Incidental Mutation 'R5177:Myorg'
ID 399560
Institutional Source Beutler Lab
Gene Symbol Myorg
Ensembl Gene ENSMUSG00000046312
Gene Name myogenesis regulating glycosidase (putative)
Synonyms NET37, AI464131
MMRRC Submission 042757-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5177 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 41495604-41503076 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 41498407 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 408 (E408*)
Ref Sequence ENSEMBL: ENSMUSP00000059038 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054920] [ENSMUST00000149596]
AlphaFold Q69ZQ1
Predicted Effect probably null
Transcript: ENSMUST00000054920
AA Change: E408*
SMART Domains Protein: ENSMUSP00000059038
Gene: ENSMUSG00000046312
AA Change: E408*

DomainStartEndE-ValueType
transmembrane domain 56 78 N/A INTRINSIC
Pfam:Glyco_hydro_31 311 712 9.7e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000149596
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.5%
Validation Efficiency 97% (71/73)
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 C T 2: 69,115,639 (GRCm39) R575Q probably damaging Het
Arhgap22 T G 14: 33,088,650 (GRCm39) V377G probably benign Het
Asic4 T C 1: 75,427,483 (GRCm39) I3T probably damaging Het
Atp2b4 T C 1: 133,656,506 (GRCm39) T715A probably benign Het
Bltp3a T C 17: 28,103,992 (GRCm39) L464P possibly damaging Het
Ccdc180 A T 4: 45,917,508 (GRCm39) H283L probably damaging Het
Cfap91 A G 16: 38,152,683 (GRCm39) S176P probably benign Het
Cfb A G 17: 35,078,002 (GRCm39) V976A probably damaging Het
Cltc T C 11: 86,595,989 (GRCm39) T1250A probably damaging Het
Cylc2 T C 4: 51,228,587 (GRCm39) probably benign Het
Dcbld1 T A 10: 52,180,730 (GRCm39) D131E probably damaging Het
Dmxl1 T C 18: 50,026,651 (GRCm39) S1920P probably damaging Het
Dnajc13 G A 9: 104,108,185 (GRCm39) H197Y probably benign Het
Dpy19l1 C T 9: 24,349,924 (GRCm39) probably null Het
Ears2 A G 7: 121,643,683 (GRCm39) probably benign Het
Epgn A C 5: 91,176,136 (GRCm39) probably benign Het
Ern1 T C 11: 106,302,601 (GRCm39) T418A probably benign Het
F12 G A 13: 55,567,981 (GRCm39) P476S probably benign Het
Gal3st2c C T 1: 93,936,930 (GRCm39) Q292* probably null Het
Galnt7 C A 8: 58,037,061 (GRCm39) Q109H possibly damaging Het
Gimap1 G T 6: 48,720,032 (GRCm39) G215W probably damaging Het
Gm28042 T A 2: 119,872,082 (GRCm39) probably null Het
Gm5414 A G 15: 101,534,252 (GRCm39) I284T possibly damaging Het
Hddc3 A G 7: 79,992,914 (GRCm39) E10G probably damaging Het
Hmgxb3 T C 18: 61,305,266 (GRCm39) K31E probably damaging Het
Hspg2 A C 4: 137,246,083 (GRCm39) Y989S probably damaging Het
Kif12 G A 4: 63,086,141 (GRCm39) T402M probably benign Het
Klhdc4 A T 8: 122,540,529 (GRCm39) L115* probably null Het
Lama2 C T 10: 27,066,699 (GRCm39) V1061M possibly damaging Het
Llgl1 C T 11: 60,602,833 (GRCm39) T836I possibly damaging Het
Map4k4 A G 1: 40,025,922 (GRCm39) D304G probably damaging Het
Matn2 A G 15: 34,433,660 (GRCm39) Q915R possibly damaging Het
Myo18a A G 11: 77,755,668 (GRCm39) probably benign Het
Nbn A T 4: 15,965,132 (GRCm39) probably null Het
Nek8 G A 11: 78,061,297 (GRCm39) Q383* probably null Het
Nme7 T G 1: 164,208,245 (GRCm39) Y304* probably null Het
Nol8 A T 13: 49,814,588 (GRCm39) H214L probably benign Het
Nostrin A T 2: 69,006,098 (GRCm39) I261F possibly damaging Het
Oprk1 T G 1: 5,672,897 (GRCm39) C345G probably damaging Het
Or13a18 A G 7: 140,190,102 (GRCm39) T8A probably benign Het
Or52j3 A T 7: 102,836,710 (GRCm39) I301L probably benign Het
Polrmt T C 10: 79,573,310 (GRCm39) S998G probably benign Het
Ppp1r12c T A 7: 4,487,495 (GRCm39) R393* probably null Het
Prpf3 T A 3: 95,757,036 (GRCm39) probably benign Het
Rabl6 T C 2: 25,475,385 (GRCm39) M563V probably benign Het
Rasa2 C A 9: 96,426,844 (GRCm39) E775* probably null Het
Rc3h1 G T 1: 160,779,222 (GRCm39) V552L probably damaging Het
Rhot1 A T 11: 80,137,592 (GRCm39) N365Y possibly damaging Het
Rimbp3 G A 16: 17,027,781 (GRCm39) V402M possibly damaging Het
Rusc2 A T 4: 43,421,805 (GRCm39) probably null Het
Slc25a11 T C 11: 70,536,643 (GRCm39) E141G probably damaging Het
Slc34a1 A T 13: 55,548,975 (GRCm39) I142F probably damaging Het
Socs6 A C 18: 88,887,504 (GRCm39) Y470* probably null Het
Sox12 A T 2: 152,239,098 (GRCm39) L174Q unknown Het
Srl A G 16: 4,314,267 (GRCm39) probably null Het
Tacc1 A T 8: 25,691,237 (GRCm39) V22E probably damaging Het
Thsd7a A T 6: 12,379,582 (GRCm39) C947* probably null Het
Tlr12 A C 4: 128,512,169 (GRCm39) V27G probably damaging Het
Tmprss4 C A 9: 45,085,260 (GRCm39) V398L probably benign Het
Trip6 T C 5: 137,310,434 (GRCm39) D270G probably damaging Het
Uba5 T G 9: 103,926,497 (GRCm39) N355T probably benign Het
Ubr5 A G 15: 38,006,761 (GRCm39) Y1171H probably benign Het
Vmn2r57 A G 7: 41,049,664 (GRCm39) I695T probably benign Het
Vmn2r68 T A 7: 84,871,199 (GRCm39) I695L probably damaging Het
Vmn2r79 T A 7: 86,651,177 (GRCm39) M192K probably damaging Het
Vps16 G T 2: 130,285,288 (GRCm39) E782* probably null Het
Zfp783 A G 6: 47,923,737 (GRCm39) noncoding transcript Het
Other mutations in Myorg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01287:Myorg APN 4 41,498,923 (GRCm39) missense possibly damaging 0.68
IGL01352:Myorg APN 4 41,499,469 (GRCm39) nonsense probably null
IGL01384:Myorg APN 4 41,498,151 (GRCm39) missense probably damaging 0.99
IGL02150:Myorg APN 4 41,499,183 (GRCm39) missense possibly damaging 0.48
IGL02557:Myorg APN 4 41,497,900 (GRCm39) missense possibly damaging 0.51
R0238:Myorg UTSW 4 41,498,912 (GRCm39) missense probably benign 0.11
R0238:Myorg UTSW 4 41,498,912 (GRCm39) missense probably benign 0.11
R0413:Myorg UTSW 4 41,498,585 (GRCm39) missense probably benign 0.00
R0455:Myorg UTSW 4 41,499,538 (GRCm39) nonsense probably null
R0511:Myorg UTSW 4 41,498,538 (GRCm39) missense probably damaging 0.96
R0560:Myorg UTSW 4 41,498,167 (GRCm39) missense probably damaging 0.99
R0785:Myorg UTSW 4 41,497,539 (GRCm39) missense probably benign 0.02
R0940:Myorg UTSW 4 41,497,996 (GRCm39) missense probably damaging 1.00
R1677:Myorg UTSW 4 41,497,947 (GRCm39) missense probably benign 0.00
R1762:Myorg UTSW 4 41,498,553 (GRCm39) missense possibly damaging 0.91
R1984:Myorg UTSW 4 41,497,501 (GRCm39) missense possibly damaging 0.95
R2192:Myorg UTSW 4 41,497,704 (GRCm39) missense probably damaging 0.99
R2496:Myorg UTSW 4 41,499,165 (GRCm39) missense probably benign 0.28
R4212:Myorg UTSW 4 41,498,307 (GRCm39) missense probably benign 0.01
R4321:Myorg UTSW 4 41,498,767 (GRCm39) missense probably benign 0.00
R4672:Myorg UTSW 4 41,499,061 (GRCm39) missense probably benign 0.00
R4890:Myorg UTSW 4 41,498,877 (GRCm39) missense probably benign 0.00
R4954:Myorg UTSW 4 41,498,241 (GRCm39) missense possibly damaging 0.89
R5967:Myorg UTSW 4 41,497,830 (GRCm39) missense probably benign 0.00
R6005:Myorg UTSW 4 41,498,895 (GRCm39) missense probably benign 0.31
R6128:Myorg UTSW 4 41,498,445 (GRCm39) missense probably damaging 1.00
R6162:Myorg UTSW 4 41,497,899 (GRCm39) missense possibly damaging 0.51
R7202:Myorg UTSW 4 41,498,268 (GRCm39) missense probably damaging 0.99
R7211:Myorg UTSW 4 41,498,028 (GRCm39) missense probably damaging 1.00
R7311:Myorg UTSW 4 41,498,577 (GRCm39) missense probably damaging 1.00
R7524:Myorg UTSW 4 41,498,779 (GRCm39) missense probably benign 0.03
R7680:Myorg UTSW 4 41,497,978 (GRCm39) missense probably damaging 1.00
R8177:Myorg UTSW 4 41,497,568 (GRCm39) nonsense probably null
R8809:Myorg UTSW 4 41,498,812 (GRCm39) missense probably benign
R8981:Myorg UTSW 4 41,498,209 (GRCm39) missense possibly damaging 0.56
R9257:Myorg UTSW 4 41,499,030 (GRCm39) missense probably benign
X0024:Myorg UTSW 4 41,498,107 (GRCm39) missense possibly damaging 0.92
Z1088:Myorg UTSW 4 41,497,557 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CGCGTCGAACTTAAAGGAGG -3'
(R):5'- CAGAACAAGGTGCTGCAATTC -3'

Sequencing Primer
(F):5'- CTTAAAGGAGGTCACGTTGTAGC -3'
(R):5'- TTTAATAGCAGCCACCTGGAAATCG -3'
Posted On 2016-07-06