Incidental Mutation 'R5204:Gpx7'
ID 398325
Institutional Source Beutler Lab
Gene Symbol Gpx7
Ensembl Gene ENSMUSG00000028597
Gene Name glutathione peroxidase 7
Synonyms 3110050F08Rik, GPX6
MMRRC Submission 042779-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.098) question?
Stock # R5204 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 108257414-108263910 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 108260512 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 95 (T95A)
Ref Sequence ENSEMBL: ENSMUSP00000030332 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030332] [ENSMUST00000184609]
AlphaFold Q99LJ6
Predicted Effect probably benign
Transcript: ENSMUST00000030332
AA Change: T95A

PolyPhen 2 Score 0.090 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000030332
Gene: ENSMUSG00000028597
AA Change: T95A

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:AhpC-TSA 21 164 3.9e-7 PFAM
Pfam:GSHPx 24 132 2.5e-40 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000184609
SMART Domains Protein: ENSMUSP00000139335
Gene: ENSMUSG00000028597

DomainStartEndE-ValueType
SCOP:d1knga_ 16 48 2e-3 SMART
PDB:2P31|B 19 45 2e-11 PDB
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased cellular sensitivity to oxidative stress, premature death, systemic disease and increased tumor incidence. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aarsd1 A T 11: 101,297,752 (GRCm39) L532Q probably damaging Het
Abt1 G A 13: 23,606,838 (GRCm39) R88C probably damaging Het
Aopep G A 13: 63,180,904 (GRCm39) V289I probably benign Het
Arhgef7 T A 8: 11,850,775 (GRCm39) L129* probably null Het
Arid1b T C 17: 5,393,316 (GRCm39) V2282A probably damaging Het
Bivm G C 1: 44,177,738 (GRCm39) G346A probably damaging Het
Cav1 T C 6: 17,339,254 (GRCm39) L102P probably damaging Het
Ccdc57 A G 11: 120,776,888 (GRCm39) V504A possibly damaging Het
Cd7 A T 11: 120,928,860 (GRCm39) probably null Het
Cdh3 T C 8: 107,270,871 (GRCm39) V508A probably benign Het
Chrd A T 16: 20,554,822 (GRCm39) I413F probably benign Het
Clec4b1 T A 6: 123,048,494 (GRCm39) *210R probably null Het
Clock A T 5: 76,391,017 (GRCm39) probably null Het
Col4a2 T A 8: 11,448,651 (GRCm39) probably null Het
Hivep3 T A 4: 119,961,053 (GRCm39) probably null Het
Hrc A G 7: 44,985,128 (GRCm39) Y93C possibly damaging Het
Igkv4-80 A C 6: 68,993,649 (GRCm39) S81A probably benign Het
Klhl5 G T 5: 65,288,781 (GRCm39) L14F possibly damaging Het
Mcm6 A G 1: 128,261,375 (GRCm39) L743P probably benign Het
Nrxn1 A T 17: 90,469,792 (GRCm39) F57Y probably damaging Het
Or51af1 C T 7: 103,141,747 (GRCm39) V113M probably damaging Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Pcdh20 G T 14: 88,706,351 (GRCm39) D316E probably damaging Het
Pcdhb12 T A 18: 37,569,142 (GRCm39) V96E probably damaging Het
Pi4ka A T 16: 17,176,909 (GRCm39) L346M possibly damaging Het
Pkhd1l1 A C 15: 44,410,437 (GRCm39) N2648T possibly damaging Het
Rufy1 C T 11: 50,297,261 (GRCm39) R397Q probably damaging Het
Sema5a G T 15: 32,686,793 (GRCm39) M968I probably benign Het
Slc33a1 A G 3: 63,871,167 (GRCm39) Y149H probably damaging Het
Tln2 T A 9: 67,261,764 (GRCm39) R658S probably benign Het
Tmem30c T C 16: 57,090,385 (GRCm39) N274S possibly damaging Het
Tor3a A G 1: 156,483,270 (GRCm39) L384P probably damaging Het
Trpm3 T A 19: 22,425,705 (GRCm39) L20* probably null Het
Ttn T A 2: 76,560,556 (GRCm39) I20955F probably damaging Het
Usp15 A T 10: 122,949,545 (GRCm39) S908R probably benign Het
Zfp866 A G 8: 70,218,690 (GRCm39) L310P probably damaging Het
Other mutations in Gpx7
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3110:Gpx7 UTSW 4 108,260,470 (GRCm39) missense probably damaging 1.00
R3112:Gpx7 UTSW 4 108,260,470 (GRCm39) missense probably damaging 1.00
R5235:Gpx7 UTSW 4 108,258,189 (GRCm39) missense probably damaging 1.00
R5302:Gpx7 UTSW 4 108,258,111 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- TGAGAAAGTATGGCTTCCTTCGC -3'
(R):5'- GTTCGATTTTGCCATGCAGG -3'

Sequencing Primer
(F):5'- TCCTCCGAGGATCAGGAAG -3'
(R):5'- GATTTTGCCATGCAGGTTTCC -3'
Posted On 2016-07-06