Incidental Mutation 'R5188:Gpr151'
| ID |
398026 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gpr151
|
| Ensembl Gene |
ENSMUSG00000042816 |
| Gene Name |
G protein-coupled receptor 151 |
| Synonyms |
GalRL, PGR7, C130082O03Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5188 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
42710946-42712717 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 42711820 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Threonine
at position 286
(M286T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000058887
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000025375]
[ENSMUST00000054738]
[ENSMUST00000173642]
|
| AlphaFold |
Q7TSN6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000025375
|
| SMART Domains |
Protein: ENSMUSP00000025375
Gene: ENSMUSG00000024498
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
13 |
N/A |
INTRINSIC |
|
low complexity region
|
40 |
92 |
N/A |
INTRINSIC |
|
WW
|
132 |
164 |
8.27e-10 |
SMART |
|
low complexity region
|
178 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
260 |
347 |
N/A |
INTRINSIC |
|
low complexity region
|
350 |
373 |
N/A |
INTRINSIC |
|
WW
|
432 |
464 |
2.65e-8 |
SMART |
|
WW
|
531 |
563 |
1.2e-6 |
SMART |
|
low complexity region
|
611 |
623 |
N/A |
INTRINSIC |
|
coiled coil region
|
629 |
654 |
N/A |
INTRINSIC |
|
FF
|
661 |
714 |
2.67e-13 |
SMART |
|
FF
|
727 |
781 |
1.51e-12 |
SMART |
|
FF
|
794 |
848 |
4.29e-17 |
SMART |
|
FF
|
898 |
954 |
8.33e-15 |
SMART |
|
FF
|
956 |
1012 |
1.47e-15 |
SMART |
|
FF
|
1014 |
1079 |
1.3e-16 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000054738
AA Change: M286T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000058887
Gene: ENSMUSG00000042816
AA Change: M286T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
57 |
310 |
1.6e-18 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173642
|
| SMART Domains |
Protein: ENSMUSP00000134458
Gene: ENSMUSG00000024498
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
13 |
N/A |
INTRINSIC |
|
low complexity region
|
40 |
92 |
N/A |
INTRINSIC |
|
WW
|
132 |
164 |
8.27e-10 |
SMART |
|
low complexity region
|
178 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
260 |
347 |
N/A |
INTRINSIC |
|
low complexity region
|
350 |
373 |
N/A |
INTRINSIC |
|
WW
|
432 |
464 |
2.65e-8 |
SMART |
|
WW
|
531 |
563 |
1.2e-6 |
SMART |
|
low complexity region
|
611 |
623 |
N/A |
INTRINSIC |
|
coiled coil region
|
629 |
654 |
N/A |
INTRINSIC |
|
FF
|
661 |
714 |
2.67e-13 |
SMART |
|
FF
|
727 |
781 |
1.51e-12 |
SMART |
|
FF
|
794 |
848 |
4.29e-17 |
SMART |
|
FF
|
898 |
954 |
8.33e-15 |
SMART |
|
FF
|
956 |
1012 |
1.47e-15 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184771
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is similar to the galanin receptor subfamily of G protein-coupled receptors. The encoded protein is found predominantly in the central nervous system. [provided by RefSeq, Feb 2017]
PHENOTYPE: Homozygous mutation of this gene does not appear to result in a phenotype. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 27 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
G |
T |
12: 71,211,320 (GRCm39) |
E685* |
probably null |
Het |
| 2700049A03Rik |
A |
T |
12: 71,211,321 (GRCm39) |
E685V |
possibly damaging |
Het |
| Abca12 |
T |
A |
1: 71,330,651 (GRCm39) |
I1335F |
probably benign |
Het |
| Amigo3 |
C |
A |
9: 107,931,882 (GRCm39) |
A435E |
probably damaging |
Het |
| Atr |
T |
A |
9: 95,803,778 (GRCm39) |
N1871K |
probably benign |
Het |
| Ctsw |
C |
T |
19: 5,517,120 (GRCm39) |
A71T |
probably damaging |
Het |
| Decr1 |
C |
T |
4: 15,924,270 (GRCm39) |
V217M |
probably damaging |
Het |
| Golgb1 |
A |
G |
16: 36,738,827 (GRCm39) |
T2389A |
probably benign |
Het |
| Katnbl1 |
T |
A |
2: 112,240,499 (GRCm39) |
I262N |
probably damaging |
Het |
| Lrp1 |
A |
G |
10: 127,443,821 (GRCm39) |
C149R |
probably damaging |
Het |
| Mpc1 |
A |
T |
17: 8,515,215 (GRCm39) |
|
probably benign |
Het |
| Ndufv1 |
A |
T |
19: 4,059,988 (GRCm39) |
N37K |
probably damaging |
Het |
| Or1n1b |
T |
A |
2: 36,780,405 (GRCm39) |
I152L |
probably benign |
Het |
| Or5af2 |
C |
A |
11: 58,708,146 (GRCm39) |
T104K |
probably damaging |
Het |
| Or8g50 |
T |
C |
9: 39,648,531 (GRCm39) |
V140A |
probably benign |
Het |
| Or8k1 |
T |
G |
2: 86,047,521 (GRCm39) |
S178R |
probably benign |
Het |
| Pnpla7 |
C |
A |
2: 24,887,312 (GRCm39) |
P52Q |
probably benign |
Het |
| Prh1 |
A |
G |
6: 132,548,670 (GRCm39) |
Q59R |
unknown |
Het |
| Ren1 |
A |
G |
1: 133,278,351 (GRCm39) |
|
probably benign |
Het |
| Rnf148 |
T |
C |
6: 23,654,139 (GRCm39) |
T286A |
probably damaging |
Het |
| Sdk1 |
T |
C |
5: 141,942,015 (GRCm39) |
|
probably null |
Het |
| Srp72 |
T |
A |
5: 77,122,598 (GRCm39) |
S10T |
possibly damaging |
Het |
| Stk11 |
G |
T |
10: 79,962,113 (GRCm39) |
G215V |
probably damaging |
Het |
| Stk4 |
T |
C |
2: 163,930,828 (GRCm39) |
M143T |
possibly damaging |
Het |
| Supt20 |
T |
A |
3: 54,617,849 (GRCm39) |
S318T |
possibly damaging |
Het |
| Tchh |
G |
C |
3: 93,353,986 (GRCm39) |
R1142P |
unknown |
Het |
| Vipas39 |
G |
T |
12: 87,301,021 (GRCm39) |
R161S |
probably benign |
Het |
|
| Other mutations in Gpr151 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02631:Gpr151
|
APN |
18 |
42,711,835 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03167:Gpr151
|
APN |
18 |
42,711,439 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1561:Gpr151
|
UTSW |
18 |
42,712,221 (GRCm39) |
missense |
probably benign |
0.42 |
|
R3875:Gpr151
|
UTSW |
18 |
42,711,661 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4294:Gpr151
|
UTSW |
18 |
42,711,602 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5431:Gpr151
|
UTSW |
18 |
42,711,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5815:Gpr151
|
UTSW |
18 |
42,712,450 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6199:Gpr151
|
UTSW |
18 |
42,711,619 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6302:Gpr151
|
UTSW |
18 |
42,712,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6891:Gpr151
|
UTSW |
18 |
42,711,985 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7180:Gpr151
|
UTSW |
18 |
42,712,021 (GRCm39) |
nonsense |
probably null |
|
|
R8262:Gpr151
|
UTSW |
18 |
42,711,437 (GRCm39) |
nonsense |
probably null |
|
|
R9328:Gpr151
|
UTSW |
18 |
42,712,270 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9421:Gpr151
|
UTSW |
18 |
42,712,220 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9524:Gpr151
|
UTSW |
18 |
42,712,710 (GRCm39) |
unclassified |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CTCTGGTGATGGAGCCTTTC -3'
(R):5'- ATTTCTGGCGAGCTTATGACC -3'
Sequencing Primer
(F):5'- AAGGGCCTCTGTGTTTCCAGC -3'
(R):5'- CTGGCGAGCTTATGACCAATGTAAG -3'
|
| Posted On |
2016-07-06 |
Incidental Mutation