Incidental Mutation 'R5270:Csf2rb2'
ID 400233
Institutional Source Beutler Lab
Gene Symbol Csf2rb2
Ensembl Gene ENSMUSG00000071714
Gene Name colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
Synonyms Bil3, BetaIl3, Il3rb2, AIC2A, Il3r
MMRRC Submission 042835-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5270 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 78166707-78189921 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 78176182 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000155013 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096356] [ENSMUST00000230115]
AlphaFold P26954
Predicted Effect probably null
Transcript: ENSMUST00000096356
SMART Domains Protein: ENSMUSP00000094083
Gene: ENSMUSG00000071714

DomainStartEndE-ValueType
SCOP:d1gh7a1 29 131 1e-57 SMART
FN3 137 225 3.73e-1 SMART
Pfam:IL6Ra-bind 248 342 6.3e-11 PFAM
FN3 343 425 2.83e0 SMART
transmembrane domain 445 467 N/A INTRINSIC
low complexity region 716 743 N/A INTRINSIC
low complexity region 824 845 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000230115
Predicted Effect probably benign
Transcript: ENSMUST00000230753
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230932
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.6%
Validation Efficiency 98% (59/60)
MGI Phenotype PHENOTYPE: Homozygotes for a targeted null mutation are apparently normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl5 T C 19: 55,282,650 (GRCm39) V585A possibly damaging Het
Adam6a A T 12: 113,507,747 (GRCm39) H40L possibly damaging Het
Adamts20 G A 15: 94,180,400 (GRCm39) P1752S probably benign Het
Atp5if1 A G 4: 132,260,611 (GRCm39) F27L probably damaging Het
B230104I21Rik A G 4: 154,434,050 (GRCm39) probably benign Het
Ciz1 C A 2: 32,264,511 (GRCm39) probably null Het
Crb1 T A 1: 139,164,602 (GRCm39) Y1174F probably damaging Het
Cyp3a25 A T 5: 145,918,312 (GRCm39) M433K probably benign Het
Dock4 A G 12: 40,783,270 (GRCm39) I735V probably benign Het
Dpp6 C T 5: 27,839,532 (GRCm39) S349L probably damaging Het
Epg5 T A 18: 78,026,778 (GRCm39) N1256K possibly damaging Het
Epha4 A G 1: 77,483,244 (GRCm39) V255A probably damaging Het
Gabrb1 A T 5: 72,265,669 (GRCm39) D155V probably damaging Het
Gpr35 A T 1: 92,910,299 (GRCm39) T4S probably benign Het
Hcrt T C 11: 100,652,823 (GRCm39) T64A probably damaging Het
Henmt1 G A 3: 108,867,530 (GRCm39) R355H probably benign Het
Hrh1 C A 6: 114,458,179 (GRCm39) R487S possibly damaging Het
Ints2 T C 11: 86,106,621 (GRCm39) S930G probably damaging Het
Irs2 G A 8: 11,056,678 (GRCm39) Q585* probably null Het
Kcns1 C A 2: 164,010,249 (GRCm39) R170L probably benign Het
Kdm3b T C 18: 34,960,467 (GRCm39) S1351P probably damaging Het
Ly9 T C 1: 171,428,730 (GRCm39) T297A probably damaging Het
M6pr G A 6: 122,292,048 (GRCm39) D127N possibly damaging Het
Macir T C 1: 97,573,720 (GRCm39) Q115R probably damaging Het
Nhsl3 T C 4: 129,118,005 (GRCm39) T208A possibly damaging Het
Nit2 G A 16: 56,977,494 (GRCm39) P179S probably damaging Het
Per1 T C 11: 68,994,424 (GRCm39) M516T probably benign Het
Pkdrej A T 15: 85,702,528 (GRCm39) I1136N probably damaging Het
Pramel27 A G 4: 143,578,468 (GRCm39) M243V probably damaging Het
Prdm9 G T 17: 15,773,625 (GRCm39) T257K probably benign Het
Prkdc T C 16: 15,552,819 (GRCm39) L2085P probably damaging Het
Rasgrf1 A C 9: 89,908,747 (GRCm39) E1240D probably benign Het
Rrh T C 3: 129,606,998 (GRCm39) I142V probably benign Het
Saal1 G T 7: 46,351,157 (GRCm39) probably benign Het
Sdcbp2 A G 2: 151,426,812 (GRCm39) I70V probably benign Het
Skida1 C A 2: 18,052,460 (GRCm39) A231S probably benign Het
Smtnl2 T A 11: 72,290,743 (GRCm39) T401S probably benign Het
Sntb1 C G 15: 55,506,191 (GRCm39) G461R probably damaging Het
Spag4 G T 2: 155,907,853 (GRCm39) probably benign Het
Tbc1d9 A G 8: 83,960,283 (GRCm39) M179V probably benign Het
Tm9sf1 G T 14: 55,873,938 (GRCm39) T520N probably damaging Het
Tmem163 G A 1: 127,419,289 (GRCm39) probably benign Het
Vmn1r47 A T 6: 89,999,525 (GRCm39) Q219L probably damaging Het
Vmn2r104 A T 17: 20,258,528 (GRCm39) C539S probably damaging Het
Wdr17 G T 8: 55,096,221 (GRCm39) S1024R probably benign Het
Zc3h4 A G 7: 16,168,440 (GRCm39) T850A unknown Het
Zfa-ps A G 10: 52,419,552 (GRCm39) noncoding transcript Het
Zfp146 G T 7: 29,861,900 (GRCm39) N47K probably benign Het
Zfp353-ps G T 8: 42,534,572 (GRCm39) noncoding transcript Het
Zfp607a A T 7: 27,577,730 (GRCm39) K267* probably null Het
Other mutations in Csf2rb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00585:Csf2rb2 APN 15 78,169,047 (GRCm39) missense possibly damaging 0.78
IGL00765:Csf2rb2 APN 15 78,176,916 (GRCm39) missense probably benign 0.17
IGL01383:Csf2rb2 APN 15 78,181,243 (GRCm39) missense possibly damaging 0.90
IGL01975:Csf2rb2 APN 15 78,173,086 (GRCm39) missense probably benign 0.01
IGL02330:Csf2rb2 APN 15 78,169,328 (GRCm39) missense possibly damaging 0.85
IGL02365:Csf2rb2 APN 15 78,171,260 (GRCm39) missense possibly damaging 0.92
IGL02756:Csf2rb2 APN 15 78,169,049 (GRCm39) missense possibly damaging 0.95
R0269:Csf2rb2 UTSW 15 78,173,065 (GRCm39) missense probably benign 0.09
R0462:Csf2rb2 UTSW 15 78,169,373 (GRCm39) missense probably damaging 1.00
R0540:Csf2rb2 UTSW 15 78,172,108 (GRCm39) missense probably benign 0.00
R0607:Csf2rb2 UTSW 15 78,172,108 (GRCm39) missense probably benign 0.00
R0636:Csf2rb2 UTSW 15 78,176,160 (GRCm39) nonsense probably null
R0782:Csf2rb2 UTSW 15 78,170,951 (GRCm39) missense probably damaging 0.98
R1387:Csf2rb2 UTSW 15 78,182,414 (GRCm39) missense probably damaging 0.99
R1799:Csf2rb2 UTSW 15 78,181,268 (GRCm39) missense probably damaging 1.00
R1881:Csf2rb2 UTSW 15 78,176,735 (GRCm39) splice site probably null
R2079:Csf2rb2 UTSW 15 78,172,207 (GRCm39) missense probably benign 0.13
R2108:Csf2rb2 UTSW 15 78,176,744 (GRCm39) missense probably damaging 0.99
R2359:Csf2rb2 UTSW 15 78,176,976 (GRCm39) missense probably benign 0.39
R4614:Csf2rb2 UTSW 15 78,175,902 (GRCm39) missense probably damaging 1.00
R4806:Csf2rb2 UTSW 15 78,169,490 (GRCm39) missense probably benign 0.11
R4900:Csf2rb2 UTSW 15 78,170,174 (GRCm39) splice site probably null
R5206:Csf2rb2 UTSW 15 78,176,952 (GRCm39) missense probably benign
R5427:Csf2rb2 UTSW 15 78,173,111 (GRCm39) missense probably damaging 1.00
R6633:Csf2rb2 UTSW 15 78,173,152 (GRCm39) missense probably benign 0.00
R7067:Csf2rb2 UTSW 15 78,176,694 (GRCm39) missense probably damaging 1.00
R7102:Csf2rb2 UTSW 15 78,181,272 (GRCm39) missense probably damaging 1.00
R7117:Csf2rb2 UTSW 15 78,169,385 (GRCm39) missense probably damaging 1.00
R7423:Csf2rb2 UTSW 15 78,176,760 (GRCm39) missense possibly damaging 0.65
R7453:Csf2rb2 UTSW 15 78,169,491 (GRCm39) missense probably benign 0.14
R7705:Csf2rb2 UTSW 15 78,168,774 (GRCm39) missense probably benign 0.02
R7788:Csf2rb2 UTSW 15 78,177,041 (GRCm39) missense probably benign 0.12
R7849:Csf2rb2 UTSW 15 78,168,621 (GRCm39) missense probably benign 0.09
R7851:Csf2rb2 UTSW 15 78,173,137 (GRCm39) missense probably benign 0.10
R8057:Csf2rb2 UTSW 15 78,169,206 (GRCm39) missense probably damaging 0.99
R8405:Csf2rb2 UTSW 15 78,172,093 (GRCm39) missense possibly damaging 0.85
R8406:Csf2rb2 UTSW 15 78,171,216 (GRCm39) missense probably benign 0.00
R8857:Csf2rb2 UTSW 15 78,178,613 (GRCm39) missense probably null 0.00
R8972:Csf2rb2 UTSW 15 78,172,115 (GRCm39) missense probably benign
R9262:Csf2rb2 UTSW 15 78,168,535 (GRCm39) missense probably damaging 1.00
R9311:Csf2rb2 UTSW 15 78,176,735 (GRCm39) splice site probably null
R9343:Csf2rb2 UTSW 15 78,171,287 (GRCm39) intron probably benign
R9478:Csf2rb2 UTSW 15 78,168,965 (GRCm39) missense probably benign 0.00
R9713:Csf2rb2 UTSW 15 78,176,730 (GRCm39) missense possibly damaging 0.78
R9789:Csf2rb2 UTSW 15 78,169,196 (GRCm39) missense probably benign 0.06
RF007:Csf2rb2 UTSW 15 78,176,126 (GRCm39) missense probably benign 0.21
RF009:Csf2rb2 UTSW 15 78,176,127 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- CAAAGAGGTATGGTCCTGGG -3'
(R):5'- TCCCTGAGTTCGTTCAAACAC -3'

Sequencing Primer
(F):5'- AGGTATGGTCCTGGGGATAAG -3'
(R):5'- CACTCAATATTTAGAGCTGGTTCC -3'
Posted On 2016-07-06