Incidental Mutation 'R5256:Vmn2r11'
ID 399622
Institutional Source Beutler Lab
Gene Symbol Vmn2r11
Ensembl Gene ENSMUSG00000091450
Gene Name vomeronasal 2, receptor 11
Synonyms EG384219
MMRRC Submission 042827-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R5256 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 109194739-109207318 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 109202658 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 140 (I140L)
Ref Sequence ENSEMBL: ENSMUSP00000133218 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164875]
AlphaFold E9Q4X4
Predicted Effect probably benign
Transcript: ENSMUST00000164875
AA Change: I140L

PolyPhen 2 Score 0.263 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000133218
Gene: ENSMUSG00000091450
AA Change: I140L

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 167 475 1.6e-29 PFAM
Pfam:NCD3G 520 574 9.1e-19 PFAM
Pfam:7tm_3 607 842 4.6e-55 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.4%
  • 20x: 92.8%
Validation Efficiency 97% (95/98)
Allele List at MGI
Other mutations in this stock
Total: 92 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A730015C16Rik C A 4: 108,705,262 (GRCm39) probably benign Het
Actr1b T C 1: 36,739,173 (GRCm39) H372R probably benign Het
Ampd2 C A 3: 107,986,865 (GRCm39) probably benign Het
Anapc4 A G 5: 53,020,936 (GRCm39) S612G probably benign Het
Arhgef7 T C 8: 11,850,811 (GRCm39) L141P probably damaging Het
Atl1 A G 12: 70,006,107 (GRCm39) D471G probably damaging Het
Atrn A G 2: 130,787,939 (GRCm39) D247G probably benign Het
Bag1 T A 4: 40,948,022 (GRCm39) R61W probably damaging Het
Card10 C T 15: 78,662,451 (GRCm39) R898H probably damaging Het
Cct6b G A 11: 82,655,046 (GRCm39) A3V probably damaging Het
Cfap54 A T 10: 92,770,953 (GRCm39) L2097* probably null Het
Cfap54 T C 10: 92,880,885 (GRCm39) probably null Het
Chd5 T C 4: 152,456,554 (GRCm39) F964L probably benign Het
Cog5 A G 12: 31,936,204 (GRCm39) T584A probably benign Het
Cpa2 T A 6: 30,547,196 (GRCm39) N157K probably damaging Het
Cpeb1 A T 7: 81,001,587 (GRCm39) M440K probably damaging Het
Cracr2a G A 6: 127,580,992 (GRCm39) C56Y probably damaging Het
Ddb2 A C 2: 91,067,073 (GRCm39) L30R probably damaging Het
Dlk1 T A 12: 109,425,697 (GRCm39) I190N probably damaging Het
Dnaaf4 T C 9: 72,879,362 (GRCm39) probably null Het
Dnajc13 T A 9: 104,080,528 (GRCm39) Y851F possibly damaging Het
Dop1a T A 9: 86,397,381 (GRCm39) L895Q probably damaging Het
F7 G A 8: 13,080,763 (GRCm39) C122Y probably damaging Het
Frrs1 T C 3: 116,696,749 (GRCm39) V573A possibly damaging Het
Galnt2l T C 8: 122,997,175 (GRCm39) probably benign Het
Gm17541 A T 12: 4,739,672 (GRCm39) probably benign Het
Gm5519 A T 19: 33,800,576 (GRCm39) H90L probably damaging Het
Gm5526 T A 1: 45,896,569 (GRCm39) noncoding transcript Het
Gm5709 A T 3: 59,509,971 (GRCm39) noncoding transcript Het
Golga4 T A 9: 118,385,569 (GRCm39) V869D possibly damaging Het
Grm7 A T 6: 111,335,182 (GRCm39) Q531L probably benign Het
Hnrnpu C A 1: 178,163,458 (GRCm39) C265F unknown Het
Hoxd3 G A 2: 74,577,211 (GRCm39) V364I possibly damaging Het
Hspb8 T C 5: 116,547,532 (GRCm39) D150G probably damaging Het
Hydin C A 8: 111,313,855 (GRCm39) N4244K possibly damaging Het
Ik A G 18: 36,881,926 (GRCm39) D136G probably benign Het
Il11ra1 T C 4: 41,767,932 (GRCm39) probably benign Het
Jph1 T C 1: 17,161,622 (GRCm39) I347V probably benign Het
Klk1 T A 7: 43,870,985 (GRCm39) probably benign Het
Lmcd1 T A 6: 112,265,087 (GRCm39) probably benign Het
Lnx1 C T 5: 74,846,315 (GRCm39) C45Y probably damaging Het
Macc1 T A 12: 119,410,264 (GRCm39) M344K possibly damaging Het
Madcam1 A G 10: 79,500,779 (GRCm39) E32G possibly damaging Het
Mat2a T C 6: 72,411,316 (GRCm39) D383G probably benign Het
Mpst T A 15: 78,297,849 (GRCm39) I289N probably damaging Het
Myh6 C T 14: 55,190,118 (GRCm39) R1055Q probably damaging Het
Myh7 T C 14: 55,216,965 (GRCm39) K1131E probably damaging Het
Ndrg3 A T 2: 156,773,125 (GRCm39) probably benign Het
Nebl A G 2: 17,438,786 (GRCm39) S209P probably benign Het
Nid2 A G 14: 19,818,276 (GRCm39) probably null Het
Nup188 A T 2: 30,220,761 (GRCm39) S945C probably damaging Het
Or1j21 A G 2: 36,683,685 (GRCm39) M146V probably benign Het
Or5g23 C T 2: 85,438,817 (GRCm39) V146I probably benign Het
Or8c11 A G 9: 38,289,213 (GRCm39) N12S probably benign Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Patl2 A G 2: 121,959,368 (GRCm39) L32P probably damaging Het
Pcdh20 T A 14: 88,705,813 (GRCm39) M496L probably benign Het
Pdzd2 A G 15: 12,373,028 (GRCm39) V2369A possibly damaging Het
Pfn2 A G 3: 57,754,812 (GRCm39) V31A probably damaging Het
Plxna4 T C 6: 32,228,007 (GRCm39) N533S probably benign Het
Plxnb1 T C 9: 108,943,661 (GRCm39) F1916S probably damaging Het
Ppp4r3b T C 11: 29,138,293 (GRCm39) F214L probably benign Het
Prox1 T C 1: 189,893,638 (GRCm39) D269G probably benign Het
Rapgef4 T C 2: 71,864,378 (GRCm39) F71S probably damaging Het
Rft1 A G 14: 30,383,243 (GRCm39) I94M probably benign Het
S100z T C 13: 95,615,127 (GRCm39) I13V probably damaging Het
Serhl T A 15: 82,986,835 (GRCm39) V117E probably damaging Het
Shroom1 G A 11: 53,356,334 (GRCm39) R336Q probably benign Het
Sik3 A T 9: 46,123,552 (GRCm39) Q1067L probably damaging Het
Slc22a30 G A 19: 8,321,757 (GRCm39) Q436* probably null Het
Slc28a1 G A 7: 80,771,869 (GRCm39) V118M probably damaging Het
Slco1a6 T A 6: 142,078,427 (GRCm39) I153F probably benign Het
Ss18l1 T C 2: 179,703,735 (GRCm39) Y323H unknown Het
Susd4 G T 1: 182,719,824 (GRCm39) A480S possibly damaging Het
Syne3 A T 12: 104,942,139 (GRCm39) M1K probably null Het
Synpo2l A T 14: 20,711,082 (GRCm39) S513T probably benign Het
Tat A T 8: 110,724,966 (GRCm39) N388I probably benign Het
Tbc1d1 A G 5: 64,439,352 (GRCm39) Y619C probably damaging Het
Tbk1 G A 10: 121,406,590 (GRCm39) T216M probably damaging Het
Tns1 C T 1: 74,034,585 (GRCm39) probably benign Het
Trbv5 T C 6: 41,039,318 (GRCm39) V9A possibly damaging Het
Trpm5 A G 7: 142,636,040 (GRCm39) Y575H probably damaging Het
Ttn A T 2: 76,570,045 (GRCm39) Y25203* probably null Het
Tubb3 C A 8: 124,148,391 (GRCm39) D441E probably benign Het
Usp33 T A 3: 152,097,333 (GRCm39) C850* probably null Het
Vdac1 G A 11: 52,274,905 (GRCm39) probably null Het
Vmn1r232 T C 17: 21,133,846 (GRCm39) I251M probably damaging Het
Vmn2r6 A T 3: 64,464,263 (GRCm39) N190K probably benign Het
Vps51 T A 19: 6,120,518 (GRCm39) H465L probably benign Het
Zfp318 T G 17: 46,722,995 (GRCm39) I1666S probably benign Het
Zfp446 C T 7: 12,713,231 (GRCm39) R90* probably null Het
Zgrf1 T A 3: 127,396,094 (GRCm39) F547I probably damaging Het
Other mutations in Vmn2r11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00925:Vmn2r11 APN 5 109,194,885 (GRCm39) missense probably benign 0.00
IGL01677:Vmn2r11 APN 5 109,201,823 (GRCm39) missense possibly damaging 0.50
IGL02048:Vmn2r11 APN 5 109,202,658 (GRCm39) missense probably benign 0.00
IGL02559:Vmn2r11 APN 5 109,200,046 (GRCm39) missense probably damaging 0.98
IGL02879:Vmn2r11 APN 5 109,201,704 (GRCm39) missense possibly damaging 0.95
IGL03084:Vmn2r11 APN 5 109,207,209 (GRCm39) missense probably benign 0.00
IGL03163:Vmn2r11 APN 5 109,201,692 (GRCm39) missense probably benign 0.41
IGL03289:Vmn2r11 APN 5 109,196,788 (GRCm39) splice site probably benign
IGL03294:Vmn2r11 APN 5 109,201,935 (GRCm39) missense probably benign 0.22
R0233:Vmn2r11 UTSW 5 109,201,968 (GRCm39) missense probably benign 0.16
R0233:Vmn2r11 UTSW 5 109,201,968 (GRCm39) missense probably benign 0.16
R0421:Vmn2r11 UTSW 5 109,207,294 (GRCm39) missense probably benign 0.00
R0549:Vmn2r11 UTSW 5 109,199,963 (GRCm39) missense possibly damaging 0.80
R0628:Vmn2r11 UTSW 5 109,195,597 (GRCm39) missense possibly damaging 0.88
R1523:Vmn2r11 UTSW 5 109,201,707 (GRCm39) missense probably benign 0.25
R1660:Vmn2r11 UTSW 5 109,201,724 (GRCm39) missense possibly damaging 0.79
R1827:Vmn2r11 UTSW 5 109,199,938 (GRCm39) missense probably benign 0.01
R1913:Vmn2r11 UTSW 5 109,202,654 (GRCm39) missense probably benign
R2260:Vmn2r11 UTSW 5 109,201,657 (GRCm39) nonsense probably null
R2400:Vmn2r11 UTSW 5 109,199,928 (GRCm39) missense probably benign 0.03
R3933:Vmn2r11 UTSW 5 109,201,260 (GRCm39) missense probably damaging 0.97
R4091:Vmn2r11 UTSW 5 109,202,616 (GRCm39) critical splice donor site probably null
R4624:Vmn2r11 UTSW 5 109,200,101 (GRCm39) missense probably damaging 0.99
R4762:Vmn2r11 UTSW 5 109,195,436 (GRCm39) missense probably damaging 1.00
R5370:Vmn2r11 UTSW 5 109,195,421 (GRCm39) missense probably damaging 1.00
R5419:Vmn2r11 UTSW 5 109,207,224 (GRCm39) missense possibly damaging 0.55
R5516:Vmn2r11 UTSW 5 109,195,032 (GRCm39) missense probably damaging 0.98
R5643:Vmn2r11 UTSW 5 109,194,869 (GRCm39) missense probably damaging 1.00
R5671:Vmn2r11 UTSW 5 109,202,772 (GRCm39) missense probably benign 0.03
R5679:Vmn2r11 UTSW 5 109,202,708 (GRCm39) missense probably benign 0.00
R5739:Vmn2r11 UTSW 5 109,207,114 (GRCm39) critical splice donor site probably null
R5746:Vmn2r11 UTSW 5 109,201,560 (GRCm39) missense probably benign 0.41
R5995:Vmn2r11 UTSW 5 109,194,921 (GRCm39) missense probably damaging 1.00
R6147:Vmn2r11 UTSW 5 109,202,700 (GRCm39) missense probably benign 0.04
R6220:Vmn2r11 UTSW 5 109,201,434 (GRCm39) missense probably benign 0.09
R6374:Vmn2r11 UTSW 5 109,201,679 (GRCm39) missense possibly damaging 0.65
R6491:Vmn2r11 UTSW 5 109,196,800 (GRCm39) missense possibly damaging 0.95
R6804:Vmn2r11 UTSW 5 109,201,350 (GRCm39) missense probably damaging 1.00
R6814:Vmn2r11 UTSW 5 109,194,976 (GRCm39) missense possibly damaging 0.81
R6872:Vmn2r11 UTSW 5 109,194,976 (GRCm39) missense possibly damaging 0.81
R7014:Vmn2r11 UTSW 5 109,201,289 (GRCm39) missense probably damaging 1.00
R7041:Vmn2r11 UTSW 5 109,202,816 (GRCm39) missense probably damaging 1.00
R7043:Vmn2r11 UTSW 5 109,200,098 (GRCm39) missense probably benign 0.00
R7050:Vmn2r11 UTSW 5 109,202,657 (GRCm39) missense probably benign 0.05
R7184:Vmn2r11 UTSW 5 109,201,281 (GRCm39) missense probably damaging 1.00
R7388:Vmn2r11 UTSW 5 109,202,742 (GRCm39) missense probably benign 0.05
R7477:Vmn2r11 UTSW 5 109,207,214 (GRCm39) missense possibly damaging 0.67
R7524:Vmn2r11 UTSW 5 109,201,848 (GRCm39) missense probably benign 0.01
R7682:Vmn2r11 UTSW 5 109,195,481 (GRCm39) missense probably benign 0.02
R7715:Vmn2r11 UTSW 5 109,195,307 (GRCm39) missense probably damaging 0.99
R7869:Vmn2r11 UTSW 5 109,199,986 (GRCm39) missense probably damaging 1.00
R8094:Vmn2r11 UTSW 5 109,201,626 (GRCm39) missense probably damaging 1.00
R8277:Vmn2r11 UTSW 5 109,202,833 (GRCm39) missense probably benign 0.00
R8506:Vmn2r11 UTSW 5 109,207,270 (GRCm39) missense probably benign 0.00
R8676:Vmn2r11 UTSW 5 109,201,626 (GRCm39) missense probably damaging 1.00
R8701:Vmn2r11 UTSW 5 109,195,556 (GRCm39) missense probably damaging 1.00
R8749:Vmn2r11 UTSW 5 109,195,319 (GRCm39) missense probably damaging 0.97
R9046:Vmn2r11 UTSW 5 109,202,850 (GRCm39) missense probably benign 0.00
R9138:Vmn2r11 UTSW 5 109,201,904 (GRCm39) missense probably damaging 1.00
R9267:Vmn2r11 UTSW 5 109,199,929 (GRCm39) missense possibly damaging 0.93
R9306:Vmn2r11 UTSW 5 109,196,831 (GRCm39) missense probably damaging 1.00
R9384:Vmn2r11 UTSW 5 109,201,266 (GRCm39) missense probably damaging 1.00
R9443:Vmn2r11 UTSW 5 109,195,159 (GRCm39) nonsense probably null
R9520:Vmn2r11 UTSW 5 109,201,455 (GRCm39) missense probably benign 0.35
R9596:Vmn2r11 UTSW 5 109,201,563 (GRCm39) missense possibly damaging 0.67
R9677:Vmn2r11 UTSW 5 109,201,332 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- TTTACTTGCAGGCACATGTAAATG -3'
(R):5'- CCTACAAGAAGATATGAGTTCTTTCTG -3'

Sequencing Primer
(F):5'- GAGGTCCTAAGTTCAATTCCCAGG -3'
(R):5'- GTCAGTGTGAAGATGAATGG -3'
Posted On 2016-07-06