRCm39) |
P224T |
possibly damaging |
Het |
| Oprl1 |
T |
A |
2: 181,360,403 (GRCm39) |
I153N |
probably damaging |
Het |
| Or13a27 |
A |
T |
7: 139,925,236 (GRCm39) |
I222N |
probably damaging |
Het |
| Or4c116 |
A |
T |
2: 88,942,140 (GRCm39) |
|
probably null |
Het |
| Or5an1 |
T |
C |
19: 12,260,670 (GRCm39) |
L86P |
possibly damaging |
Het |
| Or5b121 |
T |
A |
19: 13,507,442 (GRCm39) |
M135K |
probably damaging |
Het |
| Otud4 |
G |
A |
8: 80,382,318 (GRCm39) |
V176I |
probably damaging |
Het |
| Pcdhb5 |
T |
C |
18: 37,453,943 (GRCm39) |
F108L |
probably benign |
Het |
| Pde8b |
T |
C |
13: 95,223,250 (GRCm39) |
I335V |
probably benign |
Het |
| Pdzd7 |
T |
A |
19: 45,016,868 (GRCm39) |
I886L |
possibly damaging |
Het |
| Prune2 |
C |
T |
19: 16,980,995 (GRCm39) |
P51S |
probably damaging |
Het |
| Ptpre |
C |
T |
7: 135,270,861 (GRCm39) |
H346Y |
probably benign |
Het |
| Pwwp3a |
T |
C |
10: 80,068,702 (GRCm39) |
L282P |
probably benign |
Het |
| Rab27b |
T |
C |
18: 70,122,659 (GRCm39) |
D100G |
probably damaging |
Het |
| Rpf1 |
A |
G |
3: 146,212,293 (GRCm39) |
L349S |
probably damaging |
Het |
| Samd14 |
T |
C |
11: 94,912,409 (GRCm39) |
S233P |
probably damaging |
Het |
| Setbp1 |
A |
G |
18: 78,900,697 (GRCm39) |
I990T |
probably damaging |
Het |
| Setx |
A |
G |
2: 29,070,093 (GRCm39) |
R2633G |
probably benign |
Het |
| Siae |
T |
G |
9: 37,557,816 (GRCm39) |
I541S |
possibly damaging |
Het |
| Slc13a1 |
A |
G |
6: 24,103,428 (GRCm39) |
S372P |
possibly damaging |
Het |
| Smarcc2 |
T |
C |
10: 128,297,342 (GRCm39) |
|
probably null |
Het |
| Snrpf |
T |
C |
10: 93,423,985 (GRCm39) |
S2G |
probably benign |
Het |
| Speer2 |
C |
A |
16: 69,655,708 (GRCm39) |
K39N |
probably null |
Het |
| Spink5 |
T |
G |
18: 44,119,490 (GRCm39) |
F267C |
probably damaging |
Het |
| Tgfbrap1 |
G |
T |
1: 43,114,666 (GRCm39) |
R145S |
probably damaging |
Het |
| Tmem161b |
C |
A |
13: 84,442,887 (GRCm39) |
T269K |
possibly damaging |
Het |
| Tmem64 |
T |
C |
4: 15,281,119 (GRCm39) |
I304T |
probably damaging |
Het |
| Tomm7 |
A |
G |
5: 24,049,004 (GRCm39) |
I23T |
probably benign |
Het |
| Top6bl |
T |
A |
19: 4,708,449 (GRCm39) |
S194C |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,641,587 (GRCm39) |
L5176Q |
possibly damaging |
Het |
| Ttr |
C |
T |
18: 20,803,167 (GRCm39) |
A111V |
possibly damaging |
Het |
| Usp47 |
T |
A |
7: 111,683,089 (GRCm39) |
Y561N |
probably damaging |
Het |
| Vmn1r17 |
A |
G |
6: 57,337,828 (GRCm39) |
V130A |
probably benign |
Het |
| Wdr45b |
A |
G |
11: 121,219,621 (GRCm39) |
I309T |
probably benign |
Het |
| Wnt6 |
T |
C |
1: 74,823,755 (GRCm39) |
L364P |
probably damaging |
Het |
| Zc3h13 |
T |
C |
14: 75,573,449 (GRCm39) |
L1530P |
probably damaging |
Het |
| Zfp933 |
A |
G |
4: 147,911,321 (GRCm39) |
W60R |
probably benign |
Het |
|
| Other mutations in Sema6a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00336:Sema6a
|
APN |
18 |
47,423,042 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01351:Sema6a
|
APN |
18 |
47,414,369 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL01594:Sema6a
|
APN |
18 |
47,381,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01953:Sema6a
|
APN |
18 |
47,423,187 (GRCm39) |
nonsense |
probably null |
|
|
IGL02077:Sema6a
|
APN |
18 |
47,416,465 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02632:Sema6a
|
APN |
18 |
47,423,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02957:Sema6a
|
APN |
18 |
47,382,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03013:Sema6a
|
APN |
18 |
47,381,461 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03279:Sema6a
|
APN |
18 |
47,433,157 (GRCm39) |
nonsense |
probably null |
|
|
saphire
|
UTSW |
18 |
47,439,496 (GRCm39) |
nonsense |
probably null |
|
|
IGL02988:Sema6a
|
UTSW |
18 |
47,431,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0114:Sema6a
|
UTSW |
18 |
47,423,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0311:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0312:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0347:Sema6a
|
UTSW |
18 |
47,424,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0350:Sema6a
|
UTSW |
18 |
47,403,785 (GRCm39) |
missense |
probably benign |
|
|
R0366:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0368:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0391:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0403:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0466:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0515:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0517:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0542:Sema6a
|
UTSW |
18 |
47,381,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0557:Sema6a
|
UTSW |
18 |
47,382,567 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0569:Sema6a
|
UTSW |
18 |
47,403,872 (GRCm39) |
splice site |
probably null |
|
|
R0650:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0689:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0694:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0726:Sema6a
|
UTSW |
18 |
47,425,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0741:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0821:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0824:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0924:Sema6a
|
UTSW |
18 |
47,381,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1108:Sema6a
|
UTSW |
18 |
47,439,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1255:Sema6a
|
UTSW |
18 |
47,382,366 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1422:Sema6a
|
UTSW |
18 |
47,439,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1531:Sema6a
|
UTSW |
18 |
47,382,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1707:Sema6a
|
UTSW |
18 |
47,416,512 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1746:Sema6a
|
UTSW |
18 |
47,439,416 (GRCm39) |
splice site |
probably benign |
|
|
R1807:Sema6a
|
UTSW |
18 |
47,409,491 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1974:Sema6a
|
UTSW |
18 |
47,403,696 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1987:Sema6a
|
UTSW |
18 |
47,433,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2044:Sema6a
|
UTSW |
18 |
47,439,496 (GRCm39) |
nonsense |
probably null |
|
|
R3719:Sema6a
|
UTSW |
18 |
47,382,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4491:Sema6a
|
UTSW |
18 |
47,439,524 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R4552:Sema6a
|
UTSW |
18 |
47,424,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4707:Sema6a
|
UTSW |
18 |
47,381,779 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4710:Sema6a
|
UTSW |
18 |
47,403,750 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4713:Sema6a
|
UTSW |
18 |
47,382,363 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4963:Sema6a
|
UTSW |
18 |
47,431,318 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5088:Sema6a
|
UTSW |
18 |
47,382,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5135:Sema6a
|
UTSW |
18 |
47,424,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5141:Sema6a
|
UTSW |
18 |
47,381,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5277:Sema6a
|
UTSW |
18 |
47,409,611 (GRCm39) |
intron |
probably benign |
|
|
R5551:Sema6a
|
UTSW |
18 |
47,381,595 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5618:Sema6a
|
UTSW |
18 |
47,415,015 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5717:Sema6a
|
UTSW |
18 |
47,382,330 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5729:Sema6a
|
UTSW |
18 |
47,414,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5779:Sema6a
|
UTSW |
18 |
47,381,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5917:Sema6a
|
UTSW |
18 |
47,414,405 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6054:Sema6a
|
UTSW |
18 |
47,416,470 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6142:Sema6a
|
UTSW |
18 |
47,414,266 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6209:Sema6a
|
UTSW |
18 |
47,431,369 (GRCm39) |
splice site |
probably null |
|
|
R6307:Sema6a
|
UTSW |
18 |
47,382,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6734:Sema6a
|
UTSW |
18 |
47,412,236 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7014:Sema6a
|
UTSW |
18 |
47,431,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7033:Sema6a
|
UTSW |
18 |
47,381,637 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7574:Sema6a
|
UTSW |
18 |
47,424,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8054:Sema6a
|
UTSW |
18 |
47,424,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8250:Sema6a
|
UTSW |
18 |
47,423,182 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8408:Sema6a
|
UTSW |
18 |
47,381,958 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8411:Sema6a
|
UTSW |
18 |
47,382,022 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8900:Sema6a
|
UTSW |
18 |
47,424,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9140:Sema6a
|
UTSW |
18 |
47,415,009 (GRCm39) |
missense |
probably benign |
|
|
R9158:Sema6a
|
UTSW |
18 |
47,431,330 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9488:Sema6a
|
UTSW |
18 |
47,437,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9565:Sema6a
|
UTSW |
18 |
47,382,594 (GRCm39) |
missense |
probably null |
1.00 |
|
R9652:Sema6a
|
UTSW |
18 |
47,382,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9732:Sema6a
|
UTSW |
18 |
47,381,925 (GRCm39) |
missense |
probably damaging |
0.96 |
|
X0065:Sema6a
|
UTSW |
18 |
47,416,386 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
| Predicted Primers |
PCR Primer
(F):5'- GATGTGTAATAAACCCTCACTCACC -3'
(R):5'- AGCTGAGCTCTCTATGTATGGC -3'
Sequencing Primer
(F):5'- TCACTCACCCTAAATCAGACATC -3'
(R):5'- AGCTCTCTATGTATGGCTCAGTAG -3'
|
| Posted On |
2016-06-21 |
Incidental Mutation