Incidental Mutation 'R5163:Ifna14'
ID 397090
Institutional Source Beutler Lab
Gene Symbol Ifna14
Ensembl Gene ENSMUSG00000095896
Gene Name interferon alpha 14
Synonyms OTTMUSG00000007662
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R5163 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 88489466-88490035 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 88489599 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 146 (Y146C)
Ref Sequence ENSEMBL: ENSMUSP00000099872 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102808]
AlphaFold Q810G3
Predicted Effect probably damaging
Transcript: ENSMUST00000102808
AA Change: Y146C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000099872
Gene: ENSMUSG00000095896
AA Change: Y146C

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IFabd 58 175 2.41e-68 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
Bcor C T X: 11,906,725 (GRCm39) R1551Q probably damaging Het
Btbd19 T G 4: 116,978,628 (GRCm39) I152L probably damaging Het
Dnaaf11 T C 15: 66,314,067 (GRCm39) D311G probably benign Het
Dync2i1 C T 12: 116,219,486 (GRCm39) R152H possibly damaging Het
Ercc6l2 A G 13: 64,046,845 (GRCm39) probably benign Het
Fat4 A G 3: 39,034,946 (GRCm39) D2866G probably damaging Het
Fkbp10 C T 11: 100,313,925 (GRCm39) A311V probably benign Het
Fnbp1l T C 3: 122,338,312 (GRCm39) N511S probably benign Het
Gkn3 C T 6: 87,360,507 (GRCm39) A163T probably damaging Het
Gltp A G 5: 114,812,122 (GRCm39) I147T probably benign Het
Gpr37 A T 6: 25,669,614 (GRCm39) I410N possibly damaging Het
Hivep2 G A 10: 14,015,169 (GRCm39) G1779R probably damaging Het
Loxhd1 A G 18: 77,449,432 (GRCm39) D662G possibly damaging Het
Lrrc9 A T 12: 72,496,163 (GRCm39) I13F probably damaging Het
Map2k3 T A 11: 60,834,317 (GRCm39) I95N probably damaging Het
Mark1 A G 1: 184,637,807 (GRCm39) I594T probably damaging Het
Mettl14 T C 3: 123,168,474 (GRCm39) I189V possibly damaging Het
Msh2 C A 17: 88,030,841 (GRCm39) A906E probably benign Het
Odf4 C A 11: 68,813,672 (GRCm39) C133F probably damaging Het
Opa1 A T 16: 29,416,438 (GRCm39) Q106L probably damaging Het
Or10d5j T C 9: 39,868,216 (GRCm39) N5S probably damaging Het
Pax4 T G 6: 28,446,269 (GRCm39) S75R probably damaging Het
Ppfibp1 T A 6: 146,923,629 (GRCm39) probably null Het
Ptpn20 T C 14: 33,353,068 (GRCm39) I269T probably benign Het
Ptprq T C 10: 107,360,192 (GRCm39) Q2161R probably damaging Het
Rab22a A G 2: 173,503,280 (GRCm39) D31G probably damaging Het
Rap1gds1 A T 3: 138,664,817 (GRCm39) M296K probably damaging Het
Rfx1 A G 8: 84,819,840 (GRCm39) T692A probably damaging Het
Sf3b2 A G 19: 5,325,165 (GRCm39) V769A probably damaging Het
Skint5 A T 4: 113,652,762 (GRCm39) F621I unknown Het
Spink5 A C 18: 44,132,924 (GRCm39) R513S possibly damaging Het
Srrm2 C T 17: 24,038,524 (GRCm39) probably benign Het
Srrt A G 5: 137,295,035 (GRCm39) probably null Het
Sun3 T C 11: 8,973,295 (GRCm39) Q134R possibly damaging Het
Tpo A G 12: 30,155,979 (GRCm39) V174A probably benign Het
Ucp1 A G 8: 84,020,832 (GRCm39) R183G possibly damaging Het
Vmn2r66 A G 7: 84,656,017 (GRCm39) V333A probably benign Het
Zfp108 G T 7: 23,960,163 (GRCm39) K251N probably benign Het
Zfp936 A G 7: 42,839,664 (GRCm39) Q377R probably damaging Het
Zkscan2 T C 7: 123,099,090 (GRCm39) E34G probably benign Het
Zup1 T A 10: 33,825,439 (GRCm39) E14D probably damaging Het
Other mutations in Ifna14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02827:Ifna14 APN 4 88,489,601 (GRCm39) missense probably benign 0.02
R2398:Ifna14 UTSW 4 88,489,863 (GRCm39) missense possibly damaging 0.56
R4578:Ifna14 UTSW 4 88,489,747 (GRCm39) missense possibly damaging 0.81
R4666:Ifna14 UTSW 4 88,489,573 (GRCm39) missense probably benign 0.01
R5199:Ifna14 UTSW 4 88,489,599 (GRCm39) missense probably damaging 1.00
R9227:Ifna14 UTSW 4 88,489,752 (GRCm39) missense probably benign 0.01
R9230:Ifna14 UTSW 4 88,489,752 (GRCm39) missense probably benign 0.01
R9541:Ifna14 UTSW 4 88,490,010 (GRCm39) missense probably null
Predicted Primers PCR Primer
(F):5'- GAATGACAGTTTTGAGATGGCAGTC -3'
(R):5'- AGCAGATCCTGACCCTCTTC -3'

Sequencing Primer
(F):5'- CAGTGAGGTACAATGTCCTAGTCC -3'
(R):5'- TTCACATCAAAGGACTCATCTGCTG -3'
Posted On 2016-06-21