Incidental Mutation 'R5158:Il36g'
ID 396813
Institutional Source Beutler Lab
Gene Symbol Il36g
Ensembl Gene ENSMUSG00000044103
Gene Name interleukin 36G
Synonyms IL-36gamma, If36g, Il1f9
MMRRC Submission 042740-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R5158 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 24076488-24083579 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 24082798 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 191 (I191K)
Ref Sequence ENSEMBL: ENSMUSP00000053391 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057567]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000057567
AA Change: I191K

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000053391
Gene: ENSMUSG00000044103
AA Change: I191K

DomainStartEndE-ValueType
IL1 43 190 7.91e-5 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 C T 17: 45,825,755 (GRCm39) T357I probably benign Het
Abca14 A T 7: 119,852,652 (GRCm39) R872S probably benign Het
Adnp2 A G 18: 80,180,758 (GRCm39) Y47H probably damaging Het
Atp6v0d2 T C 4: 19,878,292 (GRCm39) N327S probably damaging Het
Ccdc190 A G 1: 169,760,578 (GRCm39) R69G probably benign Het
Cfap54 T C 10: 92,901,059 (GRCm39) D213G probably damaging Het
Clcn4 G A 7: 7,294,618 (GRCm39) T381I possibly damaging Het
Cobl A G 11: 12,206,198 (GRCm39) F477S possibly damaging Het
Ctdspl2 T A 2: 121,811,774 (GRCm39) V205E probably benign Het
Dhx37 A T 5: 125,492,216 (GRCm39) Y1128N probably damaging Het
Ehmt2 G A 17: 35,130,640 (GRCm39) E1085K probably damaging Het
Fam149a T G 8: 45,803,472 (GRCm39) I340L possibly damaging Het
Fut9 T A 4: 25,620,731 (GRCm39) I28F probably benign Het
Iqgap1 T C 7: 80,392,816 (GRCm39) N716D probably benign Het
Itgb7 T C 15: 102,125,464 (GRCm39) D672G probably benign Het
Kat6b A G 14: 21,720,054 (GRCm39) M1469V possibly damaging Het
Kif3a T C 11: 53,479,578 (GRCm39) F430L probably benign Het
L3mbtl3 T C 10: 26,179,586 (GRCm39) D523G unknown Het
Mcf2l A G 8: 13,059,715 (GRCm39) Q736R probably damaging Het
Mpl T G 4: 118,313,881 (GRCm39) D128A probably damaging Het
Myom3 T A 4: 135,492,897 (GRCm39) C149S probably damaging Het
N4bp2 A G 5: 65,965,805 (GRCm39) I1285V probably damaging Het
Nalcn T C 14: 123,753,149 (GRCm39) Q279R probably damaging Het
Ndc1 T G 4: 107,232,362 (GRCm39) S182R probably damaging Het
Ngf A T 3: 102,427,445 (GRCm39) M65L possibly damaging Het
Or2n1 T A 17: 38,486,345 (GRCm39) Y123* probably null Het
Pigb T C 9: 72,929,683 (GRCm39) Y300C probably damaging Het
Pla2g2a T G 4: 138,560,595 (GRCm39) *69G probably null Het
Ppp1r12b T C 1: 134,814,166 (GRCm39) E379G probably damaging Het
Ptdss2 T C 7: 140,731,684 (GRCm39) F164S probably benign Het
Ptprc T C 1: 138,102,822 (GRCm39) T2A possibly damaging Het
Ptprq T A 10: 107,370,565 (GRCm39) N2042I probably damaging Het
Rdh10 A T 1: 16,178,221 (GRCm39) R164S probably damaging Het
Sec31a A T 5: 100,541,180 (GRCm39) I309N probably damaging Het
Skint5 A T 4: 113,599,409 (GRCm39) I710N unknown Het
Slc25a30 A T 14: 76,008,956 (GRCm39) L26Q probably damaging Het
Sptan1 G A 2: 29,868,455 (GRCm39) V34I probably damaging Het
Sult1e1 A T 5: 87,735,453 (GRCm39) I75N probably damaging Het
Trpa1 A G 1: 14,951,885 (GRCm39) V938A probably benign Het
Vps16 C T 2: 130,283,199 (GRCm39) R531C probably damaging Het
Zbtb22 C T 17: 34,137,423 (GRCm39) H523Y probably damaging Het
Zfp39 G A 11: 58,780,671 (GRCm39) T697M possibly damaging Het
Other mutations in Il36g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02027:Il36g APN 2 24,082,797 (GRCm39) missense probably benign 0.06
IGL03190:Il36g APN 2 24,077,272 (GRCm39) nonsense probably null
IGL03047:Il36g UTSW 2 24,082,719 (GRCm39) missense probably damaging 1.00
R2384:Il36g UTSW 2 24,082,660 (GRCm39) missense probably benign 0.43
R5916:Il36g UTSW 2 24,082,806 (GRCm39) makesense probably null
R6875:Il36g UTSW 2 24,078,633 (GRCm39) critical splice acceptor site probably null
R8187:Il36g UTSW 2 24,082,617 (GRCm39) missense probably damaging 1.00
R8357:Il36g UTSW 2 24,078,661 (GRCm39) missense probably benign 0.45
R8457:Il36g UTSW 2 24,078,661 (GRCm39) missense probably benign 0.45
Predicted Primers PCR Primer
(F):5'- TTTGTACCACCACCCTGAGC -3'
(R):5'- GTCTTAGAGAACATCCTTACACCAC -3'

Sequencing Primer
(F):5'- TGAGCCAATGAAGCCATTCCTG -3'
(R):5'- AATCCCACCGACTTTGGAGTATG -3'
Posted On 2016-06-21