Incidental Mutation 'R5176:Or5g29'
ID 399255
Institutional Source Beutler Lab
Gene Symbol Or5g29
Ensembl Gene ENSMUSG00000111454
Gene Name olfactory receptor family 5 subfamily G member 29
Synonyms Olfr998, GA_x6K02T2Q125-47069356-47070300, MOR175-5
MMRRC Submission 042756-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.232) question?
Stock # R5176 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 85420854-85421865 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 85421779 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 298 (K298N)
Ref Sequence ENSEMBL: ENSMUSP00000150713 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052307] [ENSMUST00000215083]
AlphaFold Q8VF76
Predicted Effect possibly damaging
Transcript: ENSMUST00000052307
AA Change: K298N

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000059970
Gene: ENSMUSG00000111454
AA Change: K298N

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.6e-54 PFAM
Pfam:7tm_1 41 308 9.5e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215083
AA Change: K298N

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency 99% (69/70)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 C A 10: 79,834,123 (GRCm39) H116Q probably benign Het
Akap12 G T 10: 4,303,947 (GRCm39) E252D probably benign Het
Apobr A G 7: 126,184,188 (GRCm39) D2G probably damaging Het
Arhgef12 A T 9: 42,931,982 (GRCm39) H168Q probably damaging Het
Asb3 T A 11: 31,031,357 (GRCm39) probably null Het
Brip1 T C 11: 85,968,710 (GRCm39) Y825C probably damaging Het
Cacna1b A T 2: 24,525,143 (GRCm39) Y1679N probably damaging Het
Ccdc69 C T 11: 54,951,296 (GRCm39) A42T probably benign Het
Cds1 G T 5: 101,929,286 (GRCm39) D55Y possibly damaging Het
Cep135 C A 5: 76,784,873 (GRCm39) D989E probably benign Het
Cpsf6 C A 10: 117,197,189 (GRCm39) probably benign Het
Ctif C T 18: 75,770,290 (GRCm39) V32M probably damaging Het
Cylc2 T C 4: 51,228,587 (GRCm39) probably benign Het
Dao T C 5: 114,158,070 (GRCm39) probably null Het
Dop1a T A 9: 86,403,868 (GRCm39) N1689K probably damaging Het
Dop1b A G 16: 93,536,931 (GRCm39) Y14C probably damaging Het
Fam187a C T 11: 102,777,290 (GRCm39) R365C probably damaging Het
Fastkd2 A G 1: 63,770,598 (GRCm39) probably benign Het
Fhip2a A G 19: 57,359,613 (GRCm39) N51S probably damaging Het
Fkbp15 G T 4: 62,230,560 (GRCm39) L718I possibly damaging Het
Gabbr2 C A 4: 46,681,208 (GRCm39) V118F probably damaging Het
Gm13991 T A 2: 116,358,508 (GRCm39) noncoding transcript Het
H2-M9 T C 17: 36,952,523 (GRCm39) I174M probably damaging Het
Ift70a2 T C 2: 75,807,421 (GRCm39) M364V probably benign Het
Insr T A 8: 3,208,742 (GRCm39) M1240L probably benign Het
Ints15 G T 5: 143,300,830 (GRCm39) S7* probably null Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Mad2l1bp T A 17: 46,463,738 (GRCm39) E95D probably benign Het
Marchf9 T C 10: 126,895,319 (GRCm39) D102G probably benign Het
Muc19 A G 15: 91,776,374 (GRCm39) noncoding transcript Het
Nr1h4 T A 10: 89,334,117 (GRCm39) Y91F probably benign Het
Nr5a2 A T 1: 136,876,540 (GRCm39) M1K probably null Het
Oprd1 T C 4: 131,841,104 (GRCm39) T285A probably benign Het
Optc T C 1: 133,829,822 (GRCm39) N196S probably benign Het
Or51f5 T A 7: 102,424,513 (GRCm39) S261T probably damaging Het
Or7g21 A T 9: 19,032,656 (GRCm39) Y132F probably damaging Het
Panx2 G T 15: 88,944,431 (GRCm39) R52L probably damaging Het
Pdzd8 A G 19: 59,333,389 (GRCm39) F211L probably damaging Het
Pot1b T A 17: 56,006,995 (GRCm39) T41S probably benign Het
Prss56 T C 1: 87,111,880 (GRCm39) L37S probably damaging Het
Ptk2b T C 14: 66,393,864 (GRCm39) T870A probably damaging Het
Rabep2 C A 7: 126,033,465 (GRCm39) probably benign Het
Rbm48 A C 5: 3,645,444 (GRCm39) V80G probably damaging Het
Rhou G T 8: 124,380,848 (GRCm39) C55F possibly damaging Het
Rnaseh2c A G 19: 5,652,070 (GRCm39) D45G probably benign Het
Rusc1 A G 3: 88,996,389 (GRCm39) S109P probably damaging Het
Ryr3 T C 2: 112,588,012 (GRCm39) D2643G possibly damaging Het
Septin4 T A 11: 87,458,358 (GRCm39) M244K probably benign Het
Sik2 T C 9: 50,810,703 (GRCm39) E471G probably benign Het
Sipa1 A G 19: 5,709,406 (GRCm39) S310P probably damaging Het
Sp140l1 C T 1: 85,066,521 (GRCm39) probably benign Het
Spen T C 4: 141,203,587 (GRCm39) E1680G unknown Het
Steap3 C T 1: 120,171,497 (GRCm39) probably null Het
Tmeff2 T A 1: 51,110,700 (GRCm39) C171* probably null Het
Tmem138 A T 19: 10,552,634 (GRCm39) M33K probably benign Het
Trappc11 C A 8: 47,963,998 (GRCm39) V601L possibly damaging Het
Ttll4 C A 1: 74,718,445 (GRCm39) H99N probably damaging Het
Uchl4 A T 9: 64,143,022 (GRCm39) K168* probably null Het
Wdr17 C T 8: 55,106,913 (GRCm39) probably null Het
Xpo1 A G 11: 23,245,977 (GRCm39) D1029G probably damaging Het
Zfp719 G T 7: 43,240,549 (GRCm39) K712N probably damaging Het
Other mutations in Or5g29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01763:Or5g29 APN 2 85,421,691 (GRCm39) missense probably benign 0.00
R0091:Or5g29 UTSW 2 85,421,696 (GRCm39) missense probably benign 0.38
R0241:Or5g29 UTSW 2 85,421,154 (GRCm39) missense probably benign 0.20
R0241:Or5g29 UTSW 2 85,421,154 (GRCm39) missense probably benign 0.20
R0268:Or5g29 UTSW 2 85,421,645 (GRCm39) missense possibly damaging 0.78
R0481:Or5g29 UTSW 2 85,421,448 (GRCm39) missense possibly damaging 0.94
R1816:Or5g29 UTSW 2 85,421,269 (GRCm39) missense probably benign 0.00
R1988:Or5g29 UTSW 2 85,420,985 (GRCm39) missense probably benign 0.00
R2008:Or5g29 UTSW 2 85,421,766 (GRCm39) missense probably damaging 1.00
R2060:Or5g29 UTSW 2 85,421,627 (GRCm39) missense possibly damaging 0.78
R2273:Or5g29 UTSW 2 85,420,932 (GRCm39) missense probably damaging 1.00
R4409:Or5g29 UTSW 2 85,421,274 (GRCm39) missense probably damaging 1.00
R4783:Or5g29 UTSW 2 85,421,282 (GRCm39) missense probably benign 0.03
R4785:Or5g29 UTSW 2 85,421,282 (GRCm39) missense probably benign 0.03
R5098:Or5g29 UTSW 2 85,420,976 (GRCm39) missense probably benign 0.00
R5462:Or5g29 UTSW 2 85,421,640 (GRCm39) missense probably damaging 1.00
R6092:Or5g29 UTSW 2 85,420,950 (GRCm39) missense probably benign 0.14
R6278:Or5g29 UTSW 2 85,421,342 (GRCm39) missense probably benign 0.00
R7022:Or5g29 UTSW 2 85,420,942 (GRCm39) missense probably benign 0.01
R7673:Or5g29 UTSW 2 85,421,406 (GRCm39) missense possibly damaging 0.75
R8054:Or5g29 UTSW 2 85,421,184 (GRCm39) missense probably damaging 1.00
R8118:Or5g29 UTSW 2 85,421,332 (GRCm39) nonsense probably null
R8940:Or5g29 UTSW 2 85,421,528 (GRCm39) missense probably benign
R9617:Or5g29 UTSW 2 85,421,279 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCAAGATTCAAACTGCTGATGGG -3'
(R):5'- ACAGAGGCATTTCAGATAAACTGC -3'

Sequencing Primer
(F):5'- GGGAAACAAAAAGCCTTCTCTACTTG -3'
(R):5'- GGCATTTCAGATAAACTGCATAGAG -3'
Posted On 2016-07-06