Incidental Mutation 'R5197:Lrrc63'
ID 400394
Institutional Source Beutler Lab
Gene Symbol Lrrc63
Ensembl Gene ENSMUSG00000021997
Gene Name leucine rich repeat containing 63
Synonyms 4921509B22Rik
MMRRC Submission 042773-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R5197 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 75321743-75368321 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 75322322 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 594 (H594L)
Ref Sequence ENSEMBL: ENSMUSP00000022574 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022574]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000022574
AA Change: H594L

PolyPhen 2 Score 0.682 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000022574
Gene: ENSMUSG00000021997
AA Change: H594L

DomainStartEndE-ValueType
low complexity region 15 37 N/A INTRINSIC
low complexity region 139 152 N/A INTRINSIC
low complexity region 276 310 N/A INTRINSIC
LRR 412 434 2.82e0 SMART
LRR 435 458 1.45e1 SMART
LRR 481 504 1.53e-1 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.5%
Validation Efficiency 99% (67/68)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsbg1 T C 9: 54,529,866 (GRCm39) E247G possibly damaging Het
Adgra3 A G 5: 50,118,096 (GRCm39) F1151L probably benign Het
Afg3l2 G T 18: 67,554,329 (GRCm39) L458M probably damaging Het
Aldh4a1 A C 4: 139,375,612 (GRCm39) probably benign Het
Anln A T 9: 22,264,077 (GRCm39) probably null Het
Aste1 T C 9: 105,282,253 (GRCm39) S74P probably damaging Het
Atp6v0e2 G A 6: 48,517,051 (GRCm39) R77H probably benign Het
Brpf1 A G 6: 113,296,902 (GRCm39) D962G possibly damaging Het
Btbd2 T C 10: 80,482,253 (GRCm39) D249G probably damaging Het
Catsper3 T C 13: 55,955,989 (GRCm39) probably null Het
Cfap43 A G 19: 47,885,811 (GRCm39) L268P probably damaging Het
Cftr T C 6: 18,255,413 (GRCm39) V540A probably benign Het
Col22a1 C T 15: 71,881,255 (GRCm39) G32D probably damaging Het
Col5a2 G T 1: 45,432,241 (GRCm39) P804Q probably benign Het
Cyp2d41-ps A G 15: 82,662,981 (GRCm39) noncoding transcript Het
Cyp39a1 T G 17: 44,057,429 (GRCm39) L423V possibly damaging Het
Elmo1 T G 13: 20,748,607 (GRCm39) V484G probably benign Het
Eps8 C A 6: 137,467,288 (GRCm39) Q656H probably damaging Het
Eps8 T C 6: 137,467,289 (GRCm39) Q656R possibly damaging Het
Fshb T C 2: 106,887,854 (GRCm39) D55G possibly damaging Het
Garin1a G T 6: 29,281,221 (GRCm39) probably benign Het
H3c4 T A 13: 23,760,304 (GRCm39) L110Q probably damaging Het
Herc1 C A 9: 66,355,786 (GRCm39) Q2346K probably damaging Het
Htr3b T C 9: 48,856,815 (GRCm39) D221G probably benign Het
Ift74 T A 4: 94,550,833 (GRCm39) D328E probably benign Het
Kif21b A T 1: 136,072,363 (GRCm39) K23M probably damaging Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Lipc T A 9: 70,705,673 (GRCm39) E470V probably benign Het
Lrrc4 G T 6: 28,830,142 (GRCm39) T68K probably damaging Het
Mfsd14a A T 3: 116,442,150 (GRCm39) probably benign Het
Mob2 T C 7: 141,563,274 (GRCm39) probably null Het
Nckap5 T A 1: 126,150,410 (GRCm39) H105L possibly damaging Het
Ngef C A 1: 87,437,090 (GRCm39) G133* probably null Het
Or14j2 T G 17: 37,886,111 (GRCm39) I68L probably benign Het
Or1e16 AGCGGTCGTAGGC AGC 11: 73,286,480 (GRCm39) probably null Het
Or2t1 T A 14: 14,328,462 (GRCm38) M117K probably damaging Het
Or52s1 G A 7: 102,861,207 (GRCm39) V47I probably benign Het
Or5b120 G T 19: 13,479,748 (GRCm39) V14F possibly damaging Het
Or5g23 T C 2: 85,438,791 (GRCm39) I154M probably benign Het
Pard3 A G 8: 127,800,040 (GRCm39) probably null Het
Pgm2 C T 5: 64,263,175 (GRCm39) A274V possibly damaging Het
Ppp1r9a T A 6: 5,156,177 (GRCm39) S1144R probably damaging Het
Pramel23 A C 4: 143,424,632 (GRCm39) C270W possibly damaging Het
Prkcq C T 2: 11,304,227 (GRCm39) P590L probably damaging Het
Psmd13 T A 7: 140,474,374 (GRCm39) probably null Het
Rab3gap1 T A 1: 127,816,931 (GRCm39) D63E probably benign Het
Rag2 C A 2: 101,461,085 (GRCm39) T465K probably damaging Het
Rnase6 A G 14: 51,367,670 (GRCm39) M21V unknown Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Ryr2 A T 13: 11,653,316 (GRCm39) probably null Het
Sash1 T G 10: 8,615,989 (GRCm39) R624S probably damaging Het
Slc1a2 A G 2: 102,586,460 (GRCm39) I355V probably benign Het
Srrm2 T C 17: 24,036,358 (GRCm39) S1097P probably benign Het
Sugct C T 13: 17,497,861 (GRCm39) A271T probably damaging Het
Tdrd7 T C 4: 46,034,350 (GRCm39) V1065A probably damaging Het
Tmprss6 T A 15: 78,338,389 (GRCm39) Y307F probably damaging Het
Tram1 T C 1: 13,642,126 (GRCm39) N216S probably benign Het
Ttk T C 9: 83,721,394 (GRCm39) V93A probably benign Het
Ubr4 A G 4: 139,195,408 (GRCm39) Y1210C probably damaging Het
Wdr7 A G 18: 63,871,937 (GRCm39) K364E probably benign Het
Xrcc2 G T 5: 25,897,656 (GRCm39) H98N probably benign Het
Zdhhc11 A G 13: 74,113,688 (GRCm39) I77V probably benign Het
Zfp54 C T 17: 21,654,442 (GRCm39) S312L probably benign Het
Zfp647 G A 15: 76,796,285 (GRCm39) P125L probably damaging Het
Other mutations in Lrrc63
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01688:Lrrc63 APN 14 75,322,422 (GRCm39) missense possibly damaging 0.73
IGL02222:Lrrc63 APN 14 75,323,580 (GRCm39) missense probably damaging 0.99
IGL02385:Lrrc63 APN 14 75,323,640 (GRCm39) missense probably benign
FR4548:Lrrc63 UTSW 14 75,362,622 (GRCm39) small deletion probably benign
FR4589:Lrrc63 UTSW 14 75,362,622 (GRCm39) small deletion probably benign
R0398:Lrrc63 UTSW 14 75,363,910 (GRCm39) missense probably benign 0.06
R0637:Lrrc63 UTSW 14 75,335,660 (GRCm39) splice site probably benign
R0669:Lrrc63 UTSW 14 75,363,550 (GRCm39) missense probably benign 0.27
R1465:Lrrc63 UTSW 14 75,344,829 (GRCm39) missense possibly damaging 0.92
R1465:Lrrc63 UTSW 14 75,344,829 (GRCm39) missense possibly damaging 0.92
R1478:Lrrc63 UTSW 14 75,363,424 (GRCm39) missense probably benign
R1591:Lrrc63 UTSW 14 75,363,332 (GRCm39) missense possibly damaging 0.92
R1753:Lrrc63 UTSW 14 75,323,784 (GRCm39) splice site probably null
R3713:Lrrc63 UTSW 14 75,344,776 (GRCm39) missense probably benign 0.12
R4013:Lrrc63 UTSW 14 75,335,731 (GRCm39) missense probably damaging 0.98
R4793:Lrrc63 UTSW 14 75,363,601 (GRCm39) missense possibly damaging 0.93
R4888:Lrrc63 UTSW 14 75,363,406 (GRCm39) missense probably benign
R4937:Lrrc63 UTSW 14 75,322,389 (GRCm39) missense probably damaging 0.99
R5747:Lrrc63 UTSW 14 75,363,904 (GRCm39) missense probably benign
R5861:Lrrc63 UTSW 14 75,344,806 (GRCm39) missense possibly damaging 0.83
R5905:Lrrc63 UTSW 14 75,323,614 (GRCm39) missense possibly damaging 0.92
R6028:Lrrc63 UTSW 14 75,323,614 (GRCm39) missense possibly damaging 0.92
R6661:Lrrc63 UTSW 14 75,362,633 (GRCm39) missense unknown
R6982:Lrrc63 UTSW 14 75,322,211 (GRCm39) missense probably benign 0.33
R7062:Lrrc63 UTSW 14 75,323,737 (GRCm39) missense probably benign 0.00
R7439:Lrrc63 UTSW 14 75,363,697 (GRCm39) missense possibly damaging 0.84
R7440:Lrrc63 UTSW 14 75,358,453 (GRCm39) missense possibly damaging 0.91
R7441:Lrrc63 UTSW 14 75,363,697 (GRCm39) missense possibly damaging 0.84
R7474:Lrrc63 UTSW 14 75,363,643 (GRCm39) missense possibly damaging 0.83
R7604:Lrrc63 UTSW 14 75,322,409 (GRCm39) missense possibly damaging 0.68
R7703:Lrrc63 UTSW 14 75,360,447 (GRCm39) missense possibly damaging 0.91
R7819:Lrrc63 UTSW 14 75,362,661 (GRCm39) small insertion probably benign
R8519:Lrrc63 UTSW 14 75,363,312 (GRCm39) missense possibly damaging 0.96
R8970:Lrrc63 UTSW 14 75,362,631 (GRCm39) missense unknown
R9025:Lrrc63 UTSW 14 75,322,284 (GRCm39) missense probably benign
R9547:Lrrc63 UTSW 14 75,344,828 (GRCm39) missense probably damaging 0.99
R9589:Lrrc63 UTSW 14 75,322,379 (GRCm39) missense possibly damaging 0.68
R9780:Lrrc63 UTSW 14 75,360,500 (GRCm39) missense probably damaging 0.99
Z1088:Lrrc63 UTSW 14 75,363,430 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- AGAAGAACCATGGGTCCCTC -3'
(R):5'- AGTGCCTTATCTAGATGGAAGC -3'

Sequencing Primer
(F):5'- CCCGTGCTCTAAGAGGTGAATTAC -3'
(R):5'- TCTAGATGGAAGCTCAATAAAAACC -3'
Posted On 2016-07-06