Incidental Mutation 'R5256:Chd5'
| ID |
399614 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Chd5
|
| Ensembl Gene |
ENSMUSG00000005045 |
| Gene Name |
chromodomain helicase DNA binding protein 5 |
| Synonyms |
B230399N07Rik, 4930532L22Rik |
| MMRRC Submission |
042827-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5256 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
152423108-152474651 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 152456554 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 964
(F964L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000005175
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005175]
[ENSMUST00000030775]
[ENSMUST00000164662]
|
| AlphaFold |
A2A8L1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000005175
AA Change: F964L
PolyPhen 2
Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000005175
Gene: ENSMUSG00000005045
AA Change: F964L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
17 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
46 |
71 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
|
coiled coil region
|
96 |
126 |
N/A |
INTRINSIC |
|
Pfam:CHDNT
|
149 |
203 |
2e-32 |
PFAM |
|
low complexity region
|
209 |
220 |
N/A |
INTRINSIC |
|
low complexity region
|
256 |
273 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
323 |
333 |
N/A |
INTRINSIC |
|
PHD
|
347 |
390 |
1.09e-14 |
SMART |
|
RING
|
348 |
389 |
4.48e-1 |
SMART |
|
low complexity region
|
400 |
416 |
N/A |
INTRINSIC |
|
PHD
|
420 |
463 |
3.29e-14 |
SMART |
|
RING
|
421 |
462 |
4.15e0 |
SMART |
|
CHROMO
|
468 |
548 |
2.52e-13 |
SMART |
|
CHROMO
|
592 |
649 |
1.34e-8 |
SMART |
|
low complexity region
|
657 |
678 |
N/A |
INTRINSIC |
|
DEXDc
|
698 |
910 |
8.34e-33 |
SMART |
|
low complexity region
|
1023 |
1038 |
N/A |
INTRINSIC |
|
HELICc
|
1056 |
1140 |
4.02e-26 |
SMART |
|
DUF1087
|
1297 |
1361 |
2.78e-33 |
SMART |
|
DUF1086
|
1374 |
1533 |
5.11e-105 |
SMART |
|
low complexity region
|
1552 |
1567 |
N/A |
INTRINSIC |
|
low complexity region
|
1685 |
1701 |
N/A |
INTRINSIC |
|
Pfam:CHDCT2
|
1729 |
1901 |
1.7e-99 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000030775
AA Change: F964L
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000030775
Gene: ENSMUSG00000005045
AA Change: F964L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
17 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
46 |
71 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
|
coiled coil region
|
96 |
126 |
N/A |
INTRINSIC |
|
Pfam:CHDNT
|
150 |
203 |
9e-28 |
PFAM |
|
low complexity region
|
209 |
220 |
N/A |
INTRINSIC |
|
low complexity region
|
256 |
273 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
323 |
333 |
N/A |
INTRINSIC |
|
PHD
|
347 |
390 |
1.09e-14 |
SMART |
|
RING
|
348 |
389 |
4.48e-1 |
SMART |
|
low complexity region
|
400 |
416 |
N/A |
INTRINSIC |
|
PHD
|
420 |
463 |
3.29e-14 |
SMART |
|
RING
|
421 |
462 |
4.15e0 |
SMART |
|
CHROMO
|
468 |
548 |
2.52e-13 |
SMART |
|
CHROMO
|
592 |
649 |
1.34e-8 |
SMART |
|
low complexity region
|
657 |
678 |
N/A |
INTRINSIC |
|
DEXDc
|
698 |
910 |
8.34e-33 |
SMART |
|
low complexity region
|
1023 |
1038 |
N/A |
INTRINSIC |
|
HELICc
|
1056 |
1140 |
4.02e-26 |
SMART |
|
DUF1087
|
1297 |
1361 |
2.78e-33 |
SMART |
|
DUF1086
|
1374 |
1533 |
5.11e-105 |
SMART |
|
low complexity region
|
1552 |
1567 |
N/A |
INTRINSIC |
|
low complexity region
|
1685 |
1701 |
N/A |
INTRINSIC |
|
Pfam:CHDCT2
|
1730 |
1901 |
2.8e-93 |
PFAM |
|
low complexity region
|
1922 |
1936 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000124423
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164662
AA Change: F964L
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000132600
Gene: ENSMUSG00000005045
AA Change: F964L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
17 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
46 |
71 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
|
coiled coil region
|
96 |
126 |
N/A |
INTRINSIC |
|
Pfam:CHDNT
|
149 |
203 |
1.9e-32 |
PFAM |
|
low complexity region
|
209 |
220 |
N/A |
INTRINSIC |
|
low complexity region
|
256 |
273 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
323 |
333 |
N/A |
INTRINSIC |
|
PHD
|
347 |
390 |
1.09e-14 |
SMART |
|
RING
|
348 |
389 |
4.48e-1 |
SMART |
|
low complexity region
|
400 |
416 |
N/A |
INTRINSIC |
|
PHD
|
420 |
463 |
3.29e-14 |
SMART |
|
RING
|
421 |
462 |
4.15e0 |
SMART |
|
CHROMO
|
468 |
548 |
2.52e-13 |
SMART |
|
CHROMO
|
592 |
649 |
1.34e-8 |
SMART |
|
low complexity region
|
657 |
678 |
N/A |
INTRINSIC |
|
DEXDc
|
698 |
910 |
8.34e-33 |
SMART |
|
low complexity region
|
1023 |
1038 |
N/A |
INTRINSIC |
|
HELICc
|
1056 |
1140 |
4.02e-26 |
SMART |
|
DUF1087
|
1260 |
1324 |
2.78e-33 |
SMART |
|
DUF1086
|
1337 |
1496 |
5.11e-105 |
SMART |
|
low complexity region
|
1515 |
1530 |
N/A |
INTRINSIC |
|
low complexity region
|
1648 |
1664 |
N/A |
INTRINSIC |
|
Pfam:CHDCT2
|
1692 |
1864 |
1.7e-99 |
PFAM |
|
low complexity region
|
1885 |
1899 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.1061 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.4%
- 20x: 92.8%
|
| Validation Efficiency |
97% (95/98) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. [provided by RefSeq, Feb 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility with abnormal spermiogenesis and chromatin condensation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A730015C16Rik |
C |
A |
4: 108,705,262 (GRCm39) |
|
probably benign |
Het |
| Actr1b |
T |
C |
1: 36,739,173 (GRCm39) |
H372R |
probably benign |
Het |
| Ampd2 |
C |
A |
3: 107,986,865 (GRCm39) |
|
probably benign |
Het |
| Anapc4 |
A |
G |
5: 53,020,936 (GRCm39) |
S612G |
probably benign |
Het |
| Arhgef7 |
T |
C |
8: 11,850,811 (GRCm39) |
L141P |
probably damaging |
Het |
| Atl1 |
A |
G |
12: 70,006,107 (GRCm39) |
D471G |
probably damaging |
Het |
| Atrn |
A |
G |
2: 130,787,939 (GRCm39) |
D247G |
probably benign |
Het |
| Bag1 |
T |
A |
4: 40,948,022 (GRCm39) |
R61W |
probably damaging |
Het |
| Card10 |
C |
T |
15: 78,662,451 (GRCm39) |
R898H |
probably damaging |
Het |
| Cct6b |
G |
A |
11: 82,655,046 (GRCm39) |
A3V |
probably damaging |
Het |
| Cfap54 |
A |
T |
10: 92,770,953 (GRCm39) |
L2097* |
probably null |
Het |
| Cfap54 |
T |
C |
10: 92,880,885 (GRCm39) |
|
probably null |
Het |
| Cog5 |
A |
G |
12: 31,936,204 (GRCm39) |
T584A |
probably benign |
Het |
| Cpa2 |
T |
A |
6: 30,547,196 (GRCm39) |
N157K |
probably damaging |
Het |
| Cpeb1 |
A |
T |
7: 81,001,587 (GRCm39) |
M440K |
probably damaging |
Het |
| Cracr2a |
G |
A |
6: 127,580,992 (GRCm39) |
C56Y |
probably damaging |
Het |
| Ddb2 |
A |
C |
2: 91,067,073 (GRCm39) |
L30R |
probably damaging |
Het |
| Dlk1 |
T |
A |
12: 109,425,697 (GRCm39) |
I190N |
probably damaging |
Het |
| Dnaaf4 |
T |
C |
9: 72,879,362 (GRCm39) |
|
probably null |
Het |
| Dnajc13 |
T |
A |
9: 104,080,528 (GRCm39) |
Y851F |
possibly damaging |
Het |
| Dop1a |
T |
A |
9: 86,397,381 (GRCm39) |
L895Q |
probably damaging |
Het |
| F7 |
G |
A |
8: 13,080,763 (GRCm39) |
C122Y |
probably damaging |
Het |
| Frrs1 |
T |
C |
3: 116,696,749 (GRCm39) |
V573A |
possibly damaging |
Het |
| Galnt2l |
T |
C |
8: 122,997,175 (GRCm39) |
|
probably benign |
Het |
| Gm17541 |
A |
T |
12: 4,739,672 (GRCm39) |
|
probably benign |
Het |
| Gm5519 |
A |
T |
19: 33,800,576 (GRCm39) |
H90L |
probably damaging |
Het |
| Gm5526 |
T |
A |
1: 45,896,569 (GRCm39) |
|
noncoding transcript |
Het |
| Gm5709 |
A |
T |
3: 59,509,971 (GRCm39) |
|
noncoding transcript |
Het |
| Golga4 |
T |
A |
9: 118,385,569 (GRCm39) |
V869D |
possibly damaging |
Het |
| Grm7 |
A |
T |
6: 111,335,182 (GRCm39) |
Q531L |
probably benign |
Het |
| Hnrnpu |
C |
A |
1: 178,163,458 (GRCm39) |
C265F |
unknown |
Het |
| Hoxd3 |
G |
A |
2: 74,577,211 (GRCm39) |
V364I |
possibly damaging |
Het |
| Hspb8 |
T |
C |
5: 116,547,532 (GRCm39) |
D150G |
probably damaging |
Het |
| Hydin |
C |
A |
8: 111,313,855 (GRCm39) |
N4244K |
possibly damaging |
Het |
| Ik |
A |
G |
18: 36,881,926 (GRCm39) |
D136G |
probably benign |
Het |
| Il11ra1 |
T |
C |
4: 41,767,932 (GRCm39) |
|
probably benign |
Het |
| Jph1 |
T |
C |
1: 17,161,622 (GRCm39) |
I347V |
probably benign |
Het |
| Klk1 |
T |
A |
7: 43,870,985 (GRCm39) |
|
probably benign |
Het |
| Lmcd1 |
T |
A |
6: 112,265,087 (GRCm39) |
|
probably benign |
Het |
| Lnx1 |
C |
T |
5: 74,846,315 (GRCm39) |
C45Y |
probably damaging |
Het |
| Macc1 |
T |
A |
12: 119,410,264 (GRCm39) |
M344K |
possibly damaging |
Het |
| Madcam1 |
A |
G |
10: 79,500,779 (GRCm39) |
E32G |
possibly damaging |
Het |
| Mat2a |
T |
C |
6: 72,411,316 (GRCm39) |
D383G |
probably benign |
Het |
| Mpst |
T |
A |
15: 78,297,849 (GRCm39) |
I289N |
probably damaging |
Het |
| Myh6 |
C |
T |
14: 55,190,118 (GRCm39) |
R1055Q |
probably damaging |
Het |
| Myh7 |
T |
C |
14: 55,216,965 (GRCm39) |
K1131E |
probably damaging |
Het |
| Ndrg3 |
A |
T |
2: 156,773,125 (GRCm39) |
|
probably benign |
Het |
| Nebl |
A |
G |
2: 17,438,786 (GRCm39) |
S209P |
probably benign |
Het |
| Nid2 |
A |
G |
14: 19,818,276 (GRCm39) |
|
probably null |
Het |
| Nup188 |
A |
T |
2: 30,220,761 (GRCm39) |
S945C |
probably damaging |
Het |
| Or1j21 |
A |
G |
2: 36,683,685 (GRCm39) |
M146V |
probably benign |
Het |
| Or5g23 |
C |
T |
2: 85,438,817 (GRCm39) |
V146I |
probably benign |
Het |
| Or8c11 |
A |
G |
9: 38,289,213 (GRCm39) |
N12S |
probably benign |
Het |
| Otx1 |
C |
A |
11: 21,947,037 (GRCm39) |
A91S |
probably damaging |
Het |
| Patl2 |
A |
G |
2: 121,959,368 (GRCm39) |
L32P |
probably damaging |
Het |
| Pcdh20 |
T |
A |
14: 88,705,813 (GRCm39) |
M496L |
probably benign |
Het |
| Pdzd2 |
A |
G |
15: 12,373,028 (GRCm39) |
V2369A |
possibly damaging |
Het |
| Pfn2 |
A |
G |
3: 57,754,812 (GRCm39) |
V31A |
probably damaging |
Het |
| Plxna4 |
T |
C |
6: 32,228,007 (GRCm39) |
N533S |
probably benign |
Het |
| Plxnb1 |
T |
C |
9: 108,943,661 (GRCm39) |
F1916S |
probably damaging |
Het |
| Ppp4r3b |
T |
C |
11: 29,138,293 (GRCm39) |
F214L |
probably benign |
Het |
| Prox1 |
T |
C |
1: 189,893,638 (GRCm39) |
D269G |
probably benign |
Het |
| Rapgef4 |
T |
C |
2: 71,864,378 (GRCm39) |
F71S |
probably damaging |
Het |
| Rft1 |
A |
G |
14: 30,383,243 (GRCm39) |
I94M |
probably benign |
Het |
| S100z |
T |
C |
13: 95,615,127 (GRCm39) |
I13V |
probably damaging |
Het |
| Serhl |
T |
A |
15: 82,986,835 (GRCm39) |
V117E |
probably damaging |
Het |
| Shroom1 |
G |
A |
11: 53,356,334 (GRCm39) |
R336Q |
probably benign |
Het |
| Sik3 |
A |
T |
9: 46,123,552 (GRCm39) |
Q1067L |
probably damaging |
Het |
| Slc22a30 |
G |
A |
19: 8,321,757 (GRCm39) |
Q436* |
probably null |
Het |
| Slc28a1 |
G |
A |
7: 80,771,869 (GRCm39) |
V118M |
probably damaging |
Het |
| Slco1a6 |
T |
A |
6: 142,078,427 (GRCm39) |
I153F |
probably benign |
Het |
| Ss18l1 |
T |
C |
2: 179,703,735 (GRCm39) |
Y323H |
unknown |
Het |
| Susd4 |
G |
T |
1: 182,719,824 (GRCm39) |
A480S |
possibly damaging |
Het |
| Syne3 |
A |
T |
12: 104,942,139 (GRCm39) |
M1K |
probably null |
Het |
| Synpo2l |
A |
T |
14: 20,711,082 (GRCm39) |
S513T |
probably benign |
Het |
| Tat |
A |
T |
8: 110,724,966 (GRCm39) |
N388I |
probably benign |
Het |
| Tbc1d1 |
A |
G |
5: 64,439,352 (GRCm39) |
Y619C |
probably damaging |
Het |
| Tbk1 |
G |
A |
10: 121,406,590 (GRCm39) |
T216M |
probably damaging |
Het |
| Tns1 |
C |
T |
1: 74,034,585 (GRCm39) |
|
probably benign |
Het |
| Trbv5 |
T |
C |
6: 41,039,318 (GRCm39) |
V9A |
possibly damaging |
Het |
| Trpm5 |
A |
G |
7: 142,636,040 (GRCm39) |
Y575H |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,570,045 (GRCm39) |
Y25203* |
probably null |
Het |
| Tubb3 |
C |
A |
8: 124,148,391 (GRCm39) |
D441E |
probably benign |
Het |
| Usp33 |
T |
A |
3: 152,097,333 (GRCm39) |
C850* |
probably null |
Het |
| Vdac1 |
G |
A |
11: 52,274,905 (GRCm39) |
|
probably null |
Het |
| Vmn1r232 |
T |
C |
17: 21,133,846 (GRCm39) |
I251M |
probably damaging |
Het |
| Vmn2r11 |
T |
G |
5: 109,202,658 (GRCm39) |
I140L |
probably benign |
Het |
| Vmn2r6 |
A |
T |
3: 64,464,263 (GRCm39) |
N190K |
probably benign |
Het |
| Vps51 |
T |
A |
19: 6,120,518 (GRCm39) |
H465L |
probably benign |
Het |
| Zfp318 |
T |
G |
17: 46,722,995 (GRCm39) |
I1666S |
probably benign |
Het |
| Zfp446 |
C |
T |
7: 12,713,231 (GRCm39) |
R90* |
probably null |
Het |
| Zgrf1 |
T |
A |
3: 127,396,094 (GRCm39) |
F547I |
probably damaging |
Het |
|
| Other mutations in Chd5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00537:Chd5
|
APN |
4 |
152,445,059 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00886:Chd5
|
APN |
4 |
152,444,156 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00963:Chd5
|
APN |
4 |
152,467,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01399:Chd5
|
APN |
4 |
152,441,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01571:Chd5
|
APN |
4 |
152,468,572 (GRCm39) |
splice site |
probably benign |
|
|
IGL01606:Chd5
|
APN |
4 |
152,445,432 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01636:Chd5
|
APN |
4 |
152,469,110 (GRCm39) |
nonsense |
probably null |
|
|
IGL02009:Chd5
|
APN |
4 |
152,450,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02417:Chd5
|
APN |
4 |
152,451,751 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02504:Chd5
|
APN |
4 |
152,447,779 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02508:Chd5
|
APN |
4 |
152,447,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02597:Chd5
|
APN |
4 |
152,456,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02608:Chd5
|
APN |
4 |
152,440,564 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02612:Chd5
|
APN |
4 |
152,445,033 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02658:Chd5
|
APN |
4 |
152,445,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02662:Chd5
|
APN |
4 |
152,456,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02676:Chd5
|
APN |
4 |
152,440,530 (GRCm39) |
splice site |
probably benign |
|
|
IGL02871:Chd5
|
APN |
4 |
152,461,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02942:Chd5
|
APN |
4 |
152,470,182 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02956:Chd5
|
APN |
4 |
152,464,413 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03286:Chd5
|
APN |
4 |
152,469,952 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03348:Chd5
|
APN |
4 |
152,461,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03398:Chd5
|
APN |
4 |
152,461,539 (GRCm39) |
missense |
probably damaging |
0.97 |
|
PIT1430001:Chd5
|
UTSW |
4 |
152,455,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4151001:Chd5
|
UTSW |
4 |
152,462,986 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0079:Chd5
|
UTSW |
4 |
152,470,206 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0241:Chd5
|
UTSW |
4 |
152,450,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0241:Chd5
|
UTSW |
4 |
152,450,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0379:Chd5
|
UTSW |
4 |
152,467,778 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0388:Chd5
|
UTSW |
4 |
152,456,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0675:Chd5
|
UTSW |
4 |
152,470,407 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0730:Chd5
|
UTSW |
4 |
152,432,441 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R0799:Chd5
|
UTSW |
4 |
152,468,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0800:Chd5
|
UTSW |
4 |
152,440,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1276:Chd5
|
UTSW |
4 |
152,463,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1752:Chd5
|
UTSW |
4 |
152,459,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1753:Chd5
|
UTSW |
4 |
152,463,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1843:Chd5
|
UTSW |
4 |
152,470,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1850:Chd5
|
UTSW |
4 |
152,454,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1851:Chd5
|
UTSW |
4 |
152,462,727 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1859:Chd5
|
UTSW |
4 |
152,464,980 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1983:Chd5
|
UTSW |
4 |
152,469,123 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2404:Chd5
|
UTSW |
4 |
152,451,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2897:Chd5
|
UTSW |
4 |
152,456,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2898:Chd5
|
UTSW |
4 |
152,456,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3893:Chd5
|
UTSW |
4 |
152,445,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3938:Chd5
|
UTSW |
4 |
152,461,512 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4707:Chd5
|
UTSW |
4 |
152,445,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4754:Chd5
|
UTSW |
4 |
152,462,203 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4911:Chd5
|
UTSW |
4 |
152,445,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4924:Chd5
|
UTSW |
4 |
152,450,886 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4926:Chd5
|
UTSW |
4 |
152,467,768 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5524:Chd5
|
UTSW |
4 |
152,461,087 (GRCm39) |
missense |
probably benign |
|
|
R5552:Chd5
|
UTSW |
4 |
152,470,272 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5895:Chd5
|
UTSW |
4 |
152,464,389 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5945:Chd5
|
UTSW |
4 |
152,464,408 (GRCm39) |
missense |
probably benign |
|
|
R6007:Chd5
|
UTSW |
4 |
152,463,878 (GRCm39) |
missense |
probably null |
1.00 |
|
R6039:Chd5
|
UTSW |
4 |
152,438,078 (GRCm39) |
small deletion |
probably benign |
|
|
R6039:Chd5
|
UTSW |
4 |
152,438,078 (GRCm39) |
small deletion |
probably benign |
|
|
R6172:Chd5
|
UTSW |
4 |
152,463,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6173:Chd5
|
UTSW |
4 |
152,463,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6323:Chd5
|
UTSW |
4 |
152,451,791 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6331:Chd5
|
UTSW |
4 |
152,466,865 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6495:Chd5
|
UTSW |
4 |
152,451,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6528:Chd5
|
UTSW |
4 |
152,441,133 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6849:Chd5
|
UTSW |
4 |
152,462,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6854:Chd5
|
UTSW |
4 |
152,467,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6859:Chd5
|
UTSW |
4 |
152,462,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6999:Chd5
|
UTSW |
4 |
152,458,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7034:Chd5
|
UTSW |
4 |
152,445,398 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7110:Chd5
|
UTSW |
4 |
152,469,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Chd5
|
UTSW |
4 |
152,447,745 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7397:Chd5
|
UTSW |
4 |
152,452,469 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7440:Chd5
|
UTSW |
4 |
152,469,108 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7489:Chd5
|
UTSW |
4 |
152,457,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7810:Chd5
|
UTSW |
4 |
152,443,032 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8057:Chd5
|
UTSW |
4 |
152,450,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8078:Chd5
|
UTSW |
4 |
152,445,448 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8092:Chd5
|
UTSW |
4 |
152,463,261 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8170:Chd5
|
UTSW |
4 |
152,461,040 (GRCm39) |
missense |
probably benign |
0.26 |
|
R8255:Chd5
|
UTSW |
4 |
152,463,880 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8348:Chd5
|
UTSW |
4 |
152,445,173 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8448:Chd5
|
UTSW |
4 |
152,445,173 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8478:Chd5
|
UTSW |
4 |
152,441,147 (GRCm39) |
nonsense |
probably null |
|
|
R8482:Chd5
|
UTSW |
4 |
152,441,147 (GRCm39) |
nonsense |
probably null |
|
|
R8670:Chd5
|
UTSW |
4 |
152,469,953 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8733:Chd5
|
UTSW |
4 |
152,463,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8743:Chd5
|
UTSW |
4 |
152,450,862 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8941:Chd5
|
UTSW |
4 |
152,463,305 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8961:Chd5
|
UTSW |
4 |
152,467,489 (GRCm39) |
splice site |
probably benign |
|
|
R9103:Chd5
|
UTSW |
4 |
152,461,444 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R9160:Chd5
|
UTSW |
4 |
152,469,916 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9221:Chd5
|
UTSW |
4 |
152,456,122 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9399:Chd5
|
UTSW |
4 |
152,468,592 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9429:Chd5
|
UTSW |
4 |
152,447,364 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9635:Chd5
|
UTSW |
4 |
152,461,079 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9783:Chd5
|
UTSW |
4 |
152,458,865 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Chd5
|
UTSW |
4 |
152,462,936 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCAATTGCAGTGACTACGGTC -3'
(R):5'- ATAGGGACCCACCAAGATGG -3'
Sequencing Primer
(F):5'- CAGGCTGCCTCAGTTGTAG -3'
(R):5'- GATGGCCACAGGGAATCCAC -3'
|
| Posted On |
2016-07-06 |
Incidental Mutation