Incidental Mutation 'R5156:Or8k41'
ID 396710
Institutional Source Beutler Lab
Gene Symbol Or8k41
Ensembl Gene ENSMUSG00000111772
Gene Name olfactory receptor family 8 subfamily K member 41
Synonyms Olfr228, Olfr1071, GA_x6K02T0101M-139-669, MOR189-3, GA_x6K02T2Q125-47962802-47962551
MMRRC Submission 042738-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # R5156 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 86313143-86314084 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 86313362 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 241 (C241*)
Ref Sequence ENSEMBL: ENSMUSP00000149449 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000216534] [ENSMUST00000217292]
AlphaFold A0A1L1SR98
Predicted Effect probably null
Transcript: ENSMUST00000099883
AA Change: C241*
SMART Domains Protein: ENSMUSP00000097468
Gene: ENSMUSG00000075180
AA Change: C241*

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 1.5e-54 PFAM
Pfam:7tm_1 41 290 5.6e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000117635
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215705
Predicted Effect probably null
Transcript: ENSMUST00000216534
AA Change: C241*
Predicted Effect probably null
Transcript: ENSMUST00000217292
AA Change: C241*
Meta Mutation Damage Score 0.9717 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.0%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921513D11Rik G T 17: 79,935,638 (GRCm39) probably benign Het
Apeh C T 9: 107,971,486 (GRCm39) A29T probably damaging Het
Arap2 A T 5: 62,826,524 (GRCm39) Y1013* probably null Het
Arhgef4 A G 1: 34,762,355 (GRCm39) E537G unknown Het
Asf1b T C 8: 84,682,540 (GRCm39) F28S probably damaging Het
Cd46 T A 1: 194,767,693 (GRCm39) I123L possibly damaging Het
Cdca7 A T 2: 72,309,370 (GRCm39) T48S probably damaging Het
Cfap53 T A 18: 74,492,838 (GRCm39) probably benign Het
Clca3a2 T A 3: 144,511,599 (GRCm39) T599S probably benign Het
Csf1 T A 3: 107,656,252 (GRCm39) T148S probably benign Het
Dmbt1 T C 7: 130,699,400 (GRCm39) probably null Het
Dmpk A G 7: 18,818,050 (GRCm39) D44G probably damaging Het
Dnajb12 T A 10: 59,728,782 (GRCm39) N223K probably damaging Het
Dync1h1 T A 12: 110,595,264 (GRCm39) M1392K probably benign Het
Edrf1 C T 7: 133,261,908 (GRCm39) A867V probably damaging Het
Efemp2 T A 19: 5,527,706 (GRCm39) C94S possibly damaging Het
Epha8 C T 4: 136,666,037 (GRCm39) S373N probably benign Het
Foxk1 A G 5: 142,434,588 (GRCm39) D284G possibly damaging Het
Fzd10 C A 5: 128,678,366 (GRCm39) R29S possibly damaging Het
Gm13991 T C 2: 116,358,665 (GRCm39) noncoding transcript Het
Gm6818 A T 7: 38,101,471 (GRCm39) noncoding transcript Het
Hydin T A 8: 111,336,333 (GRCm39) C5037S probably benign Het
Ikzf1 T A 11: 11,719,448 (GRCm39) M492K probably damaging Het
Krt20 G T 11: 99,320,879 (GRCm39) S394R possibly damaging Het
Lrrc71 T A 3: 87,653,094 (GRCm39) R107S probably benign Het
Mia2 A G 12: 59,219,323 (GRCm39) T436A possibly damaging Het
Muc19 T A 15: 91,784,614 (GRCm39) noncoding transcript Het
Neu4 T C 1: 93,952,177 (GRCm39) V182A probably damaging Het
Notch2 T G 3: 98,031,626 (GRCm39) F1167V possibly damaging Het
Nrap A G 19: 56,360,277 (GRCm39) M189T possibly damaging Het
Nt5m A T 11: 59,765,487 (GRCm39) I172F probably damaging Het
Or5b118 G T 19: 13,449,037 (GRCm39) K234N probably damaging Het
Or5w15 G A 2: 87,568,119 (GRCm39) P183L possibly damaging Het
Plekha5 C T 6: 140,372,254 (GRCm39) T68M probably damaging Het
Ppef2 A G 5: 92,392,461 (GRCm39) probably null Het
Ppp1r37 T C 7: 19,295,900 (GRCm39) probably benign Het
Rfx4 T C 10: 84,704,218 (GRCm39) Y238H probably damaging Het
Sanbr A G 11: 23,543,424 (GRCm39) probably null Het
Sec13 G A 6: 113,707,837 (GRCm39) A161V probably benign Het
Serhl G A 15: 82,986,895 (GRCm39) probably benign Het
Slco4a1 T C 2: 180,114,572 (GRCm39) V588A probably benign Het
Slitrk3 T C 3: 72,956,592 (GRCm39) T727A probably benign Het
Sp100 T A 1: 85,601,404 (GRCm39) D241E probably damaging Het
Spata2 G T 2: 167,325,494 (GRCm39) H442N probably damaging Het
Speg T C 1: 75,404,731 (GRCm39) V2588A probably damaging Het
Tnfsf12 A G 11: 69,578,155 (GRCm39) S141P probably damaging Het
Trank1 A G 9: 111,219,762 (GRCm39) I2166M probably damaging Het
Trim10 T A 17: 37,187,948 (GRCm39) V388E probably damaging Het
Ttc23l G T 15: 10,551,636 (GRCm39) T30K possibly damaging Het
Vmn2r10 A G 5: 109,143,466 (GRCm39) V828A probably benign Het
Vmn2r75 T A 7: 85,813,436 (GRCm39) L455F possibly damaging Het
Vwa8 T A 14: 79,221,666 (GRCm39) S541T probably benign Het
Other mutations in Or8k41
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00157:Or8k41 APN 2 86,313,562 (GRCm39) missense probably benign 0.05
IGL02136:Or8k41 APN 2 86,313,809 (GRCm39) missense probably damaging 1.00
IGL02419:Or8k41 APN 2 86,313,259 (GRCm39) missense probably damaging 0.99
IGL03008:Or8k41 APN 2 86,313,678 (GRCm39) missense probably damaging 1.00
R0240:Or8k41 UTSW 2 86,313,730 (GRCm39) missense possibly damaging 0.78
R0240:Or8k41 UTSW 2 86,313,730 (GRCm39) missense possibly damaging 0.78
R1073:Or8k41 UTSW 2 86,313,984 (GRCm39) missense probably damaging 0.98
R1163:Or8k41 UTSW 2 86,313,582 (GRCm39) missense probably damaging 1.00
R1505:Or8k41 UTSW 2 86,313,557 (GRCm39) missense possibly damaging 0.94
R1806:Or8k41 UTSW 2 86,313,483 (GRCm39) missense probably damaging 0.99
R1940:Or8k41 UTSW 2 86,313,703 (GRCm39) nonsense probably null
R3025:Or8k41 UTSW 2 86,314,083 (GRCm39) start codon destroyed probably null 1.00
R3037:Or8k41 UTSW 2 86,313,987 (GRCm39) missense probably damaging 0.96
R6459:Or8k41 UTSW 2 86,313,573 (GRCm39) missense probably benign 0.23
R6472:Or8k41 UTSW 2 86,313,534 (GRCm39) nonsense probably null
R6493:Or8k41 UTSW 2 86,313,565 (GRCm39) missense possibly damaging 0.59
R6880:Or8k41 UTSW 2 86,314,069 (GRCm39) missense probably benign
R7283:Or8k41 UTSW 2 86,313,483 (GRCm39) missense probably damaging 0.99
R8113:Or8k41 UTSW 2 86,313,412 (GRCm39) missense probably damaging 1.00
R9799:Or8k41 UTSW 2 86,313,732 (GRCm39) missense probably damaging 1.00
X0028:Or8k41 UTSW 2 86,313,234 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGTGAGATACTAAAGACACCTGTC -3'
(R):5'- GTGATGGTCTCCCCTTGATATC -3'

Sequencing Primer
(F):5'- GTTTTCCCTGTTTTTCTAAGAGCAG -3'
(R):5'- TCTCTGCTCTGCTCATATAGAAAAG -3'
Posted On 2016-06-21