Incidental Mutation 'R5198:Nudt7'
ID 400487
Institutional Source Beutler Lab
Gene Symbol Nudt7
Ensembl Gene ENSMUSG00000031767
Gene Name nudix hydrolase 7
Synonyms 1300007B24Rik, 2210404C19Rik, nudix (nucleoside diphosphate linked moiety X)-type motif 7
MMRRC Submission 042774-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R5198 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 114860314-114881471 bp(+) (GRCm39)
Type of Mutation splice site (5 bp from exon)
DNA Base Change (assembly) G to A at 114862185 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000104737 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066514] [ENSMUST00000073521] [ENSMUST00000109109] [ENSMUST00000134593] [ENSMUST00000147605]
AlphaFold Q99P30
Predicted Effect probably benign
Transcript: ENSMUST00000066514
SMART Domains Protein: ENSMUSP00000065791
Gene: ENSMUSG00000031767

DomainStartEndE-ValueType
Pfam:NUDIX 15 140 4.1e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000073521
SMART Domains Protein: ENSMUSP00000073213
Gene: ENSMUSG00000031767

DomainStartEndE-ValueType
Pfam:NUDIX 38 168 4.4e-17 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000109109
SMART Domains Protein: ENSMUSP00000104737
Gene: ENSMUSG00000031767

DomainStartEndE-ValueType
Pfam:NUDIX 62 193 3.2e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000134593
SMART Domains Protein: ENSMUSP00000116868
Gene: ENSMUSG00000031767

DomainStartEndE-ValueType
Pfam:NUDIX 38 146 4.2e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000147605
SMART Domains Protein: ENSMUSP00000114598
Gene: ENSMUSG00000031767

DomainStartEndE-ValueType
Pfam:NUDIX 38 107 1.2e-8 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 A G 6: 142,571,726 (GRCm39) V1121A probably benign Het
Adamtsl3 A C 7: 82,261,006 (GRCm39) K1647Q possibly damaging Het
Adgrb1 A T 15: 74,415,550 (GRCm39) Q710L probably null Het
Alox12 T C 11: 70,145,243 (GRCm39) E110G probably damaging Het
Cep152 T A 2: 125,429,544 (GRCm39) M738L probably benign Het
Cma2 T C 14: 56,209,532 (GRCm39) V38A probably benign Het
Dlc1 C T 8: 37,405,552 (GRCm39) G79D probably damaging Het
Dmpk C G 7: 18,821,944 (GRCm39) L301V probably benign Het
Dus3l A G 17: 57,076,574 (GRCm39) I585V probably benign Het
Etl4 A G 2: 20,718,198 (GRCm39) Y313C probably damaging Het
Fbxw15 C A 9: 109,387,242 (GRCm39) S251I probably benign Het
Gata4 G A 14: 63,437,900 (GRCm39) S417L probably benign Het
Gdpd5 T A 7: 99,087,515 (GRCm39) Y60N probably damaging Het
Gm17669 T C 18: 67,695,626 (GRCm39) M57T probably benign Het
Gpr39 A T 1: 125,605,173 (GRCm39) I34F probably benign Het
Iffo2 T A 4: 139,302,528 (GRCm39) D90E probably benign Het
Il17c A G 8: 123,149,108 (GRCm39) D84G possibly damaging Het
Itih3 T C 14: 30,634,606 (GRCm39) T134A probably benign Het
Lama2 G A 10: 27,222,999 (GRCm39) A429V probably damaging Het
Muc6 G T 7: 141,218,685 (GRCm39) T1996N possibly damaging Het
Mug1 G A 6: 121,851,521 (GRCm39) R806H probably damaging Het
Naaa G A 5: 92,415,904 (GRCm39) R65* probably null Het
Nacc2 C T 2: 25,950,346 (GRCm39) M463I probably benign Het
Nemf A G 12: 69,402,821 (GRCm39) S72P probably damaging Het
Or4b1b T C 2: 90,126,737 (GRCm39) Q156R probably damaging Het
Or52z15 T C 7: 103,331,936 (GRCm39) S4P probably benign Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Pacs1 T C 19: 5,189,325 (GRCm39) D757G probably benign Het
Pkd2 A C 5: 104,630,958 (GRCm39) I461L probably benign Het
Potegl G A 2: 23,102,473 (GRCm39) C121Y probably damaging Het
Pramel5 T G 4: 144,000,064 (GRCm39) probably benign Het
Ptgdr G C 14: 45,096,300 (GRCm39) F137L probably damaging Het
Pum1 T A 4: 130,507,190 (GRCm39) C1085* probably null Het
Rfx3 T C 19: 27,808,176 (GRCm39) D189G probably damaging Het
Rlf T A 4: 121,005,750 (GRCm39) K1077* probably null Het
Slc25a30 C A 14: 76,007,056 (GRCm39) D147Y probably benign Het
Smap2 T C 4: 120,873,984 (GRCm39) E22G possibly damaging Het
Szt2 T C 4: 118,245,519 (GRCm39) T1098A probably benign Het
Tbcc T C 17: 47,201,788 (GRCm39) F58S probably damaging Het
Tekt3 G A 11: 62,961,134 (GRCm39) R101H probably damaging Het
Vcan T A 13: 89,838,991 (GRCm39) E2184D probably damaging Het
Vkorc1 T C 7: 127,493,760 (GRCm39) E18G probably benign Het
Vmn1r68 T C 7: 10,261,723 (GRCm39) H125R probably benign Het
Vmn2r63 C A 7: 42,553,169 (GRCm39) V696L probably benign Het
Wdr59 G A 8: 112,208,620 (GRCm39) H421Y probably benign Het
Xkr7 T C 2: 152,896,873 (GRCm39) Y576H probably damaging Het
Zfp112 T C 7: 23,824,281 (GRCm39) V83A possibly damaging Het
Zfp616 G A 11: 73,974,336 (GRCm39) V293I probably benign Het
Other mutations in Nudt7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01554:Nudt7 APN 8 114,874,625 (GRCm39) splice site probably benign
IGL02549:Nudt7 APN 8 114,878,688 (GRCm39) missense probably damaging 1.00
R0525:Nudt7 UTSW 8 114,878,392 (GRCm39) critical splice acceptor site probably null
R0781:Nudt7 UTSW 8 114,862,111 (GRCm39) intron probably benign
R5167:Nudt7 UTSW 8 114,878,567 (GRCm39) nonsense probably null
R5562:Nudt7 UTSW 8 114,874,723 (GRCm39) missense probably damaging 1.00
R5597:Nudt7 UTSW 8 114,878,506 (GRCm39) missense probably benign 0.12
R6957:Nudt7 UTSW 8 114,860,385 (GRCm39) missense probably benign 0.03
R7410:Nudt7 UTSW 8 114,860,559 (GRCm39) intron probably benign
R8245:Nudt7 UTSW 8 114,863,080 (GRCm39) missense probably damaging 0.99
R8248:Nudt7 UTSW 8 114,878,737 (GRCm39) missense probably benign 0.08
R9602:Nudt7 UTSW 8 114,878,499 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTCACTGTCACACACCATG -3'
(R):5'- GCTTTGGAGGAGAAATTACTATTGC -3'

Sequencing Primer
(F):5'- CATAGAGCTCATCCGAGGGAC -3'
(R):5'- TACTATTGCTATAGGAAGACAGGAC -3'
Posted On 2016-07-06