Incidental Mutation 'R5137:Gli2'
| ID |
396179 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gli2
|
| Ensembl Gene |
ENSMUSG00000048402 |
| Gene Name |
GLI-Kruppel family member GLI2 |
| Synonyms |
|
| MMRRC Submission |
042723-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5137 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
118761862-118981349 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 118783233 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 91
(I91F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124132
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000062483]
[ENSMUST00000159839]
[ENSMUST00000160991]
[ENSMUST00000161056]
[ENSMUST00000161301]
[ENSMUST00000161451]
[ENSMUST00000162552]
[ENSMUST00000162607]
|
| AlphaFold |
Q0VGT2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000062483
AA Change: I256F
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000054837
Gene: ENSMUSG00000048402
AA Change: I256F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
16 |
N/A |
INTRINSIC |
|
low complexity region
|
36 |
43 |
N/A |
INTRINSIC |
|
low complexity region
|
259 |
278 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
417 |
442 |
4.98e-1 |
SMART |
|
ZnF_C2H2
|
450 |
477 |
6.57e0 |
SMART |
|
ZnF_C2H2
|
483 |
507 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
513 |
538 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
544 |
569 |
1.84e-4 |
SMART |
|
low complexity region
|
637 |
657 |
N/A |
INTRINSIC |
|
low complexity region
|
876 |
890 |
N/A |
INTRINSIC |
|
low complexity region
|
930 |
945 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1053 |
N/A |
INTRINSIC |
|
low complexity region
|
1428 |
1435 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159839
|
| SMART Domains |
Protein: ENSMUSP00000125661
Gene: ENSMUSG00000048402
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
16 |
N/A |
INTRINSIC |
|
low complexity region
|
36 |
43 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160991
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161056
|
| SMART Domains |
Protein: ENSMUSP00000124768
Gene: ENSMUSG00000048402
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
16 |
N/A |
INTRINSIC |
|
low complexity region
|
36 |
43 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000161301
AA Change: I293F
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000125342
Gene: ENSMUSG00000048402
AA Change: I293F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
16 |
N/A |
INTRINSIC |
|
low complexity region
|
36 |
43 |
N/A |
INTRINSIC |
|
low complexity region
|
58 |
72 |
N/A |
INTRINSIC |
|
low complexity region
|
296 |
315 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000161451
AA Change: I91F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000124132
Gene: ENSMUSG00000048402
AA Change: I91F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
16 |
N/A |
INTRINSIC |
|
low complexity region
|
36 |
43 |
N/A |
INTRINSIC |
|
low complexity region
|
94 |
113 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162552
|
| SMART Domains |
Protein: ENSMUSP00000125059
Gene: ENSMUSG00000048402
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
16 |
N/A |
INTRINSIC |
|
low complexity region
|
36 |
43 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000162607
AA Change: I117F
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000123808
Gene: ENSMUSG00000048402
AA Change: I117F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
120 |
139 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 94.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted null mutations exhibit skeletal malformations, absence of floorplate and foregut, lung and anorectal defects, and altered commissural neuron guidance. Most mutants die before embryonic day 18.5. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acad9 |
T |
C |
3: 36,123,920 (GRCm39) |
V75A |
probably benign |
Het |
| Ace |
G |
C |
11: 105,865,652 (GRCm39) |
W628C |
probably damaging |
Het |
| Adh4 |
T |
C |
3: 138,127,996 (GRCm39) |
S141P |
probably benign |
Het |
| Apob |
T |
C |
12: 8,061,384 (GRCm39) |
Y3256H |
possibly damaging |
Het |
| B3galnt1 |
G |
T |
3: 69,482,282 (GRCm39) |
N326K |
probably benign |
Het |
| Bltp3a |
T |
G |
17: 28,095,964 (GRCm39) |
|
probably null |
Het |
| Catsperb |
T |
C |
12: 101,516,070 (GRCm39) |
F569L |
probably damaging |
Het |
| Cecr2 |
A |
G |
6: 120,732,478 (GRCm39) |
I225V |
probably benign |
Het |
| Cox5b |
A |
G |
1: 36,731,510 (GRCm39) |
|
probably null |
Het |
| Crybg1 |
T |
C |
10: 43,834,332 (GRCm39) |
D1953G |
probably damaging |
Het |
| Dnaaf5 |
C |
T |
5: 139,167,215 (GRCm39) |
T707M |
probably damaging |
Het |
| Dnase1l1 |
C |
T |
X: 73,320,644 (GRCm39) |
|
probably null |
Het |
| Ebf1 |
G |
A |
11: 44,882,295 (GRCm39) |
R409Q |
probably damaging |
Het |
| Eef2k |
G |
A |
7: 120,484,645 (GRCm39) |
A256T |
probably damaging |
Het |
| Eef2k |
C |
A |
7: 120,484,646 (GRCm39) |
A256D |
probably damaging |
Het |
| Evl |
C |
G |
12: 108,647,781 (GRCm39) |
T294S |
probably benign |
Het |
| Eya2 |
T |
C |
2: 165,573,548 (GRCm39) |
Y288H |
probably damaging |
Het |
| Ezh2 |
A |
T |
6: 47,509,014 (GRCm39) |
|
probably null |
Het |
| Fam171a1 |
T |
C |
2: 3,226,426 (GRCm39) |
Y395H |
probably benign |
Het |
| Gas2l3 |
C |
A |
10: 89,249,837 (GRCm39) |
R427L |
probably damaging |
Het |
| Gm4884 |
T |
C |
7: 40,692,318 (GRCm39) |
S96P |
probably damaging |
Het |
| Gprc5d |
T |
A |
6: 135,093,031 (GRCm39) |
D292V |
probably benign |
Het |
| Herc1 |
A |
G |
9: 66,355,505 (GRCm39) |
K2252R |
probably benign |
Het |
| Il1rl1 |
A |
T |
1: 40,489,285 (GRCm39) |
M346L |
probably benign |
Het |
| Kcna5 |
A |
T |
6: 126,510,946 (GRCm39) |
V394D |
probably damaging |
Het |
| Kcng4 |
A |
T |
8: 120,352,617 (GRCm39) |
M431K |
possibly damaging |
Het |
| Kifbp |
A |
T |
10: 62,414,020 (GRCm39) |
V46E |
probably damaging |
Het |
| Large1 |
A |
G |
8: 73,774,937 (GRCm39) |
F258L |
possibly damaging |
Het |
| Mapkbp1 |
T |
A |
2: 119,852,662 (GRCm39) |
C1001S |
probably damaging |
Het |
| Micu1 |
A |
G |
10: 59,663,054 (GRCm39) |
Q328R |
probably benign |
Het |
| Mmp11 |
G |
A |
10: 75,761,290 (GRCm39) |
P437S |
probably damaging |
Het |
| Msh6 |
T |
A |
17: 88,287,716 (GRCm39) |
F119I |
possibly damaging |
Het |
| Myo6 |
A |
G |
9: 80,149,531 (GRCm39) |
E159G |
probably damaging |
Het |
| Negr1 |
T |
A |
3: 156,721,833 (GRCm39) |
Y136N |
probably damaging |
Het |
| Nol9 |
T |
A |
4: 152,130,428 (GRCm39) |
C321S |
probably damaging |
Het |
| Nos1 |
T |
C |
5: 118,043,378 (GRCm39) |
F551S |
probably benign |
Het |
| Nup153 |
C |
A |
13: 46,837,629 (GRCm39) |
G1198C |
probably damaging |
Het |
| Omd |
T |
C |
13: 49,743,552 (GRCm39) |
S201P |
probably benign |
Het |
| Or1e16 |
AGCGGTCGTAGGC |
AGC |
11: 73,286,480 (GRCm39) |
|
probably null |
Het |
| Or1e35 |
T |
C |
11: 73,797,452 (GRCm39) |
I289V |
probably damaging |
Het |
| Or4c120 |
C |
A |
2: 89,000,744 (GRCm39) |
V271F |
probably benign |
Het |
| Or51l14 |
A |
G |
7: 103,100,919 (GRCm39) |
Y125C |
probably damaging |
Het |
| Or51l14 |
C |
A |
7: 103,100,920 (GRCm39) |
Y125* |
probably null |
Het |
| Oxct1 |
G |
T |
15: 4,064,832 (GRCm39) |
A57S |
probably benign |
Het |
| Pcdhga7 |
T |
G |
18: 37,850,433 (GRCm39) |
S813R |
probably damaging |
Het |
| Pcmtd2 |
A |
T |
2: 181,496,787 (GRCm39) |
I255F |
possibly damaging |
Het |
| Pdk1 |
T |
G |
2: 71,713,913 (GRCm39) |
M186R |
possibly damaging |
Het |
| Pelp1 |
T |
C |
11: 70,285,925 (GRCm39) |
T648A |
probably damaging |
Het |
| Phldb2 |
A |
T |
16: 45,628,621 (GRCm39) |
S570R |
possibly damaging |
Het |
| Pramel16 |
T |
A |
4: 143,675,690 (GRCm39) |
T379S |
probably benign |
Het |
| Ptprj |
T |
C |
2: 90,299,992 (GRCm39) |
T270A |
possibly damaging |
Het |
| Reln |
C |
T |
5: 22,160,179 (GRCm39) |
G2130D |
probably damaging |
Het |
| Rims1 |
A |
T |
1: 22,358,844 (GRCm39) |
Y663* |
probably null |
Het |
| Rit2 |
T |
C |
18: 31,286,817 (GRCm39) |
T123A |
probably benign |
Het |
| Rmdn2 |
A |
T |
17: 79,975,418 (GRCm39) |
E302D |
probably benign |
Het |
| Ryr1 |
T |
C |
7: 28,801,283 (GRCm39) |
E827G |
possibly damaging |
Het |
| Siglec1 |
C |
T |
2: 130,923,264 (GRCm39) |
G494R |
probably damaging |
Het |
| Slc16a14 |
T |
A |
1: 84,890,318 (GRCm39) |
Y329F |
probably damaging |
Het |
| Slc35d1 |
A |
T |
4: 103,071,978 (GRCm39) |
L8Q |
possibly damaging |
Het |
| Smpdl3a |
C |
T |
10: 57,677,163 (GRCm39) |
S57L |
possibly damaging |
Het |
| Snx9 |
T |
C |
17: 5,978,528 (GRCm39) |
V566A |
probably damaging |
Het |
| Spaca1 |
A |
T |
4: 34,029,095 (GRCm39) |
I126N |
probably damaging |
Het |
| Spred1 |
T |
G |
2: 116,994,052 (GRCm39) |
I94S |
probably damaging |
Het |
| Tardbp |
T |
C |
4: 148,706,494 (GRCm39) |
D105G |
possibly damaging |
Het |
| Tet2 |
T |
C |
3: 133,182,326 (GRCm39) |
S1213G |
probably benign |
Het |
| Trak1 |
A |
T |
9: 121,196,121 (GRCm39) |
|
probably benign |
Het |
| Trem3 |
G |
A |
17: 48,556,756 (GRCm39) |
V76M |
possibly damaging |
Het |
| Ttc13 |
G |
T |
8: 125,421,674 (GRCm39) |
Y250* |
probably null |
Het |
| Ttll5 |
T |
G |
12: 85,969,819 (GRCm39) |
S714R |
possibly damaging |
Het |
| Ube2l6 |
T |
G |
2: 84,633,220 (GRCm39) |
|
probably null |
Het |
| Ubr3 |
T |
C |
2: 69,803,679 (GRCm39) |
S1090P |
probably damaging |
Het |
| Vezt |
T |
C |
10: 93,806,372 (GRCm39) |
T680A |
probably benign |
Het |
| Virma |
A |
G |
4: 11,546,297 (GRCm39) |
K1762E |
probably damaging |
Het |
| Vps53 |
A |
G |
11: 76,057,074 (GRCm39) |
S57P |
probably damaging |
Het |
| Vwa7 |
G |
T |
17: 35,236,822 (GRCm39) |
D130Y |
probably damaging |
Het |
| Vwa8 |
T |
G |
14: 79,302,342 (GRCm39) |
F1004V |
probably damaging |
Het |
| Zfp35 |
A |
T |
18: 24,137,194 (GRCm39) |
K513* |
probably null |
Het |
| Zfp384 |
ACAGCAGCAGCAGCAGCAGCAGC |
ACAGCAGCAGCAGCAGCAGC |
6: 125,013,472 (GRCm39) |
|
probably benign |
Het |
| Zfp521 |
C |
A |
18: 13,978,505 (GRCm39) |
C636F |
probably damaging |
Het |
|
| Other mutations in Gli2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01410:Gli2
|
APN |
1 |
118,764,621 (GRCm39) |
missense |
probably benign |
|
|
IGL01686:Gli2
|
APN |
1 |
118,776,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01925:Gli2
|
APN |
1 |
118,781,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02106:Gli2
|
APN |
1 |
118,764,465 (GRCm39) |
missense |
probably benign |
|
|
IGL02202:Gli2
|
APN |
1 |
118,764,596 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02255:Gli2
|
APN |
1 |
118,772,079 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02437:Gli2
|
APN |
1 |
118,763,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02615:Gli2
|
APN |
1 |
118,772,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02817:Gli2
|
APN |
1 |
118,764,101 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL03294:Gli2
|
APN |
1 |
118,765,166 (GRCm39) |
missense |
probably benign |
|
|
fairyfly
|
UTSW |
1 |
118,768,220 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
flea
|
UTSW |
1 |
118,763,655 (GRCm39) |
missense |
probably damaging |
0.99 |
|
patu_digua
|
UTSW |
1 |
118,765,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB006:Gli2
|
UTSW |
1 |
118,769,772 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
BB016:Gli2
|
UTSW |
1 |
118,769,772 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0055:Gli2
|
UTSW |
1 |
118,818,138 (GRCm39) |
intron |
probably benign |
|
|
R0055:Gli2
|
UTSW |
1 |
118,818,138 (GRCm39) |
intron |
probably benign |
|
|
R0164:Gli2
|
UTSW |
1 |
118,818,013 (GRCm39) |
intron |
probably benign |
|
|
R0233:Gli2
|
UTSW |
1 |
118,763,655 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0233:Gli2
|
UTSW |
1 |
118,763,655 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0308:Gli2
|
UTSW |
1 |
118,769,792 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0418:Gli2
|
UTSW |
1 |
118,768,220 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0558:Gli2
|
UTSW |
1 |
118,765,379 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0600:Gli2
|
UTSW |
1 |
118,768,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Gli2
|
UTSW |
1 |
118,769,648 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R0690:Gli2
|
UTSW |
1 |
118,772,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0942:Gli2
|
UTSW |
1 |
118,765,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1061:Gli2
|
UTSW |
1 |
118,782,247 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1104:Gli2
|
UTSW |
1 |
118,781,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1141:Gli2
|
UTSW |
1 |
118,765,667 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1344:Gli2
|
UTSW |
1 |
118,769,666 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1418:Gli2
|
UTSW |
1 |
118,769,666 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1565:Gli2
|
UTSW |
1 |
118,769,660 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R1605:Gli2
|
UTSW |
1 |
118,782,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1640:Gli2
|
UTSW |
1 |
118,764,254 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1728:Gli2
|
UTSW |
1 |
118,929,774 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1728:Gli2
|
UTSW |
1 |
118,795,817 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1729:Gli2
|
UTSW |
1 |
118,929,774 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1729:Gli2
|
UTSW |
1 |
118,795,817 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1730:Gli2
|
UTSW |
1 |
118,929,774 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1730:Gli2
|
UTSW |
1 |
118,795,817 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1739:Gli2
|
UTSW |
1 |
118,929,774 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1739:Gli2
|
UTSW |
1 |
118,795,817 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1762:Gli2
|
UTSW |
1 |
118,929,774 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1762:Gli2
|
UTSW |
1 |
118,795,817 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1783:Gli2
|
UTSW |
1 |
118,929,774 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1783:Gli2
|
UTSW |
1 |
118,795,817 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1785:Gli2
|
UTSW |
1 |
118,929,774 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1785:Gli2
|
UTSW |
1 |
118,795,817 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1874:Gli2
|
UTSW |
1 |
118,929,779 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1969:Gli2
|
UTSW |
1 |
118,765,430 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2199:Gli2
|
UTSW |
1 |
118,765,378 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2377:Gli2
|
UTSW |
1 |
118,764,855 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2883:Gli2
|
UTSW |
1 |
118,795,874 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2924:Gli2
|
UTSW |
1 |
118,764,089 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4363:Gli2
|
UTSW |
1 |
118,781,100 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4430:Gli2
|
UTSW |
1 |
118,764,974 (GRCm39) |
missense |
probably benign |
|
|
R4463:Gli2
|
UTSW |
1 |
118,763,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4583:Gli2
|
UTSW |
1 |
118,769,798 (GRCm39) |
missense |
probably benign |
|
|
R4613:Gli2
|
UTSW |
1 |
118,765,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4674:Gli2
|
UTSW |
1 |
118,763,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4735:Gli2
|
UTSW |
1 |
118,768,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4770:Gli2
|
UTSW |
1 |
118,910,318 (GRCm39) |
intron |
probably benign |
|
|
R4936:Gli2
|
UTSW |
1 |
118,763,870 (GRCm39) |
missense |
probably benign |
|
|
R5228:Gli2
|
UTSW |
1 |
118,763,936 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5318:Gli2
|
UTSW |
1 |
118,772,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5619:Gli2
|
UTSW |
1 |
118,764,485 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5661:Gli2
|
UTSW |
1 |
118,781,032 (GRCm39) |
nonsense |
probably null |
|
|
R6005:Gli2
|
UTSW |
1 |
118,769,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6012:Gli2
|
UTSW |
1 |
118,765,445 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6341:Gli2
|
UTSW |
1 |
118,763,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6357:Gli2
|
UTSW |
1 |
118,769,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6425:Gli2
|
UTSW |
1 |
118,763,624 (GRCm39) |
nonsense |
probably null |
|
|
R6513:Gli2
|
UTSW |
1 |
118,783,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6802:Gli2
|
UTSW |
1 |
118,769,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6889:Gli2
|
UTSW |
1 |
118,772,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7259:Gli2
|
UTSW |
1 |
118,764,264 (GRCm39) |
missense |
probably benign |
|
|
R7378:Gli2
|
UTSW |
1 |
118,776,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7420:Gli2
|
UTSW |
1 |
118,763,669 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7489:Gli2
|
UTSW |
1 |
118,765,905 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7498:Gli2
|
UTSW |
1 |
118,763,565 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7929:Gli2
|
UTSW |
1 |
118,769,772 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8032:Gli2
|
UTSW |
1 |
118,763,900 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8150:Gli2
|
UTSW |
1 |
118,763,558 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8233:Gli2
|
UTSW |
1 |
118,772,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8282:Gli2
|
UTSW |
1 |
118,765,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8312:Gli2
|
UTSW |
1 |
118,795,842 (GRCm39) |
intron |
probably benign |
|
|
R8686:Gli2
|
UTSW |
1 |
118,764,417 (GRCm39) |
missense |
probably benign |
|
|
R8698:Gli2
|
UTSW |
1 |
118,769,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8935:Gli2
|
UTSW |
1 |
118,764,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8938:Gli2
|
UTSW |
1 |
118,763,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8955:Gli2
|
UTSW |
1 |
118,783,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9214:Gli2
|
UTSW |
1 |
118,795,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9232:Gli2
|
UTSW |
1 |
118,764,021 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9295:Gli2
|
UTSW |
1 |
118,764,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9369:Gli2
|
UTSW |
1 |
118,765,885 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9496:Gli2
|
UTSW |
1 |
118,764,425 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9757:Gli2
|
UTSW |
1 |
118,773,652 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0028:Gli2
|
UTSW |
1 |
118,765,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGACTGTACCAAAGAGCCAC -3'
(R):5'- GTGATACTAACAAGCCTTCCGTTG -3'
Sequencing Primer
(F):5'- CAGTTGCTAGCATGTTGAGACAC -3'
(R):5'- CGTTGGCTGTCTCCCAG -3'
|
| Posted On |
2016-06-21 |
Incidental Mutation