Incidental Mutation 'R5198:Or52z15'
ID 400479
Institutional Source Beutler Lab
Gene Symbol Or52z15
Ensembl Gene ENSMUSG00000073943
Gene Name olfactory receptor family 52 subfamily Z member 15
Synonyms MOR31-15P, GA_x6K02T2PBJ9-6416276-6417237, Olfr625
MMRRC Submission 042774-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R5198 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 103331936-103332889 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 103331936 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 4 (S4P)
Ref Sequence ENSEMBL: ENSMUSP00000095797 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098195] [ENSMUST00000190218]
AlphaFold A0A140T8L4
Predicted Effect probably benign
Transcript: ENSMUST00000098195
AA Change: S4P

PolyPhen 2 Score 0.403 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000095797
Gene: ENSMUSG00000073943
AA Change: S4P

DomainStartEndE-ValueType
Pfam:7tm_4 37 317 8.1e-110 PFAM
Pfam:7TM_GPCR_Srsx 41 225 3.6e-9 PFAM
Pfam:7tm_1 47 299 1.6e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000190218
SMART Domains Protein: ENSMUSP00000140044
Gene: ENSMUSG00000073943

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 31 214 7e-8 PFAM
Pfam:7tm_1 37 289 2.8e-26 PFAM
Pfam:7tm_4 136 282 2.7e-28 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 98% (54/55)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 A G 6: 142,571,726 (GRCm39) V1121A probably benign Het
Adamtsl3 A C 7: 82,261,006 (GRCm39) K1647Q possibly damaging Het
Adgrb1 A T 15: 74,415,550 (GRCm39) Q710L probably null Het
Alox12 T C 11: 70,145,243 (GRCm39) E110G probably damaging Het
Cep152 T A 2: 125,429,544 (GRCm39) M738L probably benign Het
Cma2 T C 14: 56,209,532 (GRCm39) V38A probably benign Het
Dlc1 C T 8: 37,405,552 (GRCm39) G79D probably damaging Het
Dmpk C G 7: 18,821,944 (GRCm39) L301V probably benign Het
Dus3l A G 17: 57,076,574 (GRCm39) I585V probably benign Het
Etl4 A G 2: 20,718,198 (GRCm39) Y313C probably damaging Het
Fbxw15 C A 9: 109,387,242 (GRCm39) S251I probably benign Het
Gata4 G A 14: 63,437,900 (GRCm39) S417L probably benign Het
Gdpd5 T A 7: 99,087,515 (GRCm39) Y60N probably damaging Het
Gm17669 T C 18: 67,695,626 (GRCm39) M57T probably benign Het
Gpr39 A T 1: 125,605,173 (GRCm39) I34F probably benign Het
Iffo2 T A 4: 139,302,528 (GRCm39) D90E probably benign Het
Il17c A G 8: 123,149,108 (GRCm39) D84G possibly damaging Het
Itih3 T C 14: 30,634,606 (GRCm39) T134A probably benign Het
Lama2 G A 10: 27,222,999 (GRCm39) A429V probably damaging Het
Muc6 G T 7: 141,218,685 (GRCm39) T1996N possibly damaging Het
Mug1 G A 6: 121,851,521 (GRCm39) R806H probably damaging Het
Naaa G A 5: 92,415,904 (GRCm39) R65* probably null Het
Nacc2 C T 2: 25,950,346 (GRCm39) M463I probably benign Het
Nemf A G 12: 69,402,821 (GRCm39) S72P probably damaging Het
Nudt7 G A 8: 114,862,185 (GRCm39) probably null Het
Or4b1b T C 2: 90,126,737 (GRCm39) Q156R probably damaging Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Pacs1 T C 19: 5,189,325 (GRCm39) D757G probably benign Het
Pkd2 A C 5: 104,630,958 (GRCm39) I461L probably benign Het
Potegl G A 2: 23,102,473 (GRCm39) C121Y probably damaging Het
Pramel5 T G 4: 144,000,064 (GRCm39) probably benign Het
Ptgdr G C 14: 45,096,300 (GRCm39) F137L probably damaging Het
Pum1 T A 4: 130,507,190 (GRCm39) C1085* probably null Het
Rfx3 T C 19: 27,808,176 (GRCm39) D189G probably damaging Het
Rlf T A 4: 121,005,750 (GRCm39) K1077* probably null Het
Slc25a30 C A 14: 76,007,056 (GRCm39) D147Y probably benign Het
Smap2 T C 4: 120,873,984 (GRCm39) E22G possibly damaging Het
Szt2 T C 4: 118,245,519 (GRCm39) T1098A probably benign Het
Tbcc T C 17: 47,201,788 (GRCm39) F58S probably damaging Het
Tekt3 G A 11: 62,961,134 (GRCm39) R101H probably damaging Het
Vcan T A 13: 89,838,991 (GRCm39) E2184D probably damaging Het
Vkorc1 T C 7: 127,493,760 (GRCm39) E18G probably benign Het
Vmn1r68 T C 7: 10,261,723 (GRCm39) H125R probably benign Het
Vmn2r63 C A 7: 42,553,169 (GRCm39) V696L probably benign Het
Wdr59 G A 8: 112,208,620 (GRCm39) H421Y probably benign Het
Xkr7 T C 2: 152,896,873 (GRCm39) Y576H probably damaging Het
Zfp112 T C 7: 23,824,281 (GRCm39) V83A possibly damaging Het
Zfp616 G A 11: 73,974,336 (GRCm39) V293I probably benign Het
Other mutations in Or52z15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02547:Or52z15 APN 7 103,331,973 (GRCm39) missense probably benign 0.01
R1160:Or52z15 UTSW 7 103,332,068 (GRCm39) missense possibly damaging 0.50
R1508:Or52z15 UTSW 7 103,332,678 (GRCm39) missense possibly damaging 0.50
R1766:Or52z15 UTSW 7 103,332,068 (GRCm39) missense possibly damaging 0.50
R1901:Or52z15 UTSW 7 103,332,750 (GRCm39) missense probably damaging 0.98
R2116:Or52z15 UTSW 7 103,332,519 (GRCm39) missense probably damaging 1.00
R4701:Or52z15 UTSW 7 103,332,269 (GRCm39) missense probably damaging 1.00
R4995:Or52z15 UTSW 7 103,332,574 (GRCm39) missense probably damaging 1.00
R5750:Or52z15 UTSW 7 103,332,362 (GRCm39) missense possibly damaging 0.95
R5776:Or52z15 UTSW 7 103,332,246 (GRCm39) missense probably damaging 1.00
R5905:Or52z15 UTSW 7 103,332,781 (GRCm39) missense probably damaging 1.00
R5933:Or52z15 UTSW 7 103,332,680 (GRCm39) missense probably damaging 1.00
R6488:Or52z15 UTSW 7 103,332,285 (GRCm39) missense probably damaging 0.98
R7846:Or52z15 UTSW 7 103,332,407 (GRCm39) missense probably benign 0.03
R7878:Or52z15 UTSW 7 103,332,471 (GRCm39) missense probably damaging 1.00
R9170:Or52z15 UTSW 7 103,332,404 (GRCm39) missense probably benign 0.00
R9347:Or52z15 UTSW 7 103,332,464 (GRCm39) missense probably damaging 0.97
R9474:Or52z15 UTSW 7 103,332,477 (GRCm39) missense probably damaging 1.00
R9781:Or52z15 UTSW 7 103,332,246 (GRCm39) missense probably damaging 1.00
RF040:Or52z15 UTSW 7 103,332,145 (GRCm39) frame shift probably null
Z1088:Or52z15 UTSW 7 103,332,393 (GRCm39) missense probably benign 0.01
Z1176:Or52z15 UTSW 7 103,332,312 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- GCAAAGCCTACCAGAGACTCTG -3'
(R):5'- AGATATCAGCAAGTGCCAACATAG -3'

Sequencing Primer
(F):5'- GCCAACTGTGAGTATCAC -3'
(R):5'- GGTTCATGAAGGCTGCATTCAG -3'
Posted On 2016-07-06