Incidental Mutation 'R5163:Or10d5j'
ID 397106
Institutional Source Beutler Lab
Gene Symbol Or10d5j
Ensembl Gene ENSMUSG00000047352
Gene Name olfactory receptor family 10 subfamily D member 5J
Synonyms GA_x6K02T2PVTD-33657378-33656440, Olfr976, MOR224-10
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R5163 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 39865553-39872340 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 39868216 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 5 (N5S)
Ref Sequence ENSEMBL: ENSMUSP00000150494 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169307] [ENSMUST00000213171] [ENSMUST00000216647] [ENSMUST00000217360] [ENSMUST00000217630]
AlphaFold Q8VF15
Predicted Effect probably damaging
Transcript: ENSMUST00000169307
AA Change: N17S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000133083
Gene: ENSMUSG00000047352
AA Change: N17S

DomainStartEndE-ValueType
Pfam:7tm_4 43 318 1.5e-48 PFAM
Pfam:7TM_GPCR_Srsx 47 271 1.1e-5 PFAM
Pfam:7tm_1 53 300 2.8e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213171
AA Change: N5S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably benign
Transcript: ENSMUST00000216647
Predicted Effect probably damaging
Transcript: ENSMUST00000217360
AA Change: N5S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000217630
AA Change: N5S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
Bcor C T X: 11,906,725 (GRCm39) R1551Q probably damaging Het
Btbd19 T G 4: 116,978,628 (GRCm39) I152L probably damaging Het
Dnaaf11 T C 15: 66,314,067 (GRCm39) D311G probably benign Het
Dync2i1 C T 12: 116,219,486 (GRCm39) R152H possibly damaging Het
Ercc6l2 A G 13: 64,046,845 (GRCm39) probably benign Het
Fat4 A G 3: 39,034,946 (GRCm39) D2866G probably damaging Het
Fkbp10 C T 11: 100,313,925 (GRCm39) A311V probably benign Het
Fnbp1l T C 3: 122,338,312 (GRCm39) N511S probably benign Het
Gkn3 C T 6: 87,360,507 (GRCm39) A163T probably damaging Het
Gltp A G 5: 114,812,122 (GRCm39) I147T probably benign Het
Gpr37 A T 6: 25,669,614 (GRCm39) I410N possibly damaging Het
Hivep2 G A 10: 14,015,169 (GRCm39) G1779R probably damaging Het
Ifna14 T C 4: 88,489,599 (GRCm39) Y146C probably damaging Het
Loxhd1 A G 18: 77,449,432 (GRCm39) D662G possibly damaging Het
Lrrc9 A T 12: 72,496,163 (GRCm39) I13F probably damaging Het
Map2k3 T A 11: 60,834,317 (GRCm39) I95N probably damaging Het
Mark1 A G 1: 184,637,807 (GRCm39) I594T probably damaging Het
Mettl14 T C 3: 123,168,474 (GRCm39) I189V possibly damaging Het
Msh2 C A 17: 88,030,841 (GRCm39) A906E probably benign Het
Odf4 C A 11: 68,813,672 (GRCm39) C133F probably damaging Het
Opa1 A T 16: 29,416,438 (GRCm39) Q106L probably damaging Het
Pax4 T G 6: 28,446,269 (GRCm39) S75R probably damaging Het
Ppfibp1 T A 6: 146,923,629 (GRCm39) probably null Het
Ptpn20 T C 14: 33,353,068 (GRCm39) I269T probably benign Het
Ptprq T C 10: 107,360,192 (GRCm39) Q2161R probably damaging Het
Rab22a A G 2: 173,503,280 (GRCm39) D31G probably damaging Het
Rap1gds1 A T 3: 138,664,817 (GRCm39) M296K probably damaging Het
Rfx1 A G 8: 84,819,840 (GRCm39) T692A probably damaging Het
Sf3b2 A G 19: 5,325,165 (GRCm39) V769A probably damaging Het
Skint5 A T 4: 113,652,762 (GRCm39) F621I unknown Het
Spink5 A C 18: 44,132,924 (GRCm39) R513S possibly damaging Het
Srrm2 C T 17: 24,038,524 (GRCm39) probably benign Het
Srrt A G 5: 137,295,035 (GRCm39) probably null Het
Sun3 T C 11: 8,973,295 (GRCm39) Q134R possibly damaging Het
Tpo A G 12: 30,155,979 (GRCm39) V174A probably benign Het
Ucp1 A G 8: 84,020,832 (GRCm39) R183G possibly damaging Het
Vmn2r66 A G 7: 84,656,017 (GRCm39) V333A probably benign Het
Zfp108 G T 7: 23,960,163 (GRCm39) K251N probably benign Het
Zfp936 A G 7: 42,839,664 (GRCm39) Q377R probably damaging Het
Zkscan2 T C 7: 123,099,090 (GRCm39) E34G probably benign Het
Zup1 T A 10: 33,825,439 (GRCm39) E14D probably damaging Het
Other mutations in Or10d5j
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00960:Or10d5j APN 9 39,867,455 (GRCm39) missense probably damaging 1.00
IGL02455:Or10d5j APN 9 39,868,198 (GRCm39) missense probably damaging 0.96
R1191:Or10d5j UTSW 9 39,868,264 (GRCm39) start codon destroyed probably null 0.02
R1962:Or10d5j UTSW 9 39,867,979 (GRCm39) missense probably benign 0.00
R2328:Or10d5j UTSW 9 39,868,196 (GRCm39) missense possibly damaging 0.95
R3847:Or10d5j UTSW 9 39,867,877 (GRCm39) missense probably damaging 1.00
R4032:Or10d5j UTSW 9 39,867,629 (GRCm39) missense probably benign 0.14
R4620:Or10d5j UTSW 9 39,868,205 (GRCm39) missense probably damaging 1.00
R5152:Or10d5j UTSW 9 39,868,202 (GRCm39) missense probably benign 0.02
R5323:Or10d5j UTSW 9 39,868,125 (GRCm39) nonsense probably null
R5709:Or10d5j UTSW 9 39,867,859 (GRCm39) missense probably damaging 0.98
R7028:Or10d5j UTSW 9 39,867,641 (GRCm39) missense probably benign 0.00
R7085:Or10d5j UTSW 9 39,867,808 (GRCm39) missense probably damaging 1.00
R7723:Or10d5j UTSW 9 39,867,920 (GRCm39) missense possibly damaging 0.92
R8308:Or10d5j UTSW 9 39,868,265 (GRCm39) start codon destroyed probably benign 0.01
R9193:Or10d5j UTSW 9 39,867,878 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGGTTCCCCAGGAAGAAATAC -3'
(R):5'- AAACAGTTGTTGCCAGTCTTCC -3'

Sequencing Primer
(F):5'- AAATACATGGGGGTGTGGAGGTTG -3'
(R):5'- GTTGCCAGTCTTCCCCACAAAAAG -3'
Posted On 2016-06-21