Incidental Mutation 'R5183:Fasn'
| ID |
397700 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fasn
|
| Ensembl Gene |
ENSMUSG00000025153 |
| Gene Name |
fatty acid synthase |
| Synonyms |
A630082H08Rik, FAS |
| MMRRC Submission |
042762-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5183 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
120696672-120715373 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 120699708 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Arginine
at position 2288
(Q2288R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000052872
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055655]
[ENSMUST00000206589]
|
| AlphaFold |
P19096 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000055655
AA Change: Q2288R
PolyPhen 2
Score 0.443 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000052872
Gene: ENSMUSG00000025153
AA Change: Q2288R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ketoacyl-synt
|
1 |
239 |
6.8e-73 |
PFAM |
|
Pfam:Ketoacyl-synt_C
|
243 |
360 |
3.7e-38 |
PFAM |
|
Pfam:KAsynt_C_assoc
|
362 |
474 |
8.2e-46 |
PFAM |
|
Pfam:Acyl_transf_1
|
493 |
810 |
9.5e-115 |
PFAM |
|
Pfam:PS-DH
|
853 |
1169 |
9.9e-24 |
PFAM |
|
low complexity region
|
1175 |
1204 |
N/A |
INTRINSIC |
|
Pfam:Methyltransf_12
|
1238 |
1337 |
2e-9 |
PFAM |
|
PKS_ER
|
1532 |
1847 |
1.44e-147 |
SMART |
|
PKS_KR
|
1878 |
2059 |
2.33e-42 |
SMART |
|
Pfam:PP-binding
|
2119 |
2185 |
1.1e-10 |
PFAM |
|
Pfam:Thioesterase
|
2235 |
2494 |
1.6e-62 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146541
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155276
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206589
AA Change: Q2286R
PolyPhen 2
Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
|
| Meta Mutation Damage Score |
0.1491 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.4%
|
| Validation Efficiency |
99% (73/74) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted mutation of this locus has implicated its product in embryogenesis as all homozygotes and most heterozygotes die prior to birth. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
A |
T |
5: 109,887,171 (GRCm39) |
D8E |
probably damaging |
Het |
| Abca3 |
T |
G |
17: 24,593,427 (GRCm39) |
S275A |
probably benign |
Het |
| Adk |
A |
G |
14: 21,290,599 (GRCm39) |
N155S |
probably damaging |
Het |
| Aqp11 |
T |
C |
7: 97,386,963 (GRCm39) |
T78A |
probably benign |
Het |
| Arhgef40 |
T |
C |
14: 52,241,556 (GRCm39) |
V1455A |
probably damaging |
Het |
| Asxl3 |
C |
G |
18: 22,658,356 (GRCm39) |
A2122G |
possibly damaging |
Het |
| Cdan1 |
T |
A |
2: 120,560,061 (GRCm39) |
I368F |
probably damaging |
Het |
| Cdc42bpg |
A |
G |
19: 6,371,835 (GRCm39) |
|
probably benign |
Het |
| Celsr3 |
A |
G |
9: 108,714,759 (GRCm39) |
D2013G |
probably damaging |
Het |
| Cep152 |
A |
G |
2: 125,408,558 (GRCm39) |
V1332A |
probably damaging |
Het |
| Cftr |
T |
C |
6: 18,299,832 (GRCm39) |
S1172P |
probably damaging |
Het |
| Commd2 |
A |
T |
3: 57,554,235 (GRCm39) |
D155E |
probably benign |
Het |
| Coq7 |
T |
A |
7: 118,127,490 (GRCm39) |
|
probably benign |
Het |
| Dnase2a |
T |
C |
8: 85,636,207 (GRCm39) |
|
probably benign |
Het |
| Dnhd1 |
G |
A |
7: 105,352,416 (GRCm39) |
R2523Q |
probably damaging |
Het |
| Dock6 |
C |
T |
9: 21,752,899 (GRCm39) |
V305I |
probably benign |
Het |
| Ehmt1 |
G |
T |
2: 24,767,509 (GRCm39) |
P135T |
probably damaging |
Het |
| Fat3 |
T |
A |
9: 15,871,609 (GRCm39) |
N3594I |
probably damaging |
Het |
| Galnt10 |
T |
C |
11: 57,660,414 (GRCm39) |
M284T |
probably damaging |
Het |
| Gatm |
A |
T |
2: 122,425,984 (GRCm39) |
F422L |
probably benign |
Het |
| Glrp1 |
A |
T |
1: 88,437,574 (GRCm39) |
I12N |
unknown |
Het |
| Gm5455 |
T |
A |
13: 110,441,962 (GRCm39) |
|
noncoding transcript |
Het |
| Gpam |
C |
T |
19: 55,071,659 (GRCm39) |
E361K |
probably damaging |
Het |
| Gps2 |
A |
G |
11: 69,806,023 (GRCm39) |
T126A |
probably benign |
Het |
| Grn |
C |
A |
11: 102,321,380 (GRCm39) |
|
probably benign |
Het |
| Gsg1 |
T |
A |
6: 135,218,368 (GRCm39) |
Q176L |
probably damaging |
Het |
| Htra1 |
C |
T |
7: 130,585,446 (GRCm39) |
A412V |
possibly damaging |
Het |
| Icosl |
C |
T |
10: 77,905,319 (GRCm39) |
|
probably benign |
Het |
| Iqgap1 |
T |
C |
7: 80,372,813 (GRCm39) |
T1509A |
probably damaging |
Het |
| Irag2 |
A |
G |
6: 145,083,946 (GRCm39) |
E37G |
probably benign |
Het |
| Itgad |
T |
C |
7: 127,797,395 (GRCm39) |
|
probably null |
Het |
| Kdm5a |
C |
A |
6: 120,406,977 (GRCm39) |
|
probably benign |
Het |
| Kidins220 |
T |
C |
12: 25,101,125 (GRCm39) |
L1017S |
probably benign |
Het |
| Lrrc37 |
T |
C |
11: 103,433,947 (GRCm39) |
Y898C |
probably damaging |
Het |
| Man2b1 |
T |
A |
8: 85,822,413 (GRCm39) |
S804R |
probably damaging |
Het |
| Miip |
A |
T |
4: 147,947,526 (GRCm39) |
F211L |
probably damaging |
Het |
| Moxd1 |
T |
G |
10: 24,155,445 (GRCm39) |
|
probably null |
Het |
| Moxd1 |
T |
G |
10: 24,163,034 (GRCm39) |
Y499D |
probably damaging |
Het |
| Mrpl45 |
T |
C |
11: 97,207,577 (GRCm39) |
I24T |
probably benign |
Het |
| Msh2 |
C |
A |
17: 88,030,841 (GRCm39) |
A906E |
probably benign |
Het |
| Mthfr |
T |
A |
4: 148,135,817 (GRCm39) |
|
probably null |
Het |
| Muc5b |
T |
A |
7: 141,404,547 (GRCm39) |
D827E |
unknown |
Het |
| Myo1g |
G |
C |
11: 6,458,243 (GRCm39) |
L866V |
probably damaging |
Het |
| Myo3a |
A |
T |
2: 22,468,170 (GRCm39) |
M475L |
probably benign |
Het |
| Ncoa2 |
A |
C |
1: 13,244,590 (GRCm39) |
L703V |
probably damaging |
Het |
| Ncoa4-ps |
A |
C |
12: 119,225,023 (GRCm39) |
|
noncoding transcript |
Het |
| Nme6 |
T |
A |
9: 109,670,557 (GRCm39) |
Y69* |
probably null |
Het |
| Nwd1 |
T |
A |
8: 73,397,714 (GRCm39) |
M651K |
probably benign |
Het |
| Or4k15c |
A |
C |
14: 50,322,003 (GRCm39) |
I45S |
probably damaging |
Het |
| Orc2 |
A |
T |
1: 58,513,977 (GRCm39) |
S298R |
possibly damaging |
Het |
| Oscp1 |
A |
T |
4: 125,981,522 (GRCm39) |
E328V |
probably damaging |
Het |
| Pan2 |
T |
C |
10: 128,153,838 (GRCm39) |
V1003A |
probably damaging |
Het |
| Pik3r4 |
T |
C |
9: 105,559,507 (GRCm39) |
V1200A |
possibly damaging |
Het |
| Prl |
T |
C |
13: 27,241,579 (GRCm39) |
|
probably benign |
Het |
| Ptprk |
T |
C |
10: 28,351,232 (GRCm39) |
V575A |
probably benign |
Het |
| Rflna |
A |
T |
5: 125,088,469 (GRCm39) |
S139C |
probably damaging |
Het |
| Robo1 |
T |
C |
16: 72,539,038 (GRCm39) |
F27S |
probably benign |
Het |
| Secisbp2 |
T |
C |
13: 51,819,460 (GRCm39) |
S347P |
probably benign |
Het |
| Shmt1 |
A |
G |
11: 60,688,308 (GRCm39) |
|
probably benign |
Het |
| Slc27a3 |
A |
G |
3: 90,296,477 (GRCm39) |
|
probably null |
Het |
| Slc6a5 |
T |
C |
7: 49,585,957 (GRCm39) |
V425A |
probably damaging |
Het |
| Slc8a3 |
A |
G |
12: 81,361,265 (GRCm39) |
V518A |
possibly damaging |
Het |
| Slco1a4 |
A |
T |
6: 141,785,357 (GRCm39) |
Y78N |
probably damaging |
Het |
| Stt3b |
A |
T |
9: 115,095,211 (GRCm39) |
H273Q |
probably damaging |
Het |
| Tle6 |
T |
A |
10: 81,428,635 (GRCm39) |
N431I |
probably damaging |
Het |
| Trim34b |
C |
A |
7: 103,979,118 (GRCm39) |
Q122K |
possibly damaging |
Het |
| Trio |
C |
A |
15: 27,902,686 (GRCm39) |
R258S |
probably benign |
Het |
| Ttc7 |
A |
T |
17: 87,600,306 (GRCm39) |
D23V |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,810,525 (GRCm39) |
M1K |
probably null |
Het |
| Ufsp2 |
T |
C |
8: 46,447,126 (GRCm39) |
V391A |
probably benign |
Het |
| Vps13c |
T |
C |
9: 67,815,334 (GRCm39) |
L990S |
probably damaging |
Het |
| Zfp108 |
G |
T |
7: 23,960,163 (GRCm39) |
K251N |
probably benign |
Het |
| Zfp618 |
G |
A |
4: 63,017,519 (GRCm39) |
M234I |
probably benign |
Het |
|
| Other mutations in Fasn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00468:Fasn
|
APN |
11 |
120,711,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01014:Fasn
|
APN |
11 |
120,708,055 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01131:Fasn
|
APN |
11 |
120,705,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01603:Fasn
|
APN |
11 |
120,706,891 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01606:Fasn
|
APN |
11 |
120,699,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01897:Fasn
|
APN |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01899:Fasn
|
APN |
11 |
120,710,975 (GRCm39) |
splice site |
probably benign |
|
|
IGL01987:Fasn
|
APN |
11 |
120,708,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02103:Fasn
|
APN |
11 |
120,702,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02212:Fasn
|
APN |
11 |
120,698,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02294:Fasn
|
APN |
11 |
120,701,102 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02336:Fasn
|
APN |
11 |
120,704,562 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02417:Fasn
|
APN |
11 |
120,711,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02452:Fasn
|
APN |
11 |
120,699,006 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02559:Fasn
|
APN |
11 |
120,699,892 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02724:Fasn
|
APN |
11 |
120,700,659 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02862:Fasn
|
APN |
11 |
120,709,805 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02947:Fasn
|
APN |
11 |
120,706,502 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03025:Fasn
|
APN |
11 |
120,708,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03131:Fasn
|
APN |
11 |
120,701,550 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03157:Fasn
|
APN |
11 |
120,698,735 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL03182:Fasn
|
APN |
11 |
120,703,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03370:Fasn
|
APN |
11 |
120,703,621 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
BB007:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
BB017:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0243:Fasn
|
UTSW |
11 |
120,706,141 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0304:Fasn
|
UTSW |
11 |
120,710,762 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0389:Fasn
|
UTSW |
11 |
120,707,008 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0449:Fasn
|
UTSW |
11 |
120,701,894 (GRCm39) |
missense |
probably benign |
|
|
R0626:Fasn
|
UTSW |
11 |
120,702,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1037:Fasn
|
UTSW |
11 |
120,700,277 (GRCm39) |
missense |
probably benign |
|
|
R1061:Fasn
|
UTSW |
11 |
120,713,008 (GRCm39) |
splice site |
probably null |
|
|
R1109:Fasn
|
UTSW |
11 |
120,703,150 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1498:Fasn
|
UTSW |
11 |
120,706,245 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1552:Fasn
|
UTSW |
11 |
120,709,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1568:Fasn
|
UTSW |
11 |
120,704,075 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1624:Fasn
|
UTSW |
11 |
120,703,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Fasn
|
UTSW |
11 |
120,707,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1826:Fasn
|
UTSW |
11 |
120,699,325 (GRCm39) |
splice site |
probably benign |
|
|
R1846:Fasn
|
UTSW |
11 |
120,704,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2298:Fasn
|
UTSW |
11 |
120,704,642 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2513:Fasn
|
UTSW |
11 |
120,705,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3001:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3002:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3154:Fasn
|
UTSW |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3434:Fasn
|
UTSW |
11 |
120,713,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4794:Fasn
|
UTSW |
11 |
120,702,121 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4840:Fasn
|
UTSW |
11 |
120,703,885 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4863:Fasn
|
UTSW |
11 |
120,699,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4876:Fasn
|
UTSW |
11 |
120,703,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4914:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4915:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4916:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4918:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4936:Fasn
|
UTSW |
11 |
120,706,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5025:Fasn
|
UTSW |
11 |
120,702,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5092:Fasn
|
UTSW |
11 |
120,705,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5120:Fasn
|
UTSW |
11 |
120,702,217 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5175:Fasn
|
UTSW |
11 |
120,707,195 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5506:Fasn
|
UTSW |
11 |
120,700,336 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5557:Fasn
|
UTSW |
11 |
120,703,252 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5614:Fasn
|
UTSW |
11 |
120,704,154 (GRCm39) |
missense |
probably benign |
|
|
R5728:Fasn
|
UTSW |
11 |
120,704,339 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5838:Fasn
|
UTSW |
11 |
120,706,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5959:Fasn
|
UTSW |
11 |
120,699,390 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6029:Fasn
|
UTSW |
11 |
120,711,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6134:Fasn
|
UTSW |
11 |
120,713,012 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6335:Fasn
|
UTSW |
11 |
120,706,185 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6452:Fasn
|
UTSW |
11 |
120,706,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6627:Fasn
|
UTSW |
11 |
120,709,753 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6742:Fasn
|
UTSW |
11 |
120,701,279 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6767:Fasn
|
UTSW |
11 |
120,708,313 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6927:Fasn
|
UTSW |
11 |
120,699,115 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6976:Fasn
|
UTSW |
11 |
120,710,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7092:Fasn
|
UTSW |
11 |
120,710,946 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7157:Fasn
|
UTSW |
11 |
120,701,291 (GRCm39) |
nonsense |
probably null |
|
|
R7373:Fasn
|
UTSW |
11 |
120,704,802 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7575:Fasn
|
UTSW |
11 |
120,703,513 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7652:Fasn
|
UTSW |
11 |
120,707,154 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7670:Fasn
|
UTSW |
11 |
120,704,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7806:Fasn
|
UTSW |
11 |
120,700,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7930:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R8007:Fasn
|
UTSW |
11 |
120,700,353 (GRCm39) |
missense |
probably benign |
|
|
R8012:Fasn
|
UTSW |
11 |
120,702,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8185:Fasn
|
UTSW |
11 |
120,702,969 (GRCm39) |
missense |
probably benign |
0.42 |
|
R8557:Fasn
|
UTSW |
11 |
120,706,610 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8711:Fasn
|
UTSW |
11 |
120,709,944 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8772:Fasn
|
UTSW |
11 |
120,711,362 (GRCm39) |
missense |
probably benign |
|
|
R8856:Fasn
|
UTSW |
11 |
120,708,979 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8875:Fasn
|
UTSW |
11 |
120,703,224 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9071:Fasn
|
UTSW |
11 |
120,708,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9153:Fasn
|
UTSW |
11 |
120,706,496 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9238:Fasn
|
UTSW |
11 |
120,705,871 (GRCm39) |
missense |
probably benign |
|
|
R9249:Fasn
|
UTSW |
11 |
120,703,915 (GRCm39) |
missense |
probably benign |
|
|
R9345:Fasn
|
UTSW |
11 |
120,706,735 (GRCm39) |
missense |
probably benign |
0.22 |
|
X0067:Fasn
|
UTSW |
11 |
120,707,129 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Fasn
|
UTSW |
11 |
120,706,297 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCAACACTTAGGACCAGTTGG -3'
(R):5'- TCCTTGTGCACCCCATTGAG -3'
Sequencing Primer
(F):5'- ACTTAGGACCAGTTGGCCCAG -3'
(R):5'- ATTGAGGGTTCCACCACCGTG -3'
|
| Posted On |
2016-07-06 |
Incidental Mutation