Incidental Mutation 'R5254:Ggt1'
ID |
399376 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Ggt1
|
Ensembl Gene |
ENSMUSG00000006345 |
Gene Name |
gamma-glutamyltransferase 1 |
Synonyms |
Ggtp, dwg, GGT, CD224 |
MMRRC Submission |
042825-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.110)
|
Stock # |
R5254 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
10 |
Chromosomal Location |
75397438-75422034 bp(+) (GRCm39) |
Type of Mutation |
splice site |
DNA Base Change (assembly) |
T to A
at 75415032 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000006508]
[ENSMUST00000124259]
[ENSMUST00000125770]
[ENSMUST00000128886]
[ENSMUST00000129232]
[ENSMUST00000134503]
[ENSMUST00000139459]
[ENSMUST00000143792]
[ENSMUST00000145928]
[ENSMUST00000151212]
[ENSMUST00000141062]
[ENSMUST00000131565]
[ENSMUST00000140219]
[ENSMUST00000143226]
[ENSMUST00000145079]
[ENSMUST00000152657]
|
AlphaFold |
Q60928 |
Predicted Effect |
probably null
Transcript: ENSMUST00000006508
|
SMART Domains |
Protein: ENSMUSP00000006508 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
low complexity region
|
5 |
22 |
N/A |
INTRINSIC |
Pfam:G_glu_transpept
|
54 |
563 |
4.9e-179 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000124259
|
SMART Domains |
Protein: ENSMUSP00000122616 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
low complexity region
|
5 |
22 |
N/A |
INTRINSIC |
Pfam:G_glu_transpept
|
54 |
235 |
1.6e-70 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000125770
|
SMART Domains |
Protein: ENSMUSP00000117968 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
low complexity region
|
5 |
22 |
N/A |
INTRINSIC |
Pfam:G_glu_transpept
|
54 |
88 |
7.9e-13 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000128886
|
SMART Domains |
Protein: ENSMUSP00000118261 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
low complexity region
|
5 |
22 |
N/A |
INTRINSIC |
Pfam:G_glu_transpept
|
54 |
126 |
2.8e-26 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000129020
|
SMART Domains |
Protein: ENSMUSP00000118825 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
Pfam:G_glu_transpept
|
1 |
263 |
3.3e-88 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000129232
|
SMART Domains |
Protein: ENSMUSP00000115118 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
low complexity region
|
5 |
22 |
N/A |
INTRINSIC |
Pfam:G_glu_transpept
|
54 |
189 |
9e-53 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000134503
|
SMART Domains |
Protein: ENSMUSP00000121312 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
low complexity region
|
5 |
22 |
N/A |
INTRINSIC |
Pfam:G_glu_transpept
|
54 |
563 |
1.4e-184 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000139459
|
SMART Domains |
Protein: ENSMUSP00000121774 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
low complexity region
|
5 |
22 |
N/A |
INTRINSIC |
Pfam:G_glu_transpept
|
54 |
243 |
1.7e-73 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000143792
|
SMART Domains |
Protein: ENSMUSP00000117851 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
low complexity region
|
5 |
22 |
N/A |
INTRINSIC |
Pfam:G_glu_transpept
|
54 |
237 |
2.2e-71 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000145928
|
SMART Domains |
Protein: ENSMUSP00000118852 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
low complexity region
|
5 |
22 |
N/A |
INTRINSIC |
Pfam:G_glu_transpept
|
54 |
210 |
6.5e-59 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148447
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000151212
|
SMART Domains |
Protein: ENSMUSP00000119387 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
low complexity region
|
5 |
22 |
N/A |
INTRINSIC |
PDB:4GDX|A
|
23 |
60 |
3e-12 |
PDB |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000141062
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000131565
|
SMART Domains |
Protein: ENSMUSP00000119844 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
low complexity region
|
5 |
22 |
N/A |
INTRINSIC |
Pfam:G_glu_transpept
|
54 |
126 |
2.8e-26 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000140219
|
SMART Domains |
Protein: ENSMUSP00000118870 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
low complexity region
|
5 |
22 |
N/A |
INTRINSIC |
Pfam:G_glu_transpept
|
54 |
126 |
2.8e-26 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000143226
|
SMART Domains |
Protein: ENSMUSP00000115115 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
low complexity region
|
5 |
22 |
N/A |
INTRINSIC |
Pfam:G_glu_transpept
|
54 |
190 |
5.9e-53 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000145079
|
SMART Domains |
Protein: ENSMUSP00000115483 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
low complexity region
|
5 |
22 |
N/A |
INTRINSIC |
Pfam:G_glu_transpept
|
54 |
110 |
2.1e-22 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000152657
|
SMART Domains |
Protein: ENSMUSP00000115818 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
low complexity region
|
5 |
22 |
N/A |
INTRINSIC |
Pfam:G_glu_transpept
|
54 |
110 |
2.1e-22 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000155186
|
SMART Domains |
Protein: ENSMUSP00000123017 Gene: ENSMUSG00000006345
Domain | Start | End | E-Value | Type |
Pfam:G_glu_transpept
|
1 |
128 |
6.3e-42 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
Validation Efficiency |
98% (82/84) |
MGI Phenotype |
FUNCTION: This gene encodes gamma-glutamyl transpeptidase, a plasmamembrane-associated enzyme that cleaves the peptide bond between gamma-glutamyl and cysteinyl glycine moieties of glutathione. The encoded protein is autocatalytically processed to generate an enzymatically active heterodimer comprised of heavy and light chains. Mice lacking the encoded protein grow slowly, develop cataracts and have elevated levels of glutathione in plasma and urine. Transgenic overexpression of the encoded protein in mice enhances osteoclastic bone resorption. The mutant alleles termed 'Dwarf grey' and 'Dwarf grey Bayer' in mice are associated with deletions in this gene. A gamma-glutamyl transpeptidase paralog is located adjacent to this gene. Alternative splicing results in multiple transcript variants. Additional transcripts using alternate promoters and differing in 5' UTRs have been described. [provided by RefSeq, Apr 2015] PHENOTYPE: Homozygous mutants may exhibit impaired growth, skeletal abnormalities, cataracts, lethargic behavior, premature greying, sterility, and shortened life span. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 78 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abhd8 |
G |
T |
8: 71,911,042 (GRCm39) |
C296* |
probably null |
Het |
Adam11 |
T |
A |
11: 102,665,098 (GRCm39) |
Y413* |
probably null |
Het |
Ankhd1 |
A |
G |
18: 36,789,768 (GRCm39) |
I907V |
probably benign |
Het |
Arrdc5 |
A |
G |
17: 56,604,897 (GRCm39) |
I130T |
probably benign |
Het |
Asic5 |
T |
A |
3: 81,928,294 (GRCm39) |
I419K |
probably damaging |
Het |
Atp4a |
A |
T |
7: 30,414,955 (GRCm39) |
E248V |
probably damaging |
Het |
Avil |
C |
A |
10: 126,847,630 (GRCm39) |
V154L |
probably benign |
Het |
Bclaf1 |
T |
A |
10: 20,199,282 (GRCm39) |
H226Q |
possibly damaging |
Het |
Cald1 |
A |
G |
6: 34,723,351 (GRCm39) |
|
probably benign |
Het |
Cd200r4 |
A |
C |
16: 44,652,453 (GRCm39) |
D27A |
possibly damaging |
Het |
Cdsn |
T |
A |
17: 35,863,099 (GRCm39) |
M1K |
probably null |
Het |
Cfap46 |
T |
A |
7: 139,258,430 (GRCm39) |
H281L |
possibly damaging |
Het |
Chaf1a |
T |
C |
17: 56,369,606 (GRCm39) |
F533L |
probably benign |
Het |
Chil4 |
T |
A |
3: 106,126,768 (GRCm39) |
I5F |
probably benign |
Het |
Ctu2 |
A |
T |
8: 123,203,327 (GRCm39) |
R48W |
probably damaging |
Het |
Daam1 |
A |
T |
12: 71,993,350 (GRCm39) |
H373L |
unknown |
Het |
Dcaf10 |
T |
A |
4: 45,370,415 (GRCm39) |
Y328N |
possibly damaging |
Het |
Dst |
A |
T |
1: 34,217,012 (GRCm39) |
K1151* |
probably null |
Het |
Ect2 |
T |
C |
3: 27,184,219 (GRCm39) |
D503G |
probably damaging |
Het |
Epm2a |
C |
A |
10: 11,333,089 (GRCm39) |
D307E |
probably benign |
Het |
Exph5 |
A |
T |
9: 53,249,230 (GRCm39) |
D73V |
probably damaging |
Het |
Fam20b |
C |
T |
1: 156,533,310 (GRCm39) |
G102D |
probably damaging |
Het |
Fat2 |
T |
C |
11: 55,172,001 (GRCm39) |
N2904S |
probably damaging |
Het |
Flt3 |
T |
A |
5: 147,312,500 (GRCm39) |
Q147L |
possibly damaging |
Het |
Fndc11 |
A |
G |
2: 180,863,956 (GRCm39) |
T254A |
possibly damaging |
Het |
Galnt15 |
C |
T |
14: 31,780,244 (GRCm39) |
R514* |
probably null |
Het |
Gbgt1 |
A |
G |
2: 28,395,220 (GRCm39) |
D286G |
probably damaging |
Het |
Gm26526 |
A |
T |
7: 39,238,658 (GRCm39) |
|
noncoding transcript |
Het |
H2-K2 |
T |
C |
17: 34,216,436 (GRCm39) |
T237A |
probably damaging |
Het |
Igf1r |
T |
A |
7: 67,857,067 (GRCm39) |
S1010T |
probably damaging |
Het |
Il21 |
T |
C |
3: 37,281,884 (GRCm39) |
T87A |
possibly damaging |
Het |
Kmt2b |
G |
A |
7: 30,268,600 (GRCm39) |
R2010C |
probably damaging |
Het |
Kmt2c |
G |
A |
5: 25,519,592 (GRCm39) |
P2173S |
probably benign |
Het |
Krt1 |
A |
T |
15: 101,754,803 (GRCm39) |
S512T |
unknown |
Het |
Krtap16-1 |
G |
A |
11: 99,876,424 (GRCm39) |
R327* |
probably null |
Het |
Lama1 |
T |
A |
17: 68,063,711 (GRCm39) |
I745N |
probably benign |
Het |
Lrrk1 |
T |
A |
7: 65,956,855 (GRCm39) |
N372I |
probably benign |
Het |
Lyst |
A |
T |
13: 13,857,655 (GRCm39) |
E2481D |
probably benign |
Het |
Map2k1 |
A |
T |
9: 64,095,027 (GRCm39) |
|
probably benign |
Het |
Mbip |
A |
G |
12: 56,384,228 (GRCm39) |
V215A |
probably damaging |
Het |
Mdc1 |
T |
A |
17: 36,158,814 (GRCm39) |
V398D |
probably benign |
Het |
Mog |
T |
G |
17: 37,323,264 (GRCm39) |
I225L |
probably benign |
Het |
Mrgprx3-ps |
T |
A |
7: 46,959,184 (GRCm39) |
|
noncoding transcript |
Het |
Muc5b |
C |
T |
7: 141,418,277 (GRCm39) |
S3741L |
probably benign |
Het |
Myo5a |
A |
T |
9: 75,037,402 (GRCm39) |
I202F |
probably damaging |
Het |
Myo5b |
A |
T |
18: 74,833,677 (GRCm39) |
I818F |
possibly damaging |
Het |
Nfia |
T |
A |
4: 97,902,534 (GRCm39) |
M262K |
probably damaging |
Het |
Nisch |
C |
T |
14: 30,928,524 (GRCm39) |
|
probably null |
Het |
Nkd1 |
A |
G |
8: 89,315,822 (GRCm39) |
D64G |
probably damaging |
Het |
Nt5c2 |
T |
A |
19: 46,881,999 (GRCm39) |
K284* |
probably null |
Het |
Or14a259 |
A |
T |
7: 86,013,398 (GRCm39) |
V49E |
possibly damaging |
Het |
Or4k15b |
C |
A |
14: 50,272,135 (GRCm39) |
A242S |
possibly damaging |
Het |
Or4l1 |
A |
T |
14: 50,166,236 (GRCm39) |
I255N |
probably damaging |
Het |
Or52z14 |
T |
G |
7: 103,252,996 (GRCm39) |
I45R |
probably benign |
Het |
Or5an1c |
A |
G |
19: 12,218,612 (GRCm39) |
S138P |
probably damaging |
Het |
Or5j3 |
A |
T |
2: 86,128,265 (GRCm39) |
Y35F |
probably damaging |
Het |
Or8g55 |
A |
T |
9: 39,784,741 (GRCm39) |
T57S |
possibly damaging |
Het |
Or8k24 |
A |
T |
2: 86,216,484 (GRCm39) |
S93T |
possibly damaging |
Het |
Pcdhb17 |
A |
T |
18: 37,619,878 (GRCm39) |
D556V |
probably damaging |
Het |
Pcdhga8 |
A |
T |
18: 37,859,673 (GRCm39) |
D243V |
probably benign |
Het |
Polq |
A |
T |
16: 36,909,681 (GRCm39) |
Q2355L |
probably damaging |
Het |
Slc22a30 |
G |
A |
19: 8,321,757 (GRCm39) |
Q436* |
probably null |
Het |
Slc5a4a |
C |
A |
10: 76,018,572 (GRCm39) |
Y506* |
probably null |
Het |
Sp110 |
G |
C |
1: 85,504,923 (GRCm39) |
|
probably benign |
Het |
Tarbp1 |
G |
A |
8: 127,193,895 (GRCm39) |
H336Y |
probably damaging |
Het |
Tas2r134 |
T |
G |
2: 51,517,559 (GRCm39) |
F13V |
probably benign |
Het |
Tgfb2 |
A |
G |
1: 186,436,680 (GRCm39) |
Y98H |
probably damaging |
Het |
Tmprss11a |
C |
A |
5: 86,559,665 (GRCm39) |
V376L |
probably damaging |
Het |
Tmprss11f |
T |
A |
5: 86,685,892 (GRCm39) |
K158N |
probably benign |
Het |
Tnip2 |
G |
T |
5: 34,660,922 (GRCm39) |
Q177K |
probably damaging |
Het |
Trp53inp1 |
T |
A |
4: 11,165,075 (GRCm39) |
|
probably null |
Het |
Ttc28 |
C |
T |
5: 111,419,104 (GRCm39) |
P1398S |
probably benign |
Het |
Umodl1 |
T |
G |
17: 31,199,333 (GRCm39) |
I308S |
possibly damaging |
Het |
Vcan |
A |
T |
13: 89,839,719 (GRCm39) |
S1942T |
probably damaging |
Het |
Vmn2r124 |
T |
A |
17: 18,283,339 (GRCm39) |
N344K |
probably benign |
Het |
Vmn2r25 |
C |
G |
6: 123,802,277 (GRCm39) |
C542S |
probably damaging |
Het |
Wiz |
T |
A |
17: 32,597,470 (GRCm39) |
|
probably benign |
Het |
Wrap73 |
A |
G |
4: 154,239,803 (GRCm39) |
Y343C |
probably benign |
Het |
|
Other mutations in Ggt1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00954:Ggt1
|
APN |
10 |
75,420,697 (GRCm39) |
missense |
probably benign |
0.15 |
IGL01593:Ggt1
|
APN |
10 |
75,421,121 (GRCm39) |
critical splice donor site |
probably null |
|
IGL02713:Ggt1
|
APN |
10 |
75,410,178 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03276:Ggt1
|
APN |
10 |
75,416,331 (GRCm39) |
unclassified |
probably benign |
|
chained
|
UTSW |
10 |
75,421,791 (GRCm39) |
missense |
probably damaging |
0.99 |
religion
|
UTSW |
10 |
75,421,290 (GRCm39) |
missense |
possibly damaging |
0.89 |
rigidity
|
UTSW |
10 |
75,415,185 (GRCm39) |
missense |
possibly damaging |
0.70 |
PIT4498001:Ggt1
|
UTSW |
10 |
75,414,689 (GRCm39) |
missense |
possibly damaging |
0.95 |
R0373:Ggt1
|
UTSW |
10 |
75,415,104 (GRCm39) |
missense |
probably benign |
0.11 |
R0420:Ggt1
|
UTSW |
10 |
75,412,047 (GRCm39) |
splice site |
probably benign |
|
R0505:Ggt1
|
UTSW |
10 |
75,421,791 (GRCm39) |
missense |
probably damaging |
0.99 |
R0630:Ggt1
|
UTSW |
10 |
75,421,336 (GRCm39) |
splice site |
probably null |
|
R1837:Ggt1
|
UTSW |
10 |
75,415,128 (GRCm39) |
missense |
probably benign |
0.00 |
R2655:Ggt1
|
UTSW |
10 |
75,417,219 (GRCm39) |
nonsense |
probably null |
|
R2656:Ggt1
|
UTSW |
10 |
75,417,219 (GRCm39) |
nonsense |
probably null |
|
R2910:Ggt1
|
UTSW |
10 |
75,416,430 (GRCm39) |
missense |
probably benign |
0.09 |
R3840:Ggt1
|
UTSW |
10 |
75,417,219 (GRCm39) |
nonsense |
probably null |
|
R3841:Ggt1
|
UTSW |
10 |
75,417,219 (GRCm39) |
nonsense |
probably null |
|
R4744:Ggt1
|
UTSW |
10 |
75,421,733 (GRCm39) |
missense |
probably benign |
0.00 |
R5323:Ggt1
|
UTSW |
10 |
75,421,495 (GRCm39) |
critical splice acceptor site |
probably null |
|
R5326:Ggt1
|
UTSW |
10 |
75,421,540 (GRCm39) |
critical splice donor site |
probably null |
|
R5512:Ggt1
|
UTSW |
10 |
75,420,718 (GRCm39) |
missense |
probably damaging |
0.99 |
R5579:Ggt1
|
UTSW |
10 |
75,421,782 (GRCm39) |
missense |
probably damaging |
1.00 |
R5707:Ggt1
|
UTSW |
10 |
75,421,072 (GRCm39) |
missense |
probably benign |
0.01 |
R5961:Ggt1
|
UTSW |
10 |
75,421,736 (GRCm39) |
splice site |
probably null |
|
R6159:Ggt1
|
UTSW |
10 |
75,420,799 (GRCm39) |
missense |
probably damaging |
1.00 |
R6239:Ggt1
|
UTSW |
10 |
75,421,515 (GRCm39) |
splice site |
probably null |
|
R7224:Ggt1
|
UTSW |
10 |
75,410,110 (GRCm39) |
missense |
possibly damaging |
0.86 |
R7570:Ggt1
|
UTSW |
10 |
75,421,428 (GRCm39) |
missense |
probably damaging |
1.00 |
R7649:Ggt1
|
UTSW |
10 |
75,421,290 (GRCm39) |
missense |
possibly damaging |
0.89 |
R7702:Ggt1
|
UTSW |
10 |
75,412,116 (GRCm39) |
missense |
probably benign |
0.00 |
R7713:Ggt1
|
UTSW |
10 |
75,421,508 (GRCm39) |
missense |
probably damaging |
1.00 |
R7823:Ggt1
|
UTSW |
10 |
75,410,175 (GRCm39) |
missense |
possibly damaging |
0.88 |
R8070:Ggt1
|
UTSW |
10 |
75,414,733 (GRCm39) |
missense |
probably damaging |
0.98 |
R8185:Ggt1
|
UTSW |
10 |
75,421,040 (GRCm39) |
missense |
possibly damaging |
0.83 |
R8260:Ggt1
|
UTSW |
10 |
75,417,245 (GRCm39) |
missense |
probably damaging |
1.00 |
R8441:Ggt1
|
UTSW |
10 |
75,415,185 (GRCm39) |
missense |
possibly damaging |
0.70 |
R8832:Ggt1
|
UTSW |
10 |
75,410,173 (GRCm39) |
missense |
possibly damaging |
0.57 |
R8988:Ggt1
|
UTSW |
10 |
75,412,056 (GRCm39) |
missense |
probably benign |
0.41 |
R9272:Ggt1
|
UTSW |
10 |
75,421,749 (GRCm39) |
missense |
probably benign |
|
R9295:Ggt1
|
UTSW |
10 |
75,421,743 (GRCm39) |
missense |
probably benign |
0.00 |
R9355:Ggt1
|
UTSW |
10 |
75,421,716 (GRCm39) |
missense |
probably benign |
0.01 |
|
Predicted Primers |
PCR Primer
(F):5'- TGCACTCTGCTTTTGAGAGCC -3'
(R):5'- TGTCTTTCACAATCTGGGCTG -3'
Sequencing Primer
(F):5'- ACACAGTCAGAGCCTGATTTAG -3'
(R):5'- CTGTGAGGCTCCCATTGTAGAAG -3'
|
Posted On |
2016-07-06 |