Incidental Mutation 'R5185:Lilra6'
ID 397812
Institutional Source Beutler Lab
Gene Symbol Lilra6
Ensembl Gene ENSMUSG00000030427
Gene Name leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
Synonyms 7M1, Pira3
MMRRC Submission 042764-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R5185 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 3911279-3918502 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 3917635 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 120 (H120L)
Ref Sequence ENSEMBL: ENSMUSP00000042636 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038176] [ENSMUST00000090689] [ENSMUST00000206077]
AlphaFold A0A0B4J1F3
Predicted Effect probably benign
Transcript: ENSMUST00000038176
AA Change: H120L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000042636
Gene: ENSMUSG00000030427
AA Change: H120L

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
IG_like 40 105 3.11e0 SMART
IG 129 315 4.53e-2 SMART
IG_like 237 302 1.54e-1 SMART
IG_like 328 415 1.79e1 SMART
IG_like 429 517 2.66e1 SMART
IG 529 618 8.59e-3 SMART
low complexity region 637 646 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000090689
AA Change: H120L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000088188
Gene: ENSMUSG00000030427
AA Change: H120L

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
IG_like 34 118 7.25e0 SMART
IG_like 129 220 1.62e2 SMART
IG_like 290 377 1.79e1 SMART
IG_like 391 479 2.66e1 SMART
IG 491 580 8.59e-3 SMART
low complexity region 599 608 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131255
Predicted Effect probably benign
Transcript: ENSMUST00000206077
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206851
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 95% (70/74)
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsf2 T C 11: 94,453,737 (GRCm39) Y408C probably damaging Het
Aox4 T C 1: 58,293,477 (GRCm39) L943S probably damaging Het
Ap1g1 G A 8: 110,589,958 (GRCm39) probably benign Het
Arsb T C 13: 93,930,667 (GRCm39) S212P probably damaging Het
Arsi A G 18: 61,049,984 (GRCm39) N289S probably damaging Het
Atp6v1h T A 1: 5,165,865 (GRCm39) F72I probably damaging Het
Atxn7 T C 14: 14,090,063 (GRCm38) I336T probably benign Het
Bak1 G A 17: 27,241,722 (GRCm39) P65L possibly damaging Het
Bcl6 A T 16: 23,791,697 (GRCm39) M219K possibly damaging Het
Brd3 T C 2: 27,352,460 (GRCm39) K157E probably damaging Het
Ccdc171 T G 4: 83,581,892 (GRCm39) S674A possibly damaging Het
Cfap43 A G 19: 47,768,833 (GRCm39) I737T probably benign Het
Cul9 A T 17: 46,836,758 (GRCm39) V1089D possibly damaging Het
Dffa C A 4: 149,201,887 (GRCm39) A155E probably benign Het
Dnhd1 G A 7: 105,352,416 (GRCm39) R2523Q probably damaging Het
Efcab12 T A 6: 115,800,451 (GRCm39) M191L probably benign Het
Efl1 T C 7: 82,421,707 (GRCm39) L1018P probably damaging Het
Fcho1 A G 8: 72,167,600 (GRCm39) probably benign Het
Fndc3b T A 3: 27,511,219 (GRCm39) T764S probably benign Het
Gm29125 T C 1: 80,361,948 (GRCm39) noncoding transcript Het
Gm5108 A G 5: 68,101,953 (GRCm39) probably benign Het
Gm9949 T G 18: 62,313,636 (GRCm39) probably benign Het
Golgb1 T C 16: 36,695,503 (GRCm39) probably benign Het
Gpd2 T C 2: 57,230,216 (GRCm39) Y323H probably damaging Het
Grip1 T G 10: 119,767,164 (GRCm39) D96E probably benign Het
Hmcn1 T C 1: 150,532,492 (GRCm39) I3132V probably benign Het
Hsd17b1 T C 11: 100,971,024 (GRCm39) W327R possibly damaging Het
Htra2 G A 6: 83,031,223 (GRCm39) P62L probably benign Het
Kdr A T 5: 76,113,077 (GRCm39) probably null Het
Kif14 T A 1: 136,455,207 (GRCm39) C1626* probably null Het
Kmt2a A T 9: 44,731,543 (GRCm39) probably benign Het
Krt15 T C 11: 100,024,259 (GRCm39) T321A probably damaging Het
Lactbl1 A T 4: 136,358,356 (GRCm39) H109L probably benign Het
Lpcat2 G A 8: 93,596,365 (GRCm39) S134N probably benign Het
Mpp4 T C 1: 59,164,742 (GRCm39) D465G probably benign Het
Naip2 A T 13: 100,325,859 (GRCm39) D16E probably damaging Het
Nek5 C T 8: 22,573,397 (GRCm39) A520T possibly damaging Het
Nfatc2 A G 2: 168,412,627 (GRCm39) F132L possibly damaging Het
Nlrp3 C A 11: 59,455,910 (GRCm39) T902N probably benign Het
Or10d1b A T 9: 39,613,172 (GRCm39) W298R probably benign Het
Or4c123 A T 2: 89,126,731 (GRCm39) H294Q probably benign Het
Or7e165 T C 9: 19,694,672 (GRCm39) M81T probably damaging Het
Or8h7 T C 2: 86,720,946 (GRCm39) D191G probably benign Het
Pcdhb16 T C 18: 37,613,142 (GRCm39) S701P possibly damaging Het
Phf7 A G 14: 30,969,994 (GRCm39) probably null Het
Plpp4 G A 7: 128,918,028 (GRCm39) V68M probably damaging Het
Pnma2 A T 14: 67,153,578 (GRCm39) M1L possibly damaging Het
Pnma8b A T 7: 16,679,901 (GRCm39) D295V probably damaging Het
Rad21l T C 2: 151,499,382 (GRCm39) D270G probably benign Het
Ralgapa2 C A 2: 146,230,406 (GRCm39) probably null Het
Rasal3 A T 17: 32,615,764 (GRCm39) L334Q probably damaging Het
Rfx4 G T 10: 84,699,114 (GRCm39) R240L probably damaging Het
Rnf19b T A 4: 128,977,713 (GRCm39) C642* probably null Het
Slc28a2 G A 2: 122,288,675 (GRCm39) E594K probably benign Het
Spata31 G T 13: 65,065,340 (GRCm39) W15L possibly damaging Het
Spink5 T C 18: 44,148,711 (GRCm39) S925P probably damaging Het
Svep1 C T 4: 58,084,534 (GRCm39) G1865S probably damaging Het
Tg T C 15: 66,645,323 (GRCm39) L791P probably damaging Het
Thbs4 A C 13: 92,911,675 (GRCm39) V247G probably damaging Het
Tpcn2 A T 7: 144,809,191 (GRCm39) F705Y probably damaging Het
Try10 A T 6: 41,333,483 (GRCm39) H76L probably damaging Het
Ttn C T 2: 76,769,565 (GRCm39) V2695I probably damaging Het
Tut1 C A 19: 8,932,814 (GRCm39) T49N probably benign Het
Vmn1r17 A G 6: 57,337,828 (GRCm39) V130A probably benign Het
Xdh G A 17: 74,232,006 (GRCm39) R235C probably damaging Het
Yipf4 A G 17: 74,799,470 (GRCm39) D70G probably null Het
Zfp108 G T 7: 23,960,163 (GRCm39) K251N probably benign Het
Other mutations in Lilra6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00508:Lilra6 APN 7 3,914,553 (GRCm39) missense probably benign 0.04
IGL00569:Lilra6 APN 7 3,917,588 (GRCm39) missense probably damaging 0.99
IGL00899:Lilra6 APN 7 3,916,056 (GRCm39) missense probably damaging 1.00
IGL00955:Lilra6 APN 7 3,914,403 (GRCm39) splice site probably benign
IGL01585:Lilra6 APN 7 3,917,498 (GRCm39) missense probably benign 0.01
IGL02195:Lilra6 APN 7 3,917,549 (GRCm39) missense probably benign 0.00
IGL02586:Lilra6 APN 7 3,911,819 (GRCm39) missense probably benign 0.36
IGL02719:Lilra6 APN 7 3,915,991 (GRCm39) missense possibly damaging 0.96
IGL03166:Lilra6 APN 7 3,915,626 (GRCm39) missense possibly damaging 0.69
IGL03329:Lilra6 APN 7 3,917,647 (GRCm39) splice site probably benign
R0233:Lilra6 UTSW 7 3,917,935 (GRCm39) missense possibly damaging 0.69
R0233:Lilra6 UTSW 7 3,917,935 (GRCm39) missense possibly damaging 0.69
R0423:Lilra6 UTSW 7 3,917,774 (GRCm39) splice site probably benign
R0483:Lilra6 UTSW 7 3,916,138 (GRCm39) missense probably benign 0.02
R0511:Lilra6 UTSW 7 3,915,784 (GRCm39) missense possibly damaging 0.77
R1472:Lilra6 UTSW 7 3,915,718 (GRCm39) missense probably damaging 1.00
R1560:Lilra6 UTSW 7 3,914,407 (GRCm39) critical splice donor site probably null
R1584:Lilra6 UTSW 7 3,915,661 (GRCm39) missense probably damaging 1.00
R1781:Lilra6 UTSW 7 3,918,066 (GRCm39) missense probably benign 0.28
R2411:Lilra6 UTSW 7 3,914,453 (GRCm39) missense probably damaging 1.00
R2420:Lilra6 UTSW 7 3,917,857 (GRCm39) missense probably damaging 1.00
R4021:Lilra6 UTSW 7 3,914,417 (GRCm39) missense probably benign 0.20
R4074:Lilra6 UTSW 7 3,917,889 (GRCm39) missense probably benign 0.23
R4284:Lilra6 UTSW 7 3,911,803 (GRCm39) missense possibly damaging 0.76
R4508:Lilra6 UTSW 7 3,915,028 (GRCm39) nonsense probably null
R4894:Lilra6 UTSW 7 3,915,530 (GRCm39) missense probably benign 0.01
R4977:Lilra6 UTSW 7 3,917,382 (GRCm39) missense probably benign 0.01
R5048:Lilra6 UTSW 7 3,918,440 (GRCm39) critical splice donor site probably null
R5164:Lilra6 UTSW 7 3,917,880 (GRCm39) missense probably damaging 1.00
R5527:Lilra6 UTSW 7 3,917,586 (GRCm39) start gained probably benign
R6281:Lilra6 UTSW 7 3,914,972 (GRCm39) missense probably damaging 1.00
R6480:Lilra6 UTSW 7 3,915,932 (GRCm39) missense probably damaging 1.00
R6512:Lilra6 UTSW 7 3,917,387 (GRCm39) missense probably benign 0.06
R6565:Lilra6 UTSW 7 3,918,019 (GRCm39) missense probably benign
R7017:Lilra6 UTSW 7 3,911,707 (GRCm39) missense possibly damaging 0.93
R7095:Lilra6 UTSW 7 3,916,196 (GRCm39) missense probably damaging 1.00
R7747:Lilra6 UTSW 7 3,915,995 (GRCm39) missense probably benign 0.16
R8056:Lilra6 UTSW 7 3,915,551 (GRCm39) missense probably damaging 1.00
R8280:Lilra6 UTSW 7 3,916,046 (GRCm39) missense probably benign 0.01
R9197:Lilra6 UTSW 7 3,915,716 (GRCm39) missense possibly damaging 0.94
R9354:Lilra6 UTSW 7 3,914,628 (GRCm39) missense probably damaging 1.00
R9379:Lilra6 UTSW 7 3,916,166 (GRCm39) missense probably damaging 1.00
R9406:Lilra6 UTSW 7 3,917,853 (GRCm39) missense probably benign
R9462:Lilra6 UTSW 7 3,914,994 (GRCm39) missense probably damaging 0.97
R9649:Lilra6 UTSW 7 3,917,521 (GRCm39) missense possibly damaging 0.47
Z1176:Lilra6 UTSW 7 3,918,073 (GRCm39) critical splice acceptor site probably null
Z1177:Lilra6 UTSW 7 3,915,580 (GRCm39) missense possibly damaging 0.48
Predicted Primers PCR Primer
(F):5'- CTGCATATCCATCTCTGGTTGG -3'
(R):5'- CTGGTGCTAGTAGTGACAGG -3'

Sequencing Primer
(F):5'- AGAACAGGGCGTGGTACTTCC -3'
(R):5'- TGCTAGTAGTGACAGGTGAGAGAC -3'
Posted On 2016-07-06