Incidental Mutation 'R5201:Or10q3'
ID 400842
Institutional Source Beutler Lab
Gene Symbol Or10q3
Ensembl Gene ENSMUSG00000067545
Gene Name olfactory receptor family 10 subfamily Q member 3
Synonyms GA_x6K02T2RE5P-2222521-2221490, Olfr1419, MOR266-10
MMRRC Submission 042776-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R5201 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 11847510-11848669 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 11847995 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 195 (I195K)
Ref Sequence ENSEMBL: ENSMUSP00000148848 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087857] [ENSMUST00000213954] [ENSMUST00000217617]
AlphaFold Q7TQS2
Predicted Effect probably benign
Transcript: ENSMUST00000087857
AA Change: I195K

PolyPhen 2 Score 0.209 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000085163
Gene: ENSMUSG00000067545
AA Change: I195K

DomainStartEndE-ValueType
Pfam:7tm_4 31 309 3.8e-55 PFAM
Pfam:7tm_1 41 291 2.8e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213954
AA Change: I195K

PolyPhen 2 Score 0.209 (Sensitivity: 0.92; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000217617
AA Change: I195K

PolyPhen 2 Score 0.209 (Sensitivity: 0.92; Specificity: 0.88)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik C A 15: 81,946,745 (GRCm39) T214N probably benign Het
Actn4 A T 7: 28,615,680 (GRCm39) probably null Het
Arap2 T C 5: 62,840,832 (GRCm39) E678G probably damaging Het
Atl2 T C 17: 80,172,580 (GRCm39) N130S probably benign Het
Cby2 A G 14: 75,821,449 (GRCm39) V101A probably damaging Het
Cyp2b10 A G 7: 25,616,419 (GRCm39) D342G probably damaging Het
Dnah6 A G 6: 73,172,715 (GRCm39) Y248H possibly damaging Het
Drd5 A T 5: 38,477,366 (GRCm39) M120L probably damaging Het
Duox1 A G 2: 122,158,403 (GRCm39) R629G probably benign Het
Dyrk1b A G 7: 27,884,521 (GRCm39) Y279C probably damaging Het
Efemp1 A T 11: 28,864,590 (GRCm39) I215L probably benign Het
Enpp6 C A 8: 47,518,486 (GRCm39) Q205K probably damaging Het
Fam170a A T 18: 50,415,193 (GRCm39) T280S probably benign Het
Fam222a G A 5: 114,749,127 (GRCm39) A108T possibly damaging Het
Fgd3 G T 13: 49,449,854 (GRCm39) P132T probably benign Het
Fzr1 A T 10: 81,203,362 (GRCm39) L399H probably damaging Het
Galnt15 G A 14: 31,771,822 (GRCm39) R289Q probably damaging Het
Hira T C 16: 18,770,865 (GRCm39) V834A probably damaging Het
Ilf3 T C 9: 21,300,679 (GRCm39) L93P probably damaging Het
Itgae G A 11: 73,001,382 (GRCm39) R71Q probably benign Het
Itprid1 T C 6: 55,944,991 (GRCm39) S571P probably benign Het
Kif14 T A 1: 136,431,145 (GRCm39) S1181T probably benign Het
Lrig3 C A 10: 125,849,020 (GRCm39) P946Q possibly damaging Het
Macf1 A T 4: 123,369,738 (GRCm39) C1674* probably null Het
Malt1 A G 18: 65,609,126 (GRCm39) K710R probably benign Het
Man1a2 A T 3: 100,524,328 (GRCm39) N373K probably benign Het
Mpped2 A G 2: 106,529,847 (GRCm39) N32S possibly damaging Het
Mrtfb A C 16: 13,219,456 (GRCm39) T701P probably benign Het
Myh10 A T 11: 68,674,021 (GRCm39) T652S probably damaging Het
Nfia A G 4: 97,999,462 (GRCm39) Y485C probably damaging Het
Olfml2b A T 1: 170,496,433 (GRCm39) T355S probably benign Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Pcdh1 A T 18: 38,331,971 (GRCm39) V344D probably damaging Het
Plekhn1 C A 4: 156,314,984 (GRCm39) V558L probably benign Het
Prr14l A G 5: 32,987,591 (GRCm39) S635P possibly damaging Het
Prss46 T A 9: 110,680,543 (GRCm39) C229* probably null Het
Rad50 A G 11: 53,589,647 (GRCm39) probably null Het
Slc27a3 A T 3: 90,296,526 (GRCm39) L191Q probably benign Het
Surf4 A G 2: 26,823,778 (GRCm39) probably benign Het
Taf3 A G 2: 9,956,995 (GRCm39) S391P probably damaging Het
Tep1 A C 14: 51,105,567 (GRCm39) L151R probably benign Het
Tmprss11d A C 5: 86,457,214 (GRCm39) N148K possibly damaging Het
Tpd52l2 G A 2: 181,156,879 (GRCm39) V172I probably benign Het
Vmn2r77 A G 7: 86,460,846 (GRCm39) D724G probably damaging Het
Wdr75 T A 1: 45,862,519 (GRCm39) D779E probably benign Het
Zfp943 A T 17: 22,211,794 (GRCm39) K293N probably damaging Het
Other mutations in Or10q3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01845:Or10q3 APN 19 11,847,888 (GRCm39) missense probably benign 0.05
IGL01979:Or10q3 APN 19 11,848,587 (GRCm39) splice site probably benign
IGL02961:Or10q3 APN 19 11,847,695 (GRCm39) missense probably damaging 1.00
R0285:Or10q3 UTSW 19 11,848,502 (GRCm39) missense probably damaging 0.97
R0347:Or10q3 UTSW 19 11,847,797 (GRCm39) missense probably damaging 1.00
R1577:Or10q3 UTSW 19 11,847,741 (GRCm39) missense probably damaging 1.00
R2391:Or10q3 UTSW 19 11,848,180 (GRCm39) nonsense probably null
R3977:Or10q3 UTSW 19 11,847,869 (GRCm39) missense possibly damaging 0.82
R4660:Or10q3 UTSW 19 11,848,412 (GRCm39) missense possibly damaging 0.64
R5995:Or10q3 UTSW 19 11,848,226 (GRCm39) missense possibly damaging 0.89
R6393:Or10q3 UTSW 19 11,848,091 (GRCm39) missense probably damaging 1.00
R7466:Or10q3 UTSW 19 11,847,680 (GRCm39) missense possibly damaging 0.94
R7828:Or10q3 UTSW 19 11,848,169 (GRCm39) missense probably damaging 1.00
R8400:Or10q3 UTSW 19 11,848,578 (GRCm39) start codon destroyed probably damaging 0.96
R9644:Or10q3 UTSW 19 11,848,574 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGAGGGTGCAACATCCATACTG -3'
(R):5'- GGCCATCTGTCATCCATTGC -3'

Sequencing Primer
(F):5'- GTGCAACATCCATACTGCAGGAC -3'
(R):5'- ACAGCCTCATTATGAGTTGGCAG -3'
Posted On 2016-07-06