Mutagenetix > Incidental Mutation

Incidental Mutation 'R5231:Vmn2r37'

398516

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r37

Ensembl Gene

ENSMUSG00000066828

Gene Name

vomeronasal 2, receptor 37

Synonyms

V2r14

MMRRC Submission

042803-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R5231 (G1)

Quality Score

119

Status

Not validated

Chromosome

Chromosomal Location

9208548-9226652 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 9209594 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 639 (L639F)

Ref Sequence

ENSEMBL: ENSMUSP00000072566 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072787]

AlphaFold

F8VQD3

Predicted Effect

possibly damaging
Transcript: ENSMUST00000072787
AA Change: L639F

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000072566
Gene: ENSMUSG00000066828
AA Change: L639F

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	157	469	2.9e-26	PFAM
Pfam:NCD3G	512	563	1.1e-16	PFAM
Pfam:7tm_3	550	783	1.7e-53	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 96.8%
20x: 94.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adat3	T	C	10: 80,442,260 (GRCm39)	S33P	possibly damaging	Het
Bche	G	A	3: 73,608,194 (GRCm39)	P411S	probably benign	Het
Chil3	A	G	3: 106,063,045 (GRCm39)	S182P	probably damaging	Het
Col6a4	T	C	9: 105,902,730 (GRCm39)	E1653G	probably damaging	Het
Csk	G	T	9: 57,537,661 (GRCm39)	H84Q	probably damaging	Het
Csmd2	A	G	4: 128,439,842 (GRCm39)	T3099A	probably benign	Het
Deup1	G	T	9: 15,486,495 (GRCm39)	A395E	probably damaging	Het
Frem2	T	C	3: 53,429,716 (GRCm39)	Y2778C	probably damaging	Het
Igfn1	T	C	1: 135,894,474 (GRCm39)	T2031A	probably benign	Het
Ighv1-53	C	A	12: 115,122,225 (GRCm39)	S50I	probably benign	Het
Ighv1-62-3	A	T	12: 115,424,671 (GRCm39)	M100K	possibly damaging	Het
Igkv2-109	T	A	6: 68,279,429 (GRCm39)	F3I	probably benign	Het
Isl1	T	C	13: 116,438,193 (GRCm39)	D296G	probably benign	Het
Klk1b16	T	A	7: 43,786,771 (GRCm39)	L10Q	probably damaging	Het
Kmt2c	A	T	5: 25,520,471 (GRCm39)	S1880T	possibly damaging	Het
Lhcgr	T	A	17: 89,063,039 (GRCm39)	N211I	probably damaging	Het
Ltb	C	T	17: 35,414,802 (GRCm39)	L201F	probably damaging	Het
Mfsd2a	A	G	4: 122,853,094 (GRCm39)	F64S	possibly damaging	Het
Mmp10	T	C	9: 7,502,501 (GRCm39)		probably null	Het
Mycbp2	A	C	14: 103,583,650 (GRCm39)		probably null	Het
Or1e34	C	A	11: 73,778,781 (GRCm39)	C139F	probably damaging	Het
Or52e2	A	T	7: 102,804,175 (GRCm39)	F260I	probably damaging	Het
Or5k17	T	C	16: 58,746,077 (GRCm39)	I286V	possibly damaging	Het
Or9i14	A	T	19: 13,792,711 (GRCm39)	I81N	probably damaging	Het
Peg10	C	T	6: 4,756,939 (GRCm39)		probably benign	Het
Plscr1	C	A	9: 92,148,784 (GRCm39)	P208H	probably damaging	Het
Rhot1	T	C	11: 80,118,160 (GRCm39)		probably null	Het
Rpl15-ps6	T	C	15: 52,341,440 (GRCm39)		noncoding transcript	Het
Smarcc2	T	C	10: 128,297,221 (GRCm39)	Y38H	probably damaging	Het
Spata31e2	T	A	1: 26,723,032 (GRCm39)	H716L	possibly damaging	Het
Stat2	T	C	10: 128,117,111 (GRCm39)		probably null	Het
Trip11	T	C	12: 101,851,860 (GRCm39)	K735E	probably damaging	Het
Ttll1	T	A	15: 83,373,667 (GRCm39)		probably null	Het
Vmn2r60	A	T	7: 41,786,448 (GRCm39)	Q417L	possibly damaging	Het
Vps8	A	T	16: 21,395,475 (GRCm39)	D1255V	probably damaging	Het
Zfp354b	A	C	11: 50,813,917 (GRCm39)	I336S	probably benign	Het
Zfp747l1	T	C	7: 126,984,586 (GRCm39)	Y172C	probably damaging	Het

Other mutations in Vmn2r37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01346:Vmn2r37	APN	7	9,209,680 (GRCm39)	missense	probably benign	0.05
IGL01909:Vmn2r37	APN	7	9,219,032 (GRCm39)	nonsense	probably null
IGL02281:Vmn2r37	APN	7	9,220,881 (GRCm39)	missense	possibly damaging	0.95
IGL02282:Vmn2r37	APN	7	9,209,761 (GRCm39)	missense	probably benign	0.19
IGL02513:Vmn2r37	APN	7	9,220,934 (GRCm39)	missense	probably benign	0.14
R0136:Vmn2r37	UTSW	7	9,220,782 (GRCm39)	nonsense	probably null
R2051:Vmn2r37	UTSW	7	9,220,792 (GRCm39)	missense	probably damaging	1.00
R2262:Vmn2r37	UTSW	7	9,220,943 (GRCm39)	missense	probably damaging	0.99
R3158:Vmn2r37	UTSW	7	9,220,713 (GRCm39)	missense	probably benign	0.03
R4084:Vmn2r37	UTSW	7	9,218,984 (GRCm39)	missense	probably benign
R4114:Vmn2r37	UTSW	7	9,213,092 (GRCm39)	critical splice acceptor site	probably null
R5462:Vmn2r37	UTSW	7	9,220,973 (GRCm39)	missense	probably damaging	1.00
R6437:Vmn2r37	UTSW	7	9,220,850 (GRCm39)	missense	probably damaging	0.98
R7104:Vmn2r37	UTSW	7	9,219,045 (GRCm39)	missense	probably damaging	1.00
R7116:Vmn2r37	UTSW	7	9,220,898 (GRCm39)	missense	probably benign	0.00
R7381:Vmn2r37	UTSW	7	9,213,032 (GRCm39)	missense	probably benign	0.21
R8775:Vmn2r37	UTSW	7	9,218,991 (GRCm39)	nonsense	probably null
R8775-TAIL:Vmn2r37	UTSW	7	9,218,991 (GRCm39)	nonsense	probably null
R8869:Vmn2r37	UTSW	7	9,209,854 (GRCm39)	missense	possibly damaging	0.50
R8884:Vmn2r37	UTSW	7	9,218,916 (GRCm39)	missense	probably benign
RF004:Vmn2r37	UTSW	7	9,220,686 (GRCm39)	missense	probably damaging	0.97
Z1177:Vmn2r37	UTSW	7	9,212,996 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CAGTAACTGAGCCCTTGTTGC -3'
(R):5'- GACACTCCTATTGTGAAGGCC -3'

Sequencing Primer
(F):5'- AGCCCTTGTTGCACACAATGATG -3'
(R):5'- CTCCTATTGTGAAGGCCAATAACAG -3'

Posted On

2016-07-06