Incidental Mutation 'R5158:Pla2g2a'
ID 396825
Institutional Source Beutler Lab
Gene Symbol Pla2g2a
Ensembl Gene ENSMUSG00000058908
Gene Name phospholipase A2, group IIA (platelets, synovial fluid)
Synonyms EF, modifier of Min1, Enhancing factor
MMRRC Submission 042740-MU
Accession Numbers
Essential gene? Not available question?
Stock # R5158 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 138559171-138562497 bp(+) (GRCm39)
Type of Mutation makesense
DNA Base Change (assembly) T to G at 138560595 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Stop codon to Glycine at position 69 (*69G)
Ref Sequence ENSEMBL: ENSMUSP00000138550 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030524] [ENSMUST00000077582] [ENSMUST00000102513] [ENSMUST00000135748]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000030524
SMART Domains Protein: ENSMUSP00000030524
Gene: ENSMUSG00000041193

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
PA2c 21 137 1.16e-52 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000077582
AA Change: H67Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000138200
Gene: ENSMUSG00000058908
AA Change: H67Q

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
PA2c 22 139 7.21e-58 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102513
SMART Domains Protein: ENSMUSP00000099571
Gene: ENSMUSG00000041193

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
PA2c 21 137 1.16e-52 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134898
Predicted Effect probably null
Transcript: ENSMUST00000135748
AA Change: *69G
SMART Domains Protein: ENSMUSP00000138550
Gene: ENSMUSG00000058908
AA Change: *69G

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
PA2c 22 132 1.69e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147728
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 C T 17: 45,825,755 (GRCm39) T357I probably benign Het
Abca14 A T 7: 119,852,652 (GRCm39) R872S probably benign Het
Adnp2 A G 18: 80,180,758 (GRCm39) Y47H probably damaging Het
Atp6v0d2 T C 4: 19,878,292 (GRCm39) N327S probably damaging Het
Ccdc190 A G 1: 169,760,578 (GRCm39) R69G probably benign Het
Cfap54 T C 10: 92,901,059 (GRCm39) D213G probably damaging Het
Clcn4 G A 7: 7,294,618 (GRCm39) T381I possibly damaging Het
Cobl A G 11: 12,206,198 (GRCm39) F477S possibly damaging Het
Ctdspl2 T A 2: 121,811,774 (GRCm39) V205E probably benign Het
Dhx37 A T 5: 125,492,216 (GRCm39) Y1128N probably damaging Het
Ehmt2 G A 17: 35,130,640 (GRCm39) E1085K probably damaging Het
Fam149a T G 8: 45,803,472 (GRCm39) I340L possibly damaging Het
Fut9 T A 4: 25,620,731 (GRCm39) I28F probably benign Het
Il36g T A 2: 24,082,798 (GRCm39) I191K probably damaging Het
Iqgap1 T C 7: 80,392,816 (GRCm39) N716D probably benign Het
Itgb7 T C 15: 102,125,464 (GRCm39) D672G probably benign Het
Kat6b A G 14: 21,720,054 (GRCm39) M1469V possibly damaging Het
Kif3a T C 11: 53,479,578 (GRCm39) F430L probably benign Het
L3mbtl3 T C 10: 26,179,586 (GRCm39) D523G unknown Het
Mcf2l A G 8: 13,059,715 (GRCm39) Q736R probably damaging Het
Mpl T G 4: 118,313,881 (GRCm39) D128A probably damaging Het
Myom3 T A 4: 135,492,897 (GRCm39) C149S probably damaging Het
N4bp2 A G 5: 65,965,805 (GRCm39) I1285V probably damaging Het
Nalcn T C 14: 123,753,149 (GRCm39) Q279R probably damaging Het
Ndc1 T G 4: 107,232,362 (GRCm39) S182R probably damaging Het
Ngf A T 3: 102,427,445 (GRCm39) M65L possibly damaging Het
Or2n1 T A 17: 38,486,345 (GRCm39) Y123* probably null Het
Pigb T C 9: 72,929,683 (GRCm39) Y300C probably damaging Het
Ppp1r12b T C 1: 134,814,166 (GRCm39) E379G probably damaging Het
Ptdss2 T C 7: 140,731,684 (GRCm39) F164S probably benign Het
Ptprc T C 1: 138,102,822 (GRCm39) T2A possibly damaging Het
Ptprq T A 10: 107,370,565 (GRCm39) N2042I probably damaging Het
Rdh10 A T 1: 16,178,221 (GRCm39) R164S probably damaging Het
Sec31a A T 5: 100,541,180 (GRCm39) I309N probably damaging Het
Skint5 A T 4: 113,599,409 (GRCm39) I710N unknown Het
Slc25a30 A T 14: 76,008,956 (GRCm39) L26Q probably damaging Het
Sptan1 G A 2: 29,868,455 (GRCm39) V34I probably damaging Het
Sult1e1 A T 5: 87,735,453 (GRCm39) I75N probably damaging Het
Trpa1 A G 1: 14,951,885 (GRCm39) V938A probably benign Het
Vps16 C T 2: 130,283,199 (GRCm39) R531C probably damaging Het
Zbtb22 C T 17: 34,137,423 (GRCm39) H523Y probably damaging Het
Zfp39 G A 11: 58,780,671 (GRCm39) T697M possibly damaging Het
Other mutations in Pla2g2a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02874:Pla2g2a APN 4 138,562,159 (GRCm39) missense probably benign 0.01
R2425:Pla2g2a UTSW 4 138,560,229 (GRCm39) missense possibly damaging 0.95
R4589:Pla2g2a UTSW 4 138,560,590 (GRCm39) missense probably damaging 1.00
R5742:Pla2g2a UTSW 4 138,560,653 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- ACTAGGAGGGAACTGGTACC -3'
(R):5'- CTGTGAGGTTCTTACAGCAGG -3'

Sequencing Primer
(F):5'- GGGAACTGGTACCCACTACCTC -3'
(R):5'- GGTTCTTACAGCAGGGATAAATTCC -3'
Posted On 2016-06-21