Incidental Mutation 'R5258:Vmn2r90'
ID 401269
Institutional Source Beutler Lab
Gene Symbol Vmn2r90
Ensembl Gene ENSMUSG00000092120
Gene Name vomeronasal 2, receptor 90
Synonyms EG626942
MMRRC Submission 042828-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # R5258 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 17924203-17954429 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 17933114 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 225 (I225V)
Ref Sequence ENSEMBL: ENSMUSP00000126650 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169805] [ENSMUST00000231659] [ENSMUST00000232078] [ENSMUST00000232113]
AlphaFold E9PXJ8
Predicted Effect probably benign
Transcript: ENSMUST00000169805
AA Change: I225V

PolyPhen 2 Score 0.115 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000126650
Gene: ENSMUSG00000092120
AA Change: I225V

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 471 1.8e-43 PFAM
Pfam:NCD3G 514 567 3e-22 PFAM
Pfam:7tm_3 600 835 9.8e-54 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231659
Predicted Effect probably benign
Transcript: ENSMUST00000232078
Predicted Effect probably benign
Transcript: ENSMUST00000232113
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.4%
Validation Efficiency 98% (55/56)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T A 14: 32,385,266 (GRCm39) D233V probably damaging Het
Abca13 A T 11: 9,199,684 (GRCm39) T128S possibly damaging Het
Abca16 T G 7: 120,035,992 (GRCm39) probably null Het
Abcc8 T C 7: 45,757,811 (GRCm39) I1313V probably benign Het
Abcc8 C T 7: 45,806,572 (GRCm39) V379I probably benign Het
Acp3 T C 9: 104,186,674 (GRCm39) I266V probably benign Het
Asf1b C T 8: 84,695,896 (GRCm39) T179I probably benign Het
B3gnt7 A G 1: 86,233,287 (GRCm39) K61E possibly damaging Het
Card11 G A 5: 140,862,180 (GRCm39) P1039L possibly damaging Het
Cd1d2 C G 3: 86,894,954 (GRCm39) R147G possibly damaging Het
Cfap68 T C 9: 50,675,633 (GRCm39) probably benign Het
Cfap69 T C 5: 5,654,271 (GRCm39) probably null Het
Ddx46 T C 13: 55,800,837 (GRCm39) F331L possibly damaging Het
Dkk4 C A 8: 23,117,031 (GRCm39) L215I probably damaging Het
Dnhd1 C T 7: 105,323,244 (GRCm39) T584I probably benign Het
Dock3 T C 9: 106,874,124 (GRCm39) Y449C probably damaging Het
Foxi2 C T 7: 135,012,256 (GRCm39) T48M probably benign Het
Gm12887 T C 4: 121,472,897 (GRCm39) K82E probably benign Het
Gm4787 G C 12: 81,424,604 (GRCm39) T518S probably benign Het
Igkv4-80 T A 6: 68,993,811 (GRCm39) T27S probably benign Het
Invs A G 4: 48,396,374 (GRCm39) D349G possibly damaging Het
Lbhd1 A G 19: 8,861,453 (GRCm39) probably benign Het
Lipo3 T A 19: 33,591,243 (GRCm39) probably benign Het
Llgl1 G C 11: 60,602,389 (GRCm39) probably null Het
Lyzl6 T A 11: 103,525,899 (GRCm39) I74F probably damaging Het
Map3k6 T C 4: 132,974,953 (GRCm39) V662A possibly damaging Het
Megf8 T A 7: 25,047,751 (GRCm39) F1645I possibly damaging Het
Mfsd4b2 T A 10: 39,798,017 (GRCm39) M113L probably benign Het
Mib1 G A 18: 10,795,856 (GRCm39) probably null Het
Mrps6 T A 16: 91,896,543 (GRCm39) V36E probably damaging Het
Nhsl1 C A 10: 18,400,070 (GRCm39) S432* probably null Het
Nle1 T C 11: 82,795,772 (GRCm39) D225G probably damaging Het
Nlrp4c T A 7: 6,069,622 (GRCm39) S508T probably benign Het
Or1e16 AGCGGTCGTAGGC AGC 11: 73,286,480 (GRCm39) probably null Het
Or5d37 A T 2: 87,923,762 (GRCm39) Y173N probably benign Het
P2rx7 A G 5: 122,819,066 (GRCm39) E496G probably damaging Het
Prdm16 A T 4: 154,451,671 (GRCm39) D179E possibly damaging Het
Psca A T 15: 74,588,240 (GRCm39) I56F probably damaging Het
Ptprg A G 14: 12,142,431 (GRCm38) T361A probably benign Het
Ptrhd1 A G 12: 4,286,481 (GRCm39) Y124C probably damaging Het
Sesn1 C T 10: 41,770,984 (GRCm39) P172S probably benign Het
Sspo T C 6: 48,453,428 (GRCm39) V2872A probably damaging Het
Stard9 T A 2: 120,529,824 (GRCm39) L2027H probably damaging Het
Tas2r114 T A 6: 131,666,504 (GRCm39) I175F probably benign Het
Tex2 T A 11: 106,458,585 (GRCm39) probably benign Het
Tfdp1 C T 8: 13,419,529 (GRCm39) T86M possibly damaging Het
Trav14-1 C T 14: 53,791,730 (GRCm39) H27Y probably benign Het
Trim24 A T 6: 37,896,335 (GRCm39) Q264L probably benign Het
Vps13b A G 15: 35,794,567 (GRCm39) T2326A possibly damaging Het
Zfp354b A C 11: 50,813,917 (GRCm39) I336S probably benign Het
Zfp407 C T 18: 84,334,051 (GRCm39) V1761I probably damaging Het
Zfp958 A T 8: 4,678,456 (GRCm39) E160D probably benign Het
Other mutations in Vmn2r90
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Vmn2r90 APN 17 17,953,758 (GRCm39) missense probably benign 0.00
IGL01330:Vmn2r90 APN 17 17,953,542 (GRCm39) missense probably benign 0.00
IGL01989:Vmn2r90 APN 17 17,933,494 (GRCm39) nonsense probably null
IGL02080:Vmn2r90 APN 17 17,933,120 (GRCm39) missense probably damaging 1.00
IGL02112:Vmn2r90 APN 17 17,932,465 (GRCm39) missense probably damaging 0.98
IGL02123:Vmn2r90 APN 17 17,953,744 (GRCm39) missense probably benign 0.01
IGL02749:Vmn2r90 APN 17 17,947,122 (GRCm39) makesense probably null
IGL03114:Vmn2r90 APN 17 17,953,771 (GRCm39) missense probably damaging 1.00
R0131:Vmn2r90 UTSW 17 17,932,511 (GRCm39) missense probably benign 0.00
R0131:Vmn2r90 UTSW 17 17,932,511 (GRCm39) missense probably benign 0.00
R0132:Vmn2r90 UTSW 17 17,932,511 (GRCm39) missense probably benign 0.00
R0184:Vmn2r90 UTSW 17 17,947,139 (GRCm39) nonsense probably null
R0379:Vmn2r90 UTSW 17 17,948,401 (GRCm39) missense probably damaging 1.00
R1022:Vmn2r90 UTSW 17 17,948,400 (GRCm39) missense probably damaging 1.00
R1024:Vmn2r90 UTSW 17 17,948,400 (GRCm39) missense probably damaging 1.00
R1897:Vmn2r90 UTSW 17 17,953,566 (GRCm39) missense probably damaging 1.00
R1993:Vmn2r90 UTSW 17 17,933,525 (GRCm39) missense probably damaging 1.00
R2472:Vmn2r90 UTSW 17 17,948,408 (GRCm39) missense probably damaging 1.00
R2508:Vmn2r90 UTSW 17 17,954,229 (GRCm39) missense probably damaging 1.00
R2679:Vmn2r90 UTSW 17 17,933,131 (GRCm39) missense possibly damaging 0.46
R3409:Vmn2r90 UTSW 17 17,953,638 (GRCm39) missense probably benign 0.00
R4693:Vmn2r90 UTSW 17 17,953,956 (GRCm39) missense possibly damaging 0.91
R4797:Vmn2r90 UTSW 17 17,932,567 (GRCm39) missense probably damaging 1.00
R5358:Vmn2r90 UTSW 17 17,924,412 (GRCm39) critical splice donor site probably null
R5445:Vmn2r90 UTSW 17 17,954,386 (GRCm39) missense probably benign 0.04
R5446:Vmn2r90 UTSW 17 17,932,464 (GRCm39) missense probably damaging 0.99
R5567:Vmn2r90 UTSW 17 17,932,336 (GRCm39) missense probably damaging 1.00
R5680:Vmn2r90 UTSW 17 17,947,034 (GRCm39) missense possibly damaging 0.93
R5686:Vmn2r90 UTSW 17 17,933,712 (GRCm39) missense probably benign 0.02
R5751:Vmn2r90 UTSW 17 17,954,128 (GRCm39) missense probably damaging 0.96
R6156:Vmn2r90 UTSW 17 17,953,606 (GRCm39) missense probably benign 0.01
R6185:Vmn2r90 UTSW 17 17,953,644 (GRCm39) missense probably damaging 1.00
R6450:Vmn2r90 UTSW 17 17,953,498 (GRCm39) missense possibly damaging 0.47
R6707:Vmn2r90 UTSW 17 17,948,364 (GRCm39) missense probably damaging 1.00
R6802:Vmn2r90 UTSW 17 17,932,351 (GRCm39) missense probably damaging 1.00
R6913:Vmn2r90 UTSW 17 17,924,323 (GRCm39) missense probably damaging 1.00
R7070:Vmn2r90 UTSW 17 17,924,313 (GRCm39) missense probably damaging 0.98
R7237:Vmn2r90 UTSW 17 17,924,249 (GRCm39) missense possibly damaging 0.92
R7503:Vmn2r90 UTSW 17 17,933,510 (GRCm39) missense not run
R7698:Vmn2r90 UTSW 17 17,953,596 (GRCm39) missense probably benign
R7943:Vmn2r90 UTSW 17 17,932,566 (GRCm39) missense probably damaging 1.00
R8072:Vmn2r90 UTSW 17 17,947,142 (GRCm39) missense probably damaging 1.00
R8128:Vmn2r90 UTSW 17 17,954,155 (GRCm39) missense probably damaging 1.00
R8295:Vmn2r90 UTSW 17 17,948,358 (GRCm39) missense probably benign 0.03
R8345:Vmn2r90 UTSW 17 17,933,127 (GRCm39) nonsense probably null
R8682:Vmn2r90 UTSW 17 17,932,344 (GRCm39) missense possibly damaging 0.95
R8716:Vmn2r90 UTSW 17 17,924,343 (GRCm39) missense probably damaging 0.98
R9041:Vmn2r90 UTSW 17 17,954,286 (GRCm39) missense probably benign 0.00
R9412:Vmn2r90 UTSW 17 17,954,213 (GRCm39) missense probably damaging 1.00
R9607:Vmn2r90 UTSW 17 17,953,638 (GRCm39) missense possibly damaging 0.88
R9705:Vmn2r90 UTSW 17 17,933,039 (GRCm39) missense possibly damaging 0.91
Z1088:Vmn2r90 UTSW 17 17,953,879 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r90 UTSW 17 17,933,079 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GATGCCAATATTCTTGCCCTTG -3'
(R):5'- CTGTGCAATATGTCGCATTAAACC -3'

Sequencing Primer
(F):5'- GTATCCAATTTTGTTTTCTGCAGC -3'
(R):5'- GTCGCATTAAACCTTGTAGAGAAAC -3'
Posted On 2016-07-06