Incidental Mutation 'R5231:Or9i14'
| ID |
398575 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Or9i14
|
| Ensembl Gene |
ENSMUSG00000045395 |
| Gene Name |
olfactory receptor family 9 subfamily I member 14 |
| Synonyms |
GA_x6K02T2RE5P-4147744-4146800, Olfr1499, MOR211-2 |
| MMRRC Submission |
042803-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.276)
|
| Stock # |
R5231 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
19 |
| Chromosomal Location |
13792008-13792952 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 13792711 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Asparagine
at position 81
(I81N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150330
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055672]
[ENSMUST00000216659]
|
| AlphaFold |
Q8VG65 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000055672
AA Change: I81N
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000059747
Gene: ENSMUSG00000045395
AA Change: I81N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
31 |
307 |
2.6e-44 |
PFAM |
|
Pfam:7tm_1
|
41 |
290 |
1.5e-19 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000216659
AA Change: I81N
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adat3 |
T |
C |
10: 80,442,260 (GRCm39) |
S33P |
possibly damaging |
Het |
| Bche |
G |
A |
3: 73,608,194 (GRCm39) |
P411S |
probably benign |
Het |
| Chil3 |
A |
G |
3: 106,063,045 (GRCm39) |
S182P |
probably damaging |
Het |
| Col6a4 |
T |
C |
9: 105,902,730 (GRCm39) |
E1653G |
probably damaging |
Het |
| Csk |
G |
T |
9: 57,537,661 (GRCm39) |
H84Q |
probably damaging |
Het |
| Csmd2 |
A |
G |
4: 128,439,842 (GRCm39) |
T3099A |
probably benign |
Het |
| Deup1 |
G |
T |
9: 15,486,495 (GRCm39) |
A395E |
probably damaging |
Het |
| Frem2 |
T |
C |
3: 53,429,716 (GRCm39) |
Y2778C |
probably damaging |
Het |
| Igfn1 |
T |
C |
1: 135,894,474 (GRCm39) |
T2031A |
probably benign |
Het |
| Ighv1-53 |
C |
A |
12: 115,122,225 (GRCm39) |
S50I |
probably benign |
Het |
| Ighv1-62-3 |
A |
T |
12: 115,424,671 (GRCm39) |
M100K |
possibly damaging |
Het |
| Igkv2-109 |
T |
A |
6: 68,279,429 (GRCm39) |
F3I |
probably benign |
Het |
| Isl1 |
T |
C |
13: 116,438,193 (GRCm39) |
D296G |
probably benign |
Het |
| Klk1b16 |
T |
A |
7: 43,786,771 (GRCm39) |
L10Q |
probably damaging |
Het |
| Kmt2c |
A |
T |
5: 25,520,471 (GRCm39) |
S1880T |
possibly damaging |
Het |
| Lhcgr |
T |
A |
17: 89,063,039 (GRCm39) |
N211I |
probably damaging |
Het |
| Ltb |
C |
T |
17: 35,414,802 (GRCm39) |
L201F |
probably damaging |
Het |
| Mfsd2a |
A |
G |
4: 122,853,094 (GRCm39) |
F64S |
possibly damaging |
Het |
| Mmp10 |
T |
C |
9: 7,502,501 (GRCm39) |
|
probably null |
Het |
| Mycbp2 |
A |
C |
14: 103,583,650 (GRCm39) |
|
probably null |
Het |
| Or1e34 |
C |
A |
11: 73,778,781 (GRCm39) |
C139F |
probably damaging |
Het |
| Or52e2 |
A |
T |
7: 102,804,175 (GRCm39) |
F260I |
probably damaging |
Het |
| Or5k17 |
T |
C |
16: 58,746,077 (GRCm39) |
I286V |
possibly damaging |
Het |
| Peg10 |
C |
T |
6: 4,756,939 (GRCm39) |
|
probably benign |
Het |
| Plscr1 |
C |
A |
9: 92,148,784 (GRCm39) |
P208H |
probably damaging |
Het |
| Rhot1 |
T |
C |
11: 80,118,160 (GRCm39) |
|
probably null |
Het |
| Rpl15-ps6 |
T |
C |
15: 52,341,440 (GRCm39) |
|
noncoding transcript |
Het |
| Smarcc2 |
T |
C |
10: 128,297,221 (GRCm39) |
Y38H |
probably damaging |
Het |
| Spata31e2 |
T |
A |
1: 26,723,032 (GRCm39) |
H716L |
possibly damaging |
Het |
| Stat2 |
T |
C |
10: 128,117,111 (GRCm39) |
|
probably null |
Het |
| Trip11 |
T |
C |
12: 101,851,860 (GRCm39) |
K735E |
probably damaging |
Het |
| Ttll1 |
T |
A |
15: 83,373,667 (GRCm39) |
|
probably null |
Het |
| Vmn2r37 |
C |
A |
7: 9,209,594 (GRCm39) |
L639F |
possibly damaging |
Het |
| Vmn2r60 |
A |
T |
7: 41,786,448 (GRCm39) |
Q417L |
possibly damaging |
Het |
| Vps8 |
A |
T |
16: 21,395,475 (GRCm39) |
D1255V |
probably damaging |
Het |
| Zfp354b |
A |
C |
11: 50,813,917 (GRCm39) |
I336S |
probably benign |
Het |
| Zfp747l1 |
T |
C |
7: 126,984,586 (GRCm39) |
Y172C |
probably damaging |
Het |
|
| Other mutations in Or9i14 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01534:Or9i14
|
APN |
19 |
13,792,666 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL01844:Or9i14
|
APN |
19 |
13,792,180 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03102:Or9i14
|
APN |
19 |
13,792,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03352:Or9i14
|
APN |
19 |
13,792,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0218:Or9i14
|
UTSW |
19 |
13,792,342 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0490:Or9i14
|
UTSW |
19 |
13,792,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0682:Or9i14
|
UTSW |
19 |
13,792,501 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1301:Or9i14
|
UTSW |
19 |
13,792,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1328:Or9i14
|
UTSW |
19 |
13,792,900 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2100:Or9i14
|
UTSW |
19 |
13,792,600 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3701:Or9i14
|
UTSW |
19 |
13,792,712 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4563:Or9i14
|
UTSW |
19 |
13,792,646 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4709:Or9i14
|
UTSW |
19 |
13,792,814 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5301:Or9i14
|
UTSW |
19 |
13,792,933 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5343:Or9i14
|
UTSW |
19 |
13,792,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6268:Or9i14
|
UTSW |
19 |
13,792,671 (GRCm39) |
nonsense |
probably null |
|
|
R6442:Or9i14
|
UTSW |
19 |
13,792,992 (GRCm39) |
start gained |
probably benign |
|
|
R7132:Or9i14
|
UTSW |
19 |
13,792,786 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7764:Or9i14
|
UTSW |
19 |
13,792,111 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7943:Or9i14
|
UTSW |
19 |
13,792,600 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8703:Or9i14
|
UTSW |
19 |
13,792,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8736:Or9i14
|
UTSW |
19 |
13,792,358 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9069:Or9i14
|
UTSW |
19 |
13,792,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9177:Or9i14
|
UTSW |
19 |
13,792,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9258:Or9i14
|
UTSW |
19 |
13,792,099 (GRCm39) |
nonsense |
probably null |
|
|
R9268:Or9i14
|
UTSW |
19 |
13,792,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Or9i14
|
UTSW |
19 |
13,792,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Or9i14
|
UTSW |
19 |
13,792,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGTTCTTTGAATGGACCCAG -3'
(R):5'- TACTGACCATCCAGAGTGGG -3'
Sequencing Primer
(F):5'- GTTCTTTGAATGGACCCAGATAACCC -3'
(R):5'- ATCCAGAGTGGGAGGTTCCTC -3'
|
| Posted On |
2016-07-06 |
Incidental Mutation