Incidental Mutation 'R5169:Zc3h7b'
ID 397473
Institutional Source Beutler Lab
Gene Symbol Zc3h7b
Ensembl Gene ENSMUSG00000022390
Gene Name zinc finger CCCH type containing 7B
Synonyms Scrg3
MMRRC Submission 042749-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.229) question?
Stock # R5169 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 81629299-81680470 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 81657515 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 185 (N185I)
Ref Sequence ENSEMBL: ENSMUSP00000105181 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109554] [ENSMUST00000230946]
AlphaFold F8VPP8
Predicted Effect probably benign
Transcript: ENSMUST00000109554
AA Change: N185I

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000105181
Gene: ENSMUSG00000022390
AA Change: N185I

DomainStartEndE-ValueType
Pfam:TPR_11 34 113 2.3e-12 PFAM
Pfam:TPR_1 82 115 2.4e-6 PFAM
Pfam:TPR_8 82 115 8.2e-4 PFAM
Pfam:TPR_8 116 143 4.8e-3 PFAM
low complexity region 294 309 N/A INTRINSIC
low complexity region 340 354 N/A INTRINSIC
ZnF_C3H1 482 508 2.15e1 SMART
ZnF_C3H1 612 638 2.03e1 SMART
ZnF_C3H1 757 782 8.31e0 SMART
ZnF_C2H2 843 867 2.86e-1 SMART
ZnF_C3H1 889 914 7.81e-1 SMART
low complexity region 959 981 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229044
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230368
Predicted Effect probably benign
Transcript: ENSMUST00000230946
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231108
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(9) : Gene trapped(9)

Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 A T 12: 118,841,552 (GRCm39) Y964* probably null Het
Acsbg2 T C 17: 57,156,913 (GRCm39) K375R probably benign Het
Ago4 C A 4: 126,405,520 (GRCm39) R415L probably benign Het
Alpk1 A T 3: 127,464,750 (GRCm39) I1176N probably damaging Het
Arhgap25 A T 6: 87,440,252 (GRCm39) I465N possibly damaging Het
Arhgef10 A G 8: 14,980,051 (GRCm39) D97G possibly damaging Het
Cdc37 T A 9: 21,052,413 (GRCm39) M299L probably benign Het
Ddx54 C A 5: 120,761,328 (GRCm39) H453Q probably damaging Het
Dip2b T C 15: 100,102,994 (GRCm39) Y1102H probably damaging Het
Dmpk C G 7: 18,821,944 (GRCm39) L301V probably benign Het
Dop1a T C 9: 86,415,074 (GRCm39) F1939L probably damaging Het
Igkv4-80 A C 6: 68,993,649 (GRCm39) S81A probably benign Het
Ints7 T C 1: 191,345,202 (GRCm39) F631L probably benign Het
Itih1 A T 14: 30,655,403 (GRCm39) Y597* probably null Het
Kctd1 T C 18: 15,195,822 (GRCm39) E267G possibly damaging Het
Lrrc8e A G 8: 4,284,329 (GRCm39) T185A probably benign Het
Maco1 T C 4: 134,555,774 (GRCm39) H233R probably benign Het
Masp2 T C 4: 148,690,571 (GRCm39) I276T probably damaging Het
Med17 A T 9: 15,188,900 (GRCm39) F122I probably benign Het
Milr1 C T 11: 106,645,754 (GRCm39) R99* probably null Het
Mpp4 T C 1: 59,169,256 (GRCm39) probably null Het
Ms4a4d C T 19: 11,535,340 (GRCm39) P213S possibly damaging Het
Mtcl1 T C 17: 66,650,818 (GRCm39) N1100S probably benign Het
Myom3 T C 4: 135,502,889 (GRCm39) I322T probably benign Het
Nav2 C T 7: 49,198,231 (GRCm39) Q1287* probably null Het
Nr3c2 A T 8: 77,635,666 (GRCm39) N256Y probably damaging Het
Nrde2 A G 12: 100,095,552 (GRCm39) probably null Het
Otog G T 7: 45,947,572 (GRCm39) A2242S probably benign Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Pcdh18 T C 3: 49,710,415 (GRCm39) D300G possibly damaging Het
Pcdh8 G A 14: 80,005,095 (GRCm39) P880S probably benign Het
Pcid2 A G 8: 13,129,632 (GRCm39) probably null Het
Phkb A G 8: 86,623,120 (GRCm39) H148R probably benign Het
Pik3r4 T C 9: 105,555,360 (GRCm39) S1106P probably benign Het
Pnpla7 A T 2: 24,940,321 (GRCm39) M1067L probably benign Het
Pp2d1 C A 17: 53,814,930 (GRCm39) G598V possibly damaging Het
Ppm1d C T 11: 85,223,196 (GRCm39) A267V probably damaging Het
Psg29 C T 7: 16,945,578 (GRCm39) P383S probably damaging Het
Rc3h2 A T 2: 37,295,324 (GRCm39) F231I probably damaging Het
Rpl14 T A 9: 120,401,254 (GRCm39) D32E possibly damaging Het
Rpl32 G T 6: 115,783,949 (GRCm39) N92K probably benign Het
Rragc A G 4: 123,829,457 (GRCm39) N391S probably damaging Het
Ryr3 C T 2: 112,501,005 (GRCm39) E3563K possibly damaging Het
Sh3rf2 A G 18: 42,286,126 (GRCm39) M508V probably benign Het
Shoc1 T A 4: 59,059,618 (GRCm39) Y1014F possibly damaging Het
Slc24a3 G A 2: 145,482,184 (GRCm39) C614Y probably benign Het
Spata31d1b T C 13: 59,864,309 (GRCm39) S486P probably damaging Het
Spi1 A T 2: 90,945,428 (GRCm39) K170* probably null Het
Srgn C A 10: 62,330,866 (GRCm39) D80Y probably damaging Het
St6galnac6 A G 2: 32,504,857 (GRCm39) K87R possibly damaging Het
Sytl3 A T 17: 6,982,945 (GRCm39) K134* probably null Het
Szt2 T C 4: 118,247,027 (GRCm39) T863A probably benign Het
Tcea3 A T 4: 135,992,181 (GRCm39) probably null Het
Tg T A 15: 66,550,629 (GRCm39) L253* probably null Het
Timm8a2 T A 14: 122,272,138 (GRCm39) S14T probably benign Het
Tppp3 G C 8: 106,194,501 (GRCm39) N166K probably benign Het
Trav2 G A 14: 52,804,759 (GRCm39) V4M probably benign Het
Trmt5 T C 12: 73,329,495 (GRCm39) D221G probably damaging Het
Ttc27 T A 17: 75,054,690 (GRCm39) L332* probably null Het
V1rd19 A G 7: 23,703,209 (GRCm39) N225S possibly damaging Het
Wdr20rt A T 12: 65,274,184 (GRCm39) Q448L probably damaging Het
Zmpste24 A T 4: 120,925,914 (GRCm39) I351N probably damaging Het
Other mutations in Zc3h7b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01726:Zc3h7b APN 15 81,656,000 (GRCm39) missense possibly damaging 0.95
IGL01955:Zc3h7b APN 15 81,676,205 (GRCm39) missense probably benign 0.10
IGL02526:Zc3h7b APN 15 81,677,338 (GRCm39) missense probably benign 0.10
IGL02582:Zc3h7b APN 15 81,653,341 (GRCm39) missense probably benign 0.05
IGL02736:Zc3h7b APN 15 81,676,175 (GRCm39) missense probably benign 0.02
F6893:Zc3h7b UTSW 15 81,662,872 (GRCm39) missense possibly damaging 0.94
R0212:Zc3h7b UTSW 15 81,660,529 (GRCm39) missense probably benign 0.00
R0242:Zc3h7b UTSW 15 81,653,031 (GRCm39) splice site probably benign
R0471:Zc3h7b UTSW 15 81,666,169 (GRCm39) missense probably damaging 1.00
R0590:Zc3h7b UTSW 15 81,661,199 (GRCm39) missense possibly damaging 0.74
R1530:Zc3h7b UTSW 15 81,661,289 (GRCm39) missense probably benign
R1563:Zc3h7b UTSW 15 81,661,289 (GRCm39) missense probably benign
R1565:Zc3h7b UTSW 15 81,661,289 (GRCm39) missense probably benign
R1566:Zc3h7b UTSW 15 81,653,035 (GRCm39) missense possibly damaging 0.91
R1670:Zc3h7b UTSW 15 81,661,268 (GRCm39) missense probably benign
R1712:Zc3h7b UTSW 15 81,661,289 (GRCm39) missense probably benign
R1727:Zc3h7b UTSW 15 81,652,230 (GRCm39) missense probably damaging 1.00
R2069:Zc3h7b UTSW 15 81,676,529 (GRCm39) missense probably damaging 0.98
R2375:Zc3h7b UTSW 15 81,676,703 (GRCm39) missense probably benign 0.17
R2656:Zc3h7b UTSW 15 81,664,631 (GRCm39) missense probably damaging 1.00
R4660:Zc3h7b UTSW 15 81,676,451 (GRCm39) missense probably benign 0.07
R4764:Zc3h7b UTSW 15 81,653,384 (GRCm39) critical splice donor site probably null
R4815:Zc3h7b UTSW 15 81,677,864 (GRCm39) missense probably damaging 1.00
R4999:Zc3h7b UTSW 15 81,663,334 (GRCm39) missense probably damaging 1.00
R5086:Zc3h7b UTSW 15 81,677,375 (GRCm39) missense probably damaging 0.96
R5395:Zc3h7b UTSW 15 81,656,702 (GRCm39) missense possibly damaging 0.50
R5407:Zc3h7b UTSW 15 81,670,092 (GRCm39) missense probably damaging 0.99
R5587:Zc3h7b UTSW 15 81,656,059 (GRCm39) missense possibly damaging 0.80
R5721:Zc3h7b UTSW 15 81,657,499 (GRCm39) missense probably benign 0.02
R6001:Zc3h7b UTSW 15 81,676,236 (GRCm39) missense possibly damaging 0.89
R6151:Zc3h7b UTSW 15 81,662,911 (GRCm39) critical splice donor site probably null
R6248:Zc3h7b UTSW 15 81,667,386 (GRCm39) missense probably damaging 1.00
R6397:Zc3h7b UTSW 15 81,677,055 (GRCm39) missense probably benign 0.03
R6502:Zc3h7b UTSW 15 81,653,252 (GRCm39) missense probably benign 0.01
R7248:Zc3h7b UTSW 15 81,655,988 (GRCm39) missense possibly damaging 0.46
R7397:Zc3h7b UTSW 15 81,653,354 (GRCm39) missense possibly damaging 0.50
R7450:Zc3h7b UTSW 15 81,667,281 (GRCm39) missense probably benign
R7471:Zc3h7b UTSW 15 81,664,682 (GRCm39) missense probably damaging 1.00
R7575:Zc3h7b UTSW 15 81,662,086 (GRCm39) nonsense probably null
R7645:Zc3h7b UTSW 15 81,664,803 (GRCm39) missense probably damaging 1.00
R7650:Zc3h7b UTSW 15 81,677,851 (GRCm39) missense possibly damaging 0.81
R7881:Zc3h7b UTSW 15 81,664,679 (GRCm39) missense probably damaging 1.00
R7918:Zc3h7b UTSW 15 81,653,189 (GRCm39) missense probably damaging 0.98
R8001:Zc3h7b UTSW 15 81,663,461 (GRCm39) nonsense probably null
R8504:Zc3h7b UTSW 15 81,664,719 (GRCm39) missense probably damaging 1.00
R8855:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8856:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8857:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8865:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8866:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8867:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8868:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R9071:Zc3h7b UTSW 15 81,677,964 (GRCm39) makesense probably null
R9136:Zc3h7b UTSW 15 81,653,312 (GRCm39) missense probably damaging 1.00
R9169:Zc3h7b UTSW 15 81,661,184 (GRCm39) missense probably benign 0.19
R9701:Zc3h7b UTSW 15 81,676,505 (GRCm39) missense probably damaging 1.00
R9802:Zc3h7b UTSW 15 81,676,505 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCAGGTAACCCTTGAAAGATGG -3'
(R):5'- TGCACCAGTAAAGAGTAGCCAG -3'

Sequencing Primer
(F):5'- AAACAAAAACAGTGTTACTCTGGAAG -3'
(R):5'- AATGACCCCAGAGCTCTT -3'
Posted On 2016-07-06