Mutagenetix > Incidental Mutation

Incidental Mutation 'R0455:Or11g24'

39976

Institutional Source

Beutler Lab

Gene Symbol

Or11g24

Ensembl Gene

ENSMUSG00000057903

Gene Name

olfactory receptor family 11 subfamily G member 24

Synonyms

GA_x6K02T2PMLR-6121675-6122604, MOR106-2, Olfr739

MMRRC Submission

038655-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

R0455 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

50661978-50662907 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 50662359 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 128 (I128V)

Ref Sequence

ENSEMBL: ENSMUSP00000150559 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075261] [ENSMUST00000216949]

AlphaFold

E9Q1P0

Predicted Effect

possibly damaging
Transcript: ENSMUST00000075261
AA Change: I128V

PolyPhen 2 Score 0.454 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000074740
Gene: ENSMUSG00000057903
AA Change: I128V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	309	1.1e-53	PFAM
Pfam:7tm_1	43	292	1.9e-22	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000216949
AA Change: I128V

PolyPhen 2 Score 0.454 (Sensitivity: 0.89; Specificity: 0.90)

Meta Mutation Damage Score

0.0908

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.7%
20x: 90.8%

Validation Efficiency

100% (56/56)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921539E11Rik	C	T	4: 103,088,180 (GRCm39)	G342D	possibly damaging	Het
Acvr2b	C	T	9: 119,261,675 (GRCm39)	R399W	probably damaging	Het
Arb2a	T	A	13: 77,982,832 (GRCm39)		probably benign	Het
Atf6	A	G	1: 170,662,492 (GRCm39)	V256A	probably benign	Het
Atp2b4	A	T	1: 133,656,454 (GRCm39)	I732N	probably damaging	Het
C1qtnf9	A	C	14: 61,009,820 (GRCm39)	Q25H	probably damaging	Het
Ccdc6	T	A	10: 69,978,401 (GRCm39)		probably benign	Het
Cds2	T	C	2: 132,127,887 (GRCm39)		probably null	Het
Chdh	A	G	14: 29,756,603 (GRCm39)	Y343C	probably damaging	Het
Col5a2	T	C	1: 45,421,262 (GRCm39)		probably benign	Het
Cts3	G	A	13: 61,716,024 (GRCm39)		probably benign	Het
Cyfip1	T	A	7: 55,541,802 (GRCm39)	D362E	probably benign	Het
Dsg1b	T	A	18: 20,529,082 (GRCm39)	S273T	probably benign	Het
Dysf	A	T	6: 84,117,649 (GRCm39)	H1274L	probably benign	Het
Eva1c	T	C	16: 90,672,986 (GRCm39)	S187P	probably benign	Het
Fam13b	G	A	18: 34,578,581 (GRCm39)		probably benign	Het
Fbn2	C	T	18: 58,168,408 (GRCm39)	G2310S	probably damaging	Het
Fcna	T	C	2: 25,515,520 (GRCm39)	Y183C	probably damaging	Het
Fnta	T	C	8: 26,491,056 (GRCm39)	T263A	probably benign	Het
Gm94	T	C	18: 43,914,309 (GRCm39)	D83G	possibly damaging	Het
Gnal	C	T	18: 67,268,720 (GRCm39)		probably benign	Het
Grb7	T	G	11: 98,343,014 (GRCm39)	S244A	probably benign	Het
Grm3	T	C	5: 9,562,477 (GRCm39)	T458A	probably benign	Het
Hdac2	C	T	10: 36,867,832 (GRCm39)	R193C	probably damaging	Het
Hycc2	T	C	1: 58,573,638 (GRCm39)		probably benign	Het
Ighmbp2	T	C	19: 3,315,072 (GRCm39)	R783G	probably benign	Het
Inpp5j	G	T	11: 3,453,122 (GRCm39)	L43I	possibly damaging	Het
Itga11	A	T	9: 62,604,243 (GRCm39)	T44S	probably damaging	Het
Itsn1	C	T	16: 91,665,036 (GRCm39)		probably benign	Het
Kdm6b	G	T	11: 69,297,822 (GRCm39)	C233*	probably null	Het
Lamb3	T	C	1: 193,025,700 (GRCm39)	L1130P	probably damaging	Het
Lrch3	T	C	16: 32,807,250 (GRCm39)	F508L	probably damaging	Het
Lrrd1	T	A	5: 3,916,425 (GRCm39)	V814E	probably benign	Het
Megf10	C	T	18: 57,386,054 (GRCm39)	P356S	probably benign	Het
Myorg	G	A	4: 41,499,538 (GRCm39)	R31*	probably null	Het
Naip1	A	T	13: 100,559,727 (GRCm39)	D1092E	probably benign	Het
Nus1	T	A	10: 52,306,190 (GRCm39)	V42E	probably damaging	Het
Or2a51	A	C	6: 43,179,006 (GRCm39)	M143L	probably benign	Het
Padi3	T	C	4: 140,523,024 (GRCm39)	N306S	probably damaging	Het
Pex13	T	C	11: 23,605,949 (GRCm39)	S94G	probably benign	Het
Ppm1h	G	T	10: 122,638,229 (GRCm39)	Q166H	probably benign	Het
Ptafr	A	T	4: 132,307,396 (GRCm39)	Y262F	probably benign	Het
Rabgap1	T	A	2: 37,377,132 (GRCm39)	D321E	probably damaging	Het
Samsn1	C	T	16: 75,742,113 (GRCm39)		noncoding transcript	Het
Scarb1	T	C	5: 125,366,745 (GRCm39)	N63D	probably damaging	Het
Serpinb7	T	C	1: 107,379,340 (GRCm39)	I249T	possibly damaging	Het
Srpra	A	G	9: 35,126,277 (GRCm39)	K490R	probably benign	Het
Sycn	A	G	7: 28,240,398 (GRCm39)	N22D	probably benign	Het
Tarbp1	C	T	8: 127,167,612 (GRCm39)	A1067T	probably benign	Het
Tex14	A	G	11: 87,405,131 (GRCm39)	D681G	possibly damaging	Het
Usp34	C	T	11: 23,396,741 (GRCm39)		probably benign	Het
Vmn2r107	T	C	17: 20,595,085 (GRCm39)		probably benign	Het
Vwde	A	T	6: 13,187,528 (GRCm39)	M653K	probably benign	Het
Wrap73	T	A	4: 154,233,200 (GRCm39)	S125T	possibly damaging	Het

Other mutations in Or11g24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01719:Or11g24	APN	14	50,662,018 (GRCm39)	missense	possibly damaging	0.88
IGL02430:Or11g24	APN	14	50,662,608 (GRCm39)	missense	probably benign
IGL02603:Or11g24	APN	14	50,662,657 (GRCm39)	missense	probably damaging	1.00
IGL02959:Or11g24	APN	14	50,662,389 (GRCm39)	missense	possibly damaging	0.76
IGL03154:Or11g24	APN	14	50,662,080 (GRCm39)	missense	probably benign	0.00
R1984:Or11g24	UTSW	14	50,662,848 (GRCm39)	missense	possibly damaging	0.93
R3160:Or11g24	UTSW	14	50,662,488 (GRCm39)	missense	probably damaging	0.99
R3161:Or11g24	UTSW	14	50,662,488 (GRCm39)	missense	probably damaging	0.99
R3162:Or11g24	UTSW	14	50,662,488 (GRCm39)	missense	probably damaging	0.99
R4821:Or11g24	UTSW	14	50,662,206 (GRCm39)	missense	possibly damaging	0.96
R4880:Or11g24	UTSW	14	50,662,758 (GRCm39)	missense	possibly damaging	0.90
R5047:Or11g24	UTSW	14	50,662,696 (GRCm39)	missense	probably damaging	1.00
R5384:Or11g24	UTSW	14	50,662,846 (GRCm39)	missense	possibly damaging	0.77
R5385:Or11g24	UTSW	14	50,662,846 (GRCm39)	missense	possibly damaging	0.77
R5386:Or11g24	UTSW	14	50,662,846 (GRCm39)	missense	possibly damaging	0.77
R5640:Or11g24	UTSW	14	50,662,111 (GRCm39)	missense	probably benign	0.18
R5809:Or11g24	UTSW	14	50,662,905 (GRCm39)	makesense	probably null
R6035:Or11g24	UTSW	14	50,661,984 (GRCm39)	missense	probably benign
R6035:Or11g24	UTSW	14	50,661,984 (GRCm39)	missense	probably benign
R6229:Or11g24	UTSW	14	50,662,662 (GRCm39)	missense	probably benign	0.38
R6614:Or11g24	UTSW	14	50,662,546 (GRCm39)	missense	probably benign	0.00
R7308:Or11g24	UTSW	14	50,662,722 (GRCm39)	missense	possibly damaging	0.57
R7443:Or11g24	UTSW	14	50,662,507 (GRCm39)	missense	probably damaging	1.00
R7699:Or11g24	UTSW	14	50,662,792 (GRCm39)	missense	probably benign
R7700:Or11g24	UTSW	14	50,662,792 (GRCm39)	missense	probably benign
R7851:Or11g24	UTSW	14	50,662,827 (GRCm39)	missense	probably damaging	0.99
R8397:Or11g24	UTSW	14	50,662,137 (GRCm39)	missense	probably damaging	1.00
R8906:Or11g24	UTSW	14	50,662,291 (GRCm39)	missense	probably damaging	1.00
R9393:Or11g24	UTSW	14	50,662,255 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GCTGTGATCAGAAACTTCACACCCC -3'
(R):5'- TGCATTCCAGCTTCATGCTCAGATG -3'

Sequencing Primer
(F):5'- AACTTCTCCTTCCTGGAAATCTG -3'
(R):5'- CTACTGTGAGATGAGATCCGC -3'

Posted On

2013-05-23