Mutagenetix > Incidental Mutation

Incidental Mutation 'R0454:Itpr3'

39928

Institutional Source

Beutler Lab

Gene Symbol

Itpr3

Ensembl Gene

ENSMUSG00000042644

Gene Name

inositol 1,4,5-triphosphate receptor 3

Synonyms

Itpr-3, Ip3r3, tf

MMRRC Submission

038654-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0454 (G1)

Quality Score

149

Status

Not validated

Chromosome

Chromosomal Location

27276278-27341197 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 27332793 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 1853 (M1853T)

Ref Sequence

ENSEMBL: ENSMUSP00000038150 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049308]

AlphaFold

P70227

PDB Structure

Crystal structure of the ligand binding suppressor domain of type 3 inositol 1,4,5-trisphosphate receptor [X-RAY DIFFRACTION]

Predicted Effect

probably benign
Transcript: ENSMUST00000049308
AA Change: M1853T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000038150
Gene: ENSMUSG00000042644
AA Change: M1853T

Domain	Start	End	E-Value	Type
MIR	113	167	7.75e-6	SMART
MIR	174	224	1.16e-4	SMART
MIR	232	288	1.21e-7	SMART
MIR	295	402	9.38e-14	SMART
Pfam:RYDR_ITPR	473	670	7.8e-64	PFAM
low complexity region	881	889	N/A	INTRINSIC
Pfam:RYDR_ITPR	1175	1333	5.8e-16	PFAM
low complexity region	1549	1567	N/A	INTRINSIC
low complexity region	1831	1851	N/A	INTRINSIC
Pfam:RIH_assoc	1863	1973	2.6e-34	PFAM
transmembrane domain	2203	2225	N/A	INTRINSIC
Pfam:Ion_trans	2235	2527	8.1e-20	PFAM
coiled coil region	2631	2660	N/A	INTRINSIC

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.6%
20x: 93.8%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile and exhibit no apparent abnormalities in pancreatic and salivary secretion. However, one mutation in this gene results in alternating abnormal hair loss and normal hair growth throughout the life of the mouse and low sweet preference. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 93 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930447F04Rik	T	C	X: 65,347,274 (GRCm39)	E91G	unknown	Het
Acot1	A	G	12: 84,064,113 (GRCm39)	Q407R	probably benign	Het
Adcy10	T	A	1: 165,398,297 (GRCm39)	Y1465N	probably damaging	Het
Ahsa2	T	A	11: 23,440,702 (GRCm39)	I249F	probably damaging	Het
Arhgap10	T	C	8: 77,977,594 (GRCm39)	N721S	probably damaging	Het
Arrdc4	T	G	7: 68,391,619 (GRCm39)	E216A	probably damaging	Het
Axin1	T	C	17: 26,392,637 (GRCm39)	V306A	probably benign	Het
Cct3	T	C	3: 88,210,173 (GRCm39)		probably null	Het
Cfap58	G	A	19: 47,963,119 (GRCm39)		probably null	Het
Chd9	T	C	8: 91,699,859 (GRCm39)	S49P	possibly damaging	Het
Clcn2	C	A	16: 20,529,178 (GRCm39)		probably null	Het
Col26a1	T	C	5: 136,783,047 (GRCm39)	N286D	probably benign	Het
Cpt1b	T	A	15: 89,308,596 (GRCm39)	I111F	possibly damaging	Het
Cyp4f16	T	A	17: 32,756,061 (GRCm39)	I30N	probably damaging	Het
Ddc	T	G	11: 11,830,587 (GRCm39)	D19A	possibly damaging	Het
Depdc1a	T	A	3: 159,222,537 (GRCm39)		probably null	Het
Evc2	T	A	5: 37,574,828 (GRCm39)	C1028S	possibly damaging	Het
Fam228a	T	C	12: 4,781,457 (GRCm39)	E134G	probably damaging	Het
Fasl	T	C	1: 161,615,523 (GRCm39)	E111G	probably benign	Het
Fbxw10	A	G	11: 62,767,564 (GRCm39)	N800S	possibly damaging	Het
Fras1	T	C	5: 96,910,524 (GRCm39)	S3318P	probably damaging	Het
G3bp1	T	C	11: 55,389,452 (GRCm39)	F383L	probably damaging	Het
Gad1	T	A	2: 70,409,545 (GRCm39)	M212K	probably damaging	Het
Gm17455	T	G	10: 60,238,752 (GRCm39)	S6A	probably benign	Het
Grm5	T	C	7: 87,779,997 (GRCm39)	S1146P	probably damaging	Het
Gsn	T	C	2: 35,194,651 (GRCm39)	L649P	probably damaging	Het
H2-DMb1	A	G	17: 34,374,685 (GRCm39)	T112A	probably benign	Het
Hcn3	T	A	3: 89,060,201 (GRCm39)	I148F	probably damaging	Het
Hdac10	T	C	15: 89,009,961 (GRCm39)		probably null	Het
Hk3	C	A	13: 55,156,518 (GRCm39)	D619Y	probably damaging	Het
Ifi44	T	A	3: 151,451,134 (GRCm39)	R272S	possibly damaging	Het
Il1rap	A	C	16: 26,517,625 (GRCm39)	D275A	probably damaging	Het
Irag2	A	G	6: 145,113,710 (GRCm39)	R293G	possibly damaging	Het
Itgam	A	T	7: 127,707,152 (GRCm39)	N660I	probably benign	Het
Lrrc8c	A	C	5: 105,754,965 (GRCm39)	K247Q	probably damaging	Het
Map3k21	T	C	8: 126,668,858 (GRCm39)	S815P	probably benign	Het
Mast4	A	G	13: 102,888,068 (GRCm39)	S1114P	probably damaging	Het
Myh8	C	T	11: 67,194,591 (GRCm39)	Q1601*	probably null	Het
Nhlrc2	A	G	19: 56,558,959 (GRCm39)	D148G	probably damaging	Het
Nos1	T	A	5: 118,081,385 (GRCm39)	S1196T	probably benign	Het
Nsmaf	C	T	4: 6,424,874 (GRCm39)		probably null	Het
Obscn	T	C	11: 58,890,449 (GRCm39)	D7361G	unknown	Het
Or2t35	T	C	14: 14,407,777 (GRCm38)	V183A	probably damaging	Het
Or52ad1	C	A	7: 102,996,085 (GRCm39)	A17S	probably benign	Het
Or5bw2	C	T	7: 6,573,359 (GRCm39)	A123V	probably damaging	Het
Pank3	T	G	11: 35,668,536 (GRCm39)	M175R	probably benign	Het
Papolg	A	G	11: 23,829,868 (GRCm39)		probably null	Het
Pcdhb21	G	A	18: 37,647,566 (GRCm39)	D232N	probably damaging	Het
Pcdhb22	T	C	18: 37,651,925 (GRCm39)	F131S	probably damaging	Het
Pik3r6	G	A	11: 68,419,608 (GRCm39)	A140T	possibly damaging	Het
Pinlyp	T	C	7: 24,241,947 (GRCm39)	T87A	possibly damaging	Het
Pld1	T	C	3: 28,178,724 (GRCm39)	S873P	probably damaging	Het
Pld5	T	A	1: 176,102,295 (GRCm39)	Y49F	probably benign	Het
Polq	T	C	16: 36,855,252 (GRCm39)	V449A	probably damaging	Het
Prkca	A	G	11: 107,869,106 (GRCm39)	V69A	probably benign	Het
Ptk6	A	G	2: 180,844,075 (GRCm39)	S75P	possibly damaging	Het
Ptprq	G	A	10: 107,418,391 (GRCm39)	Q1662*	probably null	Het
Ptprt	C	A	2: 161,395,742 (GRCm39)	A1144S	probably damaging	Het
Rrm1	T	A	7: 102,116,133 (GRCm39)	W684R	probably damaging	Het
Ryr1	T	A	7: 28,735,500 (GRCm39)	M4093L	probably damaging	Het
Scnn1a	C	T	6: 125,299,189 (GRCm39)	L90F	probably damaging	Het
Slc25a19	G	T	11: 115,508,423 (GRCm39)	Y188*	probably null	Het
Slc31a1	C	T	4: 62,303,866 (GRCm39)		probably benign	Het
Slc5a11	C	G	7: 122,864,458 (GRCm39)	S351R	possibly damaging	Het
Slc6a17	A	G	3: 107,384,183 (GRCm39)	L387P	probably benign	Het
Slitrk6	A	T	14: 110,987,364 (GRCm39)	L781H	probably damaging	Het
Spam1	T	A	6: 24,797,837 (GRCm39)	L331Q	probably damaging	Het
Spata32	A	G	11: 103,100,125 (GRCm39)	W127R	probably damaging	Het
Spring1	A	G	5: 118,393,886 (GRCm39)	E88G	possibly damaging	Het
Spta1	T	G	1: 174,041,508 (GRCm39)	I1324S	probably damaging	Het
St6galnac4	A	G	2: 32,484,330 (GRCm39)	Y176C	probably damaging	Het
Stk10	A	G	11: 32,546,724 (GRCm39)	E327G	probably damaging	Het
Stxbp5l	T	A	16: 36,954,646 (GRCm39)	Y912F	possibly damaging	Het
Tchp	G	A	5: 114,858,243 (GRCm39)	E459K	probably benign	Het
Terf2	C	T	8: 107,822,842 (GRCm39)	W100*	probably null	Het
Thoc2l	T	G	5: 104,666,077 (GRCm39)	S200A	probably benign	Het
Thrsp	T	C	7: 97,066,634 (GRCm39)	N26S	probably damaging	Het
Tln1	C	A	4: 43,553,504 (GRCm39)	R297L	probably benign	Het
Tmeff2	C	A	1: 50,967,234 (GRCm39)	T43N	possibly damaging	Het
Tmx1	C	T	12: 70,499,947 (GRCm39)	A2V	possibly damaging	Het
Tnks1bp1	T	A	2: 84,902,481 (GRCm39)	L1053Q	probably damaging	Het
Trmt10b	A	T	4: 45,304,286 (GRCm39)	K107N	probably damaging	Het
Trpa1	A	T	1: 14,955,972 (GRCm39)		probably null	Het
Trrap	A	G	5: 144,783,287 (GRCm39)	K3371R	probably damaging	Het
Tuba3b	G	A	6: 145,563,995 (GRCm39)	V14I	probably benign	Het
Usp19	T	C	9: 108,371,439 (GRCm39)		probably null	Het
Usp28	C	A	9: 48,950,401 (GRCm39)	D615E	possibly damaging	Het
Utp20	T	C	10: 88,657,931 (GRCm39)	D43G	probably benign	Het
Vmn1r58	T	G	7: 5,413,997 (GRCm39)	K78Q	possibly damaging	Het
Vmn2r10	T	C	5: 109,151,327 (GRCm39)	M96V	probably benign	Het
Wdr90	T	C	17: 26,079,023 (GRCm39)	E273G	probably damaging	Het
Xpc	C	T	6: 91,468,208 (GRCm39)	A860T	probably benign	Het
Zscan21	T	C	5: 138,131,865 (GRCm39)	I463T	possibly damaging	Het

Other mutations in Itpr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00715:Itpr3	APN	17	27,302,603 (GRCm39)	missense	probably benign	0.05
IGL00980:Itpr3	APN	17	27,329,930 (GRCm39)	missense	probably benign
IGL01151:Itpr3	APN	17	27,310,503 (GRCm39)	missense	probably damaging	1.00
IGL01289:Itpr3	APN	17	27,318,739 (GRCm39)	missense	probably damaging	0.99
IGL01403:Itpr3	APN	17	27,337,569 (GRCm39)	missense	probably damaging	0.97
IGL01666:Itpr3	APN	17	27,336,152 (GRCm39)	missense	probably benign	0.02
IGL01897:Itpr3	APN	17	27,330,236 (GRCm39)	missense	probably damaging	1.00
IGL02003:Itpr3	APN	17	27,340,449 (GRCm39)	missense	probably damaging	1.00
IGL02012:Itpr3	APN	17	27,323,069 (GRCm39)	missense	probably benign
IGL02063:Itpr3	APN	17	27,338,997 (GRCm39)	missense	probably benign	0.01
IGL02146:Itpr3	APN	17	27,336,249 (GRCm39)	missense	probably damaging	1.00
IGL02158:Itpr3	APN	17	27,317,416 (GRCm39)	missense	probably damaging	1.00
IGL02177:Itpr3	APN	17	27,318,588 (GRCm39)	missense	possibly damaging	0.74
IGL02247:Itpr3	APN	17	27,317,153 (GRCm39)	missense	probably damaging	1.00
IGL02606:Itpr3	APN	17	27,333,486 (GRCm39)	splice site	probably benign
IGL02651:Itpr3	APN	17	27,325,372 (GRCm39)	missense	probably damaging	0.99
IGL02902:Itpr3	APN	17	27,323,530 (GRCm39)	missense	probably benign	0.21
IGL03001:Itpr3	APN	17	27,308,586 (GRCm39)	splice site	probably benign
IGL03004:Itpr3	APN	17	27,316,952 (GRCm39)	missense	possibly damaging	0.90
IGL03065:Itpr3	APN	17	27,310,907 (GRCm39)	missense	probably damaging	1.00
IGL03117:Itpr3	APN	17	27,338,240 (GRCm39)	missense	probably damaging	1.00
IGL03181:Itpr3	APN	17	27,330,242 (GRCm39)	missense	probably benign
IGL03404:Itpr3	APN	17	27,310,492 (GRCm39)	missense	probably damaging	1.00
Allure	UTSW	17	27,326,277 (GRCm39)	missense	probably damaging	1.00
alopecia	UTSW	17	27,314,452 (GRCm39)	missense	probably damaging	0.98
Beauty	UTSW	17	27,325,316 (GRCm39)	missense	probably damaging	1.00
Opuesto	UTSW	17	27,306,566 (GRCm39)	missense	probably damaging	1.00
Paradox	UTSW	17	27,317,145 (GRCm39)	missense	probably damaging	1.00
Pulchritude	UTSW	17	27,305,934 (GRCm39)	missense	probably damaging	0.97
R0010:Itpr3	UTSW	17	27,339,951 (GRCm39)	missense	probably damaging	1.00
R0055:Itpr3	UTSW	17	27,317,296 (GRCm39)	missense	probably damaging	1.00
R0068:Itpr3	UTSW	17	27,323,034 (GRCm39)	splice site	probably benign
R0068:Itpr3	UTSW	17	27,323,034 (GRCm39)	splice site	probably benign
R0104:Itpr3	UTSW	17	27,314,966 (GRCm39)	missense	probably benign	0.01
R0195:Itpr3	UTSW	17	27,333,088 (GRCm39)	missense	probably damaging	1.00
R0212:Itpr3	UTSW	17	27,308,293 (GRCm39)	missense	probably damaging	1.00
R0485:Itpr3	UTSW	17	27,330,903 (GRCm39)	missense	probably damaging	0.98
R0501:Itpr3	UTSW	17	27,326,263 (GRCm39)	missense	probably benign	0.09
R0781:Itpr3	UTSW	17	27,329,529 (GRCm39)	missense	probably benign	0.00
R0890:Itpr3	UTSW	17	27,307,985 (GRCm39)	nonsense	probably null
R1028:Itpr3	UTSW	17	27,310,343 (GRCm39)	missense	probably benign	0.04
R1144:Itpr3	UTSW	17	27,333,897 (GRCm39)	missense	probably benign	0.01
R1347:Itpr3	UTSW	17	27,330,535 (GRCm39)	missense	probably benign	0.02
R1347:Itpr3	UTSW	17	27,330,535 (GRCm39)	missense	probably benign	0.02
R1458:Itpr3	UTSW	17	27,337,346 (GRCm39)	missense	probably benign	0.01
R1463:Itpr3	UTSW	17	27,336,128 (GRCm39)	splice site	probably benign
R1472:Itpr3	UTSW	17	27,333,199 (GRCm39)	missense	probably benign	0.09
R1529:Itpr3	UTSW	17	27,324,459 (GRCm39)	splice site	probably null
R1533:Itpr3	UTSW	17	27,314,534 (GRCm39)	missense	possibly damaging	0.71
R1537:Itpr3	UTSW	17	27,333,121 (GRCm39)	missense	possibly damaging	0.96
R1618:Itpr3	UTSW	17	27,335,581 (GRCm39)	critical splice acceptor site	probably null
R1672:Itpr3	UTSW	17	27,307,987 (GRCm39)	missense	probably benign
R1726:Itpr3	UTSW	17	27,330,664 (GRCm39)	missense	probably damaging	0.96
R1865:Itpr3	UTSW	17	27,338,997 (GRCm39)	missense	probably benign	0.01
R1940:Itpr3	UTSW	17	27,330,191 (GRCm39)	missense	probably damaging	1.00
R2023:Itpr3	UTSW	17	27,321,785 (GRCm39)	missense	possibly damaging	0.76
R2063:Itpr3	UTSW	17	27,317,050 (GRCm39)	missense	probably benign	0.19
R2064:Itpr3	UTSW	17	27,317,050 (GRCm39)	missense	probably benign	0.19
R2065:Itpr3	UTSW	17	27,317,050 (GRCm39)	missense	probably benign	0.19
R2067:Itpr3	UTSW	17	27,317,050 (GRCm39)	missense	probably benign	0.19
R2068:Itpr3	UTSW	17	27,317,050 (GRCm39)	missense	probably benign	0.19
R2219:Itpr3	UTSW	17	27,334,027 (GRCm39)	missense	probably benign
R2248:Itpr3	UTSW	17	27,334,033 (GRCm39)	missense	probably damaging	1.00
R2291:Itpr3	UTSW	17	27,332,553 (GRCm39)	missense	possibly damaging	0.92
R2320:Itpr3	UTSW	17	27,314,889 (GRCm39)	missense	probably benign
R2864:Itpr3	UTSW	17	27,310,525 (GRCm39)	missense	probably benign	0.01
R2865:Itpr3	UTSW	17	27,310,525 (GRCm39)	missense	probably benign	0.01
R3778:Itpr3	UTSW	17	27,314,446 (GRCm39)	missense	possibly damaging	0.57
R3881:Itpr3	UTSW	17	27,332,814 (GRCm39)	missense	probably benign	0.01
R3979:Itpr3	UTSW	17	27,310,546 (GRCm39)	missense	probably damaging	1.00
R3979:Itpr3	UTSW	17	27,304,105 (GRCm39)	missense	probably benign	0.23
R4224:Itpr3	UTSW	17	27,326,232 (GRCm39)	missense	probably damaging	1.00
R4259:Itpr3	UTSW	17	27,325,298 (GRCm39)	missense	probably damaging	1.00
R4321:Itpr3	UTSW	17	27,330,948 (GRCm39)	missense	probably benign	0.00
R4466:Itpr3	UTSW	17	27,325,316 (GRCm39)	missense	probably damaging	1.00
R4493:Itpr3	UTSW	17	27,323,586 (GRCm39)	missense	probably damaging	1.00
R4597:Itpr3	UTSW	17	27,312,257 (GRCm39)	missense	probably damaging	1.00
R4823:Itpr3	UTSW	17	27,304,121 (GRCm39)	missense	probably benign	0.30
R4921:Itpr3	UTSW	17	27,316,979 (GRCm39)	missense	probably damaging	1.00
R4974:Itpr3	UTSW	17	27,302,582 (GRCm39)	missense	probably damaging	0.96
R5063:Itpr3	UTSW	17	27,308,885 (GRCm39)	missense	possibly damaging	0.94
R5079:Itpr3	UTSW	17	27,317,397 (GRCm39)	missense	probably damaging	1.00
R5303:Itpr3	UTSW	17	27,335,663 (GRCm39)	missense	probably benign	0.38
R5518:Itpr3	UTSW	17	27,306,566 (GRCm39)	missense	probably damaging	1.00
R5521:Itpr3	UTSW	17	27,326,308 (GRCm39)	missense	probably benign	0.09
R5566:Itpr3	UTSW	17	27,334,926 (GRCm39)	missense	possibly damaging	0.71
R5567:Itpr3	UTSW	17	27,322,880 (GRCm39)	missense	possibly damaging	0.66
R5579:Itpr3	UTSW	17	27,332,493 (GRCm39)	missense	probably damaging	1.00
R5610:Itpr3	UTSW	17	27,337,540 (GRCm39)	missense	probably benign	0.42
R5658:Itpr3	UTSW	17	27,326,852 (GRCm39)	missense	possibly damaging	0.74
R5856:Itpr3	UTSW	17	27,325,379 (GRCm39)	missense	probably damaging	1.00
R5872:Itpr3	UTSW	17	27,305,950 (GRCm39)	missense	probably benign	0.02
R5878:Itpr3	UTSW	17	27,329,836 (GRCm39)	missense	probably benign	0.01
R5889:Itpr3	UTSW	17	27,334,039 (GRCm39)	missense	probably damaging	0.99
R5907:Itpr3	UTSW	17	27,336,867 (GRCm39)	missense	probably damaging	1.00
R5930:Itpr3	UTSW	17	27,329,895 (GRCm39)	missense	possibly damaging	0.49
R5987:Itpr3	UTSW	17	27,323,575 (GRCm39)	missense	probably damaging	1.00
R6029:Itpr3	UTSW	17	27,317,145 (GRCm39)	missense	probably damaging	1.00
R6195:Itpr3	UTSW	17	27,305,934 (GRCm39)	missense	probably damaging	0.97
R6213:Itpr3	UTSW	17	27,330,174 (GRCm39)	missense	probably benign	0.03
R6233:Itpr3	UTSW	17	27,305,934 (GRCm39)	missense	probably damaging	0.97
R6376:Itpr3	UTSW	17	27,314,449 (GRCm39)	missense	possibly damaging	0.94
R6514:Itpr3	UTSW	17	27,310,344 (GRCm39)	missense	probably benign
R6515:Itpr3	UTSW	17	27,310,344 (GRCm39)	missense	probably benign
R6516:Itpr3	UTSW	17	27,310,344 (GRCm39)	missense	probably benign
R6955:Itpr3	UTSW	17	27,340,441 (GRCm39)	missense	probably damaging	1.00
R7002:Itpr3	UTSW	17	27,329,554 (GRCm39)	missense	probably benign	0.00
R7064:Itpr3	UTSW	17	27,308,269 (GRCm39)	missense	probably damaging	1.00
R7257:Itpr3	UTSW	17	27,337,535 (GRCm39)	missense	probably benign	0.00
R7349:Itpr3	UTSW	17	27,326,786 (GRCm39)	splice site	probably null
R7469:Itpr3	UTSW	17	27,340,028 (GRCm39)	missense	possibly damaging	0.74
R7493:Itpr3	UTSW	17	27,313,774 (GRCm39)	missense	probably benign	0.09
R7510:Itpr3	UTSW	17	27,308,013 (GRCm39)	missense	probably damaging	0.97
R7565:Itpr3	UTSW	17	27,329,862 (GRCm39)	missense	probably benign	0.01
R7616:Itpr3	UTSW	17	27,307,951 (GRCm39)	missense	probably damaging	1.00
R7728:Itpr3	UTSW	17	27,317,088 (GRCm39)	missense	probably damaging	1.00
R7779:Itpr3	UTSW	17	27,315,037 (GRCm39)	missense	probably damaging	1.00
R7788:Itpr3	UTSW	17	27,337,571 (GRCm39)	nonsense	probably null
R7871:Itpr3	UTSW	17	27,336,153 (GRCm39)	missense	probably damaging	1.00
R7889:Itpr3	UTSW	17	27,335,751 (GRCm39)	missense	probably damaging	1.00
R7966:Itpr3	UTSW	17	27,331,002 (GRCm39)	critical splice donor site	probably null
R8065:Itpr3	UTSW	17	27,329,836 (GRCm39)	missense	probably benign	0.01
R8067:Itpr3	UTSW	17	27,329,836 (GRCm39)	missense	probably benign	0.01
R8230:Itpr3	UTSW	17	27,326,711 (GRCm39)	critical splice donor site	probably null
R8263:Itpr3	UTSW	17	27,334,887 (GRCm39)	nonsense	probably null
R8264:Itpr3	UTSW	17	27,323,086 (GRCm39)	synonymous	silent
R8269:Itpr3	UTSW	17	27,312,258 (GRCm39)	missense	possibly damaging	0.60
R8271:Itpr3	UTSW	17	27,306,622 (GRCm39)	missense	probably damaging	1.00
R8316:Itpr3	UTSW	17	27,325,199 (GRCm39)	missense	possibly damaging	0.50
R8354:Itpr3	UTSW	17	27,334,893 (GRCm39)	missense	possibly damaging	0.74
R8413:Itpr3	UTSW	17	27,330,900 (GRCm39)	missense	probably damaging	1.00
R8437:Itpr3	UTSW	17	27,326,277 (GRCm39)	missense	probably damaging	1.00
R8676:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8679:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8846:Itpr3	UTSW	17	27,330,996 (GRCm39)	missense	probably damaging	1.00
R8884:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8885:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8886:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8887:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8888:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8891:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8896:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8975:Itpr3	UTSW	17	27,335,628 (GRCm39)	missense	possibly damaging	0.56
R9025:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9026:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9063:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9087:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9088:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9089:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9090:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9091:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9200:Itpr3	UTSW	17	27,326,636 (GRCm39)	missense	probably damaging	0.99
R9270:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9271:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9294:Itpr3	UTSW	17	27,330,191 (GRCm39)	missense	probably damaging	1.00
R9389:Itpr3	UTSW	17	27,314,899 (GRCm39)	missense	possibly damaging	0.84
R9433:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9434:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9443:Itpr3	UTSW	17	27,324,523 (GRCm39)	missense	probably damaging	1.00
R9472:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9474:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9475:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9476:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9477:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9507:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9508:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9511:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9694:Itpr3	UTSW	17	27,334,927 (GRCm39)	missense	probably damaging	0.99
R9789:Itpr3	UTSW	17	27,308,915 (GRCm39)	missense	probably benign	0.15
V7732:Itpr3	UTSW	17	27,330,000 (GRCm39)	splice site	probably null
V7732:Itpr3	UTSW	17	27,329,998 (GRCm39)	splice site	probably benign
Z1088:Itpr3	UTSW	17	27,332,502 (GRCm39)	missense	possibly damaging	0.50
Z1177:Itpr3	UTSW	17	27,338,961 (GRCm39)	missense	probably damaging	1.00
Z1177:Itpr3	UTSW	17	27,333,903 (GRCm39)	missense	probably damaging	1.00
Z31818:Itpr3	UTSW	17	27,314,452 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- GCTTCTTCAAGGTGCTTCATGACCG -3'
(R):5'- TGCCACACATGATGTCCAGGAAC -3'

Sequencing Primer
(F):5'- TGTCAACATGAGCGACCTG -3'
(R):5'- GTCTCACACACCAGGTTGTAG -3'

Posted On

2013-05-23