Incidental Mutation 'R5155:Clstn2'
ID 396670
Institutional Source Beutler Lab
Gene Symbol Clstn2
Ensembl Gene ENSMUSG00000032452
Gene Name calsyntenin 2
Synonyms 2900042C18Rik, Cst-2, CS2, CSTN2
MMRRC Submission 042737-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5155 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 97326448-97915234 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 97338484 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 892 (M892L)
Ref Sequence ENSEMBL: ENSMUSP00000124081 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035027] [ENSMUST00000162295]
AlphaFold Q9ER65
Predicted Effect probably benign
Transcript: ENSMUST00000035027
AA Change: M892L

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000035027
Gene: ENSMUSG00000032452
AA Change: M892L

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
CA 67 160 2e-10 SMART
CA 183 261 1.18e-3 SMART
SCOP:d1a8d_1 358 538 5e-21 SMART
Blast:LamG 380 529 3e-41 BLAST
transmembrane domain 835 857 N/A INTRINSIC
low complexity region 901 935 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162295
AA Change: M892L

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000124081
Gene: ENSMUSG00000032452
AA Change: M892L

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
CA 67 160 2e-10 SMART
CA 183 261 1.18e-3 SMART
Pfam:Laminin_G_3 356 533 1.4e-9 PFAM
transmembrane domain 835 857 N/A INTRINSIC
low complexity region 901 935 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous KO mice display deficiency in spatial learning and memory in Morris water and Barnes maze tasks and increased locomotor activity in open field test. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T C 11: 9,482,447 (GRCm39) V4326A probably damaging Het
Actn4 A G 7: 28,661,442 (GRCm39) probably null Het
Adamts8 A G 9: 30,865,844 (GRCm39) D464G probably benign Het
Adss1 T C 12: 112,604,642 (GRCm39) I366T probably damaging Het
Alox12e T C 11: 70,207,081 (GRCm39) D575G possibly damaging Het
Ankrd44 A T 1: 54,817,489 (GRCm39) M73K probably benign Het
Ap4e1 A G 2: 126,905,289 (GRCm39) T987A probably benign Het
Banp A C 8: 122,727,759 (GRCm39) S318R probably damaging Het
Bcas1 T C 2: 170,260,538 (GRCm39) H47R probably damaging Het
Brwd1 G T 16: 95,803,993 (GRCm39) S2524* probably null Het
Btbd8 T C 5: 107,638,569 (GRCm39) I323T probably damaging Het
Cand2 T A 6: 115,769,219 (GRCm39) D676E probably benign Het
Cc2d1a A T 8: 84,867,755 (GRCm39) H224Q probably benign Het
Ccdc138 A T 10: 58,343,394 (GRCm39) Y83F probably benign Het
Ccdc162 A T 10: 41,429,576 (GRCm39) probably null Het
Ccdc162 A C 10: 41,455,147 (GRCm39) S396A probably damaging Het
Ces1e A T 8: 93,928,034 (GRCm39) *562R probably null Het
Crybg3 T C 16: 59,345,264 (GRCm39) T2673A possibly damaging Het
Cstf3 A G 2: 104,482,830 (GRCm39) N326S probably benign Het
Cux1 G A 5: 136,594,295 (GRCm39) probably benign Het
Cyb5r4 T G 9: 86,922,456 (GRCm39) M155R probably benign Het
D130043K22Rik A G 13: 25,056,273 (GRCm39) D535G probably damaging Het
Dnah2 G A 11: 69,313,362 (GRCm39) P4266S probably damaging Het
Dnah7a T A 1: 53,682,654 (GRCm39) N272I probably benign Het
Dsg2 A G 18: 20,731,715 (GRCm39) Y779C possibly damaging Het
Eif4g3 T A 4: 137,854,054 (GRCm39) N507K probably benign Het
Elavl4 T C 4: 110,149,833 (GRCm39) Q3R probably null Het
Engase T G 11: 118,372,107 (GRCm39) I133S probably benign Het
Ercc5 T C 1: 44,219,782 (GRCm39) V1018A probably damaging Het
Ext1 C A 15: 52,939,213 (GRCm39) W612L probably damaging Het
Faap100 T A 11: 120,268,458 (GRCm39) E105V possibly damaging Het
Fam8a1 G A 13: 46,827,038 (GRCm39) A270T probably benign Het
Fhdc1 T G 3: 84,353,457 (GRCm39) Q589H probably benign Het
Gatm G A 2: 122,440,334 (GRCm39) T35I probably benign Het
Gcgr T C 11: 120,427,872 (GRCm39) I271T probably benign Het
Gm527 T A 12: 64,970,381 (GRCm39) Y239N probably damaging Het
H2-Ab1 A G 17: 34,486,358 (GRCm39) H139R possibly damaging Het
Herc2 G A 7: 55,877,574 (GRCm39) R4547Q possibly damaging Het
Itga1 A T 13: 115,171,839 (GRCm39) S89T probably benign Het
Kash5 C A 7: 44,839,078 (GRCm39) E53* probably null Het
Katnip A G 7: 125,471,356 (GRCm39) T1486A probably damaging Het
Lrba A G 3: 86,258,607 (GRCm39) M1365V probably benign Het
Lrp1b A C 2: 41,618,634 (GRCm39) probably null Het
Map1a G A 2: 121,132,867 (GRCm39) A990T probably damaging Het
Micall2 C A 5: 139,695,986 (GRCm39) L784F probably damaging Het
Mmp9 T C 2: 164,790,986 (GRCm39) probably null Het
Mrps7 T A 11: 115,495,655 (GRCm39) Y64* probably null Het
Mslnl C T 17: 25,957,942 (GRCm39) Q62* probably null Het
Nfil3 A G 13: 53,122,616 (GRCm39) L96P probably damaging Het
Or2f1 A G 6: 42,721,748 (GRCm39) Y259C probably damaging Het
Phf3 T C 1: 30,863,457 (GRCm39) D756G possibly damaging Het
Plxnd1 C T 6: 115,935,949 (GRCm39) probably null Het
Prickle4 C T 17: 48,000,982 (GRCm39) probably null Het
Prr9 T A 3: 92,030,356 (GRCm39) T95S possibly damaging Het
Prrc2a A G 17: 35,379,067 (GRCm39) probably null Het
Prrt3 A G 6: 113,474,520 (GRCm39) probably null Het
Psme4 A T 11: 30,826,806 (GRCm39) Y1775F probably damaging Het
Pum2 T C 12: 8,763,572 (GRCm39) V243A possibly damaging Het
Rnf32 T C 5: 29,408,145 (GRCm39) S125P probably damaging Het
Rnf8 A G 17: 29,845,604 (GRCm39) Y65C probably damaging Het
Rph3a T C 5: 121,086,833 (GRCm39) T456A possibly damaging Het
Scaper T A 9: 55,463,370 (GRCm39) Q854L probably null Het
Sez6l2 T C 7: 126,561,545 (GRCm39) S472P probably damaging Het
Spsb3 T C 17: 25,105,969 (GRCm39) probably benign Het
Srebf2 A G 15: 82,080,427 (GRCm39) D40G probably damaging Het
Sspo A G 6: 48,437,408 (GRCm39) N1389D probably benign Het
Taf4b G T 18: 14,963,152 (GRCm39) A631S probably benign Het
Tcstv1b T C 13: 120,635,089 (GRCm39) S124P probably benign Het
Tigd4 G A 3: 84,501,970 (GRCm39) V296M possibly damaging Het
Tsc22d2 T A 3: 58,324,737 (GRCm39) probably benign Het
Uso1 T A 5: 92,315,194 (GRCm39) probably null Het
Vmn2r6 T G 3: 64,445,935 (GRCm39) N597H probably benign Het
Zfc3h1 T A 10: 115,248,026 (GRCm39) S1076R possibly damaging Het
Zfp64 T A 2: 168,748,885 (GRCm39) Q44L probably benign Het
Other mutations in Clstn2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00562:Clstn2 APN 9 97,464,505 (GRCm39) splice site probably benign
IGL00563:Clstn2 APN 9 97,464,505 (GRCm39) splice site probably benign
IGL00733:Clstn2 APN 9 97,365,102 (GRCm39) missense probably damaging 1.00
IGL01303:Clstn2 APN 9 97,365,128 (GRCm39) nonsense probably null
IGL01935:Clstn2 APN 9 97,345,521 (GRCm39) missense probably damaging 1.00
IGL02157:Clstn2 APN 9 97,423,928 (GRCm39) missense probably benign
IGL02974:Clstn2 APN 9 97,414,760 (GRCm39) missense probably damaging 1.00
IGL03164:Clstn2 APN 9 97,681,462 (GRCm39) missense possibly damaging 0.50
IGL03298:Clstn2 APN 9 97,338,625 (GRCm39) missense probably damaging 1.00
R0653:Clstn2 UTSW 9 97,340,257 (GRCm39) missense probably damaging 1.00
R0845:Clstn2 UTSW 9 97,452,681 (GRCm39) missense probably benign 0.39
R0992:Clstn2 UTSW 9 97,327,765 (GRCm39) missense probably benign 0.00
R1105:Clstn2 UTSW 9 97,465,552 (GRCm39) splice site probably null
R1112:Clstn2 UTSW 9 97,340,281 (GRCm39) missense possibly damaging 0.92
R1264:Clstn2 UTSW 9 97,339,662 (GRCm39) missense probably benign 0.28
R1275:Clstn2 UTSW 9 97,339,483 (GRCm39) missense probably benign 0.00
R1329:Clstn2 UTSW 9 97,340,227 (GRCm39) missense probably damaging 1.00
R1396:Clstn2 UTSW 9 97,343,446 (GRCm39) missense probably benign 0.02
R1556:Clstn2 UTSW 9 97,338,558 (GRCm39) missense probably benign 0.41
R1703:Clstn2 UTSW 9 97,340,290 (GRCm39) missense possibly damaging 0.90
R1837:Clstn2 UTSW 9 97,465,593 (GRCm39) missense probably benign 0.00
R2911:Clstn2 UTSW 9 97,414,775 (GRCm39) missense probably damaging 1.00
R3434:Clstn2 UTSW 9 97,336,768 (GRCm39) missense probably benign 0.17
R3771:Clstn2 UTSW 9 97,464,615 (GRCm39) missense probably damaging 1.00
R3772:Clstn2 UTSW 9 97,464,615 (GRCm39) missense probably damaging 1.00
R3854:Clstn2 UTSW 9 97,345,648 (GRCm39) nonsense probably null
R4049:Clstn2 UTSW 9 97,339,613 (GRCm39) missense possibly damaging 0.59
R4334:Clstn2 UTSW 9 97,345,581 (GRCm39) missense probably damaging 1.00
R4705:Clstn2 UTSW 9 97,345,612 (GRCm39) missense possibly damaging 0.95
R4755:Clstn2 UTSW 9 97,327,726 (GRCm39) missense probably benign 0.01
R4884:Clstn2 UTSW 9 97,681,448 (GRCm39) missense probably damaging 1.00
R5017:Clstn2 UTSW 9 97,365,139 (GRCm39) missense probably damaging 1.00
R5076:Clstn2 UTSW 9 97,365,132 (GRCm39) missense probably damaging 1.00
R5122:Clstn2 UTSW 9 97,343,474 (GRCm39) missense probably damaging 1.00
R5560:Clstn2 UTSW 9 97,351,872 (GRCm39) missense possibly damaging 0.95
R6009:Clstn2 UTSW 9 97,338,579 (GRCm39) missense probably benign 0.05
R6011:Clstn2 UTSW 9 97,338,579 (GRCm39) missense probably benign 0.05
R6029:Clstn2 UTSW 9 97,338,634 (GRCm39) missense probably benign 0.00
R6093:Clstn2 UTSW 9 97,340,263 (GRCm39) missense probably damaging 1.00
R6284:Clstn2 UTSW 9 97,336,727 (GRCm39) missense probably benign
R6676:Clstn2 UTSW 9 97,343,584 (GRCm39) missense probably damaging 1.00
R6902:Clstn2 UTSW 9 97,351,875 (GRCm39) missense probably damaging 1.00
R6946:Clstn2 UTSW 9 97,351,875 (GRCm39) missense probably damaging 1.00
R6966:Clstn2 UTSW 9 97,408,459 (GRCm39) nonsense probably null
R7329:Clstn2 UTSW 9 97,343,422 (GRCm39) missense probably benign 0.00
R7330:Clstn2 UTSW 9 97,343,422 (GRCm39) missense probably benign 0.00
R7382:Clstn2 UTSW 9 97,681,451 (GRCm39) nonsense probably null
R7410:Clstn2 UTSW 9 97,423,920 (GRCm39) missense probably benign 0.06
R7549:Clstn2 UTSW 9 97,464,597 (GRCm39) missense probably benign 0.01
R7879:Clstn2 UTSW 9 97,351,817 (GRCm39) missense possibly damaging 0.90
R8070:Clstn2 UTSW 9 97,681,523 (GRCm39) missense possibly damaging 0.79
R8193:Clstn2 UTSW 9 97,465,683 (GRCm39) missense probably damaging 1.00
R8422:Clstn2 UTSW 9 97,340,239 (GRCm39) missense probably benign 0.39
R9190:Clstn2 UTSW 9 97,414,815 (GRCm39) missense probably damaging 1.00
R9221:Clstn2 UTSW 9 97,343,395 (GRCm39) missense probably benign 0.00
R9305:Clstn2 UTSW 9 97,343,537 (GRCm39) missense probably damaging 1.00
R9347:Clstn2 UTSW 9 97,464,654 (GRCm39) missense probably damaging 1.00
R9520:Clstn2 UTSW 9 97,414,763 (GRCm39) missense probably damaging 1.00
R9751:Clstn2 UTSW 9 97,339,703 (GRCm39) missense probably damaging 0.98
X0027:Clstn2 UTSW 9 97,408,452 (GRCm39) missense probably damaging 1.00
Z1177:Clstn2 UTSW 9 97,343,409 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CACACATTTACATGAGAGAACACGG -3'
(R):5'- TTGTTTCAGTGGTCCCGAGC -3'

Sequencing Primer
(F):5'- TCACAGAGAAGTATGGCTTGCTC -3'
(R):5'- AGCATCGCCACTGTCGTC -3'
Posted On 2016-06-21