Incidental Mutation 'R5201:Zfp943'
ID 400832
Institutional Source Beutler Lab
Gene Symbol Zfp943
Ensembl Gene ENSMUSG00000053347
Gene Name zinc finger prtoein 943
Synonyms 4930432O21Rik
MMRRC Submission 042776-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.250) question?
Stock # R5201 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 22181540-22213347 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 22211794 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 293 (K293N)
Ref Sequence ENSEMBL: ENSMUSP00000059554 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055349] [ENSMUST00000153985] [ENSMUST00000174015]
AlphaFold Q6NZP4
Predicted Effect probably damaging
Transcript: ENSMUST00000055349
AA Change: K293N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000059554
Gene: ENSMUSG00000053347
AA Change: K293N

DomainStartEndE-ValueType
KRAB 13 72 2.62e-18 SMART
ZnF_C2H2 180 202 1.6e-4 SMART
ZnF_C2H2 208 230 1.38e-3 SMART
ZnF_C2H2 236 258 1.13e-4 SMART
ZnF_C2H2 264 286 1.03e-2 SMART
ZnF_C2H2 292 314 2.24e-3 SMART
ZnF_C2H2 320 342 9.58e-3 SMART
ZnF_C2H2 348 370 5.67e-5 SMART
ZnF_C2H2 376 398 4.54e-4 SMART
ZnF_C2H2 404 426 2.15e-5 SMART
ZnF_C2H2 432 454 5.59e-4 SMART
ZnF_C2H2 460 482 3.34e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000153985
SMART Domains Protein: ENSMUSP00000115817
Gene: ENSMUSG00000053347

DomainStartEndE-ValueType
KRAB 13 73 3.51e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000174015
SMART Domains Protein: ENSMUSP00000133735
Gene: ENSMUSG00000053347

DomainStartEndE-ValueType
KRAB 13 60 3.79e-15 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik C A 15: 81,946,745 (GRCm39) T214N probably benign Het
Actn4 A T 7: 28,615,680 (GRCm39) probably null Het
Arap2 T C 5: 62,840,832 (GRCm39) E678G probably damaging Het
Atl2 T C 17: 80,172,580 (GRCm39) N130S probably benign Het
Cby2 A G 14: 75,821,449 (GRCm39) V101A probably damaging Het
Cyp2b10 A G 7: 25,616,419 (GRCm39) D342G probably damaging Het
Dnah6 A G 6: 73,172,715 (GRCm39) Y248H possibly damaging Het
Drd5 A T 5: 38,477,366 (GRCm39) M120L probably damaging Het
Duox1 A G 2: 122,158,403 (GRCm39) R629G probably benign Het
Dyrk1b A G 7: 27,884,521 (GRCm39) Y279C probably damaging Het
Efemp1 A T 11: 28,864,590 (GRCm39) I215L probably benign Het
Enpp6 C A 8: 47,518,486 (GRCm39) Q205K probably damaging Het
Fam170a A T 18: 50,415,193 (GRCm39) T280S probably benign Het
Fam222a G A 5: 114,749,127 (GRCm39) A108T possibly damaging Het
Fgd3 G T 13: 49,449,854 (GRCm39) P132T probably benign Het
Fzr1 A T 10: 81,203,362 (GRCm39) L399H probably damaging Het
Galnt15 G A 14: 31,771,822 (GRCm39) R289Q probably damaging Het
Hira T C 16: 18,770,865 (GRCm39) V834A probably damaging Het
Ilf3 T C 9: 21,300,679 (GRCm39) L93P probably damaging Het
Itgae G A 11: 73,001,382 (GRCm39) R71Q probably benign Het
Itprid1 T C 6: 55,944,991 (GRCm39) S571P probably benign Het
Kif14 T A 1: 136,431,145 (GRCm39) S1181T probably benign Het
Lrig3 C A 10: 125,849,020 (GRCm39) P946Q possibly damaging Het
Macf1 A T 4: 123,369,738 (GRCm39) C1674* probably null Het
Malt1 A G 18: 65,609,126 (GRCm39) K710R probably benign Het
Man1a2 A T 3: 100,524,328 (GRCm39) N373K probably benign Het
Mpped2 A G 2: 106,529,847 (GRCm39) N32S possibly damaging Het
Mrtfb A C 16: 13,219,456 (GRCm39) T701P probably benign Het
Myh10 A T 11: 68,674,021 (GRCm39) T652S probably damaging Het
Nfia A G 4: 97,999,462 (GRCm39) Y485C probably damaging Het
Olfml2b A T 1: 170,496,433 (GRCm39) T355S probably benign Het
Or10q3 A T 19: 11,847,995 (GRCm39) I195K probably benign Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Pcdh1 A T 18: 38,331,971 (GRCm39) V344D probably damaging Het
Plekhn1 C A 4: 156,314,984 (GRCm39) V558L probably benign Het
Prr14l A G 5: 32,987,591 (GRCm39) S635P possibly damaging Het
Prss46 T A 9: 110,680,543 (GRCm39) C229* probably null Het
Rad50 A G 11: 53,589,647 (GRCm39) probably null Het
Slc27a3 A T 3: 90,296,526 (GRCm39) L191Q probably benign Het
Surf4 A G 2: 26,823,778 (GRCm39) probably benign Het
Taf3 A G 2: 9,956,995 (GRCm39) S391P probably damaging Het
Tep1 A C 14: 51,105,567 (GRCm39) L151R probably benign Het
Tmprss11d A C 5: 86,457,214 (GRCm39) N148K possibly damaging Het
Tpd52l2 G A 2: 181,156,879 (GRCm39) V172I probably benign Het
Vmn2r77 A G 7: 86,460,846 (GRCm39) D724G probably damaging Het
Wdr75 T A 1: 45,862,519 (GRCm39) D779E probably benign Het
Other mutations in Zfp943
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03101:Zfp943 APN 17 22,211,156 (GRCm39) missense probably damaging 1.00
R0019:Zfp943 UTSW 17 22,211,070 (GRCm39) intron probably benign
R0827:Zfp943 UTSW 17 22,211,071 (GRCm39) critical splice acceptor site probably null
R1824:Zfp943 UTSW 17 22,211,361 (GRCm39) missense probably benign 0.32
R1958:Zfp943 UTSW 17 22,211,979 (GRCm39) missense probably damaging 0.99
R2174:Zfp943 UTSW 17 22,211,804 (GRCm39) missense probably damaging 1.00
R3790:Zfp943 UTSW 17 22,211,403 (GRCm39) missense possibly damaging 0.81
R4093:Zfp943 UTSW 17 22,211,963 (GRCm39) missense probably damaging 1.00
R4094:Zfp943 UTSW 17 22,211,963 (GRCm39) missense probably damaging 1.00
R4352:Zfp943 UTSW 17 22,212,104 (GRCm39) missense probably damaging 0.98
R4677:Zfp943 UTSW 17 22,212,176 (GRCm39) missense probably benign 0.17
R4735:Zfp943 UTSW 17 22,211,391 (GRCm39) missense probably benign 0.03
R5492:Zfp943 UTSW 17 22,212,056 (GRCm39) missense probably damaging 1.00
R5642:Zfp943 UTSW 17 22,211,813 (GRCm39) missense probably damaging 1.00
R6031:Zfp943 UTSW 17 22,212,357 (GRCm39) missense probably benign
R6031:Zfp943 UTSW 17 22,212,357 (GRCm39) missense probably benign
R6667:Zfp943 UTSW 17 22,211,889 (GRCm39) missense probably damaging 1.00
R6864:Zfp943 UTSW 17 22,211,593 (GRCm39) missense probably damaging 1.00
R6976:Zfp943 UTSW 17 22,209,922 (GRCm39) missense possibly damaging 0.47
R7837:Zfp943 UTSW 17 22,211,346 (GRCm39) missense probably benign 0.39
R7934:Zfp943 UTSW 17 22,212,361 (GRCm39) missense probably damaging 0.97
R8302:Zfp943 UTSW 17 22,211,091 (GRCm39) missense probably benign 0.18
R8323:Zfp943 UTSW 17 22,211,763 (GRCm39) missense possibly damaging 0.95
R9025:Zfp943 UTSW 17 22,211,321 (GRCm39) missense possibly damaging 0.67
R9101:Zfp943 UTSW 17 22,212,392 (GRCm39) missense possibly damaging 0.83
R9279:Zfp943 UTSW 17 22,209,832 (GRCm39) missense possibly damaging 0.89
R9640:Zfp943 UTSW 17 22,209,899 (GRCm39) missense probably damaging 0.99
Z1176:Zfp943 UTSW 17 22,211,946 (GRCm39) missense probably damaging 1.00
Z1177:Zfp943 UTSW 17 22,207,063 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCGCAAAGGAGACGTTATTATTCATG -3'
(R):5'- TCGCCTTTCTGAGTGAAACAT -3'

Sequencing Primer
(F):5'- GAATTCATACAGGAGAGAAACCTTAC -3'
(R):5'- GCCTTTCTGAGTGAAACATTTGTCAC -3'
Posted On 2016-07-06